Gene CC1G_01170 (C.cinerea)

CC1G_01170

Species: C.cinerea
Alias: CC1G_01170
External Links:
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1-G

Sequence

Name Sequence Type Origin Length Description Download
CC1G_01170.AA Protein None 458 None Fasta, JSON
CC1G_01170.NA RNA None 1377 None Fasta, JSON
CC1G_01170.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of CC1G_01170.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CC1G_01170.AA CK1-G 18-280 70 2.9e-207 694.87 In-house 1-266 (266) Show / Hide 
Range on Protein: 18-280
Range on HMM: 1-266/266
Sequence Identity: 70% (187 aa)

YRVGKKIGEGSFGVIFEGTNLLNSQTVAIKFEPRKAEAPQLRDECRSYRILAGCT-GIPQIYHFGQEGLHNILVIDLLGPSLEDLFDMCGRKFSIKTVCM
||||||||.|.||..|||.|..|   |||||||.| .||||.|| | |.||.||  ||||.| |||.|..||.|.||||||||||||.|.||||.|||||
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCM

AAKQMITRVQTIHEKNLIYRDIKPDNFLIGRPGTKGANVIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFMY
 |.|||.|.. .|...|||||.||||||||||..| ..|||..||||||||.||.|||||||||.|||.|||||||||||||||||||||.|||||.|||
VAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMY

FLRGSLPWQGLKAATNKQKYEKIGEKKQTTPIKELCEG--FPEEFGIYLNYVRKLGFEETPDYDFL
||||||||||||| .||..|.|||..|. |.|. ||..  |||.|. || |||.| |.|.||||.|
FLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase CC1G_01170.AA CK1 18-278 62 1.3e-189 636.21 In-house 1-271 (271) Show / Hide 
Range on Protein: 18-278
Range on HMM: 1-271/271
Sequence Identity: 62% (170 aa)

YRVGKKIGEGSFGVIFEGTNLLNSQT---VAIKFEPRKAEAPQLRDECRSYRILAG------CTGIPQIYHFGQE--GLHNILVIDLLGPSLEDLFDMCG
||||.|||.||||.|..|.|. ...    ||||.|..|...||| .| . |.|| |      | |||..|..|||  | .||.|.|||||||||||..|.
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCN

RKFSIKTVCMAAKQMITRVQTIHEKNLIYRDIKPDNFLIGRPGTKGANVIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDD
||||.|||.| | |||.|.. .|.||.|.|||||||||.|| . | .......|||.||.|||.||.||||||| |.| |||||.|||||||.|||||||
RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR-YGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD

LEALGHVFMYFLRGSLPWQGLKAATNKQKYEKIGEKKQTTPIKELCEG-FPEEFGIYLNYVRKLGFEETPDYD
.|.||.|.|||||||||||||||.|.|||||||.|||..||. .||.| ||.||  ||||.|.|.|||.|||.
MESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase CC1G_01170.AA CK1-Unclassified 18-252 54 1.9e-158 471.19 In-house 1-244 (244) Show / Hide 
Range on Protein: 18-252
Range on HMM: 1-244/244
Sequence Identity: 54% (135 aa)

YRVGKKIGEGSFGVIFEGTNLLNSQTVAIKFEPRKAEAPQLRDECRSYRILAGCT-------GIPQIYHFGQE--GLHNILVIDLLGPSLEDLFDMCGRK
|||..||| |||| |....|. . . ||||.| .... |||  | . ...| ..        ||| .|..|||  | .||.| ||||||||||| ||.||
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK

FSIKTVCMAAKQMITRVQTIHEKNLIYRDIKPDNFLIG-RPGTKGANVIHVVDFGMAKQYRDP-KTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDD
||.||| | | |||.|.. .|.||.|.|||||||||.| . .   ..... .||| .| |.|. ||..|||||| |.| ||||| |||.||| |||||||
FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKN--HHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDD

LEALGHVFMYFLRGSLPWQGLKAATNKQKYEKIGEKKQTTPIKELC
||.|| |..|||.||||||..|| . |.||||| |.|..||. .||
LESLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase CC1G_01170.AA CK1-D 18-280 61 1.4e-143 483.34 In-house 1-261 (261) Show / Hide 
Range on Protein: 18-280
Range on HMM: 1-261/261
Sequence Identity: 61% (161 aa)

YRVGKKIGEGSFGVIFEGTNLLNSQTVAIKFEPRKAEAPQLRDECRSYRILAGCTGIPQIYHFGQEGLHNILVIDLLGPSLEDLFDMCGRKFSIKTVCMA
||.|.||| |||| |. |||. .   |||| |. |.. |||  | . |... |  |||.|  .||||  |..|.|||||||||||  |.||||.||| | 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML

AKQMITRVQTIHEKNLIYRDIKPDNFLIGRPGTKGANVIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFMYF
| |||.|.. || .| | |||||||||.|  | .| |.....|||.||.|||..|.||||||| |.| ||||| |||||.| |||||||||.|| |.|||
ADQMICRIEYIHCRNFIHRDIKPDNFLMGL-GKRG-NMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYF

LRGSLPWQGLKAATNKQKYEKIGEKKQTTPIKELCEGFPEEFGIYLNYVRKLGFEETPDYDFL
 ||||||||||||| .||||.| |||  |.|..||.|.|.||  |.||.|.| |.. ||| .|
NRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase CC1G_01170.AA CK1-A 18-280 60 6.8e-136 457.77 In-house 1-261 (261) Show / Hide 
Range on Protein: 18-280
Range on HMM: 1-261/261
Sequence Identity: 60% (160 aa)

YRVGKKIGEGSFGVIFEGTNLLNSQTVAIKFEPRKAEAPQLRDECRSYRILAGCTGIPQIYHFGQEGLHNILVIDLLGPSLEDLFDMCGRKFSIKTVCMA
||. .||| |||| |. | |. | . |||| | .||  |||  | . ||||.|| |||.. ..|.|  .|..|.||||||||||| .| |.|..||| | 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML

AKQMITRVQTIHEKNLIYRDIKPDNFLIGRPGTKGANVIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFMYF
| |||.|.  .|||| | |||||||||.|    .  | ....|||.||.|||..|.||||||| | | ||||| ||| ||| |||||||.|..| |.|||
ADQMIMRIEYVHEKNFIHRDIKPDNFLMGI--GRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYF

LRGSLPWQGLKAATNKQKYEKIGEKKQTTPIKELCEGFPEEFGIYLNYVRKLGFEETPDYDFL
 ||.|||||.||.| ||||||| ||| .|||..|| ||| || .|.||.|.|.|||.||| .|
NRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase CC1G_01170.AA CK1 18-280 35 2.4e-124 419.42 In-house 1-339 (339) Show / Hide 
Range on Protein: 18-280
Range on HMM: 1-339/339
Sequence Identity: 35% (122 aa)

YRVGKKIGEGSFG-VIFEG-----TNLLNS-----QTVAIKFEPRKAE--APQLRDECRSYRILAGC-------------------TGIPQIYHFGQEGL
..|.||||||.||  |...     ... |.     . .|.| ||.|..   ||| .| . |..| |.                    ..| .|....|. 
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

--HNILVIDLLGPSLEDLFD---MCGRKFSIKTVCMAAKQMITRVQTIHEKNLIYRDIKPDNFLIGRPG-----------TKGANVIHVVDFGMAK-QYR
  .|..|..||||.||||..   ||.|||| ||. | | ||. ... .|... |.||||||||..|| .            . .......|||||. .||
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DP-----------KTKQHIPYRE---RKSLSG-TARYMSINTHLGREQSRRDDLEALGHVFMYFLRGS--LPWQGLKAATN-------KQKYEKIGEKKQ
|.           ||.||.|.||   .|.. | ||||.|||.|||.||.|||||..........|.|.  ||||..|. ..       |.|||.| ||| 
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

TTPIKELCEG-----FPEEFGIYLNYVRKLGFEETPDYDFL
 ||.. ||..     .|.||  ...|.|.| ....|||...
STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase CC1G_01170.AA TTBKL 18-284 24 8.9e-50 166.25 In-house 1-288 (288) Show / Hide 
Range on Protein: 18-284
Range on HMM: 1-288/288
Sequence Identity: 24% (75 aa)

YRVGKKIGEGSFGVIFEGTNLLNSQTVAIKFEPRKAEAPQLRD-ECRSYRI---------LA--GCTGIPQIYHFGQEGLHNILVIDLLGPSLEDLF-DM
... |.|||| ||..... .. .....|.. |.       ..  |  . |.         |.  |.. .|...  |...  | .|  |.||.| ||  .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEE-------KNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMM

CGRK-FSIKTVCMAAKQMITRVQTIHEKNLIYRDIKPDNFLIGRPG--TKGANVIHVVDFGMAKQYRDP----------KTKQHIPYRE---RKSLSGTA
. .| ||  |.   . | .  .. .|..  | ||.|| |. .|  .  .. . .....|||||.||...          ..... . |.   . .. || 
PNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTT

RYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYEKIGEKKQTTPIKELCEG------FPEEFGIYLNYVRKLGFEETPDYDFLRE
||.|.| |...||.| ||| ..  ...... | |||.... .      ..|...|. .  . |. .      .| ||.    ..| | . ..|||. ..|
RYCSPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDK------MEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYE

LF
.|
CF
Kinase CC1G_01170.AA TTBK 18-280 32 1.4e-43 151.06 In-house 1-257 (257) Show / Hide 
Range on Protein: 18-280
Range on HMM: 1-257/257
Sequence Identity: 32% (87 aa)

YRVGKKIGEGSFGVIFEGTNLLNS-QTVAIKFEPRKAEAPQLRDECRSYRILAGCTGIPQIYHFGQEGLHNILVIDLLGPSLEDLFDMCGR-KFSIKTVC
 .| |||| | || |.|.....|    |||| |  ..    |. |    . | ||  . . .  | .   | .| .|.| .| ||     | .||. |  
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

MAAKQMITRVQTIHEKNLIYRDIKPDNFLIGRPGTKGANVIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFM
   .|..  .. ||.     ||||| || .||   .  . .  .|||.| ||   .     | ||     ||.|| ||| |. ||  |.|||  |  .  
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPST-CRKCYMLDFGLARQYTNACGEVRPP-REVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLV

YFLRGSLPWQGLKAATNKQKYEKIGEKKQTTPIKELCEGFPEEFGIYLNYVRKLGFEETPDYDFL
 |. | |||  .|        ...|| |.    . | .  |.|| .... .. |..|..||| ..
EFVQGQLPWRKIKDK------DQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase CC1G_01170.AA Pkinase 18-243 21 9.2e-40 141.67 Pfam 1-234 (293) Show / Hide 
Range on Protein: 18-243
Range on HMM: 1-234/293
Sequence Identity: 21% (54 aa)

YRVGKKIGEGSFGVIFEGTNLLNSQTVAIKFEPRKAEAPQLRD------ECRSYRILAGCTGIPQIYHFGQEGLHNILVIDLLGPSLEDLFDMC------
|..|.|||.||||. .....  ....||.|  ... | .. .       |..  . | ..  | ..|.. ... |  .| ....  |. ..| .      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTW

-GRKF--SIKTVCMAAKQMITRVQTIHEKNLIYRDIKPDNFLIGRPGTKGANVIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHL-GREQ
 ...|  | ..... ..|..  .. .|... |.||.||.|.|| . |. .|  ... ||| |||..      . ...  ... || .||.   .. |.. 
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYY

SRRDDLEALGHVFMYFLRGSLPWQGL----KAATNKQKYEKIGEKK
... |  ..| .. ..| | .|..|     . .. .|....|....
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPP
Kinase CC1G_01170.AA Worm6 18-280 26 1.4e-39 137.78 In-house 1-279 (279) Show / Hide 
Range on Protein: 18-280
Range on HMM: 1-279/279
Sequence Identity: 26% (75 aa)

YRVGKKIGEGSFGVIFEGTNLLNSQ--TVAIKFEP--RKAEAPQLRDECRSYRILAGCT--GIPQIYHFGQEGL--HNILVIDLLGPSLEDLFDMC-GRK
. |.||||||.|| ... ..  .     .|.| |   .... ..|. ||     .. .   . ..|   |. .    | .|. |.|..|.||   . .||
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSIKTVCMAAKQMITRVQTIHEKNLIYRDIKPDNFLIGR---PGTKGANVIHVVDFGMAK--QYRDPKTKQHIPYR-ERKSLSGTARYMSINTHLGREQS
||  |    | |.. ...  |    | ||.|| || |||      .    |  .||||..  .|.. | .. .. | ..    || ||.... | |.||.
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCN-KGNELRTPRWTACGFRGTVRYAPLACHKGQEQC

RRDDLEALGHVFMYFLRGSLPWQGLKAATNKQ-KYEKIGEKKQTTPIKELCEGFPE-EFGIYLNYVRKLGFEETPDYDFL
|.||.|    .   ...| |||...|.  ...  ....  ... .  ... ...|  ||   . |. .. ....|||.|.
RKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase CC1G_01170.AA S_TKc 18-299 18 6.5e-17 63.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-299
Range on HMM: 1-231/231
Sequence Identity: 18% (55 aa)

YRVGKKIGEGSFGVIFEGTNLLNSQTVAIKFEPRKAEAPQLRDECRSYRILAGCTGIPQIYHFGQEGLHNILVIDLLGP---SLEDLFDMCGRK-----F
|....|||.|.||. . ...    . ||||  .      ..| | .  .   ..  | ..| . |.  |  .| ....    .| |. . .||.     |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SIKTVCMAAKQMITRVQTIHEKNLIYRDIKPDNFLIGRPGTKGANVIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSR-RDDLE
.  ...  ..|..  .. .|... |.||.||.| |. .       .| . |||.|.|.              ... ||  ||.         .. . |  
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWW

ALGHVFMYFLRGSLPWQGLKAATNKQKYEKIGEKKQTTPIKELCEGFPEEFGIYLNYVRKLGFEETPDYDFLRELFTKV----LKSNGDVE-------DN
..| ..  .| |  |..     . .. ..|||                                  .  ||.| ...|     .      .       . 
SCGCILYEMLCGYPPFP-----QMQMMFKKIG--------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

VF
 |
WF
Kinase CC1G_01170.AA Ciliate-E2 128-192 25 1e-11 36.48 In-house 176-255 (365) Show / Hide 
Range on Protein: 128-192
Range on HMM: 176-255/365
Sequence Identity: 25% (23 aa)

IHEKN-LIYRDIKPDNFLIGRPGTKGANVIHVVDFGMAKQYRDPKTKQHIPYRERK-------------------------SLSGTARYMS
.|.||  |.|||||.| |.          | ..|||..|.| |.  .. .  ...|                         .. ||. ||.
LHSKNNIIHRDIKPENILF----------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMA
Kinase CC1G_01170.AA Ciliate-E2 18-49 34 1e-06 19.05 In-house 1-32 (365) Show / Hide 
Range on Protein: 18-49
Range on HMM: 1-32/365
Sequence Identity: 34% (11 aa)

YRVGKKIGEGSFGVIFEGTNLLNSQTVAIKFE
| . ||||.|.||....... .. . .|||..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKII
Kinase CC1G_01170.AA Pkinase_Tyr 18-47 38 3.9e-05 18.02 Pfam 1-34 (270) Show / Hide 
Range on Protein: 18-47
Range on HMM: 1-34/270
Sequence Identity: 38% (13 aa)

YRVGKKIGEGSFGVIFEGTNL----LNSQTVAIK
 . |||.|||.||....||       . ..||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK
Kinase CC1G_01170.AA TyrKc 18-284 18 4.3e-05 -140.24 SMART 1-280 (280) Show / Hide 
Range on Protein: 18-284
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

YRVGKKIGEGSFGVIFEGTNLLNSQTVAIKFEPRKAEAPQLRDECRSYRIL-AGCTGIPQIYHFGQEGL------HNILVIDLLGP--SLEDLFDMCGRK
 . |||.||| ||....||     ..||.|     |    ...| |  . |      | ..|    ..       . ....  . |  .| |    ...|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

FSIKTVCMAAKQMITRVQTIHEKNLIYRDIKPDNFLIGRPGTKGANVIHVVDFGMAKQYRDP----KTKQHIPYRERKSLS--GTARYMSINTHLGREQS
.. |. .  . |     . .|.||.| ||.   | |.|...     .. . |||...   |       |. .  .|.|.       | |..         
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP---------

RRDDLEAL-GH-------VFMY-------FLRGSLPWQGLKA--ATNKQKYEKIGEKKQTTPIKELCEG-----FPEEFGIYLNYVRKLGFEETPDYDFL
     |..  .       |...       | .|  |. |      .|.. .|.. . .   . .. .        |.|         .   |. |    .
-----ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

RELF
.|.|
HECF