Gene n1164 (Tetrahymena)

n1164

Species: Tetrahymena
Alias: 1164, n.22242, n1164
External Links:
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
n1164.AA Protein None 1236 None Fasta, JSON
n1164.NA RNA None 2103 None Fasta, JSON
n1164.kin_dom Protein Kinase Domain None 238 None Fasta, JSON

Protein domain

Protein domains of n1164.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase n1164.AA NEK 143-383 45 8.4e-146 490.67 In-house 1-286 (286) Show / Hide 
Range on Protein: 143-383
Range on HMM: 1-286/286
Sequence Identity: 45% (129 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNV-----YVMKQINISKMNSRMKQDAI-NEVHILSKLNNPYVVKYYDSFVDKN--LLCIVMEYCD-SGDLSSF---
.. . |.||||||.||||.|  ||..     ||.|.||...|... ||.|. |||.||..|..|..|||||||....   ||||||||.  |||. .   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IKSQL--GRPLQEMKIW--------------KK-----KILHRDIKAMNIFLNKDDS----LRIGDLGVAKVLSDQGNFAST-MVGTPFYLSPEMCEEKP
|| |   | ...|..||              ..     |||||||| .||||.|...    ..|||.|..|||..   .|.| .|||| |.|||.|..||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNEKSDIWSLGCVLYELCTY--RHPFEAQ--NQGALVLRIIRG-KYNPIPTS--YSKDLVSMVDMCLCKDYKKRPNARDILQTQRK
||.|||||||||||||.||   .|||||.  |. .|...|..| .|.|||    ||.|| ... ..|.|| ..||....||..   
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase n1164.AA NEK4 143-383 38 2.3e-81 276.65 In-house 1-257 (257) Show / Hide 
Range on Protein: 143-383
Range on HMM: 1-257/257
Sequence Identity: 38% (98 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNVYVMKQINISKMNSRMKQDAINEVHILSKLNNPYVVKYYDSF-VDKN-LLCIVMEYCDSGDLSSFIKSQLGRPLQ
.. .   |.||.| |. |.   |.  |||| ..  .  .| ...|  |. .||.|  | .|.| .|.  . . .|.||| .|..|||    | | .  |.
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EMKI--W------------KKKILHRDIKAMNIFLNKDDSLRIGDLGVAKVLSDQGNFASTMVGTPFYLSPEMCEEKPYNEKSDIWSLGCVLYELCTYRH
|  .  |            .|.||||| |  |||| |   ..|||.|...|| . ...|.||.|||.|.|||.   .||. ||||||||| .||. | .|
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

PFEAQNQGALVLRIIRGKYNPIPTSYSKDLVSMVDMCLCKDYKKRPNARDILQTQRK
 |.| .   |. .|| |.  |.|  ||.||  .|   | |  .|||  .||.|    
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase n1164.AA S_TKc 143-383 30 1.8e-74 254.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 143-383
Range on HMM: 1-231/231
Sequence Identity: 30% (81 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNVYVMKQINISKMNSRMKQDAINEVHILSKLNNPYVVKYYDSFVDKNLLCIVMEYCDS--GDLSSFIKSQLGRP--
.. | |.|.|.||.|||.. . .| .. .|.|.         .....|. ||.| . |..||.||.|.| . |..||||||   ||| ..||.. ...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LQEMKIW--------------KKKILHRDIKAMNIFLNKDDSLRIGDLGVAKVLSDQGNFASTMVGTPFYLSPEMCEEKPYNE-KSDIWSLGCVLYEL
  . |  ..              ...|.|||.|  ||.|..   . |.| |.|..|       .|..|||.|..||..   .|.  |.|.||.||.|||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

CTYRHPFEAQNQGALVLRIIRGKYNPIPTSYSKDLVSMVDMCLCKDYKKRPNARDILQ-------TQRK
.. . ||.   | ......|.          |... .... ||.|| .||| | ..||        .  
LCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase n1164.AA NEK8 246-378 45 2.7e-72 205.66 In-house 137-273 (278) Show / Hide 
Range on Protein: 246-378
Range on HMM: 137-273/278
Sequence Identity: 45% (63 aa)

KKKILHRDIKAMNIFLNKD-DSLRIGDLGVAKVLSDQGNFA-S-TMVGTPFYLSPEMCEEKPYNEKSDIWSLGCVLYELCTYRHPFEAQNQGALVLRIIR
.. |||||.|  |||....   . ||| | .|....    . . | |||| |.|||||| ||||.|||.|.|||||||.|. .  ||| |. |||. |..
QHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQ

G-KYNPIPTSYSKDLVSMVDMCLCKDYKKRPNARDIL
. .|.||.  ||... ..|  || .|  .|| |  |.
CRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIM
Kinase n1164.AA NEK1 246-379 48 4.9e-66 225.7 In-house 122-272 (276) Show / Hide 
Range on Protein: 246-379
Range on HMM: 122-272/276
Sequence Identity: 48% (73 aa)

KKKILHRDIKAMNIFLN--KDD---------------SLRIGDLGVAKVLSDQGNFASTMVGTPFYLSPEMCEEKPYNEKSDIWSLGCVLYELCTYRHPF
..||||||||. ||||   |..                ...|| |.|..|..   .|.| .||| |||||.|. |||| ||||||||||||||||  |||
DRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNNKSDIWSLGCVLYELCTLKHPF

EAQNQGALVLRIIRGKYNPIPTSYSKDLVSMVDMCLCKDYKKRPNARDILQ
||.|  .|||.|..| | |||  ||..| | |   . .. . || . .||.
EANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILE
Kinase n1164.AA STE 143-379 22 9.3e-65 221.46 In-house 1-353 (359) Show / Hide 
Range on Protein: 143-379
Range on HMM: 1-353/359
Sequence Identity: 22% (82 aa)

FDTLGKLGQGSFGVVYKVKRVV---------------DGNVYVMKQINISKMNS---------------RMKQDAINEVHILSKLN--NPYVVKYYDSFV
.. ..|.|.|.||.||| ...                 |... .||.|... |.                 .|. ..|. |..|.|   |..||||....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DK-------NLLCIVMEYCDSGDLSSFIK---------------------SQLGRPLQE-----MKIWK-KKILHRDIKAMNIFLNKDDSLRIGDLGVAK
..       . |.|.|||.| | |...||                     ||... ...     .. .  ..| |||||. ||.|       . | ||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VLSD----------------QGNFASTMVGTPFYLSPEMCEE------KPYNEKSDIWSLGCVLYELCTYRHPFEAQNQGALVLRIIRG-----------
 |.|                ..    |.|||| . .||. .       |.|..|.|||||||.. |..| ..|.   .     ..|...           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----KYNPIPT-------------------SYSKDLVSMVDMCLCKDYKKRPNARDILQ
    .  |.|.                   ..|...   .. || ||..|||.| . |.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLK
Kinase n1164.AA NEK-Unclassified 143-383 33 2.2e-60 198.54 In-house 1-258 (258) Show / Hide 
Range on Protein: 143-383
Range on HMM: 1-258/258
Sequence Identity: 33% (87 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNVYVMKQINISKMNSRMKQDAINEVHILSKLNNPYVVKYYDSFVDKNLLCIVMEYCDSGDLSSFIKSQLGR--PLQ
.| .  ||||  | || |.  .     | .   |||   . |    | . |||.|  | .| | ||| .   |    .||| |.|   |. . ..  |. 
YDKITTLGQGGGGAVYLVRHQISKRHLVQQ---ISKRKKKKKRQ--NKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFD

EMKIWK--------------KKILHRDIKAMNIFLNKDDSLRIGDLGVAKVLSDQGNFASTMVGTPFYLSPEMCEEKPYNEKSDIWSLGCVLYELCTYRH
|  | .              .||.||| |  |||| .|| . .|| |..... .    | | |||. ..||| |...|||..||.|||||..||.||.  
EGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEP

PFEAQNQGALVLRIIRGKY------NPIPTSYSKDLVSMVDMCLCKDYKKRPNARDILQTQRK
 | ..| | .   | ..         |.   || ||  ..   | ... .|| | .|.     
FFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase n1164.AA Ciliate-E2 143-379 21 3.5e-56 191.37 In-house 1-361 (365) Show / Hide 
Range on Protein: 143-379
Range on HMM: 1-361/365
Sequence Identity: 21% (80 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNVY------------------VMKQINISKMNSRMKQDAINEVHIL----------------SKLNNPYVVKYYDS
.. . |.|||.||.|||.|.  ... .                   .|....  |. ....   .| ||.                ..||.|...|.|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FV--DKNLLCIVMEYCDSGDLSSFIK-----------------SQLGRPLQEMKIW---------------------KKK-ILHRDIKAMNIFLNKDDSL
|   |.| . .|||||. ||| ..||                  .  . . .  .                      .|. |.|||||  ||..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

RIGDLGVAKVLSDQ----------G---------------------NFASTMVGTPFYLSPEMCEEKP---------YNEKSDIWSLGCVLYELCTYRHP
 | |.| .| ..|.          .                     | . | .||| |..||. . |.         |..|.||||||..|||... ..|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FEAQNQGALVLRIIRG-KYN-P----------------IPTSYSKDLVSMVDM----CLCKDYKKRPN-ARDILQ
|         ...|   |.. |                .. . |..   .       .|.|| .||.. . .||.
F---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase n1164.AA NEK6 143-374 37 3.8e-56 183.19 In-house 1-252 (252) Show / Hide 
Range on Protein: 143-374
Range on HMM: 1-252/252
Sequence Identity: 37% (95 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNVYVMKQINISKM-NSRMKQDAINEVHILSKLNNPYVVKYYDSFVDKNLLCIVMEYCDSGDLSSFIK--SQLGRPL
|    |.|.| |  ||. . ..|. .  .|.. |  |   . .|| | |. .| .|| | |.|||.||.. | | ||.|  | ||.|  ||   . .| .
FQIEKKIGKGQFSEVYRAQCLWDDKHVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNVIKYYASFIENNELNIVLELADAGDMSRMIKHFKKQKRLI

QEMKIWK--------------KKILHRDIKAMNIFLNKDDSLRIGDLGVAKVLSDQGNFASTMVGTPFYLSPEMCEEKPYNEKSDIWSLGCVLYELCTYR
 |  |||              |...|||||  |.|.  .   ..||||. .  | .   |  .||||.|.|||  .|. || |||||||||.|||.    
PERTIWKYFVQLCSALEHMHSKRVMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQ

HPF--EAQNQGALVLRIIRGKYNPIPTS-YSKDLVSMVDMCLCKDYKKRPNA
 ||  .  |  .|  .| .  | |.|.  ||..|  .| ||.. | ..||. 
SPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase n1164.AA CAMK 148-379 16 7.7e-56 178.07 In-house 1-421 (425) Show / Hide 
Range on Protein: 148-379
Range on HMM: 1-421/425
Sequence Identity: 16% (71 aa)

KLGQGSFGVVYKVKRVVDG------------NVYVMKQINISKMN--------------------------SRMKQDAINEVHILSK-------LNNPYV
.||.||||.|.....  ..              . .| |. .|.                            ....   .|..|..|       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKYYDSFVD-------------------KNLLCIVM---EYCDSG----DLSSFIKSQLG-------------RPLQEMK--------------IWKKKI
.| |. . |                   .. ...||   |||. |    || ..|... .             . ..|                . ...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDIKAMNIFLNKDD-----------------SLRIGDLGVAKVLSD-----------------------QGNFASTMVGTPFYLS-PEMCE-------
 |||.|  || |....                  . | | | |... .                       .|   .|..||| | . ||. .       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------EKPYNEKSDIWSLGCVLYELCTYRHPFEAQ-------------NQGALVLRIIRGKYNPIPTSYSK-----------------------DLVS
       ...|..|.|.||.|..|| . . . ||..              |.  |  .|..|||. .|   |.                       .  .
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

MVDMCLCKDYKKRPNARDILQ
..  .|..| .||... ..|.
LIRKMLQVDPEKRMTIEQCLN
Kinase n1164.AA NEK2 246-383 35 1.5e-49 164.94 In-house 143-319 (319) Show / Hide 
Range on Protein: 246-383
Range on HMM: 143-319/319
Sequence Identity: 35% (62 aa)

KKKILHRDIKAMNIFLNKDDS---------------------------------------LRIGDLGVAKVLSDQGNFASTMVGTPFYLSPEMCEEKPYN
|. |||||||  ||||  |..                                          || | |..|     || | ||||.| |||  .  .||
KHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYN

EKSDIWSLGCVLYELCTYRHPFEAQNQGALVLRIIRGKYNPIPTSYSKDLVSMVDMCLCKDYKKRPNARDILQTQRK
|||||||.||..||.|. . ||.| || .|   |  |....||  ||..|   .   .  | ..||.   |||  . 
EKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase n1164.AA Pkinase 247-380 30 1.6e-36 130.21 Pfam 127-290 (293) Show / Hide 
Range on Protein: 247-380
Range on HMM: 127-290/293
Sequence Identity: 30% (50 aa)

KKILHRDIKAMNIFLNKDDSL----RIGDLGVAKVL-SDQGNFASTMVGTPFYLSPEMCE-EKPYNEKSDIWSLGCVLYELCTYRHPFEAQ------NQG
..|.|||.|  ||...... .    .|.| |.||..    .  ..| .|||.|..|| .   ..|  |.|.||.||.|||... | ||  .      .| 
MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQM

ALVLRIIRGKYNPI-PTSYS-------------------KDLVSMVDMCLCKDYKKRPNARDILQT
... || ....    |...|                   ... . .. ||||| ||||.|..||| 
QMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH
Kinase n1164.AA NEK1 143-244 41 4.7e-32 108.55 In-house 1-106 (276) Show / Hide 
Range on Protein: 143-244
Range on HMM: 1-106/276
Sequence Identity: 41% (44 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNVYVMKQINISKMNSRMKQDAINEVHILSKLNNPYVVKYYDSFVDKNL--LCIVMEYCDSGDLSSFIKSQ--LGRP
.. . ..|.|||| ...||.  || .||.| ||..|| .  .... ||| ||.|.  | .|||..||.      | ||||||| |||   |. |   | .
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

LQEMKI
 .|  |
FSEDQI
Kinase n1164.AA NEK2 143-232 42 3.6e-29 95.3 In-house 1-92 (319) Show / Hide 
Range on Protein: 143-232
Range on HMM: 1-92/319
Sequence Identity: 42% (39 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNVYVMKQINISKMNSRMKQDAINEVHILSKLNNPYVVKYYDSFVDKN--LLCIVMEYCDSGDLSSFIK
 . |. .|.||||...||.|  || . | | |.  .|..  .|  ..|. ||..|  |..|.|||  .|.    | ||||||  ||||. ||
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIK
Kinase n1164.AA Pkinase 143-244 31 1.4e-28 102.1 Pfam 1-110 (293) Show / Hide 
Range on Protein: 143-244
Range on HMM: 1-110/293
Sequence Identity: 31% (35 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNVYVMKQINISKMNSRMKQDAIN--EVHILSKLNNPYVVKYYDSFVDKNLLCIVMEYCDSG----DLSSFIKSQLG
. ...|.|.||||.||| ... .| ....|.|. .. .| ..| ...  |..|. .|| |..|..||.| ||. ...|||||. |    ||...|. . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RPL--QEMKI
...  .|  .
GCFYFSEWEC
Kinase n1164.AA NEK8 149-243 36 1.9e-28 78.2 In-house 7-103 (278) Show / Hide 
Range on Protein: 149-243
Range on HMM: 7-103/278
Sequence Identity: 36% (35 aa)

LGQGSFGVVYKVKRVVDG--NVYVMKQINISKMNSRMKQDAINEVHILSKLNNPYVVKYYDSFVDKNLLCIVMEYCDSGDLSSFIKSQLGRPLQEMK
.|.|.||..    |  |.     . |||| . | ..  |.| ||. .||.|. | .. |||.| . | | |.|||.| | |  .| .| .  . |..
VGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFEEER
Kinase n1164.AA TyrKc 143-381 20 6.8e-17 50.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 143-381
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

FDTLGKLGQGSFGVVYK--------VKRVVDGNVYVMKQINISKMNSRMKQDAINEVHILSKL--NNPYVVKYYDSFVDK-------NLLCIVMEYCDSG
   . ||| | ||.|||        || . ..                 ..| ..|  |..||  ..| .|. |   ...         |.|||||.. |
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA----------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

DLSSFIKSQLGRPLQEMKIW-------------KKKILHRDIKAMNIFLNKDDSLRIGDLGVAKVLSDQ---GNFASTMV-----GTP-----FYLSPEM
|| .....  ..   . ..              .|.. |||. | |. ....   .|.| | .. . |    |   .. .     |.        ..|| 
DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

CEEKPYNEKSDIWSLGCVLYELCTY-RHPFEA-----QNQGALVLRIIRGKYNPIPTS--------YSKDLVSMVDMCLCKDYKKRPNARDILQTQ
  .. ...|||.|| | ...|..||   | .       .   .. .. .|.. |.| .         .... ..  .|   | ..||. ..| .  
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase n1164.AA Pkinase_Tyr 143-239 26 6.2e-09 30.89 Pfam 1-108 (270) Show / Hide 
Range on Protein: 143-239
Range on HMM: 1-108/270
Sequence Identity: 26% (29 aa)

FDTLGKLGQGSFGVVYKVKRV-----VDGNVYVMKQINISKMNSR-MKQDAINEVHILSKL-NNPYVVKYYDSFV-DKNL--LCIVMEYCDSGDLSSFIK
   . |||.|.||.||| .        .  |   | .. . | .  ...| ..|. |...| ..| .|..|   . ..    ..|||||.  ||| .. .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPV-AVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SQ--LGRPL
..   ..||
KHREDKQPL
Kinase n1164.AA Pkinase_Tyr 247-324 27 2.9e-07 25.24 Pfam 130-210 (270) Show / Hide 
Range on Protein: 247-324
Range on HMM: 130-210/270
Sequence Identity: 27% (22 aa)

KKILHRDIKAMNIFLNKDDSLRIGDLGVAKVL--SDQG-NFASTMVGTPFYLSPEMCEEKPYNEKSDIWSLGCVLYELCTY
|.. |||. | |. ....   .|.| | |. .   |.    ..      . ..||   .. ...|||.|| | ...|..||
KNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTY