Gene n1212 (Tetrahymena)
n1212
Species: Tetrahymena
Alias: 1212, 356.m00012, n1212
External Links:
Annotation:
Group:
Other
Family:
Ciliate-E4
Sequence
Protein domains of n1212.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PX | n1212.AA | PX | 17-127 | 18 | 2.3e-10 | 38.03 | Pfam | 1-120 (120) | Show / Hide |
Range on Protein: 17-127 Range on HMM: 1-120/120 Sequence Identity: 18% (22 aa) NKIQQFGSELQSSKK---NKEGHTEYLINAFYQDL---LNPIQFKSRYSTLLELHKALIPLNKKDSLPQFPGKNLFGT---KSQDLILKRLSDINEYFDN ...| ... . .. ....|..|... ... . . . ||| ..||| | .. .| .|.|..||. .... | || ....|. . DHFLQ-VHVVDPETHKHYGDKMHYYYVYEIHMNTNPFQKKEWHVWRRYSDFHWLHKQLKRHFPMCIIPPLPPKHWFGRYNNFDEEFIEKRRQMLEQYLQR LLRLPQLGG-YSIIIYFINNK ... | | . . . |.. VCQHPELCNHCEVFHDFLHPD |
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| PX | n1212.AA | PX | 17-127 | 14 | 1.8e-07 | 32.03 | SMART | 1-142 (142) | Show / Hide |
Range on Protein: 17-127 Range on HMM: 1-142/142 Sequence Identity: 14% (21 aa) NKIQQFGSELQSSKK----NKEGHTEYLINAFYQDLL--NPIQFKSRYSTLLELHKALIPLNK----KDSLPQFPGKNLFGT------------------ .|.. ... .. .. |. |... ... . . . ||| ..||. | . . .|..|.|..|.. DHIFI-ITVVEFFTHGKHYHDGKHYYYVYEIHTKTNNHVKMWTVYRRYSDFHWLHHQLKRHFPQEKRMCIIPPLPPKHWFVRYRYWMEHMSMMWWYSFNN KSQDLILKRLSDINEYFDNLLRLPQLGG----YSIIIYFINNK ...|.| || ....|. |...|.. . ... |. .. FDEDFIEKRRRGLERYLQRLCHHPEWINHYMVCEVVYEFFESS |
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| Kinase | n1212.AA | Ciliate-C6 | 228-288 | 26 | 2.1e-10 | 33.11 | In-house | 97-176 (306) | Show / Hide |
Range on Protein: 228-288 Range on HMM: 97-176/306 Sequence Identity: 26% (21 aa) ESTLESEIDLRYKN------------------KKSFSSNEIMDIFRNIMKGLEELYI-NQLYHRNLKPSNVGILKQNQKF ||||...| ...| .. |. ||| .. | | | .|. . || .||||. | ... .. ESTLQDCIQMKQANVNNFYFKQEINIFSFNYKYEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNY |
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| Kinase | n1212.AA | Ciliate-E1 | 209-291 | 20 | 8e-08 | 22.02 | In-house | 61-151 (202) | Show / Hide |
Range on Protein: 209-291 Range on HMM: 61-151/202 Sequence Identity: 20% (19 aa) CNCKSKEFYTKLWIVSPYYESTLESEID---------LRYKNKKSFSSNEIMDIFRNIMKGLEELYINQLYHRNLKPSNVGILKQNQKFVYQ .... .... |. ... .|. ... . .|...|. ..| |. .. .||.||... ..||..||.|. | .| ..||. IDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC |
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| Kinase | n1212.AA | ULK | 187-278 | 19 | 1.2e-07 | 23.21 | In-house | 108-156 (324) | Show / Hide |
Range on Protein: 187-278 Range on HMM: 108-156/324 Sequence Identity: 19% (18 aa) IKSDKYLSMIEQLFINSDPYRKCNCKSKEFYTKLWIVSPYYESTLESEIDLRYKNKKSFSSNEIMDIFRNIMKGLEELYINQLYHRNLKPSN || .|.|.. . . .|| .| .|. .|. |. |. ||. .. || .||.| IKKNKKLPE-T-E-----------------------------------------EKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQN |
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| Kinase | n1212.AA | ULK | 241-279 | 35 | 4.4e-07 | 20.85 | In-house | 123-161 (329) | Show / Hide |
Range on Protein: 241-279 Range on HMM: 123-161/329 Sequence Identity: 35% (14 aa) NKKSFSSNEIMDIFRNIMKGLEELYINQLYHRNLKPSNV .|| .| .|. .|. |. |. ||. .. || .||.|. EKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNI |
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| Kinase | n1212.AA | IKS | 246-283 | 34 | 1e-06 | 16.31 | In-house | 151-188 (360) | Show / Hide |
Range on Protein: 246-283 Range on HMM: 151-188/360 Sequence Identity: 34% (13 aa) SSNEIMDIFRNIMKGLEELYINQLYHRNLKPSNVGILK . |.|. .|| | .|. .| . || .||.|. |.. PENQIWSFFRDICHGIHYLHHIGIIHRDIKPPNCLIHQ |
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| Kinase | n1212.AA | Ciliate-B2 | 231-286 | 19 | 3e-06 | 10.56 | In-house | 87-142 (197) | Show / Hide |
Range on Protein: 231-286 Range on HMM: 87-142/197 Sequence Identity: 19% (11 aa) LESEIDLRYKNKKSFSSNEIMDIFRNIMKGLEELYINQLYHRNLKPSNVGILKQNQ |..|... | .| | .. .. .. . . || .. .. | .||.|. . .... LKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGN |
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| S_TKc | n1212.AA | S_TKc | 136-428 | 12 | 1.9e-05 | -97.01 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 136-428 Range on HMM: 1-231/231 Sequence Identity: 12% (39 aa) WRLQ---------KVYKLIKNN--QPFVLKKYGLDDEINKKDPSSLQSWRVTVDQFSNRVSKIKSDKYLSMIEQLFINSDPYRKCNCKSKEFYT--KLWI ... |||| .... . . .|. . | . . .| .... .|.. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------------------------EHIRREIQILKK--HHPNIVKLYDVFQDDHLYM VSPYYES---TLESEIDLRYKNK--KSFSSNEIMDIFRNIMKGLEELYINQLYHRNLKPSNVGILKQNQKFVYQLMDYHDLLLRKKEKSMAQGNANSNRY | | . .| . |. | ... . |. .. ... | ..|| . .. || |||.|. . . . . | | .. . . VMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFG---LARQL----------TTF SINLAYKSPKRISQIRLTDNSKNSDEDYK--NFDMYALGIILLQLCL-VLPTSELQGFQEISQLRDDMINNQLQQIKQKYDESLYQYICVLLNKSTLSVF . | .| . | |....|.|| .. | . .. ...|. .... . |. .|.| CGTPWYMAPEVL--------------GYGKCKCDWWSCGCILYEMLCGYPPFP--------------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRP SNQDKYQ----LQKLSIF . . | . | TA-EALQDEWDIKCHPWF |
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| Kinase | n1212.AA | CMGC | 219-279 | 20 | 5.4e-05 | 11.35 | In-house | 129-215 (513) | Show / Hide |
Range on Protein: 219-279 Range on HMM: 129-215/513 Sequence Identity: 20% (18 aa) KLWIVSPYYESTLESEID-LR--YKN---------------------KKSFSSNEIMDIFRNIMKGLE--ELYINQ--LYHRNLKPSNV .| .| | . .| |. . |.. .|.|. | ... | .||. . . || |||.|. HLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENI |
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| Kinase | n1212.AA | Ciliate-E2 | 194-279 | 19 | 0.000145 | 11.57 | In-house | 58-192 (365) | Show / Hide |
Range on Protein: 194-279
Range on HMM: 58-192/365
Sequence Identity: 19% (26 aa)
SMIEQLFINSDPYRKCN--------------------CKSKEFYT-----KLWIVSPYYES-TLESEIDLRYKNK-------KSFSSNEIMDIFRNIMK-
..|||.. . .|. | .| .|.. .. .| |.. .|.. | ..|.. |.|. .|| .|.. | .
NQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQG
--------------GLEELYINQ-LYHRNLKPSNV
.||.| . ||..||.|.
FKTKAEFYIACIILALEYLHSKNNIIHRDIKPENI
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| Kinase | n1212.AA | Ciliate-E3 | 349-361 | 46 | 0.000422 | 9.02 | In-house | 190-202 (202) | Show / Hide |
Range on Protein: 349-361 Range on HMM: 190-202/202 Sequence Identity: 46% (6 aa) DMYALGIILLQLC |.| .| ...||| DYYSVGAVFCQLC |
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| Kinase | n1212.AA | Ciliate-A1 | 344-361 | 55 | 0.003833 | 6.47 | In-house | 205-222 (301) | Show / Hide |
Range on Protein: 344-361 Range on HMM: 205-222/301 Sequence Identity: 55% (10 aa) DYKNFDMYALGIILLQLC .|| ||| ||.|.. || IYKQSDMYSLGCIICFLC |
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| Kinase | n1212.AA | Ciliate-A1 | 240-279 | 27 | 0.011584 | 4.81 | In-house | 93-132 (301) | Show / Hide |
Range on Protein: 240-279 Range on HMM: 93-132/301 Sequence Identity: 27% (11 aa) KNKKSFSSNEIMDIFRNIMKGLEELYINQLYHRNLKPSNV .... . ||..| |..|. . || ||| |. YQNDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNI |
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| Kinase | n1212.AA | Ciliate-E3 | 246-278 | 30 | 0.035825 | 2.92 | In-house | 101-133 (202) | Show / Hide |
Range on Protein: 246-278 Range on HMM: 101-133/202 Sequence Identity: 30% (10 aa) SSNEIMDIFRNIMKGLEELYINQLYHRNLKPSN . |.|.||. .|..|. .. .. | .||.| TQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDN |
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