Gene n803.5 (Tetrahymena)

n803.5

Species: Tetrahymena
Alias: 227.m00041.5, n803.5, 803.5
External Links:
Annotation:

Classification

Group: Other
Family: Ciliate-E1

Sequence

Name Sequence Type Origin Length Description Download
n803.5.AA Protein None 287 None Fasta, JSON
n803.5.NA RNA None 861 None Fasta, JSON
n803.5.kin_dom Protein Kinase Domain None 141 None Fasta, JSON

Protein domain

Protein domains of n803.5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase n803.5.AA Ciliate-E1 44-257 24 9.5e-36 113.89 In-house 1-202 (202) Show / Hide 
Range on Protein: 44-257
Range on HMM: 1-202/202
Sequence Identity: 24% (58 aa)

IGKGSFGLVFKITYNSQQ---KAVKIIESKDQ-NQNSINQLKKEYD-LLKNFNKSKYVLQIQNTQEINLAKPTIFIFTDLCDGELTTLI-----------
||.|||..|||. .....   .|.|||. ... |||......|||. ..| |.| .|..||.....| ... .|.||. .|.  . .|            
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

---EQQISKKQIISIMMQLLMGLEELKQMKVIHRDLKPENILFNKKGQNYQIYIDIYSLGIVFIELLCGRRFNFQTEVRPIRNGNQQILSDINAMYKTKN
   ..| . .|...|..||..||.||.|...||||.||.|||.|..  ||...                                .. .|..    ....
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC--------------------------------DFGISKFLKNNQNQQ

RVFEQNIDSFLIENVIK-NMV--QQNPKSRYSSDEL
 .... ....  ..... ...  ..| |  | ||  
CQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
S_TKc n803.5.AA S_TKc 38-263 19 7.4e-27 96.46 SMART 1-231 (231) Show / Hide 
Range on Protein: 38-263
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

YKFVNIIGKGSFGLVFKITYNS--QQKAVKIIESKDQNQNSINQLKKEYDLLKNFNKSKYVLQIQNTQEINLAKPTIFIFTDLCDG---ELTTLIEQQ--
|.....||||.|| |.| . ..  .. |.|||          .....| ..||.  . ... ..  . .       .......|||   .| ..|...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGR

------ISKKQIISIMMQLLMGLEELKQMKVIHRDLKPENILFNKKGQ---------------------------NYQI-YIDIYSLGIVFIELLCGRR-
      ..  .. ..| |.. .|| . ....|||||||||||...  .                            |    .|..|.|....|.|||.  
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPP

FNFQTEVRPIRNGNQQILSDINAMYKTKNRVFEQNIDSFLIENVIKNMVQQNPKSRYSSDELLN-------ILFK
|                  ....|.|           |    . |... | .|. |..  |.|.         . 
FP-----------------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase n803.5.AA ULK 38-170 25 1.1e-24 83.13 In-house 1-166 (329) Show / Hide 
Range on Protein: 38-170
Range on HMM: 1-166/329
Sequence Identity: 25% (42 aa)

YKFVNIIGKGSFGLVFKIT-YNS-----QQKAVKIIESKDQNQNS--------INQLKKEYDLLKNFN---KSKY----VLQIQNTQEINLAKPTIFIFT
|   ...|||||| |.| .  ..     .. |.|.|... .||..        ...||.| ...|  .   ..|.    . .    .|       |.|..
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH-NNIYIIM

DLCDG-ELTTLIEQQ------------ISKKQIISIMMQLLMGLEELKQMKVIHRDLKPENILFNKK
..|.|  | ..|...            .| ...|....|.| |. || ....||||.||.||| ...
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNG
Kinase n803.5.AA STE 38-167 20 1.3e-22 76.73 In-house 1-185 (359) Show / Hide 
Range on Protein: 38-167
Range on HMM: 1-185/359
Sequence Identity: 20% (38 aa)

YKFVNIIGKGSFGLVFKITYN-----------------SQQKAVKIIESKDQNQ---------------NSINQLKKEYDLLKNFNK-SKYVLQIQNTQE
.... .||||.|| |.|  ..                  .  |.|... ...|.               . ..|..|| ...|..|. .... .   . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

INL----AKPTIFIFTDLCD-GELTTLIE----------------QQISKKQIISIMMQLLMG-LEELKQMKVIHRDLKPENILF
 .     .. ...|.  ..| | |. .|.                . .. .||. |  |.| | |. | ....||||.|| |||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL
Kinase n803.5.AA ULK 38-170 25 4.2e-22 75.26 In-house 1-162 (324) Show / Hide 
Range on Protein: 38-170
Range on HMM: 1-162/324
Sequence Identity: 25% (42 aa)

YKFVNIIGKGSFG-LVFKIT-YNS----QQKAVKIIESKDQNQNSIN--------QLKKEYDLLKNFN--KSKY--VLQIQNTQEINLAKPTIFIFTDLC
|   ...||||||  |.| .  ..    |. |.|.|. | .|... .        .||.|  ..| ..  |...  . .    .|       |.|....|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNH-NNIYIIMEYC

DG-ELTTLIEQQ-----------ISKKQIISIMMQLLMGLEELKQMKVIHRDLKPENILFNKK
.|  | ..|...           .| ...|....|.. |. || ....||||.||.||| ...
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNG
Kinase n803.5.AA Ciliate-E2 38-167 23 1.2e-21 71.02 In-house 1-194 (365) Show / Hide 
Range on Protein: 38-167
Range on HMM: 1-194/365
Sequence Identity: 23% (46 aa)

YKFVNIIGKGSFGLVFKITYNSQQK--------------------AVKIIESKDQNQNSINQLKKEYDLLK---------N------FNKSKYVLQIQNT
|||...||.|.|| |.| .  ..||                    ..||.. | ...| |.|.|.| ....         |      ..........  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

QE-INLAKPTIFIFTDLCDG-ELTTLIEQQ-------------ISKKQIISIMMQLL---------------MGLEELKQMK-VIHRDLKPENILF
 . ..  . .|.. ...|.| .|  .|...             .. |.|. || |.|                .||.|.. . .||||.|||||||
FQEKD--DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF
Kinase n803.5.AA CAMK 43-176 14 1.6e-21 65.48 In-house 1-235 (425) Show / Hide 
Range on Protein: 43-176
Range on HMM: 1-235/425
Sequence Identity: 14% (34 aa)

IIGKGSFGLVFKITYN-S-------------QQKAVKIIESKDQN--------------------------QNSINQLKKEYDLLKNFNK------SKYV
..|.|||| |.. .   .             |. |.|||. |                             ...  ....|....|. ..       . .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LQIQNTQEI-----------NLAKP------TIFIFT---DLCDG-EL----TTLIEQQ-----------------ISKKQIISIMMQLLMGLEELKQMK
...  . |            .  |.       .....   ..|.| ||       | ..                 .. ..   .. |.. ... . ...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VIHRDLKPENILFNKKG--------------QNYQI
..||||||||||.....              .|..|
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNI
Kinase n803.5.AA CMGC 38-178 14 9.8e-21 64.02 In-house 1-245 (513) Show / Hide 
Range on Protein: 38-178
Range on HMM: 1-245/513
Sequence Identity: 14% (37 aa)

YKFVNIIGKGSFGLVFKITY----------------NSQQKAVKIIESKDQNQNSIN----------QLKKEYDLLKNFN----------------KSKY
|. .. ||.|..| |.| .                 . .. |.|.| ..  ...                 |  .||..|                . ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VLQIQNTQEINL-AKP-------------TIFIFTDLCDGELTTLIEQ-----------QISKKQ------------IISIM------MQLLMGLE--EL
......    .  ...              ... ....|  |  .|..             |  .            | ..|       |.| ||.   .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

KQMK--VIHRDLKPENILFNKKGQN-----------------YQIYI
 ...  .|||||||||||.|.....                 ... |
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKI
Kinase n803.5.AA Pkinase 38-173 29 1.7e-20 73.58 Pfam 1-147 (293) Show / Hide 
Range on Protein: 38-173
Range on HMM: 1-147/293
Sequence Identity: 29% (44 aa)

YKFVNIIGKGSFGLVFKITYNSQQK--AVKIIESKDQNQNSINQLKK--EYDLLKNFNKSKYVLQIQNTQEINLAKPTIFIFTDLCDG-----ELTTLIE
|... .||.|||| |.| .  . .|  |||||. .... .   .. .  |  ..|.. ........  . |    |. | . ...|.|     .| ..|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED---KDHIYMVMEYCEGGLYVMDLFDYIS

----QQI--SKKQIISIMMQLLMGLEELKQMKVIHRDLKPENILFNKKGQN
      .  | ......| |.| ||| . .|..|||||||||||....|..
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHI
Kinase n803.5.AA Ciliate-E2-Unclassified 38-176 24 6e-19 62.38 In-house 1-186 (352) Show / Hide 
Range on Protein: 38-176
Range on HMM: 1-186/352
Sequence Identity: 24% (48 aa)

YKFVNIIGKGSFGLVFKITYNSQQKA------VKIIESKDQNQNS----------INQLKKEYDL-------------LKNFNKSKYVLQIQNTQEINLA
||.. .||.|.|| |.|   ..|...       ||.. |......          .|..|| |.              ... .. |.. . |..|     
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQ-----

KPTIFIFTDLC-DGELTTLIE-------------------QQISKKQII-----SIMMQLLMGLEELKQMK-VIHRDLKPENILFNKKGQNYQI
  .|.| ...| .|.|   |.                   .... .|..      .. |.| ||| | . . .||||.|||||||...|.||.|
--NIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYI
Kinase n803.5.AA Ciliate-E2a 111-175 32 1.1e-17 48.62 In-house 73-144 (275) Show / Hide 
Range on Protein: 111-175
Range on HMM: 73-144/275
Sequence Identity: 32% (24 aa)

TIFIFTDLCDGELTTLI-----EQQISKK--QIISIMMQLL-MGLEELKQMKVIHRDLKPENILFN-KKGQNYQ
.... ...|.|   .|.      ... ..  .| .|| |||  ||. ..| ...|||||||||||. .. ...|
NYYLVMEYCEG--GELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQ
Kinase n803.5.AA STE20 38-172 20 7.1e-17 58.45 In-house 1-155 (288) Show / Hide 
Range on Protein: 38-172
Range on HMM: 1-155/288
Sequence Identity: 20% (32 aa)

YKFVNIIGKGSFGLVFKITY-NSQQK-----AVKIIESKDQNQ--NSINQLKKEYDLLKNFNKSKYVLQIQNTQEINLAK-PTIFIFTDLCDG----ELT
|...  ||.||.| |.| .   ....     |.|... ....   .... ..||.. .|... .... .  ..   .  .   ..|  ..|.|    .. 
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

T---LIEQ-----QISKKQIISIMMQLLMGLEELKQMKVIHRDLKPENILFNKKGQ
.    ...      .. .||  |. ..| ||. | ....||||.|  ||| ...|.
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGE
Kinase n803.5.AA TyrKc 38-261 13 6.9e-08 -95.12 SMART 1-280 (280) Show / Hide 
Range on Protein: 38-261
Range on HMM: 1-280/280
Sequence Identity: 13% (40 aa)

YKFVNIIGKGSFGLVFKITYNSQQKAVKIIESKDQNQNSINQLKKEYDLLKNF-NKSKYVLQIQNTQEIN-----LAKPTIFIFTDLCDGELTTLI-EQQ
 ..  ..| | || |.| |.. .| ||| . .       .  . .|  .....  . . ....             ..|   ..   . | |   . . .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--ISKKQIISIMMQLLMGLEELKQMKVIHRDLKPENILFNKKG-----------QNYQI--------YIDI----YSL--GIVF---IELLCGRRFNFQT
  .. |. .|.. |   | | | ....|||||   |.| ....             |          |..      .     .    .| .  ..|....
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

----------------EVRPIR-----NGNQQILSDINAMYKTKNRVFEQN--------IDSFLIENVIKNMVQQNPKSRYSSDELLNIL
                .  .         ||... .. . |  .     .|          . . . ..|   . .|..| .  |.  ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMP---QPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase n803.5.AA Ciliate-E2 168-259 18 1.7e-07 21.78 In-house 267-361 (365) Show / Hide 
Range on Protein: 168-259
Range on HMM: 267-361/365
Sequence Identity: 18% (22 aa)

NKKGQNYQIYIDIYSLGIVFIELLCGRR-FNFQTEVRPIRNGNQQILSDINAMYKTKNRVFEQNIDSFLIE-----------------------NVIKN-
..|.. |   .||.|||... |.|.|.. |                           .   ...|| .  |                       . ||. 
QQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKF

---MVQQNPKSRYS-SDELLN
   | | .|. |..  ...||
GKRMLQKDPEKRITGWEQILN
Kinase n803.5.AA Ciliate-E2a 38-89 29 4.5e-05 10.91 In-house 1-55 (275) Show / Hide 
Range on Protein: 38-89
Range on HMM: 1-55/275
Sequence Identity: 29% (16 aa)

YKFVNIIGKGSFGLVFKIT--YNSQQKAVKIIESKDQNQN-SINQLKKEYDLLKN
|||...||||.|| |.. .   . .|.|.|... |...|     ....| .....
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQ
Kinase n803.5.AA Pkinase 178-261 16 0.000399 15.67 Pfam 193-293 (293) Show / Hide 
Range on Protein: 178-261
Range on HMM: 193-293/293
Sequence Identity: 16% (17 aa)

IDIYSLGIVFIELLCGRRFNFQTEVRPIRNGNQQILSDINAMYKTKNRVFEQNIDS-----------------FLIENVIKNMVQQNPKSRYSSDELLNI
.|..|.|....|.|||| . |. .. ...  .|. . . . . ...   .. .  |                      .||.. ...||.|.. ...|. 
VDMWSCGCILYEMLCGR-PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF
Kinase n803.5.AA Ciliate-E2-Unclassified 178-263 16 0.001067 8.73 In-house 251-352 (352) Show / Hide 
Range on Protein: 178-263
Range on HMM: 251-352/352
Sequence Identity: 16% (17 aa)

IDIYSLGIVFIELLCGRRFNFQTEVRPIRNGNQQILSD---INAMYKTK-NRVFEQNIDSF-------------LIENVIKNMVQQNPKSRYSSDELLNI
.||.|||... |.| |..  ...     .. ..|..     .  .|. . .. ....  ..             .|.. .. | . ||..|.. ...|| 
CDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNH

LFK
 . 
PWF
Kinase n803.5.AA STE 179-194 50 0.003084 7.43 In-house 250-265 (359) Show / Hide 
Range on Protein: 179-194
Range on HMM: 250-265/359
Sequence Identity: 50% (8 aa)

DIYSLGIVFIELLCGR
||.|||.. ||...|.
DIWSLGCTIIEMATGK
Kinase n803.5.AA Ciliate-E2a 240-259 35 0.005744 4.6 In-house 252-271 (275) Show / Hide 
Range on Protein: 240-259
Range on HMM: 252-271/275
Sequence Identity: 35% (7 aa)

IKNMVQQNPKSRYSSDELLN
.| |.. .|| |..  ..||
MKKMLEKDPKKRITAQQALN
Kinase n803.5.AA STE20 179-191 61 0.096101 2.51 In-house 209-221 (288) Show / Hide 
Range on Protein: 179-191
Range on HMM: 209-221/288
Sequence Identity: 61% (8 aa)

DIYSLGIVFIELL
||.||||  ||..
DIWSLGITAIEMA
Kinase n803.5.AA ULK 179-194 56 0.158562 1.2 In-house 238-253 (329) Show / Hide 
Range on Protein: 179-194
Range on HMM: 238-253/329
Sequence Identity: 56% (9 aa)

DIYSLGIVFIELLCGR
||.|||..| |.| |.
DIWSLGCIFYEMLYGK