Gene n1058 (Tetrahymena)

n1058

Species: Tetrahymena
Alias: 1058, 615.m00002, n1058
External Links:
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
n1058.AA Protein None 210 None Fasta, JSON
n1058.NA RNA None 630 None Fasta, JSON
n1058.kin_dom Protein Kinase Domain None 120 None Fasta, JSON

Protein domain

Protein domains of n1058.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase n1058.AA Ciliate-C7 78-210 82 4.90000000001e-102 327.85 In-house 1-134 (164) Show / Hide 
Range on Protein: 78-210
Range on HMM: 1-134/164
Sequence Identity: 82% (111 aa)

FRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQ-GTLTQILERNQNKRLN
||||||| |||||||||.|||||||||||||||.|||.|.|.||.|.||..|||.|.||||||.|..|||||||.||||.||| |||.||.|||||||||
FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN

EISAIKYANDIAQGLYYIHSKSCLVNDLKMDNIL
||||||||.||||||||||||.|.||||||||||
EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNIL
Pkinase n1058.AA Pkinase 75-210 27 2.6e-20 72.9 Pfam 1-140 (293) Show / Hide 
Range on Protein: 75-210
Range on HMM: 1-140/293
Sequence Identity: 27% (39 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQG-----TLTQILER
|   | .|.|  | | .... .|. ..|.| . .|.   . |. . ..  .|..|.|.. ..|..| |.| ||  .  |.|.  |.|      |  ....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

NQNKRL--NEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNIL
 .....   |  ...|.  |..||.|.||....  ||| .|||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENIL
Kinase n1058.AA ULK 75-210 25 7.4e-17 55.45 In-house 1-162 (329) Show / Hide 
Range on Protein: 75-210
Range on HMM: 1-162/329
Sequence Identity: 25% (42 aa)

YSDFRFLGQGVQGLVLLAKDSKT----NMRYAIKGVQ----VRDPQ---GNLDEDLNNRVKQEVEILKKCRD---SPY----VVSLIDQFEGQQF--SYL
|.  . ||.|  | |  ... ||    |  .|.| ..     ....   |   . . . .|.|..|.||  .   ...    .| |.| || ...   |.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEG---QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYI

VLTECQG-TLTQILERNQN--------KRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNIL
..  |.| .| |....|..        |||.|  ||..  .|..|. ..|.. .   |.| .|||
IMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNIL
Kinase n1058.AA ULK 75-210 26 1.5e-16 55.32 In-house 1-158 (324) Show / Hide 
Range on Protein: 75-210
Range on HMM: 1-158/324
Sequence Identity: 26% (43 aa)

YSDFRFLGQGVQG-LVLLAKDSKT---NMRYAIKGVQ--------VRDPQGNLDEDLNNRVKQEVEILKKCR--DSPY--VVSLIDQFEGQ--QFSYLVL
|.  . ||.|  |  |  ... ||   |  .|.| ..         ... |   . . .  |.|..|.||     .|.  .| |.| || .   . |...
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQE-G---QYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIM

TECQG-TLTQILERNQN-------KRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNIL
  |.| .| |....|..       |||.|  ||..  .|..|. ..|.. .   |.| .|||
EYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNIL
Kinase n1058.AA CAMK 80-197 17 1.1e-15 46.33 In-house 1-198 (425) Show / Hide 
Range on Protein: 80-197
Range on HMM: 1-198/425
Sequence Identity: 17% (35 aa)

FLGQGVQGLVLLAKDSKTN------------MRYAIKGVQV----------------RDPQGNLD------EDLNNRVKQEVEILKKCR------DSPYV
 ||.|  | | |... .|.             ..||| .                  .| ... .      .    .|..|.||.||..      | | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSLIDQFEG-------------------QQFSYLVL---TECQGT------LTQILERNQN------------KRLNEISAIKYANDIAQGLYYIHSK
..|.. .|                    ... |.|.     |.|       .  | |. ..            .|..|  | .|   |.... |.||.
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH
Kinase n1058.AA Ciliate-E2 75-210 20 1.3e-15 50.0 In-house 1-193 (365) Show / Hide 
Range on Protein: 75-210
Range on HMM: 1-193/365
Sequence Identity: 20% (40 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRYAIK-------------GVQ-VRDPQGNLDEDLNNRVKQEVEILKKCR---------------DSPYVVSLIDQ
|   . .||| .| | ..|. |.. ..|||             .|.       .. ..  . .|||  |... .               ..|... ... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--GQQFSYLVLTECQG-TLTQILERN----------QNKRLNEISAIKYANDIAQ---------------GLYYIHSKS-CLVNDLKMDNIL
|.   ..  |||.  ||| .| .... |          . |...|  ....   |.|               .| |.|||  ..  |.| .|||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENIL
Kinase n1058.AA STE 75-197 18 2.8e-15 50.53 In-house 1-171 (359) Show / Hide 
Range on Protein: 75-197
Range on HMM: 1-171/359
Sequence Identity: 18% (31 aa)

YSDFRFLGQGVQGLVLLAKDSK---------------TNMRYAIKGVQVRDPQGNLDE------------DLNNRVKQEVEILKKCRD-SPYVVSLIDQF
. . ...|.|  | | .|.. |               |. ..||| . ... . .  |            .  .....|..|.|||.. .|..|  .. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

EGQ-------QFSYLVLTECQ-GTLTQILE------RNQN------KRLNEISAIKYANDIAQG-LYYIHSK
.         .  ....  .  |.|..|..      ...|      .|..|   .... .| .| |||.||.
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSH
Kinase n1058.AA Ciliate-E2-Unclassified 75-210 22 2.8e-15 49.48 In-house 1-176 (352) Show / Hide 
Range on Protein: 75-210
Range on HMM: 1-176/352
Sequence Identity: 22% (40 aa)

YSDFRFLGQGVQGLVLLAKDSKTN----MRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILK---------------KCRDSPYVVSLIDQFEGQQFSYLV
|   . .||| .| | .....|..    | |..|  .. . | .  .   .. ..|....|               .  ..|..| ....|. .|  |.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LTEC-QGTLTQILE---------------RNQNKRLNEISAI-----KYANDIAQGLYYIHSKS-CLVNDLKMDNIL
.  | .|.| |...               ..|.|.. |  |.     .|.  | ||| |.|.|  ..  |.| .|||
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENIL
Kinase n1058.AA Ciliate-E1 81-210 18 1.2e-14 44.43 In-house 1-141 (202) Show / Hide 
Range on Protein: 81-210
Range on HMM: 1-141/202
Sequence Identity: 18% (26 aa)

LGQGVQGLVLLAKDSKTN-MRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQ--FSYLVLTECQGTLTQILE---------
.|.| ...|. ||  ..|   .|.| ..... .   ......  |.. .|.|  .   |.. .||... .|  ........|. .|.. |.         
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNY--NQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ

--RNQNKRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNIL
  ..... ...   .. . .. .|| ..|..  .  |.|..|||
QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNIL
Kinase n1058.AA CMGC 75-197 17 8.7e-14 40.76 In-house 1-201 (513) Show / Hide 
Range on Protein: 75-197
Range on HMM: 1-201/513
Sequence Identity: 17% (35 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMR--------------YAIKGVQVRDPQGN------LDEDLNNRVKQEVEILKKCR----------------DSPY
|   . .|.|  | |  ..| .|| .              .||| .  .    .      . . .. |   |..|||. .                . ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVSLIDQFEGQQFS-----------------YLVLTECQGTLTQILERNQ-------NKRLNEIS------------AIKYA------NDIAQGLY--YI
.|.|.| |   .                   |||   .. .| |....||       .. |.|                ..         | .||   |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSK
||.
HSH
Kinase n1058.AA CAMKL 75-210 25 1.2e-13 39.78 In-house 1-159 (297) Show / Hide 
Range on Protein: 75-210
Range on HMM: 1-159/297
Sequence Identity: 25% (41 aa)

YSDFRFLGQGVQGLVLLAKD-SKTNMRYAIKGVQVR----DPQGNLD------EDLNNRVKQEVEILKKCR--DSPYVVSLIDQFEGQQF------SYLV
|   . ||.|  | | ||.. . |. ..||| .  .    ||. .        |.   |...|..|.|. .    | ...| . .| ...       |||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LTECQGT---LTQILERNQNKR--LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNIL
.  |.|    | . .... ..|  . |  | .|   |  ...|.||.     |.| .|||
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENIL
Kinase n1058.AA S_TKc 75-210 14 5.2e-07 -74.16 SMART 1-231 (231) Show / Hide 
Range on Protein: 75-210
Range on HMM: 1-231/231
Sequence Identity: 14% (37 aa)

YSDFRFLGQGVQGLVLLAKDSKTNMRYAIKGVQVRDPQGNLDEDLNNRVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQG---TLTQILERNQ
|   | .|.|  | | .... ||. ..||| .              .....|..||||  . |..| |.| |.  .. |.|.  | |   .| .......
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

NKR----LNEISAIKYANDIAQGLYYIHS-----------------------------------------------------------------------
 ..    ..|  | .|.  |...| |.||                                                                       
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPF

-------------------KSCLVND--------LKM-------DNIL
                   . ||. |        .         .  .
PQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF