Gene n1163 (Tetrahymena)

n1163

Species: Tetrahymena
Alias: n.5825, n1163, 1163
External Links:
Annotation:

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
n1163.AA Protein None 1884 None Fasta, JSON
n1163.NA RNA None 3311 None Fasta, JSON
n1163.kin_dom Protein Kinase Domain None 455 None Fasta, JSON

Protein domain

Protein domains of n1163.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase n1163.AA GSK 1316-1770 37 6.4e-211 651.24 In-house 1-328 (328) Show / Hide 
Range on Protein: 1316-1770
Range on HMM: 1-328/328
Sequence Identity: 37% (176 aa)

ITLDKIIGNGTFGVVYLAKMN----DTQEQ----VAIKKVFQDKRYK-NREFEIIKSL---NHQNLIKLKQAYYTTQNNNVDSFFFHTFNSKINSQLRFF
.. .| ||.|.||||| |.||    .|.|.    ||||||.|||||| |||..|.| |   .|.|...||...|. .... ..                 
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDEN-----------------

LRYKKTQNCLHSLIQFTRYIQKHSKKSNTKTLIQIFNLRELDFPASHPVFYTNPILTRRYSTVIPDEVYLN-IVMEYVPETLSKVIRTYRKSKQPFPPLL
                                                                  .||.| .||||.|.||..||| |.|.||..| ..
------------------------------------------------------------------HVYCNCLVMEYMPQTLYQVIRHYVKNKQQMPIIH

LKVFSYQMFRALAYLKGIGICHRDIKPQNILCDQKTMQLKICDFGSAKKLIKGKLDILFVSYSSVVSKNLVFILISSLTAKKQIDYQQFLFKSNKKPKQL
.|...|||||.|||| ..|||||||||||||.|..|..||||||||||.|...|                                              
IKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNK----------------------------------------------

LNIQTAPFNKHQKQSEPNVSYICSRYYRAPELIFGAEQYTTAIDTWSIGTVIAEMILGEPLFPGENAVEQLVEIIKILGTPTKEQVQKMNPQHNQFNFP-
              .|||.||||||||||||||||...||..||.||.|.|.|||..|.|||||...| |||||||.||||||||.|.|||....|.|| 
--------------NEPNISYICSRYYRAPELIFGCTNYTCQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPY

----SIKPTSWTKLIKQISTVINKYSNKKQQQNANIFAKQKPDP-MLIDLISRLLVFVPTDRPTPLETLLHPYF
     |||..|.|....... .. |..||.. ....| ....|. ..|||||..||. |. |..||| ..||.|
WSFQQIKPHPWQKNDTKYEY-QT-YYHKKYR-TVYMFKWCHTDMQDWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase n1163.AA CMGC 1316-1770 19 1.3e-114 378.24 In-house 1-513 (513) Show / Hide 
Range on Protein: 1316-1770
Range on HMM: 1-513/513
Sequence Identity: 19% (124 aa)

ITLDKIIGNGTFGVVYLAKM--------------NDTQEQVAIKKVFQDKRYKN----------------REFEIIKSLN-----------------HQN
 . .| || ||.|||| ..               ..|.|.|||||..... |..                || .| | ||                 | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LIKLKQAYYTTQNNNVDSFFFHTFNSKINSQLRFFLRYKKTQNCLHSLIQFTRYIQKHSKKSNTKTLIQIFNLRELDFPASHPVFYTNPILTRRYSTVIP
..||.  .|. .... .. ..|.                                                                  |        . 
IVKLYDIFYHKNSDGNEYEDKHI------------------------------------------------------------------I-S------Q-

DEVYLNIVMEYVPETLSKVIRTYRK-----SKQPFPPLL------------LKVFS------YQMFRALA--YLKGIG--ICHRDIKPQNILCDQKT---
....|..|.||.. .| ..|. ...      ..|...               | |.      ||..|.|.  |.   .  |.|||.||.||| ....   
HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELI

----------------MQLKICDFGSAKKLIKG----------------KLDILFVSYSSVVSKNLVFILISSLTAKKQIDYQQFLFKSNKKPKQLLNIQ
                ..|||||||.|... .                 |                                                  
TRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNK--------------------------------------------------

TAPFNKHQKQSEPNVSYICSRYYRAPELIFGAEQYT---------TAIDTWSIGTVIAEMILG--------EPLFPGENA-----------VEQLVEIIK
        | ..|. .|...|.|||||...|...||         |.|| ||.| ..|||..|        .|||||..            ..|| .|.|
-----DD-KPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFK

ILGTPT---------------KEQVQKMNPQHNQFN---------------------------FPSIKPTSWTKLIKQISTVINKYSNKKQQQNANIFAK
.|||||               .|.  .|..  . ..                           || ..| .|..|.. ... .. . |||    |..| .
VLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKK----AMVF-N

Q------------------KPDPMLIDLISRLLVFVPTDRPTPLETLLHPYF
.                  . || .|||....|.. |..|.|. . | ||||
WIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase n1163.AA S_TKc 1316-1770 17 8.7e-69 235.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 1316-1770
Range on HMM: 1-231/231
Sequence Identity: 17% (81 aa)

ITLDKIIGNGTFGVVYLAKMNDTQEQVAIKKVFQDKRYKNREFEIIKSLNHQNLIKLKQAYYTTQNNNVDSFFFHTFNSKINSQLRFFLRYKKTQNCLHS
 .. ..|| |.||.||... ..|...||||..                                                                    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

LIQFTRYIQKHSKKSNTKTLIQIFNLRELDFPASHPVFYTNPILTRRYSTVIPDEVYLNIVMEYVPE---TLSKVIRTYRKSK--QPFPPLLLKVFSYQM
                      .  .||..   .       | . . | .      .| .||||..    .| ..|. ... .  .|||.   . . ||.
----------------------EHIRREIQILKK-----HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQI

FRALAYLKGIGICHRDIKPQNILCDQKTMQLKICDFGSAKKLIKGKLDILFVSYSSVVSKNLVFILISSLTAKKQIDYQQFLFKSNKKPKQLLNIQTAPF
..||.|.   ||.|||.||.|||.|.   ..||||||.|..|                                                          
CCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL----------------------------------------------------------

NKHQKQSEPNVSYICSRYYRAPELIFGAEQYTT-AIDTWSIGTVIAEMILGEPLFPGENAVEQLVEIIKILGTPTKEQVQKMNPQHNQFNFPSIKPTSWT
           ... ...|.|||..    .|.. ..| ||.| ...||. |.|.||      |. ...|..|                            
----------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG----------------------------

KLIKQISTVINKYSNKKQQQNANIFAKQKPDPMLIDLISRLLVFVPTDRPTPLETLL-------HPYF
                              .| ..|.|...|.. |..|||  | |        ||.|
------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase n1163.AA MAPK 1623-1770 31 9.9e-38 127.94 In-house 191-328 (328) Show / Hide 
Range on Protein: 1623-1770
Range on HMM: 191-328/328
Sequence Identity: 31% (50 aa)

YICSRYYRAPELIFG--AEQYTTAIDTWSIGTVIAEMIL-GEPLFPGENAVEQLVEIIKILGTPTKEQVQKMN-PQHN-----QFN-FPSIKPTSWTKLI
|.  |.|||||....  .  ||.|.| ||.|   |||.  . |||||.. ..|.  |...||||..| .|..  ..|      ... .|  .. .|.|..
YVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMF

KQISTVINKYSNKKQQQNANIFAKQKPDPMLIDLISRLLVFVPTDRPTPLETLLHPYF
.  .                     . .|. |||....||| | .| |  | | ||||
PNANF--------------------NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase n1163.AA CDK 1627-1770 27 1e-36 114.88 In-house 183-284 (284) Show / Hide 
Range on Protein: 1627-1770
Range on HMM: 183-284/284
Sequence Identity: 27% (42 aa)

RYYRAPELIFGAEQYT--TAIDTWSIGTVIAEMIL---GEPLFPGENAVEQLVEIIKILGTPTKEQ---VQKMNPQHNQFNFPSIKPTSWTKLIKQISTV
. |||||| .|...|.  |.|| ||.| ..|||..   ..|||||..  .||  |..|.|||| ..   | |.                           
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------

INKYSNKKQQQNANIFAKQKPDPMLIDLISRLLVFVPTDRPTPLETLLHPYF
                          ||....|.. |. | .  . | ||||
--------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase n1163.AA ERK 1623-1770 33 2.8e-35 123.54 In-house 176-307 (307) Show / Hide 
Range on Protein: 1623-1770
Range on HMM: 176-307/307
Sequence Identity: 33% (51 aa)

YICSRYYRAPELIFGAEQYTTAIDTWSIGTVIAEMILGEPLFPGENAVEQLVEIIKILGTP-TKEQVQKM-NPQHNQF--NFPS--IKPTSWTKLIKQIS
|. .|.|||||..  .. ||.|.| ||.|  .|||. . |||||.. |.|. .|..|.||| ..|..|.  ...  ..  |.|   ..| .| ....  .
YVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNAN

TVINKYSNKKQQQNANIFAKQKPDPMLIDLISRLLVFVPTDRPTPLETLLHPYF
                        |  |||....||| |..| |  | | ||||
----------------------CNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase n1163.AA CDK7 1627-1687 50 8.8e-35 89.73 In-house 166-226 (288) Show / Hide 
Range on Protein: 1627-1687
Range on HMM: 166-226/288
Sequence Identity: 50% (31 aa)

RYYRAPELIFGAEQYTTAIDTWSIGTVIAEMILGEPLFPGENAVEQLVEIIKILGTPTKEQ
|.|||||| ||| .|.|..| ||.| ..|| .|  | .||.. . ||. | ..||||| |.
RWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEE
Kinase n1163.AA DYRK 1622-1770 33 9.5e-34 118.44 In-house 163-320 (320) Show / Hide 
Range on Protein: 1622-1770
Range on HMM: 163-320/320
Sequence Identity: 33% (55 aa)

SYICSRYYRAPELIFGAEQYTTAIDTWSIGTVIAEMILGEPLFPGENAVEQLVEIIKILGTPTKEQVQKM-NPQHNQFNFPS------------IKPTSW
.|| ||.||||| | |  .| .||| || | ..||. .|.||||||| ..||  |. .|| |.|. ..|   .  ..| | .            .|.|  
TYIQSRFYRAPEVILGC-PYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKF-FDCFMYCECDEWTKQNKITDH

TKLIKQISTVINKYSNKKQQQNANIFAKQKPDPMLIDLISRLLVFVPTDRPTPLETLLHPYF
.. .|.. | . .. . . . | . . . . | ...|.| ..|.. |. |.|| . | || |
YMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase n1163.AA CDC2 1629-1770 32 1.6e-31 93.71 In-house 171-301 (301) Show / Hide 
Range on Protein: 1629-1770
Range on HMM: 171-301/301
Sequence Identity: 32% (48 aa)

YRAPELIFGAEQYTTAIDTWSIGTVIAEM---ILGEPLFPGENAVEQLVEIIKILGTPTKEQVQKMNPQH-NQFNFPSIKPTSWTKLIKQISTVINKYSN
|||||. .|...|.|..| |||| ..|||   .  .|||.|.   .||  | .|||||. .  . .      .  ||  ||.  .|..... .       
YRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKK------

KKQQQNANIFAKQK--PDPMLIDLISRLLVFVPTDRPTPLETLLHPYF
           |.    ||  |||....|.  | .| .  | | ||||
-----------KNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase n1163.AA Pkinase 1617-1770 23 1.7e-30 108.9 Pfam 166-293 (293) Show / Hide 
Range on Protein: 1617-1770
Range on HMM: 166-293/293
Sequence Identity: 23% (37 aa)

SEPNVSYICSRYYRAPELIFGAEQYTTAIDTWSIGTVIAEMILGEPLFPGE----NAVEQLVEIIKILGTPTKEQVQKMNPQHNQFNFPSIKPTSWTKLI
.. . .. ....|.|||.| |.. |....| ||.| ...||..|.|.|||.    | ..|.. | .|.|.|.... .. ..  . | |.  . .      
NS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------

KQISTVINKYSNKKQQQNANIFAKQKPDPMLIDLISRLLVFVPTDRPTPLETLLHPYF
                   . .   . .. ..|.|...| . |..|||. . | ||.|
-----------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase n1163.AA RCK 1623-1770 27 3.2e-28 86.4 In-house 173-298 (298) Show / Hide 
Range on Protein: 1623-1770
Range on HMM: 173-298/298
Sequence Identity: 27% (40 aa)

YICSRYYRAPELIFGAEQYTTAIDTWSIGTVIAEMILGEPLFPGENAVEQLVEIIKILGTPTKEQVQKMNPQHNQFNFPSIKPTSWTKLIKQISTVINKY
|. .|.|||||..  . .|.. .| |..| ...|     ||||| . . |. .|.|..|||.|.                     |.. .|. |..  ..
YVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKK--------------------DWPDGYKLASQMNFNF

SNKKQQQNANIFAKQKPDPMLIDLISRLLVFVPTDRPTPLETLLHPYF
 ..| .    ..  . .|  .|.|.  .|   |  |.|. . | ||||
PQCKGMPLKQLIPNCSQD--CIELMEKMLQWDPQKRITAQQALQHPYF
Kinase n1163.AA CDK-Unclassified 1627-1687 47 7.7e-26 81.88 In-house 202-262 (324) Show / Hide 
Range on Protein: 1627-1687
Range on HMM: 202-262/324
Sequence Identity: 47% (29 aa)

RYYRAPELIFGAEQYTTAIDTWSIGTVIAEMILGEPLFPGENAVEQLVEIIKILGTPTKEQ
| |||||| ||  .|.|..| ||.| ..||.. | |.|.| . .||.  |.|.||||. ..
RWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDM
Kinase n1163.AA Pkinase 1469-1552 35 7.2e-25 89.01 Pfam 71-162 (293) Show / Hide 
Range on Protein: 1469-1552
Range on HMM: 71-162/293
Sequence Identity: 35% (33 aa)

DEVYLNIVMEYVPETLSKVIRTY----RKSKQPF--PPLLLKVFSYQMFRALAYLKGIGICHRDIKPQNILCDQKTMQL----KICDFGSAKKL
|. .. .||||.. .|. |.  .    .... .|  ..  .| . ||..|.|.|.   ||.|||.||.|||.| .....    ||||||.||..
DKDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQF
Kinase n1163.AA CDK 1473-1551 33 2.8e-18 54.93 In-house 93-162 (284) Show / Hide 
Range on Protein: 1473-1551
Range on HMM: 93-162/284
Sequence Identity: 33% (28 aa)

LNIVMEYVPETLSKVIRTYRKSKQPFPPLLLKVFSYQMFRALAYLKGIGICHRDIKPQNILCDQKT----MQLKICDFGSAKK
| .|.||..  |.|...              | . .|. |.|.|.   .| |||.|||||| . .     ..||| ||| |..
LYMVFEYMDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARA
Kinase n1163.AA Pkinase 1316-1381 25 2.1e-16 59.09 Pfam 1-74 (293) Show / Hide 
Range on Protein: 1316-1381
Range on HMM: 1-74/293
Sequence Identity: 25% (19 aa)

ITLDKIIGNGTFGVVYLAKMNDTQEQVAIKKVFQDKRYKNR--------EFEIIKSLNHQNLIKLKQAYYTTQN
... ..|| |.||.||...  .|...||.|..  ... ..         | .| |.||| | ..|. .... ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDH
Kinase n1163.AA RCK 1466-1550 28 7.3e-16 46.53 In-house 66-162 (298) Show / Hide 
Range on Protein: 1466-1550
Range on HMM: 66-162/298
Sequence Identity: 28% (28 aa)

VIPDEV--YLNIVMEYVPETLSKVIRTYRKSKQPFPPLL--LKVFSYQMFRALAYLKGIGICHRDIKPQNILCDQK--------TMQLKICDFGSAK
|| |.    | .|.||. . |.. .... ......|     .|   || . .||..   |. |||.|| ||.|  .        .  .||.|||...
VIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCR
Kinase n1163.AA CDK-Unclassified 1475-1549 38 4.4e-15 45.94 In-house 98-173 (324) Show / Hide 
Range on Protein: 1475-1549
Range on HMM: 98-173/324
Sequence Identity: 38% (32 aa)

IVMEYVPETLSKVIRTYRKSKQPFPPLL---LKVFSYQMFRALAYLKGIGICHRDIKPQNILCDQKT-----MQLKICDFGSA
.||||.| |.. .    |       .|     . |  ||.  .|||   .| |||||||||. . ..     | ||| |||.|
MVMEYMPYTWYNQLHNNRY------NLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPM-LKIADFGQA
Kinase n1163.AA CDC2 1473-1547 38 7.9e-14 38.36 In-house 75-148 (301) Show / Hide 
Range on Protein: 1473-1547
Range on HMM: 75-148/301
Sequence Identity: 38% (29 aa)

LNIVMEYVPETLSKVIRTYRKSKQPFPPLLLKVFSYQMFRALAYLKGIGICHRDIKPQNILCDQKTMQLKICDFG
| .| ||.   | |  . . ......|| |.| . ||. ......   .| |||.|||||| | |   .|| |||
LYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-IKIADFG
Kinase n1163.AA MAPK 1475-1547 37 9.3e-13 40.23 In-house 93-162 (328) Show / Hide 
Range on Protein: 1475-1547
Range on HMM: 93-162/328
Sequence Identity: 37% (28 aa)

IVMEYVPETLSKVIRTYRKSKQPFPPLLLKVFSYQMFRA--LAYLKGIGICHRDIKPQNILCDQKTMQLKICDFG
||||.    | ..|.. .    |      . | ||. |.  | |.   .. |||.|| |||...    |||||||
IVMELMETDLHQIIKSQQ----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCD-LKICDFG
Kinase n1163.AA CDC2 1320-1384 31 3.4e-12 33.26 In-house 5-75 (301) Show / Hide 
Range on Protein: 1320-1384
Range on HMM: 5-75/301
Sequence Identity: 31% (23 aa)

KIIGNGTFGVVYLAKMNDTQEQVAIKKVFQDKRYKN--------REFEIIKSLN-HQNLIKLKQAYYTTQNNNV
. || ||.|||| .| ..|...||.||.  .             ||  ..| |. |.|..||.  ..    |..
EKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKL
Kinase n1163.AA CDK-Unclassified 1318-1377 30 9.3e-12 34.82 In-house 3-78 (324) Show / Hide 
Range on Protein: 1318-1377
Range on HMM: 3-78/324
Sequence Identity: 30% (23 aa)

LDKIIGNGTFGVVYLAKMNDTQEQVAIKKVFQDK-------------RYK---NREFEIIKSLNHQNLIKLKQAYY
 ....| |||| |..|   .|| .|||||..                . |   .||  . . .|| |.||. . .|
MQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHY
Kinase n1163.AA Pkinase_Tyr 1316-1372 30 1.1e-11 40.16 Pfam 1-69 (270) Show / Hide 
Range on Protein: 1316-1372
Range on HMM: 1-69/270
Sequence Identity: 30% (21 aa)

ITLDKIIGNGTFGVVYLAKMN----DTQEQVAIKKVFQDKRYKN-------REFEIIKSL-NHQNLIKL
||..| .| | ||.||.....    .|. .||.|.. ..   ..       || .| |.| .|.|...|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL
Kinase n1163.AA CDK 1317-1373 30 2.8e-11 32.17 In-house 2-73 (284) Show / Hide 
Range on Protein: 1317-1373
Range on HMM: 2-73/284
Sequence Identity: 30% (22 aa)

TLDKIIGNGTFGVVYLAKMNDTQ-----EQVAIKKVF--------QDKRYKN---REFEIIKSLNHQNLIKLK
   . || ||.|||| |.  .|.     . ||.||.          .        ||  . | | |.| .||.
EKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLH
Kinase n1163.AA DYRK 1494-1549 33 7.8e-11 36.98 In-house 95-154 (320) Show / Hide 
Range on Protein: 1494-1549
Range on HMM: 95-154/320
Sequence Identity: 33% (20 aa)

SKQPF-PPLLLKVFSYQMFRALAYLKGI-GICHRDIKPQNILCDQ--KTMQLKICDFGSA
..|.| .  | ..| .|.. .| .|.    | | |.|| ||.  |  .  ..|..||||.
HFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSS
Kinase n1163.AA CDK7 1317-1347 45 4e-10 22.72 In-house 2-32 (288) Show / Hide 
Range on Protein: 1317-1347
Range on HMM: 2-32/288
Sequence Identity: 45% (14 aa)

TLDKIIGNGTFGVVYLAKMNDTQEQVAIKKV
.  | || |.|..||.|    | . |||||.
EKIKHIGEGQFATVYKACDHQTGQIVAIKKI
Kinase n1163.AA RCK 1317-1373 36 3.2e-09 25.11 In-house 2-64 (298) Show / Hide 
Range on Protein: 1317-1373
Range on HMM: 2-64/298
Sequence Identity: 36% (24 aa)

TLDKIIGNGTFGVVYLAKMNDTQEQVAIKKVFQDKRYKN-------REFEIIKSLN-HQNLIKLK
.. | .| ||.|.| .|.  .|.| |||||    .....       ||   .. || | |.||||
QIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLK
Kinase n1163.AA CDK7 1743-1770 35 7.3e-09 19.29 In-house 261-288 (288) Show / Hide 
Range on Protein: 1743-1770
Range on HMM: 261-288/288
Sequence Identity: 35% (10 aa)

LIDLISRLLVFVPTDRPTPLETLLHPYF
|.||..... . |  | |  . | .|||
LLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase n1163.AA TyrKc 1316-1628 13 4.4e-08 -91.94 SMART 1-280 (280) Show / Hide 
Range on Protein: 1316-1628
Range on HMM: 1-280/280
Sequence Identity: 13% (50 aa)

ITLDKIIGNGTFGVVYLAKMNDTQEQVAIKKVFQDKRYKN--REFEIIKSL--NHQNLIKLKQAYYTTQNNNVDSFFFHTFNSKINSQ------LRFFLR
|||.|..|.| ||.||.....   .|||.|..  |.  .   || .| ..|  .|.|...|  .  . . |     |       |         |. .||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-----FMYIEPLMIVMEYMPHGDLKDYLR

YKKTQNCLHSLIQFTRYIQKHSKKSNTKTLIQIFNLRELDFPASHPVFYTNPILTRRYSTVIPDEVYLNIVMEYVPETLSKVIRTYRKSKQPFPPLLLKV
... .                                                                                       ...  |  
KHRPK---------------------------------------------------------------------------------------LCMKDLLS

FSYQMFRALAYLKGIGICHRDIKPQNILCDQKTMQLKICDFGSAKKLIKG-KL----DILFVSY--SSV-----------VSKNLVF-------------
|..|  .  .||   .. |||.   |.| . .  . ||.||| ....  . .     |   ..   ..            . .  .|             
FCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCM

-----------IL-----ISSLTAKKQIDYQQFLFKSNK--------KPKQLLNIQTAPFNKHQKQSEPNVSYICSRY
                  .|   . ....    . .            |. . .       ...  . |. | |... 
WEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase n1163.AA MAPK 1316-1387 27 2.3e-07 21.26 In-house 1-88 (328) Show / Hide 
Range on Protein: 1316-1387
Range on HMM: 1-88/328
Sequence Identity: 27% (24 aa)

ITLDKIIGNGTFGVVYLAKMND------TQEQVAIKKV---FQDKRYKN---REFEIIKSL-NHQNLIKLKQAYYTTQ---NNNVDSF
 ...| || | .|||  |. .       ....|||||.   ||.. .     ||  . . . .| | |||.  .. ..   .|. ..|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEF
Kinase n1163.AA ERK 1506-1547 47 6.6e-07 21.96 In-house 113-153 (307) Show / Hide 
Range on Protein: 1506-1547
Range on HMM: 113-153/307
Sequence Identity: 47% (20 aa)

FSYQMFRALAYLKGIGICHRDIKPQNILCDQKTMQLKICDFG
| ||. ..| |.   .. |||.|| |||.  .  .|||||||
FMYQILCGLKYIHSANVIHRDLKPSNILVN-SNCDLKICDFG
Kinase n1163.AA CDK7 1522-1550 55 8e-06 10.98 In-house 123-150 (288) Show / Hide 
Range on Protein: 1522-1550
Range on HMM: 123-150/288
Sequence Identity: 55% (16 aa)

ICHRDIKPQNILCDQKTMQLKICDFGSAK
| |||.|| | | ..   |||| ||| |.
ILHRDLKPNNLLMNENG-QLKIADFGLAR
Kinase n1163.AA ERK 1317-1373 31 2.6e-05 15.93 In-house 2-70 (307) Show / Hide 
Range on Protein: 1317-1373
Range on HMM: 2-70/307
Sequence Identity: 31% (22 aa)

TLDKIIGNGTFGVVYLAKMND-----TQEQVAIKKV---FQDKRYKN---REFEIIKSLN-HQNLIKLK
 . | || |..|||  |. .      |.. |||||.   | ...| .   ||  . . .. | |.|.|.
QIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLF
Kinase n1163.AA DYRK 1316-1345 40 4.5e-05 15.2 In-house 1-30 (320) Show / Hide 
Range on Protein: 1316-1345
Range on HMM: 1-30/320
Sequence Identity: 40% (12 aa)

ITLDKIIGNGTFGVVYLAKMNDTQEQVAIK
 . ...|| |.|| |  .. . |.| ||||
YEILEYIGKGSFGQVVKCWDHKTNEMVAIK
Kinase n1163.AA CDK-Unclassified 1744-1770 25 0.004403 5.83 In-house 298-324 (324) Show / Hide 
Range on Protein: 1744-1770
Range on HMM: 298-324/324
Sequence Identity: 25% (7 aa)

IDLISRLLVFVPTDRPTPLETLLHPYF
..... .... |  |..  | | ||.|
NNCEFQMVMYQPYNRWKCMEILQHPWF
Kinase n1163.AA Pkinase_Tyr 1475-1547 36 0.286969 4.92 Pfam 84-156 (270) Show / Hide 
Range on Protein: 1475-1547
Range on HMM: 84-156/270
Sequence Identity: 36% (27 aa)

IVMEYVPE-TLSKVIRTYRKSKQPFPPLLLKVFSYQMFRALAYLKGIGICHRDIKPQNILCDQKTMQLKICDFG
|||||.|   | .  |. | .|||...  |  ...|  ....||  ... |||.   |.| .  ... ||||||
IVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFG