Gene AqueK194 (A.queenslandica)

AqueK194

Species: A.queenslandica
Alias: AqueK194
External Links:
Annotation: Secondary Group: Other, Secondary Family: PEK, Secondary Subfamily: GCN2

Classification

Group: Other
Family: PEK
Subfamily: GCN2

Sequence

Name Sequence Type Origin Length Description Download
AqueK194.AA Protein None 1398 None Fasta, JSON
AqueK194.kin_dom Protein Kinase Domain None 427 None Fasta, JSON
AqueK194.kin_dom2 Protein Kinase Domain None 265 None Fasta, JSON

Protein domain

Protein domains of AqueK194.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RWD AqueK194.AA RWD 5-124 25 6.5e-22 82.95 Pfam 1-119 (119) Show / Hide 
Range on Protein: 5-124
Range on HMM: 1-119/119
Sequence Identity: 25% (32 aa)

SYEERQRDELEFLQFVFMSDFEDMREKDTWKIQRPPEIMIKLTPQKSISTSVQRLQISVKLHAKYSSDYP-DTPPQLD-LIEPHLLS---KDLVKELLTE
 ..|.| |||| |.  .. |||| | .  |.  .|... ||.      ..  .    ...|| ....||| |.||... . . ..|.   .. ...|...
MCQEEQEDELEALESIYPDDFEDLRGTICWTEISPWHFTIKI------DECESSHHPPLVLHFQCPEDYPSDEPPIISIISC-WNLHKLPDYQIQQLCKK

INDLAKSRI-GEVMMLEIAQHVQSFL
....... . |.||  |.....| .|
LQEYWEENCHGMVMIFEWIEWLQENL
RWD AqueK194.AA RWD 12-127 24 2.2e-20 74.93 SMART 1-128 (128) Show / Hide 
Range on Protein: 12-127
Range on HMM: 1-128/128
Sequence Identity: 24% (32 aa)

DELEFLQFVFMSDFEDMREKDTWKIQRPPEIMIKLTPQKSI---------STSVQRLQISVKLHAKYSSDYPDTPPQLDLIEPH-LLSKDLV--KELLTE
.||| |. ....|||. .|   . . ....| |...|.            .. . .  ....|| . . .|||..|...|..|.  ||.. .  .||...
MELEALESIYPDDFECIDEDRHHWV-INCCIQIHIHPHEDEMQITNYDNFYE-GEDHYWCITLHFHCPENYPDEAPPIFLENPQKWLSDEQKYYQELQKH

INDLAKSR--IGEVMMLEIAQHVQSFLHKH
......    .|..|. |..|.||.||  |
LQEIWEENWCRGMCMIFEWVQWVQEFLSEH
Kinase AqueK194.AA GCN2 316-406 29 9.2e-14 44.18 In-house 261-350 (511) Show / Hide 
Range on Protein: 316-406
Range on HMM: 261-350/511
Sequence Identity: 29% (27 aa)

SHSSIVKYLLMRHNLTEHGILVEVGMEYITGGSLNSLLQGSSSSPITGKS-LQLYSKQLLEAVAYLHSQGIVHNDIRPSLVFIDPVQGVKLA
.| ..|.|..|. .  . ....   |||. |..| ...  ......  .  |  |  |.||...|.||||..| |..|| .|.|  . || .
QHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYI--DNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIG
Kinase AqueK194.AA STE11 341-390 45 2.6e-12 41.09 In-house 92-142 (303) Show / Hide 
Range on Protein: 341-390
Range on HMM: 92-142/303
Sequence Identity: 45% (23 aa)

MEYITGGSLNSLLQ-GSSSSPITGKSLQLYSKQLLEAVAYLHSQGIVHNDI
|||. |||| |.|. .      . .  . | ||.||...||||.||.| ||
MEYCPGGSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDI
Kinase AqueK194.AA STE 341-406 27 2.9e-10 32.59 In-house 116-189 (359) Show / Hide 
Range on Protein: 341-406
Range on HMM: 116-189/359
Sequence Identity: 27% (22 aa)

MEYITGGSLNSLLQ---GSSS---------SPITGKSLQLYSKQLLEA-VAYLHSQGIVHNDIRPSLVFIDPVQGVKLA
|||. |||| ....   |            ...  . .  . .|.|..  .||||..|.| || |. ...     |||.
MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLC
Kinase AqueK194.AA Pkinase 341-406 26 6e-10 36.25 Pfam 79-154 (293) Show / Hide 
Range on Protein: 341-406
Range on HMM: 79-154/293
Sequence Identity: 26% (20 aa)

MEYITGG----SLNSLLQGSSSSPI--TGKSLQLYSKQLLEAVAYLHSQGIVHNDIRPSLVFIDPVQGV----KLA
|||  ||    .| ........ ..  . . .. | .|.|....|.||.||.| |. |. ..||    .    |..
MEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC
Kinase AqueK194.AA Ciliate-E2 341-406 23 1.6e-09 28.88 In-house 113-198 (365) Show / Hide 
Range on Protein: 341-406
Range on HMM: 113-198/365
Sequence Identity: 23% (22 aa)

MEYITGGSLNSLLQGS----------SSSPITGKSLQLYSKQLLE---------------AVAYLHSQG-IVHNDIRPSLVFIDPVQGVKLA
|||. ||.| .... .             ..| |  . ..||.|.               |. ||||.. |.| || |. ...     .|..
MEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKII
Kinase AqueK194.AA PEK 371-398 50 4.3e-09 27.02 In-house 434-461 (655) Show / Hide 
Range on Protein: 371-398
Range on HMM: 434-461/655
Sequence Identity: 50% (14 aa)

KQLLEAVAYLHSQGIVHNDIRPSLVFID
.|.||...|.||||..| |..|| .|.|
RQILEGLNYIHSQGMIHRDLKPSNIFLD
Kinase AqueK194.AA STE-Unique 341-406 25 9.2e-07 19.43 In-house 373-452 (616) Show / Hide 
Range on Protein: 341-406
Range on HMM: 373-452/616
Sequence Identity: 25% (21 aa)

MEYITGGSLNSLLQGSSSSP---------ITGKSLQLYSKQLLEAVAYLHSQG--IVHNDIRPSLVFIDPVQ-----GVKLA
|||  .|.|  ...  ....         .       | .|.||.  |||||.  |.| |. |. .|..  .      ||..
MEYCEHGTLQQIIK--RCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKIC
Kinase AqueK194.AA WEE 372-397 37 2e-06 17.65 In-house 119-145 (297) Show / Hide 
Range on Protein: 372-397
Range on HMM: 119-145/297
Sequence Identity: 37% (10 aa)

QLLEAVAYLHSQ-GIVHNDIRPSLVFI
.........||. |.||.|| |. .||
DICQGLHHIHSNCGMVHMDIKPENIFI
Kinase AqueK194.AA PEK 371-396 46 3e-06 15.63 In-house 449-474 (758) Show / Hide 
Range on Protein: 371-396
Range on HMM: 449-474/758
Sequence Identity: 46% (12 aa)

KQLLEAVAYLHSQGIVHNDIRPSLVF
.|..|.| |.|| |. | |  || .|
HQICEGVNYIHSKGMIHRDLKPSNIF
Kinase AqueK194.AA Pkinase_Tyr 341-387 30 0.000406 14.57 Pfam 86-134 (270) Show / Hide 
Range on Protein: 341-387
Range on HMM: 86-134/270
Sequence Identity: 30% (15 aa)

MEYITGGSLNSLLQGS--SSSPITGKSLQLYSKQLLEAVAYLHSQGIVH
|||  .|.| . |.    .  |.| | |  .. |  .. .||.|....|
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH
Kinase AqueK194.AA STE20 341-390 29 0.001206 9.54 In-house 87-143 (288) Show / Hide 
Range on Protein: 341-390
Range on HMM: 87-143/288
Sequence Identity: 29% (17 aa)

MEYITGGSLNSLLQGS-SSS------PITGKSLQLYSKQLLEAVAYLHSQGIVHNDI
|||  ||||  ..... .        |.. .      ...|.. .||||..|.| ||
MEYCGGGSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDI
Kinase AqueK194.AA NEK 372-405 27 0.053097 3.31 In-house 122-164 (286) Show / Hide 
Range on Protein: 372-405
Range on HMM: 122-164/286
Sequence Identity: 27% (12 aa)

QLLEAVAYLHSQ-----GIVHNDIRPSLVFIDPVQG----VKL
|.. |. |.|..      |.| || |. .|..        ||.
QMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKI
Kinase AqueK194.AA STE 464-499 47 5.8e-14 45.8 In-house 322-359 (359) Show / Hide 
Range on Protein: 464-499
Range on HMM: 322-359/359
Sequence Identity: 47% (18 aa)

VPEHFSEDFKDFLNKCLNNNEYQRYPAHELLV--HPFI
.|...|..||||.||||. .  .|  |..||   ||||
YPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase AqueK194.AA STE11 461-499 40 1.3e-12 42.14 In-house 259-303 (303) Show / Hide 
Range on Protein: 461-499
Range on HMM: 259-303/303
Sequence Identity: 40% (18 aa)

PPDVPEHFS------EDFKDFLNKCLNNNEYQRYPAHELLVHPFI
.|  |||.|      |. .|||..|.  . . |. |..|| ||||
HPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase AqueK194.AA GCN2 436-499 23 1.2e-10 33.06 In-house 430-511 (511) Show / Hide 
Range on Protein: 436-499
Range on HMM: 430-511/511
Sequence Identity: 23% (19 aa)

GKKTDILKL-GMVIFCMSVGRVTVSYP----------PDVPEHFS-------EDFKDFLNKCLNNNEYQRYPAHELLVHPFI
..| |.  | | ..| |. .   ....          . .|. |        .|..|....||| .. .|. | .|| |.|.
NQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLRSCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase AqueK194.AA STE20 465-499 45 2.1e-10 34.51 In-house 254-288 (288) Show / Hide 
Range on Protein: 465-499
Range on HMM: 254-288/288
Sequence Identity: 45% (16 aa)

PEHFSEDFKDFLNKCLNNNEYQRYPAHELLVHPFI
|...| .|.||..|||. .  .|  | .|| ||||
PHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase AqueK194.AA NEK 460-499 28 5.2e-10 31.84 In-house 245-286 (286) Show / Hide 
Range on Protein: 460-499
Range on HMM: 245-286/286
Sequence Identity: 28% (12 aa)

YPPDVPEH--FSEDFKDFLNKCLNNNEYQRYPAHELLVHPFI
..| .|.|  .|.| .......|. .  ||. . ..| .|||
QYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase AqueK194.AA Pkinase 460-499 23 3.6e-07 26.43 Pfam 235-293 (293) Show / Hide 
Range on Protein: 460-499
Range on HMM: 235-293/293
Sequence Identity: 23% (14 aa)

YPPDVPEHFS-------------------EDFKDFLNKCLNNNEYQRYPAHELLVHPFI
.. | |.  |                   |..|||...||. . ..|. |...| ||..
LHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK194.AA PEK 461-499 30 4.4e-07 19.89 In-house 613-655 (655) Show / Hide 
Range on Protein: 461-499
Range on HMM: 613-655/655
Sequence Identity: 30% (13 aa)

PPDVP-EHFSED---FKDFLNKCLNNNEYQRYPAHELLVHPFI
| | | ..|  .   ..||....|...  ||. | ..| |.|.
PGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase AqueK194.AA Ciliate-E2 458-499 16 2e-06 18.07 In-house 305-365 (365) Show / Hide 
Range on Protein: 458-499
Range on HMM: 305-365/365
Sequence Identity: 16% (10 aa)

VSYPPD--------------VPEHFSEDFKDFLNK----CLNNNEYQRYP-AHELLVHPFI
...|.                ... |.. ||...|    .|. .. .|.  . ..| ||..
IDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase AqueK194.AA STE-Unique 461-499 31 0.000147 11.46 In-house 573-616 (616) Show / Hide 
Range on Protein: 461-499
Range on HMM: 573-616/616
Sequence Identity: 31% (14 aa)

PP-----DVPEHFSEDFKDFLNKCLNNNEYQRYPAHELLVHPFI
||     . |. .. .. .|. |||. |  .| .||.|| |.. 
PPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase AqueK194.AA WEE 461-499 25 0.09244 1.77 In-house 258-297 (297) Show / Hide 
Range on Protein: 461-499
Range on HMM: 258-297/297
Sequence Identity: 25% (10 aa)

P-PDVPEHFSEDFKDFLNKCLNNNEYQRYPAHELLVHPFI
| |.... .|...|...   .. .  ||  . .|| || .
PFPEFDNIISQELKQLIKWMMHPDPEQRPTCQQLLQHPVL
Kinase AqueK194.AA PEK 548-937 19 1.7e-99 336.84 In-house 1-612 (655) Show / Hide 
Range on Protein: 548-937
Range on HMM: 1-612/655
Sequence Identity: 19% (137 aa)

FEVLEVLGKGGF-GDVIKVRNYLDSRLYAIKKVRLTGGS----------------KMMTKLTREVELLSQMNHENIVRYYNAWIEKYSEPN---------
||....|||||| |.|.||.| ||...||||...|   .                | ..| .||| .|...||.|||||.||||||  |..         
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

---------------------------HHGNEEEGEEFSDSSEDEDTTEEEEEEE-----------EREEGLSFIEFKLDES------------------
                               ..|....|.  ||....  .....           |. .. |..|.  ..|                  
LDSSTDWPNGKHKSKDYNFHPFEKEWDD-EEAQESNVMSE-CEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTENEN

-------------------------------------------------------------------------TRLDSSDQIRDDSYSFSSDVFTDTEDR
                                                                         .. ..||| .... .....  .|... 
ESHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQ

D---------------------------------------------------VFKGKVDTPGTNVATLLEADLMVTTPRRGFIHSESSDSVVFQDTSLMA
.                                                   ..                                              
SHKKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQ----------------------------------------------

PPGGEGEEGSTATGGGGAGGRAKQKQTGQSQYLYIQMEYCSNQTLKVLIDSGQ-----------------------------------------LIKSSG
                           .| .|||||||||.  ||. .||...                                           ..  
---------------------------YQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWD

FELGWQLFREITEGLAHIHSQGMIHRDLKPVNIFLNSSGH-----CKIGDFGLATT---------------FSKYHTGLSRQQSIPSNTSILAGD-----
 .. |..||.| |||..|||||||||||||.|||| ..|.      |||||||||.               .|..   .  .. .... .    .     
KDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTH

---------------------TGLVGTMLYLAPELLKSV----VKYTQKVDMYSLGIILYEMSHPPPATVMERVKILTDVRKKEIVF
                     || ||| || .||.|.       .|..||||||||||. ||..|.  | |||||.|||.|.  | |
MWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQF
Kinase AqueK194.AA GCN2 770-933 42 1.9e-61 210.45 In-house 278-466 (511) Show / Hide 
Range on Protein: 770-933
Range on HMM: 278-466/511
Sequence Identity: 42% (82 aa)

QSQYLYIQMEYCSNQTLKVLIDSGQLIKSSGFELGWQLFREITEGLAHIHSQGMIHRDLKPVNIFLNSSGHCKIGDFGLATT------------------
...|||||||||.. ||. .||.. ..  .  || |..||.| |||..|||||||||||||.|||| ..|. |||||||||.                  
EVHYLYIQMEYCEGKTLRQYIDNHGWCMDHD-EL-WRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQA

FSKYHTGLSRQQSIPSNT-SILAGDTG----------LVGTMLYLAPELLKSVVKYTQKVDMYSL-GIILYEMSHPPPATVMERVKILTDVRKK
.|..     ..|. ..|   . .....           ||| .| .||..    .|.|||||||| |||. ||..||  | ||||.||.. | .
SSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQ--KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLR-S
Kinase AqueK194.AA STE 548-912 15 4e-47 162.87 In-house 1-261 (359) Show / Hide 
Range on Protein: 548-912
Range on HMM: 1-261/359
Sequence Identity: 15% (65 aa)

FEVLEVLGKGGFGDVIKVRNYL---------------DSRLYAIKKVRLTGGS----------------KMMTKLTREVELLSQMN--HENIVRYYNAWI
.| .|..|||.|| | | .|                   ...|||...|   .                . | .. .|.......|  |.|||.|| . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EKYSEPNHHGNEEEGEEFSDSSEDEDTTEEEEEEEEREEGLSFIEFKLDESTRLDSSDQIRDDSYSFSSDVFTDTEDRDVFKGKVDTPGTNVATLLEADL
 .  .                                                                                               
KEGHN-----------------------------------------------------------------------------------------------

MVTTPRRGFIHSESSDSVVFQDTSLMAPPGGEGEEGSTATGGGGAGGRAKQKQTGQSQYLYIQMEYCSNQTLKVLIDSGQLIKSSG-----------FEL
                                                     ... ..|.| |||... .|  .|..   .. .             ..
-----------------------------------------------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQ

GWQLFREITEG-LAHIHSQGMIHRDLKPVNIFLNSSGHCKIGDFGLATTFSKYHTGLSRQQSIPSNTSI---LAGDTG---LVGTMLYLAPELLKS----
     |.| .| |...||.. ||||.|| ||.|     .|. |||... ... .... .     .| .|   . ..     .|||  . ||| ..     
IAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANI-Q-S---NN-IIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG

-VVKYTQKVDMYSLGIILYEM
 . .|. |.|..|||. . ||
RDKGYDTKCDIWSLGCTIIEM
Kinase AqueK194.AA S_TKc 548-985 15 1.5e-34 122.0 SMART 1-231 (231) Show / Hide 
Range on Protein: 548-985
Range on HMM: 1-231/231
Sequence Identity: 15% (72 aa)

FEVLEVLGKGGFGDVIKVRNYLDSRLYAIKKVRLTGGSKMMTKLTREVELLSQMNHENIVRYYNAWIEKYSEPNHHGNEEEGEEFSDSSEDEDTTEEEEE
.|.|...|||.|| | |.|.  . |..|||...                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

EEEREEGLSFIEFKLDESTRLDSSDQIRDDSYSFSSDVFTDTEDRDVFKGKVDTPGTNVATLLEADLMVTTPRRGFIHSESSDSVVFQDTSLMAPPGGEG
                                                            .. | ...              . .|    .         
----------------------------------------------------------EHIRREIQILKK----------HHPNIVKLYDVFQD------

EEGSTATGGGGAGGRAKQKQTGQSQYLYIQMEYCSN--QTLKVLIDSGQLIKS---SGFELGWQLFREITEGLAHIHSQGMIHRDLKPVNIFLNSSGHCK
                        ..||. ||||..   .|. .|.. .  .          . ....| ..|...||.| ||||||| ||.|..  | |
------------------------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIK

IGDFGLATTFSKYHTGLSRQQSIPSNTSILAGDTGLVGTMLYLAPELLKSVVKYTQ-KVDMYSLGIILYEMSH---PPPATVMERVKILTDVRKKEIVFS
|.|||||. .                       | ..||  |.|||.|    .|.  |.|..|.|.|||||     | | ....  |..           
ICDFGLARQL-----------------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG----------

ERFKTSKKMSKQAVEHTLQNPNSSQYKRLMEKLFSQE------NSKLFE-------MSFF
                      |.. | ...|..  .        ....       . .|
----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK194.AA Pkinase 771-912 32 4.6e-34 121.52 Pfam 72-205 (293) Show / Hide 
Range on Protein: 771-912
Range on HMM: 72-205/293
Sequence Identity: 32% (50 aa)

SQYLYIQMEYCSN-----QTLKVLI--DSGQLIKSSGFELGWQLFREITEGLAHIHSQGMIHRDLKPVNIFLNSSGHC----KIGDFGLATTFSKYHTGL
....|. |||| .         ..   ..| ..     .     ...| .||...||.| ||||||| ||.... ||.    ||.|||||  |.      
KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY--FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------

SRQQSIPSNTSILAGDTGLVGTMLYLAPELLKSVVKYTQKVDMYSLGIILYEM
         .      |...||  |.|||....  .|..||||.|.|.|||||
---------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase AqueK194.AA Ciliate-E2 772-912 23 1e-32 109.62 In-house 107-289 (365) Show / Hide 
Range on Protein: 772-912
Range on HMM: 107-289/365
Sequence Identity: 23% (45 aa)

QYLYIQMEYCSNQTLKVLIDSGQLIKSSG--------FELGWQLFREITE---------------GLAHIHSQG-MIHRDLKPVNIFLNSSGHCKIGDFG
...|. ||||. ..|. .| . .. . .          .   .....|..               .| ..||..  ||||.|| ||..     .|| |||
NNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFG

LAT---TFSKYHTGLSRQQSIPSNTSILAGDTG-------------LVGTMLYLAPELLKSVVK--------YTQKVDMYSLGIILYEM
|..   ......|...... ..   .   . .|             ..||  |.||| |..           |. |.|..|||.|||||
LSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase AqueK194.AA GCN2 548-683 27 1.3e-31 107.76 In-house 1-180 (511) Show / Hide 
Range on Protein: 548-683
Range on HMM: 1-180/511
Sequence Identity: 27% (50 aa)

FEVLEVLGKGGFGDVIK-VRNYLDSRLYAIKKVRLTGGSKMMTK---LTREVELLSQMNHENIVRYYNAWIEKYSE--------------PNHHGNEEEG
||....|||||||.|.| ||| .|.|.||||| ..   ... ..    .|||.||.  .|...||||.|||||  |                | ..|.|.
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSDDESEC

EEFSDSSEDEDTTEEEEEEEEREEGLSFI-EFKLDE---STRLDSSDQ----------------------IRDDSYSFSS
.. ........  .||  ..| . ..| . |.  ..   ..  .|..                         ||.||. .
FSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQKRTFDLTDDHYSYCH
Kinase AqueK194.AA STE-Unique 774-912 27 7.6e-31 106.49 In-house 369-546 (616) Show / Hide 
Range on Protein: 774-912
Range on HMM: 369-546/616
Sequence Identity: 27% (50 aa)

LYIQMEYCSNQTLKVLIDSGQLIKSSGF------------ELGWQLFREITEGLAHIHSQG--MIHRDLKPVNIFLNSSG-----HCKIGDFGLATTFSK
..|.||||.. ||.      |.||..|             ..   . ..| ||| ..|||.   ||||||| |||....|     . ||.|||.||. . 
VWIFMEYCEHGTLQ------QIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQP

YHT----GLSRQQSIPSNTSI------------------LAGDTGLVGTMLYLAPELLKSV----VKYTQKVDMYSLGIILYEM
 |      ..   .  . .                    . . ....||. | .|| .         |  |||..|||... .|
DHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHM
Kinase AqueK194.AA PEK 763-850 35 1.6e-23 74.38 In-house 403-514 (758) Show / Hide 
Range on Protein: 763-850
Range on HMM: 403-514/758
Sequence Identity: 35% (40 aa)

AKQKQTGQSQYLYIQMEYCSNQTLKVLIDSGQLIKSSGFELGWQLFREITEGLAHIHSQGMIHRDLKPVNIFLNSSGH----------------------
.| . ||.  |.||||..|  .||| ..     ..|   ..   .|  | ||.  ||| ||||||||| |||. . .                       
WKMHPTGNCIYMYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDGGH

--CKIGDFGLAT
   |||||||.|
QIIKIGDFGLVT
Kinase AqueK194.AA PEK 548-615 39 5e-23 72.7 In-house 1-76 (758) Show / Hide 
Range on Protein: 548-615
Range on HMM: 1-76/758
Sequence Identity: 39% (30 aa)

FEVLEVLGKGGFGDVIKVRNYLDSRLYAIKKVRLTG--------GSKMMTKLTREVELLSQMNHENIVRYYNAWIE
||. ..||.|||| | .. | .|  .||||....           ..   |  |||  |   .| |||||.||| |
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLE
Kinase AqueK194.AA WEE 774-856 32 1.1e-22 72.95 In-house 80-190 (297) Show / Hide 
Range on Protein: 774-856
Range on HMM: 80-190/297
Sequence Identity: 32% (36 aa)

LYIQMEYCSN--QTLKVLIDSGQLIKS--SGFELGWQLFREITEGLAHIHSQ-GMIHRDLKPVNIFLNSSG--------------------HCKIGDFGL
.||||||| .    |  .| .    .   .  .. ||....| .||.||||. ||.| |.|| |||... .                     |||||||.
MYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMI-WQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGH

ATTFS----KYH
.|. .    ..|
VTDMNSNNNNPH
Kinase AqueK194.AA WEE 548-616 35 4.2e-22 71.0 In-house 1-77 (297) Show / Hide 
Range on Protein: 548-616
Range on HMM: 1-77/297
Sequence Identity: 35% (27 aa)

FEVLEVLGKGGFGDVIKVRNYLDSRLYAIKKV-RLTGGSKMMTKLTREVELLSQMN-------HENIVRYYNAWIEK
|......|.| ||.| |.|. .|...|||||  .   |..      |||. ...         |..|||||.||.|.
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEED
Kinase AqueK194.AA NEK 548-619 32 9.7e-22 73.62 In-house 1-79 (286) Show / Hide 
Range on Protein: 548-619
Range on HMM: 1-79/286
Sequence Identity: 32% (26 aa)

FEVLEVLGKGGFGDVIKVRNYLDSRL-----YAIKKVRLTGGSKMMTKLTR--EVELLSQMNHENIVRYYNAWIEKYSE
.|.....|.| || | |||   |..      |..||. ... |   .. .   || .|.|..|.|||.||...||. ..
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNN
Kinase AqueK194.AA STE20 809-912 34 3.4e-21 74.42 In-house 124-220 (288) Show / Hide 
Range on Protein: 809-912
Range on HMM: 124-220/288
Sequence Identity: 34% (37 aa)

REITEGLAHIHSQGMIHRDLKPVNIFLNSSGHCKIGDFGLATTFSKYHTGLSRQQSIPSNTSILAGDTGLVGTMLYLAPELLKSV----VKYTQKVDMYS
||. .||...||...||||.|  || |...| .|. |||..  ..|   .    .. . ||        .|||  ..|||... .     .|..|.| .|
REVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHG-R-D-TMQFKRNT--------FVGTPYWMAPEVIQCMEGPDKGYDYKCDIWS

LGIILYEM
||| . ||
LGITAIEM
Kinase AqueK194.AA STE20 548-616 27 9.2e-17 58.04 In-house 1-76 (288) Show / Hide 
Range on Protein: 548-616
Range on HMM: 1-76/288
Sequence Identity: 27% (21 aa)

FEVLEVLGKGGFGDVIKVRNYLDSRL----YAIKKVRLTGGS---KMMTKLTREVELLSQMNHENIVRYYNAWIEK
.| ||..|.|..|.| |...    ..    .||||. |   .   ...  .  |.  ..| .|.|||.||.. . .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKD
Kinase AqueK194.AA STE-Unique 549-616 27 2.8e-16 53.82 In-house 1-73 (616) Show / Hide 
Range on Protein: 549-616
Range on HMM: 1-73/616
Sequence Identity: 27% (20 aa)

EVLEVLGKGGFGDVIKVRNYLDSRLYAIKKVRLTGGS--K---MMTKLTREVELLSQMNHENIVRYYNAWIEK
.  . .|.|.|| | . .|  |.. .|||...| . .  .   .  .. .|.|...  .|.|||.|| .|...
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWG
Kinase AqueK194.AA NEK 770-854 31 4.2e-16 53.55 In-house 77-175 (286) Show / Hide 
Range on Protein: 770-854
Range on HMM: 77-175/286
Sequence Identity: 31% (32 aa)

QSQYLYIQMEYCS-NQTLKVLIDSGQLIKSS---GFELG----WQLFREITEGLAHIHSQ-----GMIHRDLKPVNIFLNSSGH----CKIGDFGLATTF
|...|.| ||||  . .|  .| |   ||     |  .     |  |  .  .| ..|..       .|||.|| ||||....      ||||||..  .
QNNCLCIVMEYCEGGGDLYQKIKS---IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVL

SK
..
NH
Kinase AqueK194.AA Pkinase 548-616 25 8.4e-16 56.96 Pfam 1-72 (293) Show / Hide 
Range on Protein: 548-616
Range on HMM: 1-72/293
Sequence Identity: 25% (18 aa)

FEVLEVLGKGGFGDVIKVRNYLDSRLYAIKKVRLTGGSKMMTKLTR---EVELLSQMNHENIVRYYNAWIEK
.......|.|.|| | | ..  .....|.|.... . .. . .  |   |....  .||.||||.| .. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDK
Kinase AqueK194.AA STE11 809-912 32 5.2e-15 50.96 In-house 123-231 (303) Show / Hide 
Range on Protein: 809-912
Range on HMM: 123-231/303
Sequence Identity: 32% (38 aa)

REITEGLAHIHSQGMIHRDLKPVNIFLNSSGH-CKIGDFGLATTFSKYHTGLSR-----------QQSIPSNTSILAGDTGLVGTMLYLAPELLKSVVK-
. | |||.  ||.| ||||.|. ||.|.| |. ||..||| |. ... .|  .            . .. .         . .||  . ||| .|   . 
KQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYN---------SMMGTPMWMAPEVIKQEGRD

-YTQKVDMYSLGIILYEM
 |. |.|  ||| . .||
GYGRKADIWSLGCTVIEM
Kinase AqueK194.AA PEK 876-932 36 7.4e-15 44.87 In-house 646-717 (758) Show / Hide 
Range on Protein: 876-932
Range on HMM: 646-717/758
Sequence Identity: 36% (26 aa)

TGLVGTMLYLAPELLKSV---------------VKYTQKVDMYSLGIILYEMSHPPPATVMERVKILTDVRK
|. ||| || .|| ..                   |. ||| ||||.|. |. ||   | |||.....|.|.
TVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLRN
Kinase AqueK194.AA STE11 548-610 30 5e-14 47.36 In-house 1-76 (303) Show / Hide 
Range on Protein: 548-610
Range on HMM: 1-76/303
Sequence Identity: 30% (23 aa)

FEVLEVLGKGGFGDVIKVRNYLDSRLYAIKKVRLTGGS-------KMMTK------LTREVELLSQMNHENIVRYY
.   |..||| || | | .|    .|.|.|.... . .       |.. .      .  |..|....||.||||||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYY
Kinase AqueK194.AA Ciliate-E2 548-616 19 1.5e-12 39.42 In-house 1-104 (365) Show / Hide 
Range on Protein: 548-616
Range on HMM: 1-104/365
Sequence Identity: 19% (20 aa)

FEVLEVLGKGGFGDVIKVRNYLDSR-----------------------LYAIKKVRLTGGSKMMTKLT--REVE----------LLSQMNHENIVRYYNA
.......|.|.||.| |...... .                       .||.| ..  .   .. ..   ||..          .|.|.|| ||...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WIEK
..||
FQEK
Kinase AqueK194.AA TyrKc 548-956 11 4e-10 -58.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 548-956
Range on HMM: 1-280/280
Sequence Identity: 11% (55 aa)

FEVLEVLGKGGFGDVIKVRNYLDSRLYAIKKVRLTGGSKMMTKLTREVELLSQM--NHENIVRYYNAWIEK-----YSEP------------------NH
 . ...|| | || | | . .   .  |.|...       .  . || .....   .|.|||| | . ...     |.||                  .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

HGNEEEGEEFSDSSEDEDTTEEEEEEEEREEGLSFIEFKLDESTRLDSSDQIRDDSYSFSSDVFTDTEDRDVFKGKVDTPGTNVATLLEADLMVTTPRRG
...                                                                                                 
RPK-------------------------------------------------------------------------------------------------

FIHSESSDSVVFQDTSLMAPPGGEGEEGSTATGGGGAGGRAKQKQTGQSQYLYIQMEYCSNQTLKVLIDSGQLIKSSGFELGWQLF----REITEGLAHI
                                                                                | .. .      | .| ...
--------------------------------------------------------------------------------LCMKDLLSFCWQIACGMEYL

HSQGMIHRDLKPVNIFLNSSGHCKIGDFGLATTFSKY-HTGLSRQQSIPSNTSILAGDTGLV----GTM--L---YLAPELLKSVVKYTQKVDMYSLGII
||.. |||||   |. ... ...||.||||.     . ..|              ..|.  .    |.   |    .||| .    |.| | | .| |. 
HSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-------------ESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVWSFGVC

LYEM----SHPPPA-----TVMERVKILTDVRKKEIVFSE---------------------RFKTSKKMSKQAVEHTL
..|.      |.|         ..|  . . ..      .                     ... ..  . ... . .
MWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK194.AA NEK 878-912 45 4.6e-09 28.47 In-house 184-217 (286) Show / Hide 
Range on Protein: 878-912
Range on HMM: 184-217/286
Sequence Identity: 45% (16 aa)

LVGTMLYLAPELLKSVVKYTQKVDMYSLGIILYEM
.|||  |..||...   .|..|.|. ||| .||||
QVGTPYYMSPEVCQ-NKPYNNKSDIWSLGCVLYEM
Kinase AqueK194.AA Pkinase_Tyr 809-849 39 1.1e-07 26.61 Pfam 118-158 (270) Show / Hide 
Range on Protein: 809-849
Range on HMM: 118-158/270
Sequence Identity: 39% (16 aa)

REITEGLAHIHSQGMIHRDLKPVNIFLNSSGHCKIGDFGLA
..| .|... .|...|||||   |. .......||.|||||
WQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase AqueK194.AA Pkinase_Tyr 548-610 25 2.9e-05 18.44 Pfam 1-70 (270) Show / Hide 
Range on Protein: 548-610
Range on HMM: 1-70/270
Sequence Identity: 25% (18 aa)

FEVLEVLGKGGFGDVIKVRNY----LDSRLYAIKKVRLTGGSKM--MTKLTREVELLSQM-NHENIVRYY
 . ...||.| ||.| | . .     .    |.|... .  ..   . .. ||.....|. .|.||||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase AqueK194.AA WEE 884-912 41 0.008895 5.23 In-house 199-229 (297) Show / Hide 
Range on Protein: 884-912
Range on HMM: 199-229/297
Sequence Identity: 41% (13 aa)

YLAPELLKS--VVKYTQKVDMYSLGIILYEM
|.|||.|       .  | | .|||| .||.
YMAPEILQGYYHYTHLYKADIFSLGITIYEL
Kinase AqueK194.AA Pkinase_Tyr 885-912 32 0.614508 3.8 Pfam 181-207 (270) Show / Hide 
Range on Protein: 885-912
Range on HMM: 181-207/270
Sequence Identity: 32% (9 aa)

LAPELLKSVVKYTQKVDMYSLGIILYEM
.||| ..  . .| | | .| |. ..|.
MAPECINYGK-FTTKSDVWSFGVLMWEI