Gene n1170 (Tetrahymena)

n1170

Species: Tetrahymena
Alias: n1170, n.8238b, 1170
External Links:
Annotation:

Classification

Group: Other
Family: PLK
Subfamily: PLK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
n1170.AA Protein None 802 None Fasta, JSON
n1170.NA RNA None 2026 None Fasta, JSON
n1170.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of n1170.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase n1170.AA PLK-Unclassified 46-301 73 9.20000000001e-207 693.18 In-house 1-264 (264) Show / Hide 
Range on Protein: 46-301
Range on HMM: 1-264/264
Sequence Identity: 73% (194 aa)

YQRGSLLGKGGFAKCFQVTNLENKKVMAAKIIPKSTLVKNRARQKLISEIKIHKSLHHNNIVKFEHVFEDHDNVYILLELCPHQTLNELIKRR-------
|.||..|||||||||.||.|.|.||..||||||||.| ||||||||||||||||||||.|||||||.||||.|||||||.||..||.|.||||       
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

KRITELETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEKMEIKLGDFGLATKLEFDGEKKRTICGTPNYIAPEILDGRV-GHSYEVDIWSLGVILYT
||.||.|. |||.|||||||||||||.|||||||||.|....||.|..|||||||||.|||||.||||||||||||||||.  |||||||.||.|.||||
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

LLIGKPPFETHDVKTTYRKIKSNQYSFPDHAPIPDSAKALIQLILQQDPAKRPTLDEILAHPFI
||||||||||.|||.||.|||.||||||....|.|.||.||| ||...|..|||.|.|..||| 
LLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase n1170.AA PLK 46-301 63 4.90000000001e-196 643.73 In-house 1-258 (258) Show / Hide 
Range on Protein: 46-301
Range on HMM: 1-258/258
Sequence Identity: 63% (164 aa)

YQRGSLLGKGGFAKCFQVTNLENKKVMAAKIIPKSTLVKNRARQKLISEIKIHKSLHHNNIVKFEHVFEDHDNVYILLELCPHQTLNELIKRR-KRITEL
|.||..|||||||||...|....|.|.|.|..|||...|...|.|...||.||..||| |||||.|.||||.||||.||.|....|....||| ||.|| 
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

ETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEKMEIKLGDFGLATKLEFDGEKKRTICGTPNYIAPEILDGRV-GHSYEVDIWSLGVILYTLLIGKP
|. .|..||||.||||||.|.|||||||||||  ..|..|.|||||||.||.|||.|.|.||||||||||.|||   |||||||.||||.|.||||||||
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFETHDVKTTYRKIKSNQYSFPDHAPIPDSAKALIQLILQQDPAKRPTLDEILAHPFI
||||.|||.||..|| |.||||.|.|| |.|| ||| .|...|..|||.|.|| ||| 
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase n1170.AA PLK2 46-301 51 3.3e-131 424.87 In-house 1-257 (257) Show / Hide 
Range on Protein: 46-301
Range on HMM: 1-257/257
Sequence Identity: 51% (133 aa)

YQRGSLLGKGGFAKCFQVTNLENKKVMAAKIIPKSTLVKNRARQKLISEIKIHKSLHHNNIVKFEHVFEDHDNVYILLELCPH----QTLNELIKRRKRI
| || ||||||||.|.  | ... .| |.||.|.|   | . | |   || .|  |.| .||.| | ||| ||.|||||.| .    . .    | |.  
YCRGKLLGKGGFARCYEMTDMDTHYVYAVKIVPHSRVAKPHQREKMEREIELHRQLRHRHIVQFHHHFEDRDNIYILLEYCSRQVPLKSMAHMWKVRHHL

TELETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEKMEIKLGDFGLATKLEFDGEKKRTICGTPNYIAPEILDGRVGHSYEVDIWSLGVILYTLLIG
|| |   |  |||  |.|||| ..|||||||||.|. . ||.| |||||| .||. .. .||.||||||||||.| .| ||| | |||.|| | ||.|.|
TEPEVRYYMRQIVSGLRYLHQQCIIHRDLKLGNFFINDNMEVKIGDFGLAARLEPEEHCHRTMCGTPNYIAPEVL-NRQGHSCESDIWALGCIMYTMLCG

KPPFETHDVKTTYRKIKSNQYSFPDHAPIPDSAKALIQLILQQDPAKRPTLDEILAHPFI
 ||||| . | ||| |. | | .| |   |  |. ||  .| .||. || ||.|. | | 
RPPFETANLKETYRCIRHNHYHMPTHLSPP--ARHLIARMLSPDPEDRPSLDHIIRHDFF
Kinase n1170.AA PLK1 46-301 55 6.9e-131 432.61 In-house 1-253 (253) Show / Hide 
Range on Protein: 46-301
Range on HMM: 1-253/253
Sequence Identity: 55% (141 aa)

YQRGSLLGKGGFAKCFQVTNLENKKVMAAKIIPKSTLVKNRARQKLISEIKIHKSLHHNNIVKFEHVFEDHDNVYILLELCPHQTLNELIKRRKRITELE
|..|  |||||||.|. ... . |.|.|.|..||| |.|. .|.|.  ||.||..|||..|||| | |||..||||.|||| .. | || |||| ||| |
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPE

TLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEKMEIKLGDFGLATKLEFDGEKKRTICGTPNYIAPEILDGRVGHSYEVDIWSLGVILYTLLIGKPPF
.  |. |||.. .|||.|..|||||||||||. .....|.||||||||.|.|||.|.|.||||||||||.|  . |||.||||||.| |.|.||.|.|||
CRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLN-KKGHSFEVDIWSIGCIMYILLFGQPPF

ETHDVKTTYRKIKSNQYSFPDHAPIPDSAKALIQLILQQDPAKRPTLDEILAHPFI
||. .| || .|| |.|. |.|.  |  |. ||. .|..|| .||| ...|   |.
ETKCLKETYSRIKKNEYRIPSHISQP--AAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase n1170.AA AGC 46-301 22 8.9e-105 271.26 In-house 1-395 (395) Show / Hide 
Range on Protein: 46-301
Range on HMM: 1-395/395
Sequence Identity: 22% (90 aa)

YQRGSLLGKGGFAKCFQVTNL------ENKKVMAAKIIPKST-LVKNR--ARQKLISE------------IKIHKSLH----------HNNIVK-FEHVF
..   ..|||.| |...|          ..|. | |.. |..  |...    .. ..|             .| . ..          | .|||   . |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EDHDN--VYILLELCP----------H-QTLNELIK--RRKRITELETLCYTVQ-------IVQALKYLHQ-NRVIHRD-LKLGNLFVGEKMEIKLGDFG
.| |.  .|...|..|             ..  | .  ...| .| ..  |. .       || || |||. . .|||| ||. |.   |.  ||| |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LATKLEFDG--------------------------------------------------EKKRTICG--TPNYIAPEILDGRVGHSYEVDIWS--LGVIL
|....  ||                                                  ..  |.||  ||.|.|||||     .....|.||  ||...
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLM

YTLLIGKPPFETH----------DVKTTYRKIK------SNQYSFPDH--------APIPDSAKALIQLILQQDPAKRPT----------LDEILAHPFI
| .|.|.|||  .          . . .. ||.      ...  ||..          . . || ||.  |. ||.||..           .|| .||. 
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase n1170.AA S_TKc 46-301 35 2.1e-104 354.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 46-301
Range on HMM: 1-231/231
Sequence Identity: 35% (96 aa)

YQRGSLLGKGGFAKCFQVTNLENKKVMAAKIIPKSTLVKNRARQKLISEIKIHKSLHHNNIVKFEHVFEDHDNVYILLELCPH--QTLNELIKRRKR---
|. . ..|||.|.|...... . ....| |||.          .....||.|.|. || ||||.  ||.| |..|. .|.|..   .| ..||.|.|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---ITELETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEKMEIKLGDFGLATKLEFDGEKKRTICGTPNYIAPEILDGRVGHSY-EVDIWSLGVILY
   ..| .. .|. ||..||.|.|....||||||  |... |  .||..|||||..|       .|.||||.|.|||.|    |... ..|.||.|.|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILY

TLLIGKPPFETHDVKTTYRKIKSNQYSFPDHAPIPDSAKALIQLILQQDPAKRPTLDEILA-------HPFI
 .| |.|||.  .......||.            ...|| .|. .|| ||.||||  |.|.       ||..
EMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase n1170.AA Pkinase 46-301 31 4.3e-99 340.29 Pfam 1-293 (293) Show / Hide 
Range on Protein: 46-301
Range on HMM: 1-293/293
Sequence Identity: 31% (93 aa)

YQRGSLLGKGGFAKCFQVTNLENKKVMAAKIIPKSTLVKNRARQKLI-SEIKIHKSLHHNNIVKFEHVFEDHDNVYILLELCPHQ----TLNELIK--RR
|..|. .|.|.|..... ..  . |. | |||.|..  ..  ....  |||.|.|.|.| |||.. ..|||.|..|. .|.|..      | ..|.  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KRI--TELETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEKMEI----KLGDFGLATKL-EFDGEKKRTICGTPNYIAPEILDGRVGHSYEVDIWSL
...  .| |  .|  ||...|.|.|....||||||. |... ....|    |..||||| .. .  ..   |.||||.|.|||.. |. .....||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVILYTLLIGKPPFETH------DVKTTYRKIKSNQYSFPDHAPIP-------------------DSAKALIQLILQQDPAKRPTLDEILAHPFI
|.||| .| |.|||  |      | .  ...|.. ...|.   ...                   ...| .|  .|..||.|||| ..|| ||..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase n1170.AA CAMK 51-301 22 5e-99 319.76 In-house 1-425 (425) Show / Hide 
Range on Protein: 51-301
Range on HMM: 1-425/425
Sequence Identity: 22% (96 aa)

LLGKGGFAKCFQVTNLENK------------KVMAAKIIPKSTLVK-------------------------NRARQKLISEIKIHKS-------LHHNNI
 ||.|.|.| . ... ...            .  |.|||.|. | .                          . |... .||.|.|.       |.| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKFEHVFEDHDN-------------------VYILL---ELCPHQ----TLNELIKRR---------------KRITELETLCYTVQIVQALKYLHQNRV
.|. .|.||...                   .|. .   |.|.       | . |...               .|.|| |.  |  ||..|..|.|.. .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKLGNLFVGEKM-----------------EIKLGDFGLATKLEF-----------------------DGEKKRTICGTPNYIA-PEILDG------
.|||||. |. . ...                  ||. |||.|.|..                        .|.| .| |||| |.| ||.| |      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------RVGHSYEVDIWSLGVILYTLLIGKPPFETH-------------DVKTTYRKIKSNQYSFPDHA----------------------PIPDSAKA
       . ......|.||.|||||..| |.|||.               . . ...||.. .|.||..                        . ...| 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIQLILQQDPAKRPTLDEILAHPFI
||. .|| || ||.|....|.||..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase n1170.AA CAMKL 46-301 31 7e-90 287.02 In-house 1-297 (297) Show / Hide 
Range on Protein: 46-301
Range on HMM: 1-297/297
Sequence Identity: 31% (94 aa)

YQRGSLLGKGGFAKCFQVTN-LENKKVMAAKIIPKSTLVKNRARQK------------LISEIKIHKSLH---HNNIVKFEHVFEDHDN------VYILL
|. |  ||||.|.|    |. . ...  | ||| |. . ..   .|            .  ||.|.|.|.   | ||.|. .|.|. ..      .|. .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCPHQT--LNELIKRR----KRITELETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEKM--EIKLGDFGLATKLE-F---DGEKKRTICGTPNYI
|.|.     | . |...    .|..| |.  |  ||| |..|.|.....|||.|. |. . |..   ||. |||.... .     .|.| .| ||.|.| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEILDG--RVGHSYEVDIWSLGVILYTLLIGKPPFETH--------DVKTTYRKIKSNQYSFPDHAPIPDSAKALIQLILQQDPAKRPTLDEILAHPFI
||||. |  .  . ..|||||.|||||... |. ||.          .. . |.||..  | .| .  .. ... ||. .|| .| ||||...|. ||. 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase n1170.AA MARK 46-301 35 3.1e-83 271.93 In-house 1-262 (262) Show / Hide 
Range on Protein: 46-301
Range on HMM: 1-262/262
Sequence Identity: 35% (93 aa)

YQRGSLLGKGGFAKCFQVTNLENKKVMAAKIIPKSTLVKNRARQKLISEIKIHKSLHHNNIVKFEHVFE--DHDN-VYILLELCPHQTLNELIKRR--KR
|  .  .|.|..||   ....  ..  | ||..|  | .. ..... .||.|.|.|.| ||.|. ||.|  .  . .|. .|... . | . || .   |
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

ITELETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEKM--EIKLGDFGLATKLEFDGEKKRTICGTPNYIAPEILDGRVGHSYEVDIWSLGVILYTL
..| |.  .  ||| |..|.|.....|||.|. |. . |..   ||. |||.... .  |.|  | |||| | ||||. ..    ..||||||||.||..
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPP-GQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFM

LIGKPPFE--THDVKTTYRKIKSNQYSFPDHAPIPDSAKALIQLILQQDPAKRPTLDEILAHPFI
. |. ||.  | | |. |.|| . .|..|.|  ...... |||..|. .| .|||..||. ||..
VCGYFPFDGDTQDYKELYKKILRGKYDIPCH--VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase n1170.AA Ciliate-E2 46-301 26 7.1e-79 268.34 In-house 1-365 (365) Show / Hide 
Range on Protein: 46-301
Range on HMM: 1-365/365
Sequence Identity: 26% (100 aa)

YQRGSLLGKGGFAKCFQVTNLENKKVM------------------AAKIIPKSTLVKN--RARQKLISEIK-------------IHKSLHHNNIVKFEHV
|    ..|.|.|.. ..... ...|                    ..||. . .. ||  ..  . |....             | ..| |.||.|.  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--DHDNVYILLELCPHQTLNELIKRR-----------KRITELETLCYTVQIVQ---------------ALKYLHQNR-VIHRDLKLGNLFVGEKMEI
|.  | .|.|. .|.| ...| ..|| .           |..|| | . .. ||.|               ||.|||..  .||||.|. |...     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDFGLATKLEFDGEKKR-------------------------------TICGTPNYIAPEILDG--------RVGHSYEVDIWSLGVILYTLLIGKPP
|. ||||..|.  | ....                               ||||||.| ||||| |        . |..|..|||||||||| .| ||||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FETHDVKTTYRKIKSNQYSFP----------------DHAPIPDSAKALIQL----ILQQDPAKRPT-LDEILAHPFI
|        ...|| ....||                ..  .....| ||.     .|| || ||.|  ..|| ||..
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase n1170.AA ULK 46-301 29 2.3e-77 263.36 In-house 1-329 (329) Show / Hide 
Range on Protein: 46-301
Range on HMM: 1-329/329
Sequence Identity: 29% (97 aa)

YQRGSLLGKGGFAKCFQVTNLENK----KVMAAKIIPKSTLVKNR-------ARQKLISEIKIHKSLH----HNN----IVKFEHVFEDH--DNVYILLE
|.    |||| |.| .. .| ..|    .. |.|.|.|... ..        . | |..|||| | |.    |.|    |||. ..||.   .|.|| .|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LCPHQTLNELIKRR----------KRITELETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEK------------MEIKLGDFGLATKLEFDG----
.|.. .| ..||..          ||..| |.. .  ||....|.||....||||.|. |  . ..            . .|..|||.| ... |.    
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-EKKRT----ICGTPNYIAPEILD---GRVGHS-YEVDIWSLGVILYTLLIGKPPFETHDVKTTY-----RK----------IKSNQYSFP---DHAPIP
 ..  .    .|||| | ||.||    ..  .. |..||||||.|.| .| |||||..    ..|     .           ||...  ||   .. .| 
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

DSAKALIQLILQQDPAKRPTLDEILAHPFI
.  | ||.  || |. .| . .|...||..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase n1170.AA Pkinase_Tyr 86-236 29 2e-21 73.2 Pfam 43-205 (270) Show / Hide 
Range on Protein: 86-236
Range on HMM: 43-205/270
Sequence Identity: 29% (49 aa)

RA--RQKLISEIKIHKSL-HHNNIVKFEHVFE-DHDN--VYILLELCPHQTLNELIKR----RKRITELETLCYTVQIVQALKYLHQNRVIHRDLKLGNL
..  |.....|.|| |.| || |||..  |   . .   .|| .|..||  | .  ..    ....|  . |.. .|| ... ||.... |||||   | 
EQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNC

FVGEKMEIKLGDFGLATKL-------EFDGEKKRTICGTPNYIAPEILDGRVGHSYEVDIWSLGVILY
 |.|.. .| .|||||  .          |. |  |  .    ||| .  ..  . . |.|| || ..
LVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGK-FTTKSDVWSFGVLMW
Kinase n1170.AA TyrKc 46-301 23 2.8e-17 56.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 46-301
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

YQRGSLLGKGGFAKCFQVTNLENKKVMAAKIIPKSTLVKNRARQKLISEIKIHKSL--HHNNIVKFEHVFEDH-------DNVYILLELCPHQTLNELIK
 . |  || | | . .. |        | | . ...      |. ...|..| ..|  || |||..  |  ..       . ..|..|..||  |.. ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RRKR-ITELETLCYTVQIVQALKYLHQNRVIHRDLKLGNLFVGEKMEIKLGDFGLATKLEFD---GEKKRTIC-----GTP-----NYIAPEILDGRVGH
.... ..  . | . .|| .   |||....|||||   |  |||.  .| .||||. ... |   || | ..      |.         ||| .. ..  
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK-F

SYEVDIWSLGVILY---TLLIGKPPFET-----HDVKTTYRKIKSNQYSFPDHAP-------IPDSAKALIQLILQQDPAKRPTLDEILAHPFI
. . |.|| || ..   |.  |..| .       . .  ....|.  .  . . .        ||    ...   . ||..|||  ||  | ..
TTKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
POLO_box n1170.AA POLO_box 504-570 38 5.4e-23 87.5 Pfam 1-74 (74) Show / Hide 
Range on Protein: 504-570
Range on HMM: 1-74/74
Sequence Identity: 38% (30 aa)

YSSKYGLGYLLSNQSAGVV-FNDTTKIILDPKAE-YFEYIY--KKDQDEITEKHSLTE------YPTDLQKKVTLLQ
|..|||..|.||| . .|  ||| |||||.|... ...||   .   .  .  ..|..      || |||||.|.|.
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDP---NWQRQTYPLSTILEHGCYPEDLQKKLTYLK
POLO_box n1170.AA POLO_box 616-683 33 2.5e-24 91.93 Pfam 1-74 (74) Show / Hide 
Range on Protein: 616-683
Range on HMM: 1-74/74
Sequence Identity: 33% (25 aa)

MQTRHAIMFRLSNKIVQVQ-FSDKTEILLNSTDK-IVSFMN--KKGERFHYPLADAMNS--TNQDMTKRLRYTK
..|...||..|||..|||. | |.|.|.|... |  |....  ....|..||| ... .   ..|. |.|.|.|
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK