Gene AqueK023 (A.queenslandica)

AqueK023

Species: A.queenslandica
Alias: AqueK023
External Links:
Annotation: Secondary Group: AGC, Secondary Family: RSK, Secondary Subfamily: MSK

Classification

Group: AGC
Family: RSK
Subfamily: MSK

Sequence

Name Sequence Type Origin Length Description Download
AqueK023.AA Protein None 704 None Fasta, JSON
AqueK023.kin_dom Protein Kinase Domain None 266 None Fasta, JSON
AqueK023.kin_dom2 Protein Kinase Domain None 257 None Fasta, JSON

Protein domain

Protein domains of AqueK023.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK023.AA AGC 10-275 32 2.8e-170 444.56 In-house 1-395 (395) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-395/395
Sequence Identity: 32% (132 aa)

FELLTVLGTGGYGKVFLVRKVTGA---DQKQLYAMKVLKKTS-VVRKKK-VMEHTLTE------------RSVLEAIRD---------FPFLVT-LHYAF
||.|.|.|.|..|||.||||..|    | ...||||||||   .|.|||  .|||.||            | .|| ..           ||.|  |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTETK--LHLVMDYLC---------GG-ELFTHLH---QIGPFSESGSRLYGAE-------ITLALEHLHS-LNILYRD-IKLENILLDRDGHIVLTDFG
|....  |..||.|..         || |||.||.   . | |.|. .| | ||       |.||||.||| ..| .|| .|.||||||.|||| |||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKTMKPD---------------------------------------------------QVAHSYCG--TVEYMAPEIIRGGDDGHNLLVDWWS--LGVL
|.| .. |                                                   . ... ||  | |||||||.      ..  .||||  ||.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL------YGKACDWWSFGLGCL

LHELLTCESPFAPTGEDNS--------QKEISRRIL------YEAPPIP----------HKLSPSCRELLFGLMRKNKDERLGAN-------GAHEVKSH
. |.||  .||  .|...         ..|.  .|.       . ...|           ..|| .. |. .|. |. ..|||..       || |.|.|
MYEMLTGYPPF--YGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNH

RWF
 ||
PWF
Kinase AqueK023.AA RSK 13-275 48 6.30000000001e-133 447.91 In-house 1-278 (278) Show / Hide 
Range on Protein: 13-275
Range on HMM: 1-278/278
Sequence Identity: 48% (135 aa)

LTVLGTGGYGKVFLVRKVTGADQKQLYAMKVLKKTSVVRKKKVMEHTLTERSVLEAIRDFPFLVTLHYAFQTETKLHLVMDYLCGGELFTHLHQIGP---
| |||.||||||||.||.|. |..|.||||||||  .|...|  .||.|||..||...  ||.||||||||||.||.|.|.|. |||||||| . .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSESGSRLYGAEITLALEHLHSLNILYRDIKLENILLDR---DGHIVLTDFGLSKTMKPD--QVAHSYCGTVEYMAPEIIRGGD-DG-HNLLVDWWSLGV
|||.  . | |||.||.||||.. | .||.|.||||.|    .|||.|||||..| ...|  | ....|.|.||||||... .. .| |.  .|||||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LLHELLTCESPFAPTGEDNSQKEISRRILYEA--PPIP--HKLSPSCRELLFGLMRKNKDERLG--ANGAHEVKSHRWF
|..|.||  .||.  ..||..|||..||.     ...|  ..||. ...|. ... ..   |||   ..| |.|.| ||
LMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase AqueK023.AA MSK 13-270 42 2.7e-124 419.22 In-house 1-277 (277) Show / Hide 
Range on Protein: 13-270
Range on HMM: 1-277/277
Sequence Identity: 42% (119 aa)

LTVLGTGGYGKVFLVRKVTGADQKQLYAMKVLKKTSVVRKKKVMEHTLTERSVLEAIRDFPFLVTLHYAFQTETKLHLVMDYLCGGELFTHLHQIGPFSE
| |||||||||.|..||... |. .|||||.|.|. || |.|. ||| |||..||...  |..|.||||||......|||.|. |||||||. . . |.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

SGSRLYGAEITLALEHLHSLNILYRDIKLENILLDRD---GHIVLTDFGLSKTMKPD--QVAHSYCGTVEYMAPEIIRG---GDDGHNLLVDWWSLGVLL
|  | . .|. .|..|.|.. | .||.|.||||.| .   ||..|.|||...   .|  . ..|.|.| .|||||..|.   .| |..  .|||||||.|
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

HELLTCESPFA--PTGED---NSQKEISRRILYEAPPIP----HKLSPSCRELLFGLMRKNKDERLGAN--GAHEVK
 ..||  .||.    ...   ||..||..||. . ...|     . ||  ..|. .|  |.   |||.|  .|||.|
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase AqueK023.AA Akt 10-275 47 6.4e-120 385.05 In-house 1-264 (264) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-264/264
Sequence Identity: 47% (131 aa)

FELLTVLGTGGYGKVFLVRKVTGADQKQLY-AMKVLKKTSVVRKKKVMEHTLTERSVLEAIRDFPFLVTLHYAFQTETKLHLVMDYLCGGELFTHLHQIG
|..| ||| | .||||||.|    | ...| |||||||   . |.   |||.||| .|. .. .||.| |||.|||..|| .||||  |||||.||.. .
FDFLKVLGKGSFGKVFLVKK---KDTQKWYYAMKVLKKDYIIQKN-QVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKR

PFSESGSRLYGAEITLALEHLHSLNILYRD-IKLENILLDRDGHIVLTDFGLSK-T-MKPDQVAHSYCGTVEYMAPEIIRGGDDGHNLLVDWWS-LGVLL
 |||.  | |.||| ||.||||| || |||  |.||||.|.|||| ||||||.|   .| .... . ||| ||.||||. |   ||   ||||. ||...
RFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNG--NGHTKAVDWWGSLGCVM

HELLTCESPFAPTGEDNSQKEISRRILYEAPPIP--HKLSPSCRELLFGLMRKNKDERLG--ANGAHEVKSHRWF
 |...   ||    .|  ...    |...   .|  ...|| |. |. ||  |....|||   |.|.|.|.| ||
YEMMCGRPPFYN--QD--HHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase AqueK023.AA AktR 10-275 45 1.3e-114 387.08 In-house 1-268 (268) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-268/268
Sequence Identity: 45% (126 aa)

FELLTVLGTGGYGKVFLVRKVTGADQKQLYAMKVLKKTSVVRKKKVMEHTLTERSVLEAIRDFPFLVTLHYAFQTETKLHLVMDYLCGGELFTHLHQIGP
|... .|| |..|||.||.|    | ...||||..|| .  .... |.||.||| ..|.. ..||.| |||.|||..|| ..|.| .|||||.|| ... 
FHVYKCLGKGAFGKVYLVQKKR--DNQKQYAMKMIKK-KKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKK

FSESGSRLYGAEITLALEHLHSL-NILYRDIKLENILLDRDGHIVLTDFGLSK---TMKPDQVAHSYCGTVEYMAPEIIRGGDDGHNLLVDWWSLGVLLH
|||. .| | |.| ||||.||.  || |||.| |||||| |||. .|||||||    |  |..|.| |||.||||||.|.   .|||  ||||..|... 
FSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKK-KGHNKSVDWWAFGIFIY

ELLTCESPFAPTGEDNSQKEISRRILYEA---PPIPHKLSPSCRELLF-GLMRKNKDERLG--ANGAHEVKSHRWF
|..|   ||    ....|...  .|...    .|.| ..|. |..|.  .|. ||  .|||  .||. |.||| ||
EMVTGCPPF----YHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase AqueK023.AA p70 10-275 42 1.1e-110 373.96 In-house 1-299 (299) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-299/299
Sequence Identity: 42% (130 aa)

FELLTVLGTGGYGKVFLVRKVTGADQKQLYAMKVLKKTSVVRKKKVMEHTL-------------------------TERSVLEAIRDFPFLVTLHYAFQT
|||| ||| |||||||.||||||.|. ..||||||.| ..||  |  .||                           ||..||..   ||.. |||||||
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKH-PFICDLHYAFQT

ETKLHLVMDYLCGGELFTHLHQIGPFSESGSRLYGAEITLALEHLHSLNILYRDIKLENILLDRDGHIVLTDFGLSK-TMKPDQV----------AHSYC
. || |. .|| |||||.||   | . |   . | .||..||||||.. | ||| | ||..|.  ||.|||||||.|  .. ..|           |. |
NGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFC

GTVEYMAPEIIRGGDDGHNLLVDWWSLGVLLHELLTCESPFAPTGEDNSQKEISRRILYEA--PPIPHKLSPSCRELLFGLMRKNKDERLG--ANGAHEV
|| |||||||...   |||  |||||||.|.   ||   ||  |||    |..   ||     . .| .|... | |.  |. .. ..|.|   . | ..
GTIEYMAPEILMR--CGHNHAVDWWSLGCLMYDMLTGGPPF--TGEN--RKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADI

KSHRWF
..| .|
QEHPFF
Kinase AqueK023.AA RSK 10-275 37 9.1e-96 324.47 In-house 1-271 (271) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-271/271
Sequence Identity: 37% (103 aa)

FELLTVLGTGGYGKVFLVRKVTGADQKQLYAMKVLKKTSVVRKKKVMEHTLTERSVLEAIRDFPFLVTLHYAFQTETKLHLVMDYLCGGELFTHLHQIGP
.||. ..|.| ..||....|... | .|.||||..|| ... | .    . .|| .|. . . || |.|||.||.|.|. ..|| . ||.||..|   . 
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR--VCWEEERIILRYG-HHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKM

FSESGSRLYGAEITLALEHLHSLNILYRDIKLENILLDRD----GHIVLTDFGLSKTMKPDQV-AHSYCGTVEYMAPEIIRGGDDGHNLLVDWWSLGVLL
|||.  . | |||.||.|.|||. | .|| | ||||.| .    ||| ..|||..| .. .   . . |.|..|||||...  . ||   .||||.|||.
FSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLK--RQGHDQACDWWSFGVLM

HELLTCESPFAPTGEDNSQKEISRRILYE---APPIPHKLSPSCRELLFGLMRKNKDERLGA--NGAHEVKSHRWF
.| ||   ||. .  |     | |  |       ......|. . .|| ..   ..  ||||  ||. ..|.| ||
YEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase AqueK023.AA S_TKc 10-275 30 1.5e-94 321.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-231/231
Sequence Identity: 30% (85 aa)

FELLTVLGTGGYGKVFLVRKVTGADQKQLYAMKVLKKTSVVRKKKVMEHTLTERSVLEAIRDFPFLVTLHYAFQTETKLHLVMDYLCG--GELFTHLHQI
.|.| ..| |..|||...|..     ....|.|..|           ||.. |...|.   . |..|.|...||. ..|..||.|. |  |.||..... 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

GP------FSESGSRLYGAEITLALEHLHSLNILYRDIKLENILLDRDGHIVLTDFGLSKTMKPDQVAHSYCGTVEYMAPEIIRGGDDGHNL-LVDWWSL
|.      |.|   | | ..| .|||..||..|..||.| ||||||.  || ..||||.. .      ...||| .|||||..     |..   .||||.
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL-----GYGKCKCDWWSC

GVLLHELLTCESPFAPTGEDNSQKEISRRILYEAPPIPHKLSPSCRELLFGLMRKNKDERLGANGAHE----VKSHRWF
|..| |.|. . ||        .... ..|.          ||...... ....|. ..|..|  | .    .|.| ||
GCILYEMLCGYPPFP------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK023.AA Pkinase 10-275 26 5.9e-78 270.08 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

FELLTVLGTGGYGKVFLVRKVTGADQKQLYAMKVLKKTSVVRKKKVMEHTL-TERSVLEAIRDFPFLVTLHYAFQTETKLHLVMDYLCGG----ELFTHL
.... ..| |..|.|.. ...   .   ..|.|..||    ...| ..|.. .| ...  . . |. |.|...|........||.|. ||    .||...
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

H--QIGPF--SESGSRLYGAEITLALEHLHSLNILYRDIKLENILLDRDGHI----VLTDFGLSKT--MKPDQVAHSYCGTVEYMAPEIIRGGDDGHNLL
.  . |.|  ||   . |  .|  .||..|| .|..||.|.||||.|..|||     ..||||.|     ... ....||| .|||||.|| |. ..   
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPK

VDWWSLGVLLHELLTCESPFAPTG----EDNSQKEISRRILYEAPPIPHKLS---------------------PSCRELLFGLMRKNKDERLGANGAHEV
||.||.|..|.|.|. . ||        . ..|... .||..  .. .   .                     ..|.... .. .|.  .|..   |...
VDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQI

KSHRWF
. | ||
LQHPWF
Kinase AqueK023.AA Ciliate-E2 10-275 22 4.6e-72 245.71 In-house 1-365 (365) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-365/365
Sequence Identity: 22% (87 aa)

FELLTVLGTGGYGKVFLVRK-VTGA-------------------DQKQLYAMKVLKKTSVVRKKKVMEHTL----------TERSVLEAIRDFPFLVTLH
.... ..|.|..|.|.....  ..                    .....||||..||  .  .|. ..| .           |...|| . ..|... ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQ-EIHIMREINCFYKKINEKNILE-QLNHPNIIKMY

YAFQ--TETKLHLVMDYLCGGELFTHLHQI-----------GPFSESGSRLYGAEITL---------------ALEHLHSLN-ILYRDIKLENILLDRDG
..||  ..... |||.|. ||.|| .. .            ..|.|   . . ..|.                |||.||| | |..||||.||||.    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

HIVLTDFGLSKTMKPD--------------------------------QVAHSYCGTVEYMAPEIIRGGDDG-------HNLLVDWWSLGVLLHELLTCE
 | ..||||||  ..|                                ......||| .||||||..|....       ..  .|.|||||.|.|.|. .
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

SPFAPTGEDNSQKEISRRILYEAPP--------------IPHKLSPSCRELLFG----LMRKNKDERLGANGAHEVKSHRWF
 ||        |..|    .   .|              ...|.|..|  |.      .. |. ..|..  |. ... | ||
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF
Kinase AqueK023.AA CAMK 15-275 19 6.3e-71 227.56 In-house 1-425 (425) Show / Hide 
Range on Protein: 15-275
Range on HMM: 1-425/425
Sequence Identity: 19% (83 aa)

VLGTGGYGKVFLVRKV-TGADQK--------QLYAMKVLKKTSVVR------------------------KKKVMEHTLTERSVLEAIR------DFPFL
.||.|..|||.|..   |. ...        | .|.|...|. .                          . | ..  . | ...  ..      | | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VTLHYAFQ------------TETK--------LHLVM---DYLCGGEL----FTHLHQIGP---------------FSESGSRLYGAEITLALEHLHSLN
. |. ...            | .|        ...||   .|  ||||    | .. . |.               |.|.  | |   |  |....||.|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILYRDIKLENILLDRD-----------------GHIVLTDFGLSKTMKP------------------------DQVAHSYCGTVEYMA-PEIIRG-G---
|  ||.|.|||||| .                 . | ..|||... ..|                        .|  . .||| |||| ||...| |   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------DDGHNLLVDWWSLGVLLHELLTCESPFAPTGEDN---------SQKEISRRILYEAPP-IPHKLSP-----------------------SCR
         ....  .| ||.||.|  .|. ..||    ...         ...|. ..|.      .|...||                       .|.
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

ELLFGLMRKNKDERLGANGAHEVKSHRWF
 |. ...... ..|.    ......| |.
DLIRKMLQVDPEKRM---TIEQCLNHPWM
Kinase AqueK023.AA CAMKL 10-275 26 5.9e-59 186.71 In-house 1-297 (297) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-297/297
Sequence Identity: 26% (83 aa)

FELLTVLGTGGYGKVFLVRK-VTGADQKQLYAMKVLK--KTSV-----------VRKKKVMEHTLTERSVLEAIR--DFPFLVTLHYAFQTETK------
.... .||.|..||| | .   |    .. .|.|...  |..             . ...| .   | . .. ..    |  . |.  ..|...      
YRIGKTLGKGSFGKVKLATHIRTT---GEKVAIKIIDKKKIWNDPWMKKNKCGQKH-ESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKK

LHLVMDYLCGGE--LFTHLHQI----GPFSESGSRLYGAEITLALEHLHSLNILYRDIKLENILLDRDG--HIVLTDFGLSKTMKP-----DQVAHSYCG
..||| | .|||  || .. .     |...|.  | |   |  |....||..|  ||||.|||||| .|   | ..|||.|  ..|     .|  .  ||
IYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCG

TVEYMAPEIIRGGDDGHN-LLVDWWSLGVLLHELLTCESPF-APTGE-----DNSQKEISRRILYEAPPIPHKLSPSCRELLFGLMRKNKDERLGANGAH
. .||||||. |. . ..   || ||.||.|  ... . || ..| .     ..  ..   ... . |||. ..| .|| |. ... .| ..|     .|
SPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRP---TIH

EVKSHRWF
....|.|.
QIMNHPWM
Kinase AqueK023.AA S_TK_X 276-336 26 3.9e-20 74.14 SMART 1-79 (79) Show / Hide 
Range on Protein: 276-336
Range on HMM: 1-79/79
Sequence Identity: 26% (21 aa)

SSLNWDDVLA--KKVRPPFKPYVS----NEMDVGNFADEFTNQDPVDSPALP--ISKHNQV----------FRGYSFIG
....||....  |.. ||||| ..    .. |..|| .|||...|...|. |  .. ..|           |||.... 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase AqueK023.AA TyrKc 10-275 20 3.9e-13 -10.38 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

FELLTVLGTGGYGKVFLVRKVTGADQKQLYAMKVLKKTSVVRKKKVMEHTLTERSVLEAI-RDFPFLVTLHYAFQTE-------TKLHLVMDYLCGGELF
 .|. .|| | .|.|.. .        .  | |.||. .       .|  . | ...  .  . | .| |. .  ..         | .|| | ..| | 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

THLHQIGP-FSESGSRLYGAEITLALEHLHSLNILYRDIKLENILLDRDGHIVLTDFGLSKTMKPD--------QVAHSY--CGT----VEYMAPEIIRG
 .|.  .| .. .    .   |    |.||| |.  ||.   |.|.......  .|||||.  . |           ..   .|     .  |||| |  
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

GDDG-HNLLVDWWSLGVLLHELLTCESPFAPT---GEDNSQKEISRRILYE-APPIPHK--------LSPSCRELLFGLMRKNKDERLGANGAHEVKSHR
 ..|  .   | || ||.. |..|   .  |      . | .|. ...     .|.|.          ..   ..     . . ..|   .       |.
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HE

WF
 |
CF
Kinase AqueK023.AA Pkinase_C 295-338 31 3e-10 39.34 Pfam 1-46 (46) Show / Hide 
Range on Protein: 295-338
Range on HMM: 1-46/46
Sequence Identity: 31% (15 aa)

YVSNEMDVGNFADEFTNQDPVDSP---ALPISKHNQVFRGYSFIGPP
 |... |. || .|||...|.|.|       | ..  |||...  | 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase AqueK023.AA Pkinase_Tyr 90-215 27 1.6e-05 19.31 Pfam 84-217 (270) Show / Hide 
Range on Protein: 90-215
Range on HMM: 84-217/270
Sequence Identity: 27% (37 aa)

LVMDYLCGGELFTHLHQ----IGPFSESGSRLYGAEITLALEHLHSLNILYRDIKLENILLDRDGHIVLTDFGLSKTMKPDQVAHSYCGT-----VEYMA
.|| | ..| | ..|..     .|.. .    . ..|  ..|.|.| |.  ||.   |.|.......  .||||.... .|    .. ..     .  ||
IVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMA

PEIIRGGDDGHNLLVDWWSLGVLLHELLT-CESP-FA
|| |. |    .   | || |||. |..| .|.| ..
PECINYGK--FTTKSDVWSFGVLMWEIFTYGEQPTYP
Kinase AqueK023.AA MSK 366-621 40 1.7e-113 383.35 In-house 1-277 (277) Show / Hide 
Range on Protein: 366-621
Range on HMM: 1-277/277
Sequence Identity: 40% (113 aa)

LSNT-NLGTGSFSTCRVCIEKETKQEFAVKIVS--------KRHNP-MREISILQLCQGHPNIVRLHEVLQDQLHVYIIMERLRGGELLDRIRSNNSFTE
|.    .| |.|..|| |  ..| ...|.||.|        |.    ..|...|..||.||||| ||.. |||.| |..|| ..||||. .||.   |.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

AQASHLFRQLVSAVHFIHSKRVVHRDLKPENLIFSNEDDDTAVLKIIDFGFARLLPEA-PQVLTTPCYTLPYGAPEVISH---SNG-YTESCDIWSLGVI
. ..  .|.||.|| ..|.|...||||||||. | .|.|. . .|.||||||||.|.   . . .||.|| | |||..     ..| | |.||.||||||
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDN-GHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVI

LYTLLSGQAPFH--APTWP-----TEKIVDCIQHGSVSFDSDEWSSVSSTAKSLIKGLLTVNTSQRLTIDSLSVHPWL
|||.|.|| ||.  ..           |   |..|..||....|...|  || ||..|||.. . ||. . | .| |.
LYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase AqueK023.AA CAMK 370-621 25 1.7e-113 367.25 In-house 1-425 (425) Show / Hide 
Range on Protein: 370-621
Range on HMM: 1-425/425
Sequence Identity: 25% (110 aa)

NLGTGSFSTCRVCIEKETK------------QEFAVKIVSKR---------------------------------HNPMREISILQLCQG------HPNI
 ||.|||.. . ||.|.|.            |..|.||..|.                                 .| .|||.|....||      ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLHEVLQD-------------------QLHVYIIM---ERLRGGEL----LDRIRSNNS---------------FTEAQASHLFRQLVSAVHFIHSKRV
..|.|| .|                   . |.|..|   |   ||||    .|.|... .               |||..|...|||..||||..||. .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENLIFSNEDDDT-------------AVLKIIDFGFARLLPEAP-----------------------QVLTTPCYTLPYGA-PEVISH------
|||||||||. ... .||.             . .||||||||. ...                         | ..|.| |..| | |||..       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------SNGYTESCDIWSLGVILYTLLSGQAPFHAPTWP-----------TEKIVDCIQHGSVSFDSDE------------WSSVSST--------AKS
         .|...||.||.|||||..|.|  || ...              ...   |. |  .|....            |...|          .|.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIKGLLTVNTSQRLTIDSLSVHPWL
||...|.|. ..|.||.    |||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase AqueK023.AA RSK 366-621 33 7e-109 368.02 In-house 1-278 (278) Show / Hide 
Range on Protein: 366-621
Range on HMM: 1-278/278
Sequence Identity: 33% (94 aa)

LSNT-NLGTGSFSTCRVCIEKETKQEFAVKIVSK----RHNP-----MREISILQLCQGHPNIVRLHEVLQDQLHVYIIMERLRGGELLDRIRSNNS---
|.    .| |....|| |. . |.|..|.|...|    ...      |.|..||..||.||.||.||.. |.....|.||| .|||||.....   .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEAQASHLFRQLVSAVHFIHSKRVVHRDLKPENLIFSNEDDDTAVLKIIDFGFARL-LPEAPQVLTTPCYTLPYGAPEVIS---HSNGYTESCDIWSLG
|.|  |.  ....|.|| ..|.. ..|||||||| .. .|. . . .|..||||...  ..  | . |.|||. | |||..    . .|....||.||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VILYTLLSGQAPFHAPTW-PTEKIVDCIQHGSVSFDSDEWSSVSSTAKSLIKGLLTVNTSQRLT-----IDSLSVHPWL
|..|..|.|. ||..|     ..| . ||.|  |.....|...| .||.||...|... ..||.     .. .  |||.
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase AqueK023.AA AGC 371-621 21 7.7e-100 258.19 In-house 7-395 (395) Show / Hide 
Range on Protein: 371-621
Range on HMM: 7-395/395
Sequence Identity: 21% (87 aa)

LGTGSFSTCRVCIEK------ETKQEFAVKIVSKRH-----------NPMRE------------ISILQLCQG---------HPNIVR-LHEVLQDQLH-
.|.|||.... . .|       |.. .|.|...|.|           . |.|              ||..|..         ||.||. ||   ||. | 
IGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHT

-VYIIMERLR---------GG-ELLDRIR---SNNSFTEAQASHLFRQ-------LVSAVHFIHS-KRVVHRD-LKPENLIFSNEDDDTAVLKIIDFGFA
 .|..|| .          || ||. ...    . .|.| .| . . .       .|.|....|| . ..||| |||||. . ..      .|. |||..
YLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED----GHIKLTDFGLC

RLLPEAP-------------------------------------------------QVLTT----PCYTLPYGAPEVISHSNGYTESCDIWS--LGVILY
  ..  .                                                 ...|.    || |  | |||..     |. .||.||  ||...|
KEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL-----YGKACDWWSFGLGCLMY

TLLSGQAPFHAPTWP--------TEKIVDCIQ------HGSVSFDSD------EWSSVSSTAKSLIKGLLTVNTSQRLT----------IDSLSVHPWL
 .|.|. ||.. .           ... . |.      .  | |...      |....|. ||.|||.||... ..||.          .. .  ||| 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
S_TKc AqueK023.AA S_TKc 364-621 33 4.3e-94 319.82 SMART 1-231 (231) Show / Hide 
Range on Protein: 364-621
Range on HMM: 1-231/231
Sequence Identity: 33% (91 aa)

YELSNTNLGTGSFSTCRVCIEKETKQEFAVKIVSKRHNPMREISILQLCQGHPNIVRLHEVLQDQLHVYIIMERLRG--GELLDRIRSNNS------FTE
||. .. .| |.|.... |..|.|....|.||..   . .|||.||.   .|||||.|..| ||  |.|..|| . |  |.|.|.|.....      |.|
YEILRK-IGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

AQASHLFRQLVSAVHFIHSKRVVHRDLKPENLIFSNEDDDTAVLKIIDFGFARLLPEAPQVLTTPCYTLPYGAPEVISHSNGYTE-SCDIWSLGVILYTL
 .| ....|...|. ..||....||||||||. ...      ..||.|||.||.|       || | |. | ||||.    ||.  .||.||.|.||| .
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

LSGQAPFHAPTWPTEKIVDCIQHGSVSFDSDEWSSVSSTAKSLIKGLLTVNTSQRLTIDSLSV-------HPWL
|.|. ||.      ... . |               |. ||..|...|... ..|.|.  .         |||.
LCGYPPFP----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK023.AA Pkinase 371-621 31 1.8e-91 314.97 Pfam 7-293 (293) Show / Hide 
Range on Protein: 371-621
Range on HMM: 7-293/293
Sequence Identity: 31% (93 aa)

LGTGSFSTCRVCIEKETKQEFAVKIVSKRHNPM---------REISILQLCQGHPNIVRLHEVLQDQLHVYIIMERLRGG----ELLDRIR--SNNSF--
.| |||.... |..| | ...||||..|||. .         .||.|.. . .|||||||... .|  |.|..|| ..||    .| |.|.  ....|  
IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYF

TEAQASHLFRQLVSAVHFIHSKRVVHRDLKPENLIFSNEDDDTAVLKIIDFGFARLL-PEAPQVLTTPCYTLPYGAPEVISHSNGYTESCDIWSLGVILY
.| .. . ..|..... ..||....||||||||. ..|...  | .||.|||.|...     . .||.| |..| ||||| ....|. ..|.||.|.|||
SEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILY

TLLSGQAPFHAP----TWPTEKIVDC-IQHGSVSFDSDEWSSVS-----------------STAKSLIKGLLTVNTSQRLTIDSLSVHPWL
 .|.|. ||       .  ... . | | .. ..||...|.|.|                 ...|..||..|... ..|.|.. .  |||.
EMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK023.AA CAMKL 364-621 31 2.3e-90 288.56 In-house 1-297 (297) Show / Hide 
Range on Protein: 364-621
Range on HMM: 1-297/297
Sequence Identity: 31% (95 aa)

YELSNTNLGTGSFSTCRVCIE-KETKQEFAVKIVSKRHNPM--------------------REISILQLCQ--GHPNIVRLHEVLQDQLH------VYII
|..    ||.|||.. . ..  . |... |.||. |.   .                    |||.|... .  .||||..|.||.... |      .|..
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

MERLRGGE--LLDRIRSN----NSFTEAQASHLFRQLVSAVHFIHSKRVVHRDLKPENLIFSNEDDDTAVLKIIDFGFARLLPE----APQVLTTPCYTL
||   |||  |.|.|...     ...| .| ..|||.||||...||...||||.||||. ... ..   ..|||||||. .  .      | |.| | ..
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

PYGAPEVISH-SNGYT-ESCDIWSLGVILYTLLSGQAPFHAPTWP----TEKIVDCIQHGSVSFDSDEWSSVSSTAKSLIKGLLTVNTSQRLTIDSLSVH
|| |||...     |     ||||.|||||... |. || ..| .    . .     .  .  .  . |..||  ...||...|.|| ..| ||. .  |
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PWL
||.
PWM
Kinase AqueK023.AA RSK 364-621 36 1e-82 281.12 In-house 1-271 (271) Show / Hide 
Range on Protein: 364-621
Range on HMM: 1-271/271
Sequence Identity: 36% (99 aa)

YELSNTNLGTGSFS---TCRVCIEKETKQEFAVKIVSKRHNPMR------EISILQLCQGHPNIVRLHEVLQDQLHVYIIMERLRGGELLDRIRSNNSFT
|||    .|.||||    |. |. | |.|..|.||. |  .  .      |. |.     ||.||.||.| ||. .||.||. .|||.|.||.    .|.
YELHEC-IGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EAQASHLFRQLVSAVHFIHSKRVVHRDLKPENLIFSNEDDDTAVLKIIDFGFARLLPEAPQVLTTPCYTLPYGAPEVISHSNGYTESCDIWSLGVILYTL
|  ..   . . .|. . ||. .||||||||| ... |. .   .|| |||||  |      | |.|||  | ||||..   |....||.||.||..|. 
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKR-QGHDQACDWWSFGVLMYEM

LSGQAPFHA-PTWPTEKIVDCIQHGSVSFDSDEWSSVSSTAKSLIKGLLTVNTSQRLTI-----DSLSVHPWL
|.|  ||.. |   .. |   |. |  |. .  |...| .||.|. ..|...  .||.           |||.
LTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase AqueK023.AA Ciliate-E2 365-621 23 2e-76 260.21 In-house 1-365 (365) Show / Hide 
Range on Protein: 365-621
Range on HMM: 1-365/365
Sequence Identity: 23% (89 aa)

ELSNTNLGTGSFSTCRVCIEKETK-----------------------QEFAVKIVSKR--HNPMREISIL--------------QLCQG-HPNIVRLHEV
   .  .|.|.|.. . |  ....                       ...|.||..|.   . ..||.|.               | |  ||||....|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

LQ--DQLHVYIIMERLRGGELLDRIRSN-----------NSFTEAQASHLFRQLVS---------------AVHFIHSKR-VVHRDLKPENLIFSNEDDD
 |  |. ..|..|| . ||.|.|.|..|           ..||| .......|...               |....|||  ..|||.||||..|      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

TAVLKIIDFGFAR----------------LLPEAP----------------QVLTTPCYTLPYGAPEVISH--------SNGYTESCDIWSLGVILYTLL
   .||||||...                ....                  ..  | |.|..| |||...         ..||...||||||||||| .|
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

SGQAPFHAPTWPTEKIVDCIQHG-SVSFDSDE--------------WSSVSSTAKSLIKG----LLTVNTSQRLT-IDSLSVHPWL
.|. ||             ...   ..|.. |              | ..|  .| |||     .| .. ..|.| .. .  |||.
FGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase AqueK023.AA AktR 364-621 28 1.5e-28 101.16 In-house 1-268 (268) Show / Hide 
Range on Protein: 364-621
Range on HMM: 1-268/268
Sequence Identity: 28% (80 aa)

YELSNTNLGTGSFSTCRVCIEK-ETKQEFAVKIVSK--------RHNPMREISILQLCQGHPNIVRLHEVLQDQLHVYIIMERLRGGELLDRIRSNNSFT
... . .|| | |..   . .| .... .| |...|        .|   .|  |.. |. || ||.||.  |.. . ..|||  .||||.. ..... |.
FHVYK-CLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFS

EAQASHLFRQLVSAVHFIHSK-RVVHRDLKPENLIFSNEDDDTAVLKIIDFGFARLLPE--APQVLTTPCYTLPYGAPEVISHSNGYTESCDIWSLGVIL
| ||   | | . |. . |..  .. |||||||.    .      .||.||| ..|..     .. .. | |  | |||.|  . |.. |.|.|..|. .
EEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDED----GHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFI

YTLLSGQAPFHA--PTWPTEKIVDCIQHGSVSFDSDEWSSVSSTAKSLIK-GLLTVNTSQRLT-----IDSLSVHPWL
| ...|. || .   ..  .||  . |     .  .. | .||..|.||. .||  |  .||.     .. .  ||| 
YEMVTGCPPFYHKNQNQMFQKIKIKQQ-----NKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase AqueK023.AA p70 415-621 26 1.8e-21 74.57 In-house 87-299 (299) Show / Hide 
Range on Protein: 415-621
Range on HMM: 87-299/299
Sequence Identity: 26% (60 aa)

HPNIVRLHEVLQDQLHVYIIMERLRGGELLDRIRSNNSFTEAQASHLFRQLVSAVHFIHSKRVVHRDLKPENLIFSNEDDDTAVLKIIDFGFARLLPEAP
||.|. ||   |.    | | | | ||||         . |  |.      . |  . |.. .. ||||||| .     .    ..  |||      .  
HPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCML----NQQGHVVLTDFGLCKESIHDG

QV----------LTTPCYTLPYGAPEVISHSNGYTESCDIWSLGVILYTLLSGQAPFHAPTWPTEKIVDCIQHGS--VSFDSDEWSSVSSTAKSLIKGLL
.|          . | | |  | |||... . |.   .| ||||. .|  | |. || . .    |..| |. |   ..         .  .. ||| ||
AVDEEDPENVNATHTFCGTIEYMAPEILMRC-GHNHAVDWWSLGCLMYDMLTGGPPFTGEN--RKKTIDKILKGKQGLKL----PPYLTHEMRDLIKKLL

TVNTSQRLT-----IDSLSVHPWL
  ...||..     .    .||. 
KRHPTQRWGAGPEDAADIQEHPFF
Kinase AqueK023.AA Akt 528-563 37 1.2e-10 30.17 In-house 170-205 (264) Show / Hide 
Range on Protein: 528-563
Range on HMM: 170-205/264
Sequence Identity: 37% (14 aa)

APEVISHSNGYTESCDIWS-LGVILYTLLSGQAPFHA
|||...  ||.| ..|.|. ||...| .. |. ||..
APEILNG-NGHTKAVDWWGSLGCVMYEMMCGRPPFYN
Kinase AqueK023.AA Akt 408-487 39 1.9e-10 29.54 In-house 53-132 (264) Show / Hide 
Range on Protein: 408-487
Range on HMM: 53-132/264
Sequence Identity: 39% (32 aa)

ILQLCQGHPNIVRLHEVLQDQLHVYIIMERLRGGELLDRIRSNNSFTEAQASHLFRQLVSAVHFIHSKRVVHRD-LKPENL
||| |. || || ||   |.| . |..|.   ||||   ..  . |.| .|     ....|  . ||| .. || |||||.
ILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENI
Kinase AqueK023.AA Pkinase_Tyr 403-482 33 4e-07 24.76 Pfam 51-137 (270) Show / Hide 
Range on Protein: 403-482
Range on HMM: 51-137/270
Sequence Identity: 33% (29 aa)

MREISILQLCQGHPNIVRLHEVLQ-DQLH--VYIIMERLRGGELLDRIRS----NNSFTEAQASHLFRQLVSAVHFIHSKRVVHRDL
|||..|.     |||||||. |   .. .  .||.||   .| |||  |.    ....|  .  .  .|  ..  . .||. .||||
MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase AqueK023.AA Akt 590-621 32 0.000107 10.85 In-house 228-264 (264) Show / Hide 
Range on Protein: 590-621
Range on HMM: 228-264/264
Sequence Identity: 32% (12 aa)

VSSTAKSLIKGLLTVNTSQRL-----TIDSLSVHPWL
.|  .|.||.|||. . ..||     ... .  |||.
ISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase AqueK023.AA Pkinase_Tyr 528-552 40 0.689798 3.63 Pfam 182-205 (270) Show / Hide 
Range on Protein: 528-552
Range on HMM: 182-205/270
Sequence Identity: 40% (10 aa)

APEVISHSNGYTESCDIWSLGVILY
|||.|...  .|.  |.|| || ..
APECINYGK-FTTKSDVWSFGVLMW