Gene n1179 (Tetrahymena)

n1179

Species: Tetrahymena
Alias: n1179, 1179, n3816.m257
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
n1179.AA Protein None 198 None Fasta, JSON
n1179.NA RNA None 594 None Fasta, JSON
n1179.kin_dom Protein Kinase Domain None 189 None Fasta, JSON

Protein domain

Protein domains of n1179.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase n1179.AA PITSLRE 10-198 52 2.1e-100 339.9 In-house 1-191 (295) Show / Hide 
Range on Protein: 10-198
Range on HMM: 1-191/295
Sequence Identity: 52% (100 aa)

FTQIHQLGEGTFGKVYKAQDKKNNEIVAVKQVKIH--DEREGFPVTSVREIK-LLSELQNHPNIVQFKEVVVGQNQNSIFLIFEYCQMDIANLIFRMDQE
|  . . .|||.| ||.|.||. .|||| | .|.    |.||||.||.|||. .| .|| |||||. ||.|.| | ..|....||   |.. |.  | . 
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQ-HPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRR

REYFSESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVVKIADFGLAREYNKPNKPYTPKVVTLWYRSPELLLEMEQYTTSIDIW
.  |...|||| ..|||.||.|||.   |||| | || |.. ||. ||.||||||||  | ||||| |||||||.|||||. . |.| .|.|
NQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMW
Kinase n1179.AA CDK 10-198 39 4.3e-97 311.18 In-house 1-206 (284) Show / Hide 
Range on Protein: 10-198
Range on HMM: 1-206/284
Sequence Identity: 39% (88 aa)

FTQIHQLGEGTFGKVYKAQDKKNN-----EIVAVKQVKIHD-----EREGFPVTSVREIKLLSELQNHPNIVQFKEVVVGQN---------QNSIFLIFE
. .. ..||||.|.||||.||...     .||| |....       |.|||| |..|||.|| ||  |||||. ..|... |         .|.....||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

YCQMDIANLIFRMDQEREYFSESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGV-----VKIADFGLAREYNK------PNKPYTPKVVTLWY
|. .| . ..              |||...|||.|. ..|..  ||||.| .| |||..|.     .|||||||||...       ||..||..||||||
YMDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RSPELLLEMEQYT--TSIDIW
|.|||||  ..|.  |.||.|
RAPELLLGSKHYSGGTPIDMW
Kinase n1179.AA CDC2 10-198 41 6.1e-88 270.3 In-house 1-190 (301) Show / Hide 
Range on Protein: 10-198
Range on HMM: 1-190/301
Sequence Identity: 41% (81 aa)

FTQIHQLGEGTFGKVYKAQDKKNNEIVAVKQVKIHDEREG--FPVTSVREIKLLSELQNHPNIVQFKEVVVGQNQNSIFLIFEYCQMDIANLIFRMDQER
...|  .||||.|.|||..|.. |.|||.|....  | ||  .| |..||| .| ||..|||||. ..|..    |.....|||. ||  ..  .  . .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

EYFSESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVVKIADFGLAREYNKPNKPYTPK--VVTLWYRSPELLLEMEQYTTSIDIW
...... .| .. |.|.|| . | .  ||||.| .| ||..||..|||||||||  . | ..||.   |||||||.||.||  ..|.|..|.|
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMW
Kinase n1179.AA CDK10 10-198 50 4.5e-83 282.31 In-house 1-185 (285) Show / Hide 
Range on Protein: 10-198
Range on HMM: 1-185/285
Sequence Identity: 50% (96 aa)

FTQIHQLGEGTFGKVYKAQDKKNNEIVAVKQVKIHDEREGFPVTSVREIKLLSELQNHPNIVQFKEVVVGQNQNSIFLIFEYCQMDIANLIFRMDQEREY
| ..  .||||.| ||.| | . .||||.|.|..  |..| |. ..|||.|| ... |.|||. .||||||  .||||. .||  |.| |.  | |    
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQCR-HENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQP---

FSESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVVKIADFGLAREYNKPNKPYTPKVVTLWYRSPELLLEMEQYTTSIDIW
|.|...|||.||.| |.. .|... .|||.| ||.|. ||| .|.||||||| |  | || |||.|||||| |||||   . ||.||.|
FTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMW
Kinase n1179.AA CMGC 10-198 26 1.6e-82 270.84 In-house 1-319 (513) Show / Hide 
Range on Protein: 10-198
Range on HMM: 1-319/513
Sequence Identity: 26% (85 aa)

FTQIHQLGEGTFGKVYKAQD--------------KKNNEIVAVKQVK---IHD------EREGFPVTSVREIKLLSELQ----------------NHPNI
.. | ..||||.|.|||..|              ...|||||.| .|    ..      |..||| .. ||||.| .|.                .|.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VQFKEVVVGQN---------------QNSIFLIFEYCQMDIANLIFRMDQ-----EREYFSESE------------IKCII------LQLLNGVQ--HMH
|. .....  |                |...|.|||...| ...| .. .      . ..|| .            ||...       |.|.|.   ..|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

KQY--QMHRDIKLSNVLINDK--------------------GVVKIADFGLAREYNKP---------------------NKPYTPKVVTLWYRSPELLLE
..    .|||.| .|.|||..                    |..||.|||||| |...                     |.|||. |||.|||.||.|| 
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

MEQYT---------TSIDIW
...||         |.||.|
WKHYTNHNYSMHYTTPIDMW
Kinase n1179.AA CRK7 10-198 39 2.6e-82 279.76 In-house 1-237 (343) Show / Hide 
Range on Protein: 10-198
Range on HMM: 1-237/343
Sequence Identity: 39% (95 aa)

FTQIHQLGEGTFGKVYKAQDKKNNEIVAVKQVKIHDE---REGFPVTSVREIKLLSELQNHPNIVQFKEVVVGQ-------NQN-SIFLIFEYCQMDIAN
.  | | ||||.|.||||..|...|.|| | |.  .|   .||||.|..||||.| .| ||.|||. ||.|.         ..  |....|||   | . 
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQL-NHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMG

LIFRMDQEREYFSESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVVKIADFGLAREYNKPN--KPYTPKVVTLWYRSPELLLEMEQY-----
|      |  .||....||.  ||| |.. .||.  .||||| ||.|.| .| |||||||||| ||. .  .||| .|.||||| |||||  |.|     
LL--ESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHI

---------------------------------TTSIDIW
                                 ...||.|
LKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMW
Kinase n1179.AA CDK7 10-198 37 2.3e-76 202.74 In-house 1-187 (288) Show / Hide 
Range on Protein: 10-198
Range on HMM: 1-187/288
Sequence Identity: 37% (73 aa)

FTQIHQLGEGTFGKVYKAQDKKNNEIVAVKQVK----IHDEREGFPVTSVREIKLLSELQNHPNIVQFKEVVVGQNQNSIFLIFEYCQMDIANLIFRMDQ
.. | ..|||.|. ||||.|.. ..|||.| .|      . . |   | .||||.| |.| |.|..    .     . .| |.|.. . |    |   |.
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQ-HDNVIGLIDIFM--HKSNIQLVFDFMDWDLEVVI--KDK

EREYFSESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVVKIADFGLAREYNKPNKPYTPKVVTLWYRSPELLLEMEQYTTSIDIW
.   .  ..|| . ...| |. ..|. .  |||.|  | |.|  |..||||||||| |  ||. ||..||| |||.||||    .|.|..|.|
SI-ILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMW
Kinase n1179.AA Pkinase 10-198 32 2.9e-67 234.57 Pfam 1-196 (293) Show / Hide 
Range on Protein: 10-198
Range on HMM: 1-196/293
Sequence Identity: 32% (66 aa)

FTQIHQLGEGTFGKVYKAQDKKNNEIVAVKQVKIHDEREGFPVTSVR--EIKLLSELQNHPNIVQFKEVVVGQNQNSIFLIFEYCQM-----DIANLIFR
.. . ..|.|.||.|||...|....|||||..| ..|......| .|  ||... .| ||||||......     ..| ...|||..     | . .| .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

MDQEREYF--SESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVV----KIADFGLAREY-NKPNKPYTPKVVTLWYRSPELLLEMEQYTTSI
  ...  |  || |.|....|.| |....|..  .|||.|..|.||...|..    ||.|||||. . . .|  .|  ..|.||..||.... . |....
--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIW
|.|
DMW
Kinase n1179.AA CDK5 10-198 42 9.1e-65 203.39 In-house 1-183 (287) Show / Hide 
Range on Protein: 10-198
Range on HMM: 1-183/287
Sequence Identity: 42% (81 aa)

FTQIHQLGEGTFGKVYKAQDKKNNEIVAVKQVKIHDEREGFPVTSVREIKLLSELQNHPNIVQFKEVVVGQNQNSIFLIFEYCQMDIANLIFRMDQEREY
. ..  .||||.| ||||..|.  |||| |.|.. .| || | | .||| || ||. |.|||    |.   .   . |.||.|  |.      ||.  ..
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELK-HKNIVRLHDVIHSEKK--LTLVFEFCDQDLKKY---MDSCNGE

FSESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVVKIADFGLAREYNKPNKPYTPKVVTLWYRSPELLLEMEQYTTSIDIW
 .   || ...||| |..  |..  .||| |  | ||| .|  | ||||||| .  | . |.  ||||||| |  |.   .|.||||.|
MDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMW
Kinase n1179.AA RCK 10-198 38 5.3e-57 179.26 In-house 1-198 (298) Show / Hide 
Range on Protein: 10-198
Range on HMM: 1-198/298
Sequence Identity: 38% (80 aa)

FTQIHQLGEGTFGKVYKAQDKKNNEIVAVKQVKIHDEREGFP----VTSVREIKLLSELQNHPNIVQFKEVVVGQNQNSIFLIFEYCQMDIANLIFRMDQ
 . | |||.||.| | |||.|...|||| |. |       |.    ....|||| |  |  ||||.. |||.  ..  . ...|||..|..  ..    .
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK-----QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKE

EREY-FSESE--IKCIILQLLNGVQHMHKQYQMHRDIKLSNVLIND---------KGVVKIADFGLARE-YNKPNKPYTPKVVTLWYRSPELLLEMEQYT
 |.  ..|..  || |. |.| |  ||||.  .|||.|  | ....          ...|||||||.|| ..||  |||  | | |||.||.||   .|.
-RRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKP--PYTDYVSTRWYRAPECLLRCTYYN

TSIDIW
. .|||
SPMDIW
Kinase n1179.AA CDK9 10-198 39 4.8e-52 177.8 In-house 1-210 (340) Show / Hide 
Range on Protein: 10-198
Range on HMM: 1-210/340
Sequence Identity: 39% (84 aa)

FTQIHQLGEGTFG-----------KVYKAQDKKNNEIVAVKQVKIHDEREGFPVTSVREIKLLSELQNHPNIVQFKEV-------VVGQNQ-NSIFLIFE
.  .   | ||||            |.||. |||  .|| | |    |.||||.|  ||||.|  |. |.|.|   |.         .     ...|.|.
YEKLAKIGQGTFGQVLQGRKSRNSEVFKARHKKNKRMVAMKKVLMENEKEGFPITALREIKMLQLLK-HENVVNLIEICRTKATAYNRYKDRATFYLVFD

YCQMDIANLIFRMDQEREYFSESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVVKIADFGLAR-----EYNKPNKP-YTPKVVTLWYRSPEL
.|  | | |   |      || ..|| .. .|.||   .|.   .||| |  ||||   |. | |||||||     . . || | ||  ||||||| |||
FCEHDLAGLLSNMNVK---FSLGHIKKMMQHLMNGLYYIHRNKILHRDMKAANVLITKDGILKLADFGLARAFSQPKNDAPNRPLYTNRVVTLWYRPPEL

LLEMEQYTTSIDIW
||   .| . ||.|
LLGDRNYGPPIDMW
Kinase n1179.AA S_TKc 10-198 22 4.7e-35 123.7 SMART 1-220 (231) Show / Hide 
Range on Protein: 10-198
Range on HMM: 1-220/231
Sequence Identity: 22% (57 aa)

FTQIHQLGEGTFGKVYKAQDKKNNEIVAVKQVKIHDEREGFPVTSVREIKLLSELQNHPNIVQFKEVVVGQNQNSIFLIFEYCQM---DIANLIFRMDQE
.. . ..|.|.||||||...|| ..|||.|..|          .  |||..|..  .|||||....| .    .......|||     |   .| ..  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH

R--EYFSESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVVKIADFGLAREYNKPNKPYTPKVVTLWYRSPELLLEMEQYTT-SIDI------
.   .|.| ...... |........|..  .|||.| .|.|...  ..||.||||||..       |  ..|.||..||.|    .|.. ..|.      
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

-----------------------------------------------W
                                                
LYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQ
Kinase n1179.AA Pkinase_Tyr 10-93 35 4.3e-14 48.36 Pfam 1-90 (270) Show / Hide 
Range on Protein: 10-93
Range on HMM: 1-90/270
Sequence Identity: 35% (33 aa)

FTQIHQLGEGTFGKVYKAQDK----KNNEIVAVKQV--KIHDE---REGFPVTSVREIKLLSELQNHPNIVQFKEVVVGQNQN-SIFLIFEYCQ
 | ...|||| ||.|||.  |    ...  |||| .  . ..|   || |     ||.|....| .|||||..  |.. | .  .|....||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF----MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMP
Kinase n1179.AA TyrKc 10-198 18 6.1e-12 -29.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-198
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)

FTQIHQLGEGTFGKVYKAQDKKNNEIVAVKQVKIHDEREGFPVTSVREIKLLSEL-QNHPNIVQFKEVVVGQ-----NQNSIFLIFEYCQMDIANLIFRM
 | ...|||| ||.|||.. |   . |||| .| .  || |     ||......|  .|||||..  |.. |         .....||.    . . .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDF----MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLR

DQEREYFSESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVVKIADFGLAR------------EYNKP----NKP-----------------Y
. ... .. ..   . .|  .| .. |..   |||.   |.|......|||.||||.|            .| ..    ..                  .
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TPKV------VTLW---------YRSP----------------ELLLEMEQY-------------------------------TTSIDIW
|.|       |..|         |  .                   ..  ..                               .. ....
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase n1179.AA Pkinase_Tyr 143-161 63 4e-06 21.45 Pfam 141-159 (270) Show / Hide 
Range on Protein: 143-161
Range on HMM: 141-159/270
Sequence Identity: 63% (12 aa)

NVLINDKGVVKIADFGLAR
|.|.....||||.||||||
NCLVTENNVVKICDFGLAR