Gene AqueK025 (A.queenslandica)

AqueK025

Species: A.queenslandica
Alias: AqueK025
External Links:
Annotation: Secondary Group: AGC, Secondary Family: RSK, Secondary Subfamily: RSKp90

Classification

Group: AGC
Family: RSK
Subfamily: RSKp90

Sequence

Name Sequence Type Origin Length Description Download
AqueK025.AA Protein None 759 None Fasta, JSON
AqueK025.kin_dom Protein Kinase Domain None 259 None Fasta, JSON
AqueK025.kin_dom2 Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of AqueK025.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK025.AA AGC 68-326 34 4.1e-181 473.21 In-house 1-395 (395) Show / Hide 
Range on Protein: 68-326
Range on HMM: 1-395/395
Sequence Identity: 34% (138 aa)

FELVKVLGQGSFGKVFLVRRLVGH---DAGKLYAMKVLKKAT---LKVR-DRIRTKME------------RDILADVR----------HPFVVA-LEYAF
||..||.|.||||||.|||.  |.   | ||.||||||||..   .| . .  .|. |            |.||. ..          |||.|  | |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTEGK--LYLVLEFLR---------GG-DLFTRLS---KEVMFTEEDVKFYLAE-------LALALHHLHG-LGIVYRD-LKPENILLDADGHIKLTDFG
|.. .  ||.|.|..          || .||..|    ||  |.|| ..||.||       ..|||..||  .||..|| |||||||||.||||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKESVDD---------------------------------------------------KKTFSFCG--TVEYMAPEVVNRKGHDITADWWS--FGVLMY
|.|| ..|                                                   ..| .|||  | ||||||..    .. ..||||  .|.|||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLTGSLPFQGEN----------RKATMNMIL------KAKLGMP----------QFLSPEAQSLLRVLFKRNPLNRLCYGTN-----GIDNIKAHPFF
|||||  ||.|.|          .. ... |.      . |. .|          ...||||..|.. |....| .|| .| |     |.. ||.||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase AqueK025.AA RSK 68-326 52 2.1e-170 572.42 In-house 1-271 (271) Show / Hide 
Range on Protein: 68-326
Range on HMM: 1-271/271
Sequence Identity: 52% (142 aa)

FELVKVLGQGSFGKVFLVRRLVGHDAGKLYAMKVLKKATLKVRDRIRTKMERDILADVRHPFVVALEYAFQTEGKLYLVLEFLRGGDLFTRLSKEVMFTE
.|| ...|||||.||..... .. |....||||..||||..|.||.....||.||... |||.| | |.||.|||.|....|.||||||.||.|..||.|
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

EDVKFYLAELALALHHLHGLGIVYRDLKPENILLDAD----GHIKLTDFGLSKESVDDKK-TFSFCGTVEYMAPEVVNRKGHDITADWWSFGVLMYEMLT
..||||.||.|||. .|| .|||.|||||||||.|..    ||||..|||..|.. |. . . .||.|..||||||..|.|||  .||||||||||||||
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GSLPFQGENRKATMNMILKAKLGM-------PQFLSPEAQSLLRVLFKRNPLNRLCYGTNGIDNIKAHPFF
| .|||. .|. .||.|...||||       ..|.|.||..||| ...|.| |||  | ||.  || ||.|
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase AqueK025.AA RSK 71-326 53 4.90000000001e-160 537.97 In-house 1-278 (278) Show / Hide 
Range on Protein: 71-326
Range on HMM: 1-278/278
Sequence Identity: 53% (149 aa)

VKVLGQGSFGKVFLVRRLVGHDAGKLYAMKVLKKATLKVRDR-IRTKM-ERDILADVR-HPFVVALEYAFQTEGKLYLVLEFLRGGDLFTRLSKEVM---
.||||||..|||||.|. ..||.|..|||||||||....|.. .|..| ||.||.... |||.| | |||||||||||..|..|||.|||.|.||..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEEDVKFYLAELALALHHLHGLGIVYRDLKPENILLDA---DGHIKLTDFGLSKE-SVD-DKKTFSFCGTVEYMAPEVVN----RKGHDITADWWSFGV
|.|....||.||..||. ||| .||..|||||||||.|    .|||||||||..|. . |  ..| .||.|.||||||...    ..|||  .||||.||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMYEMLTGSLPFQG---ENRKATMNMILKAK--LGMP--QFLSPEAQSLLRVLFKRNPLNRLCYGTNGIDNIKAHPFF
|||||||| .||||   .||| .|. |.|.|  |.||  |.||.||..|.| ...|.| .|| .| .... ||.||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase AqueK025.AA Akt 68-326 47 1.2e-137 442.67 In-house 1-264 (264) Show / Hide 
Range on Protein: 68-326
Range on HMM: 1-264/264
Sequence Identity: 47% (126 aa)

FELVKVLGQGSFGKVFLVRRLVGHDAGKLY-AMKVLKKATLKVRDRIR-TKMERDILADVRHPFVVALEYAFQTEGKLYLVLEFLRGGDLFTRLSKEVMF
|...||||.|||||||||.     | .|.| |||||||  .  .. .. || || ||  ..|||.| | |.|||. |||.|...  ||.||. |...  |
FDFLKVLGKGSFGKVFLVKK---KDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF

TEEDVKFYLAELALALHHLHGLGIVYRD-LKPENILLDADGHIKLTDFGLSKES-VDD-KKTFSFCGTVEYMAPEVVNRKGHDITADWWS-FGVLMYEML
.|.  .|| ||. ||. |||  .|.||| |||||||.|.||||.||||||.||  . |  || .|||| ||.|||. | .||. ..|||. .|..||||.
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

TGSLPFQGENRKATMNMILKAKLGMP--QFLSPEAQSLLRVLFKRNPLNRLCYGTNGIDNIKAHPFF
.| .||  ....  .  |. ... .|   ..|||...|.. | ...| .|| .| |... ||.||.|
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase AqueK025.AA p70 68-326 47 4.90000000001e-137 461.55 In-house 1-299 (299) Show / Hide 
Range on Protein: 68-326
Range on HMM: 1-299/299
Sequence Identity: 47% (142 aa)

FELVKVLGQGSFGKVFLVRRLVGHDAGKLYAMKVLKKA--TLKVRDRIRTK-------------------------MERDILADVRHPFVVALEYAFQTE
|||.||||.| .||||.||   |.|.||.||||||.||  .   .|   |.                          || ||  | |||.. | |||||.
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

GKLYLVLEFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALHHLHGLGIVYRDLKPENILLDADGHIKLTDFGLSKESV-DDKK----------TFSFCG
|||||.||.| || ||. | .. .. |. ..|||.|  .|| |||..||.||||||||..|.. ||..||||||.|||. |...          |..|||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TVEYMAPEVVNRKGHDITADWWSFGVLMYEMLTGSLPFQGENRKATMNMILKAK--LGMPQFLSPEAQSLLRVLFKRNPLNRLCYGTNGIDNIKAHPFF
| ||||||.. |.||.   |||| |.||| ||||. || ||||| |.. |||.|  | .|  |..|.  |.. | ||.|  |.  | . . .|..||||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase AqueK025.AA AktR 68-326 45 1.7e-118 399.95 In-house 1-268 (268) Show / Hide 
Range on Protein: 68-326
Range on HMM: 1-268/268
Sequence Identity: 45% (123 aa)

FELVKVLGQGSFGKVFLVRRLVGHDAGKLYAMKVLKKATLKVRDRI-RTKMERDILA-DVRHPFVVALEYAFQTEGKLYLVLEFLRGGDLFTRLSKEVMF
|.. |.||.| ||||.||...   | .|.||||..|| ... | .. .| .||.|..  ..||| | |.|.|||. ||....|. .||.||. |.|.  |
FHVYKCLGKGAFGKVYLVQKKR--DNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKF

TEEDVKFYLAELALALHHLHGL-GIVYRDLKPENILLDADGHIKLTDFGLSK-ESV--DDKKTFSFCGTVEYMAPEVVNR-KGHDITADWWSFGVLMYEM
.||...|| |.  ||| .||    |.|||||||||||| |||.|.||||||| . .  .| |. |||||.||||||.... |||. ..|||.||.. |||
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

LTGSLPFQGENRKATMNMILKAK-LGMPQF--LSPEAQSLLR-VLFKRNPLNRLCYGTNGIDNIKAHPFF
.||  ||. .|..    .|..   .  |.   .|.....|.   |...|| .|| |..||.. || ||.|
VTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase AqueK025.AA S_TKc 68-326 34 3e-102 346.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 68-326
Range on HMM: 1-231/231
Sequence Identity: 34% (94 aa)

FELVKVLGQGSFGKVFLVRRLVGHDAGKLYAMKVLKKATLKVRDRIRTKMERDILADVRHPFVVALEYAFQTEGKLYLVLEFLRG--GDLFTRLSKEVM-
.|.....|.|.||||...|       |...|.|..|         .... |..||   .||..| | ..||. ..||.|.|.. |  ||||... |    
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FTEEDVKFYLAELALALHHLHGLGIVYRDLKPENILLDADGHIKLTDFGLSKESVDDKKTFSFCGTVEYMAPEVVNRKGHDI-TADWWSFGVLMY
     |.| ...||......|| ..| .||..|||||||||||   |||..||||...        .|||| .||||||.   |..   .||||.|...|
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLTGSLPFQGENRKATMNMILKAKLGMPQFLSPEAQSLLRVLFKRNPLNRLCYGTNGI--DNIKAHPFF
|||.|  ||.  . ......|.          |||| ...| .....| .|.           ||.||.|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK025.AA MSK 71-321 39 7.6e-100 338.02 In-house 1-277 (277) Show / Hide 
Range on Protein: 71-321
Range on HMM: 1-277/277
Sequence Identity: 39% (110 aa)

VKVLGQGSFGKVFLVRRLVGHDAGKLYAMKVLKKATLKVRDRIRTK--MERDILADVR-HPFVVALEYAFQTEGKLYLVLEFLRGGDLFTRLSKEVMFTE
 ||||.|. ||.|..|..|.||.|||||||.|.|||.  . .       || .| ... ||..| | ||||.. ..|||.|...|| |||...|   |.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

EDVKFYLAELALALHHLHGLGIVYRDLKPENILLDAD---GHIKLTDFGLSKESVDD--KKTFSFCGTVEYMAPEVVN----RKG-HDITADWWSFGVLM
. . ....|| .|. |.| .||..|||||||||.| .   ||.||.|||.... . |  ....|.|.| .|||||...     .| .|   |||| ||..
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

YEMLTGSLPFQ--GENRK-------ATMNMILKAKLGMP----QFLSPEAQSLLRVLFKRNPLNRLCYGTNGIDNIK
|.||||  |||  .. |.         |  |.|..   |    |  ||.|. |.. |  ..|  || ..  . . .|
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase AqueK025.AA Pkinase 68-326 29 2.1e-91 314.79 Pfam 1-293 (293) Show / Hide 
Range on Protein: 68-326
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

FELVKVLGQGSFGKVFLVRRLVGHDAGKLYAMKVLKKATLKVRDRIRTKM--ERDILADVRHPFVVALEYAFQTEGKLYLVLEFLRGG----DLFTRLS-
.......|.||||.|.. ..   .. ||..|.|..|| . |   ...     |  |.. ..||..| | ..|......|.|.|...||    |||...| 
YHIGRKIGSGSFGCVYKCHH---KGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-KEVMF--TEEDVKFYLAELALALHHLHGLGIVYRDLKPENILLDADGHI----KLTDFGLSKE--SVDDKKTFSFCGTVEYMAPEVVN-RKGHDITADW
 ..  |  .|...|||. ... .| ..|  ||..|||||||||.| .|||    |..||||.|      .  . .|||| .||||||.. .....  .|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSFGVLMYEMLTGSLPFQGE------NRKATMNMILKAKLGMPQFLS---------------------PEAQSLLRVLFKRNPLNRLCYGTNGIDNIKAH
||.|...||||.| .||.|.      . .. ...|....|  . . .                     .|...... .....|  |.      .. |. |
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQH

PFF
|.|
PWF
Kinase AqueK025.AA Ciliate-E2 68-326 25 3.2e-86 292.77 In-house 1-365 (365) Show / Hide 
Range on Protein: 68-326
Range on HMM: 1-365/365
Sequence Identity: 25% (97 aa)

FELVKVLGQGSFGKVFLVRR-LVGH-------------------DAGKLYAMKVLKKATLKVRDRIRTKM-----------ERDILADVRHPFVVALEYA
....|..|||.||.|..... .|..                   ...|.||||..||  ..   ..   |           |. ||  . ||... . ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TEGKLYLVLEFLRGGDLFTRLS------------------KEVM-FTEEDVK-------FYLAELALALHHLHGLG-IVYRDLKPENILLDADGHI
||  .. ..|||.|.. ||||| ..                   ||.  .... ..       ||.|.. |||..||  . |..||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLTDFGLSKESVDD--------------------------------KKTFSFCGTVEYMAPEVVNRKG---------HDITADWWSFGVLMYEMLTGSLP
|..||||||.  ||                                  ....||| .|||||..|.|.         .|  .|.||.||..||||.| .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FQGENRKATMNMILKAKLGMPQF------------------LSPEAQSLLRV----LFKRNPLNRLCYGTNGIDNIKAHPFF
|        .. |.. |.  |..                  .|.|.. |..     .....| .|.     |.. |. ||.|
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase AqueK025.AA CAMK 73-326 22 3.3e-85 274.42 In-house 1-425 (425) Show / Hide 
Range on Protein: 73-326
Range on HMM: 1-425/425
Sequence Identity: 22% (97 aa)

VLGQGSFGKVFLVRRL-VG---------HDAGKLYAMKVLKKATLK--------------------------VRDRIRTKMERDILAD-------VRHPF
.||.||||||.|...   .          . |. .|.|...|  ||                           .|| . . | .|.         ..|| 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

VVALEYAFQ------------TEGK--------LYLVL---EFLRGG----DLFTRLSKE---------------VMFTEEDVKFYLAELALALHHLHGL
.. |  ...            |  |        .|.|.   |.  ||    ||| .. .                  |||.....|   .. |.|..| .
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

GIVYRDLKPENILLDAD-----------------GHIKLTDFGLSKESVD------------------------DKKTFSFCGTVEYMA-PEVVNR----
.|| ||||||||||| .                 . ||..|||....  .                        ..|   |||| |||| |||.|.    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------KGHDITADWWSFGVLMYEMLTGSLPFQGE-------------NRKATMNMILKAKLG-MPQFLSP-----------------------EA
          ....  .| || ||..| ||.| .||.|.             | . .. .|.|.|    | ..||                       |.
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

QSLLRVLFKRNPLNRLCYGTNGIDNIKAHPFF
..|.| . ...| .|.      |. ...||..
KDLIRKMLQVDPEKRMT-----IEQCLNHPWM
Kinase AqueK025.AA CAMK1 68-326 30 7.7e-68 196.27 In-house 1-276 (276) Show / Hide 
Range on Protein: 68-326
Range on HMM: 1-276/276
Sequence Identity: 30% (87 aa)

FELVKVLGQGSFGKVFLVRRLVG-HDAGKLYAMKVLK-KATLKVRDR---IRTKMERDILADV---RHPFVVALEYAFQTEGKLYLVLEFLRGGDLFTRL
.|. |..| |.|..|.|. .       || ||.|... |  .|  |.    . ..| .|.  |    ||......  .... ..|||.| . ||.|| | 
YEFGKEIGRGAFSEVYLCTHKETQT-NGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

SKEVMFTEEDVKFYLAELALALHHLHGLGIVYRDLKPENILL---DADGHIK--LTDFGLSKESVDDK-KTFSFCGTVEYMAPEVVNR---KGHDITADW
 .   .||.|      ... |....| .||| |||||||.|.   | |  ||  . ||||||   .|  . .  ||| .|.||||...   |..| . | 
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM

WSFGVLMYEMLTGSLPFQGEN-RKATMNMILKAKLGMPQF----LSPE-AQSLLRVLFKRNPLNRLCYGTNGIDNIKAHPFF
|| ||  | .|.|  ||..||  .  . .|.|.....| .     | . |  ... . . .| .|..     .. . .||..
WSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYT-----CEQCLNHPWI
Kinase AqueK025.AA S_TK_X 327-388 36 4.8e-21 77.17 SMART 1-79 (79) Show / Hide 
Range on Protein: 327-388
Range on HMM: 1-79/79
Sequence Identity: 36% (29 aa)

KSINWDKLYK--REVMPPFKPACG----SADDAFYFDSEFTSRTPKDSPGAPVSAHSKEL-----------FRXFSYVA
..|.|||||.  .|. ||||| .     |. |. .|| |||. ||...|  |.. .|              || |.||.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase AqueK025.AA Pkinase_Tyr 68-269 26 1.3e-20 70.42 Pfam 1-218 (270) Show / Hide 
Range on Protein: 68-269
Range on HMM: 1-218/270
Sequence Identity: 26% (58 aa)

FELVKVLGQGSFGKVFLVRRL-VGHDAGKLYAMKVLKKATLKVRD--RIRTKMERDILADV-RHPFVVALEYAFQ-TEGK--LYLVLEFLRGGDLFTRLS
 .. |.||.|.||.|.. .    . . .   | |.| | .   ..  |     |  |.    .|| .| |  .    ..   .|.|.|.  .||| . | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----EVMFTEEDVKFYLAELALALHHLHGLGIVYRDLKPENILLDADGHIKLTDFGLSKES-------VDDKKTFSFCGTVEYMAPEVVNRKGHDITAD
|    .  .| .|   . .. | .. .|.  ... |||   |.|.. ....| .||||..         .  ...  .   .  ||||. | .   .  |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LP--IKWMAPECINYGKFTTKSD

WWSFGVLMYEMLT-GSLP-FQG
 |||||||.|..| |  | ..|
VWSFGVLMWEIFTYGEQPTYPG
Kinase AqueK025.AA TyrKc 68-320 22 2.1e-16 42.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 68-320
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FELVKVLGQGSFGKVFLVRRLVGHDAGKLYAMKVLKKATLKVRDRIRTKMERDILADV--RHPFVVALEYAFQTE-------GKLYLVLEFLRGGDLFTR
 .| |.|| | ||.|.. .           | |.||. .     |     |  |.  .  .|| .|.|  .  ..       . |..|.|.  .|||  .
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LSKEVM-FTEEDVKFYLAELALALHHLHGLGIVYRDLKPENILLDADGHIKLTDFGLSKESVDD------KKTFSF----CGT----VEYMAPEVVNRKG
| |    .. .|   .    |    .||  ... |||   |.|.......| .|||||..  ||      |.. .     .|     .  ||||. | . 
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

HDITADWWSFGVLMYEMLT-GSLPFQG-----ENRKATMNMILKAKLGMPQFL---------SPEAQSLLRVLFKRNPLNRLCYGTNGIDNI
  .  | |||||.|.|..| |  |  |      . .  .. . . .  ..            ..|  .. .   ...| .| .  .  .. .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase AqueK025.AA Pkinase_C 349-390 40 1.8e-08 33.13 Pfam 4-46 (46) Show / Hide 
Range on Protein: 349-390
Range on HMM: 4-46/46
Sequence Identity: 40% (18 aa)

SADDAFYFDSEFTSRTPKDSP--GAPVSAHSKELFRXFSYVAPL
|..|. .|| |||. .|.|.|  .   |.   |.|| |.||.| 
SPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase AqueK025.AA RSK 437-699 51 1.9e-157 529.35 In-house 1-271 (271) Show / Hide 
Range on Protein: 437-699
Range on HMM: 1-271/271
Sequence Identity: 51% (141 aa)

YDIKEDMLLGYGSYS---RCVRCIHRATNQEFAVKIISKEKSTRDVD-----EEIEILLRYAPQHENIIKLRDVYDDGTYIYMVMELMRGGELLDKIISQ
|...|.  .| ||.|    | .|.|..|||..|.|||  .|.||||      ||..|.|||  .| .|.||..|..|....||.|..||||.|.|..  |
YELHEC--IGQGSFSKVYVCKKCQHKDTNQHYAMKII--KKATRDVKDRVCWEEERIILRYG-HHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQ

KFFSEKEAAAVLAILTDTVSYLHLKGVVHRDLKPSNILYADPSCSPRSLRIADFGFAKQLRAENGLLMTPCYTANYVAPEVLKKQGYDAAIDIWSLGVLL
|.|||.|.....| .. .. ||| .|.|||||||.||||.| | .| ...|.|||||||||.|||.|||.||||||.||||||.||.|.| |.||.|||.
KMFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLM

YTMLAGECPFAAGPDDGPDKILSRISEGKINLTGGNWDTVSAAAKDLVLRMLHVDPQQRCTA-----AQILQHPWI
|.||.|  ||...|.| |. |. || .|.. .|.||||..|. ||||. .|||.||..| .|     .||.||||.
YEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase AqueK025.AA RSK 439-699 41 1.4e-134 453.39 In-house 1-278 (278) Show / Hide 
Range on Protein: 439-699
Range on HMM: 1-278/278
Sequence Identity: 41% (117 aa)

IKEDMLLGYGSYSRCVRCIHRATNQEFAVKIISK-EKSTRDVD-----EEIEILLRYAPQHENIIKLRDVYDDGTYIYMVMELMRGGELLDKIISQKF--
.|..  .|||... | .|.|..|.|..|.|...| .  .|..|     .|..||.|.  || .|..| .........|..||..|||||....  .|.  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQ-QHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFG

-FSEKEAAAVLAILTDTVSYLHLKGVVHRDLKPSNILYADPSCSPRSLRIADFGFAKQLRAE-NGLLMTPCYTANYVAPEVLK---KQG-YDAAIDIWSL
 |||.||....| .. .|..|| .|..||||||.||||.| | ....... ||||.||.|.. |...||.|||..|.|||.||   .|| .|.| |.|||
CFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GVLLYTMLAGECPFAAGPDD-GPDKILSRISEGKINLTGGNWDTVSAAAKDLVLRMLHVDPQQRCT-----AAQILQHPWI
|||.|.||.|  ||.. |.|  ...|. || .||..||..||...|..||||. .|||.||..| .     |..|.||||.
GVLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase AqueK025.AA CAMK1 437-699 36 6.6e-111 323.65 In-house 1-276 (276) Show / Hide 
Range on Protein: 437-699
Range on HMM: 1-276/276
Sequence Identity: 36% (103 aa)

YDIKEDMLLGYGSYSRCVRCIHRAT---NQEFAVKIIS-KE---KSTR----DVDEEIEILLRYA-PQHENIIKLRDVYDDGTYIYMVMELMRGGELLDK
| ...   .| |. |  ..|.|. |   ....|.|.|. |.   |...     .. ||||. .    .|.||||. ..|.. ...|.||||. ||||.|.
YEFGK--EIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDR

IISQKFFSEKEAAAVLAILTDTVSYLHLKGVVHRDLKPSNILYADPSCSPRS-LR--IADFGFAKQLRAENGLLMTPCYTANYVAPEVLKK---QGYDAA
|.  ....||.|. .   . . | |.| ||.||||||| |.||.|.  .. | ..  ||||| .|..  ...|. |.| |  |||||||.    ..|| |
IVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDK--DEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKA

IDIWSLGVLLYTMLAGECPFAAGPDDGPDKILSRISEGKINLTGGNWDTVSAA-AKDLVLRMLHVDPQQRCTAAQILQHPWI
.|.|| || .|..| |  || .  ... ..... |......     || .|   |||..  || |||..| |..|.|.||||
CDMWSIGVITYILLCGYPPFYD--ENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase AqueK025.AA CAMK 444-699 25 2.1e-97 314.45 In-house 1-425 (425) Show / Hide 
Range on Protein: 444-699
Range on HMM: 1-425/425
Sequence Identity: 25% (110 aa)

LLGYGSYSRCVRCIHRATN------------QEFAVKIISK------------------------------EKSTRDVDEEIEILLRYA-----PQHENI
 || ||..   .|||. |.            |..|.|||.|                              .|. . |  ||||. .        .|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLRDVYDDGTY-------------------IYMVM---ELMRGGEL----LDKIISQKF---------------FSEKEAAAVLAILTDTVSYLHLKGV
||| .||.|..|                   .||||   |.. ||||    .|.|....                |.|.||. .   . . | |.| ...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPSNILYADPS-------------CSPRSLRIADFGFAKQLRA-----------------------ENGLLMTPCYTANYVA-PEVLKK------
||||||| |||. | .             ..   . |.|||||....                        |. .. |.| |  |.| ||||..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QGYDAAIDIWSLGVLLYTMLAGECPFAAGPDD----------GPDKILSRISEGKINLTGGN------------WDTVSAA--------AKD
        ..|. ..|.||.||.||.|| |. || .  |.           . ... .| .|| .                 || .|          .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LVLRMLHVDPQQRCTAAQILQHPWI
|. .|| |||..| |..|.|.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase AqueK025.AA S_TKc 439-699 32 4.4e-97 329.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 439-699
Range on HMM: 1-231/231
Sequence Identity: 32% (91 aa)

IKEDMLLGYGSYSRCVRCIHRATNQEFAVKIISKEKSTRDVDEEIEILLRYAPQHENIIKLRDVYDDGTYIYMVMELMRG--GELLDKIISQKF------
 .   ..| |..... .|.|. |....|.|||.     ...  ||.|| .   .|.||.|| ||..| ...|||||.. |  |.|.| | ...       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FSEKEAAAVLAILTDTVSYLHLKGVVHRDLKPSNILYADPSCSPRSLRIADFGFAKQLRAENGLLMTPCYTANYVAPEVLKKQGYDA-AIDIWSLGVLLY
|.| .|. ... . . . |.| .|..||||||.|||  .       . |.|||.|.||       .| | | .|.|||||   ||.  ..|.||.|..||
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

TMLAGECPFAAGPDDGPDKILSRISEGKINLTGGNWDTVSAAAKDLVLRMLHVDPQQRCTAAQILQ-------HPWI
 ||.|. ||       ..... .|               |  |||.. ..|..||..| || ..||       |||.
EMLCGYPPFP-----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK025.AA Pkinase 439-699 32 7.2e-95 326.28 Pfam 1-293 (293) Show / Hide 
Range on Protein: 439-699
Range on HMM: 1-293/293
Sequence Identity: 32% (98 aa)

IKEDMLLGYGSYSRCVRCIHRATNQEFAVKIISKEKSTRDVDE------EIEILLRYAPQHENIIKLRDVYDDGTYIYMVMELMRGG----ELLDKII--
..    .| ||.... .|.|. |....|||||.|..   ..|.      ||.|..|   .|.||..|.|.. |...||||||...||    .| | |   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL--NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

SQKFF--SEKEAAAVLAILTDTVSYLHLKGVVHRDLKPSNILYA-DPSCSPRSLRIADFGFAKQL-RAENGLLMTPCYTANYVAPEVLK-KQGYDAAIDI
... |  ||.|.  ..  .   . |.| .|..||||||.|||.  .. ... ...|.|||.|||.    |. ..|.| | .|.||||..  |.|. ..|.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSLGVLLYTMLAGECPFAAG----PDDGPDKILSRISEGKINLTGGNWDTVS-----------------AAAKDLVLRMLHVDPQQRCTAAQILQHPWI
||.|..|| || |. ||       . . ..... || ....     .|...|                  ..||.. ..|..||..|.||.|||||||.
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK025.AA AGC 439-699 20 9.7e-94 242.06 In-house 1-395 (395) Show / Hide 
Range on Protein: 439-699
Range on HMM: 1-395/395
Sequence Identity: 20% (84 aa)

IKEDMLLGYGSYSRCVRCIHR------ATNQEFAVKIISKEK--------STRDVDEE------------IEILLRYAPQ--------HENIIK-LRDVY
 .   ..| ||....  . ..      .|.. .|.|...|..          . .  |             .|| ..           | .|.| |   .
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

DDGTY--IYMVMELMR---------GG-ELLDKII---SQKFFSEKEAAAVLAI-------LTDTVSYLHL-KGVVHRD-LKPSNILYADPSCSPRSLRI
 | ..  .|.|||.|          || ||.  .     .. |.|..|   .|        ..  . |||  .|..||| ||| |||  .       ...
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED----GHIKL

ADFGFAKQLRAE-----------------------------------------------------NGLLMTPCYTANYVAPEVLKKQGYDAAIDIWS--L
.|||..|... .                                                     .  .  || |..|.|||.|    |. | |.||  |
TDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL----YGKACDWWSFGL

GVLLYTMLAGECPFAAGPDD-------GPDKILSRIS------EGKINLTGG------NWDTVSAAAKDLVLRMLHVDPQQRCT----------AAQILQ
|.|.| ||.|  || . ...        |...  .|       . |. .          .. .|  ||||. ..|..|| .| .          | .| .
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN

HPWI
||| 
HPWF
Kinase AqueK025.AA MSK 440-699 34 1.7e-87 295.85 In-house 1-277 (277) Show / Hide 
Range on Protein: 440-699
Range on HMM: 1-277/277
Sequence Identity: 34% (96 aa)

KEDM-LLGYGSYSRCVRCIHRATNQEFAVKIIS------KEKSTRDVDEEIEILLRYAPQHENIIKLRDVYDDGTYIYMVMELMRGGELLDKIISQKFFS
...   .|||... | .| |. |....|.||.|      | | .  .. |. .|..   || || .| ... | .  |.|||. .||||. .| . . |.
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQ-QHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFD

EKEAAAVLAILTDTVSYLHLKGVVHRDLKPSNILYADPSCSPRSLRIADFGFAKQLRAE-NGLLMTPCYTANYVAPEVLK----KQG-YDAAIDIWSLGV
|.|.. ... |   |...| ||..|||||| |||..| . . . ... |||||. . .. .  . .||.|  | |||.|.    ..| ||.|.|.|||||
ESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDN-GHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGV

LLYTMLAGECPFA---AGPD---DGPDKILSRISEGKINLTGGNWDTVSAAAKDLVLRMLHVDPQQRCTAAQILQHPWI
.||||| |  ||.   .. .        |  || .|. ...|  | ..|..||||. ..| .||. | ..  ...| |.
ILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase AqueK025.AA Ciliate-E2 439-699 24 1.4e-72 247.44 In-house 1-365 (365) Show / Hide 
Range on Protein: 439-699
Range on HMM: 1-365/365
Sequence Identity: 24% (93 aa)

IKEDMLLGYGSYSRCVRCIHRATNQEFA----------------VKIISKEKSTRDVDEEIEILLRYAPQ--------------------HENIIKLRDV
.|   ..| |...   .| .. ....||                |||  ... .   .. ..|.                          | ||||. ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YD--DGTYIYMVMELMRGGELLDKIISQKFFS-----------EKEAAAVLAILTD---------------TVSYLHLKG-VVHRDLKPSNILYADPSCS
.   | ..||.|||.  ||.|.| |...| ..           |||.. . . ...                . ||| |. ..|||.||.|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

PRSLRIADFGFAKQLRAENG-------------------------------LLMTPCYTANYVAPEVLK---------KQGYDAAIDIWSLGVLLYTMLA
   . |.|||..|..  .|                                .  | |.|..|.|||.|.         ..||| ..|||||||.|| || 
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GECPFAAGPDDGPDKILSRISEGKINLTGG--------------NWDTVSAAAKDLVLR----MLHVDPQQRCT-AAQILQHPWI
|. ||           .  | ..||..                 .|. .|  .|||  .    || .||..| | . |||.|||.
GKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase AqueK025.AA p70 492-699 28 2.3e-27 96.16 In-house 86-299 (299) Show / Hide 
Range on Protein: 492-699
Range on HMM: 86-299/299
Sequence Identity: 28% (63 aa)

QHENIIKLRDVYDDGTYIYMVMELMRGGELLDKIISQKFFSEKEAAAVLAILTDTVSYLHLKGVVHRDLKPSNILYADPSCSPRSLRIADFGFAKQLRAE
.| .|..|   . ..   | . | . ||||      .  . |  |   |.  .    .|| .|.. ||||| |..          .   |||  |.   .
KHPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGH----VVLTDFGLCKESIHD

NGL----------LMTPCYTANYVAPEVLKKQGYDAAIDIWSLGVLLYTMLAGECPFAAGPDDGPDKILSRISEGK--INLTGGNWDTVSAAAKDLVLRM
             . | | |  | |||.| . |.. |.| ||||.|.| || |  || .   . . |.   |  ||  ..|        .. ..||. ..
GAVDEEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTG---ENRKKTIDKILKGKQGLKLPP----YLTHEMRDLIKKL

LHVDPQQRCT-----AAQILQHPWI
|  .|.|| .     ||.| .||. 
LKRHPTQRWGAGPEDAADIQEHPFF
Kinase AqueK025.AA Akt 577-638 35 6.8e-18 53.71 In-house 140-203 (264) Show / Hide 
Range on Protein: 577-638
Range on HMM: 140-203/264
Sequence Identity: 35% (23 aa)

LRIADFGFAKQL-RAENGLLMTPCYTANYVAPEVLKKQGYDAAIDIWS-LGVLLYTMLAGECPF
....||| .|.    ..   .| | |. | |||.|...|.. | |.|. ||...| |. |  ||
ICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF
Kinase AqueK025.AA AktR 549-638 33 3e-16 59.26 In-house 116-205 (268) Show / Hide 
Range on Protein: 549-638
Range on HMM: 116-205/268
Sequence Identity: 33% (32 aa)

YLHLK-GVVHRDLKPSNILYADPSCSPRS--LRIADFGFAK--QLRAENGLLMTPCYTANYVAPEVLKK-QGYDAAIDIWSLGVLLYTMLAGECPF
||| .  .. ||||| |||            ..|.||| .|    .... .  . | |  |.|||...| .|.. ..|.|..|...| |..|  ||
YLHQHMNIIYRDLKPENILLD------EDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPF
Kinase AqueK025.AA TyrKc 439-699 18 3.3e-14 7.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 439-699
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

IKEDMLLGYGSYSRCVRCIHRATNQEFAVKIISKEKSTRDVDEEIEILLRYAPQHENIIKLRDVYDDG-------TYIYMVMELMRGGELLDKI-ISQKF
|. .  || | . . .... .   .. ||| . ...  .|  .|..|. .. ..|.||..|  |  ..         ...|||.| .| |.| .  ... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

FSEKEAAAVLAILTDTVSYLHLKGVVHRDLKPSNILYADPSCSPRSLRIADFGFAKQLRAE------NGLLMT----PC---YTANYVAPEVLKKQGYDA
.. |.         .  .||| |...||||   |.|....       .|.||| .. .  .          ..     .         |||....  .  
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

AIDIWSLGVLLYTMLAGECPFAAGP---DDGPDKILSRISEGKINLTGGN-----WDTVSAAAKDLVLRMLHVDPQQRCTAAQILQHPWI
. |.|| ||... ..    .   |.   .  .. .. .. .|.      |       . ...  .. ..  | || .|.| ..|  |  .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase AqueK025.AA Akt 507-566 37 3.8e-10 28.53 In-house 73-133 (264) Show / Hide 
Range on Protein: 507-566
Range on HMM: 73-133/264
Sequence Identity: 37% (25 aa)

TYIYMVMELMRGGELLDKIISQKFFSEKEAA-----AVLAILTDTVSYLHLKGVVHRD-LKPSNIL
...|.||. . ||||   .  ...|||..|       .|||      .|| |... || ||| |||
DKLYFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAI-----EHLHSKNIIYRDYLKPENIL
Kinase AqueK025.AA Pkinase_Tyr 548-629 28 3e-06 21.67 Pfam 125-205 (270) Show / Hide 
Range on Protein: 548-629
Range on HMM: 125-205/270
Sequence Identity: 28% (25 aa)

SYLHLKGVVHRDLKPSNILYADPSCSPRSLRIADFGFAKQL-------RAENGLLMTPCYTANYVAPEVLKKQGYDAAIDIWSLGVLLY
.||. |. .||||   |.| ..    ..  .|.||| |. .       |.  |  .    .    |||...   .  . |.|| |||..
EYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKFTTKSDVWSFGVLMW
Kinase AqueK025.AA AktR 668-699 28 1.7e-05 17.62 In-house 231-268 (268) Show / Hide 
Range on Protein: 668-699
Range on HMM: 231-268/268
Sequence Identity: 28% (11 aa)

VSAAAKDLVL-RMLHVDPQQRCT-----AAQILQHPWI
.| ..|||.  . |  .|..| .     . .|  ||| 
FSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase AqueK025.AA AktR 437-536 22 2.9e-05 16.69 In-house 1-103 (268) Show / Hide 
Range on Protein: 437-536
Range on HMM: 1-103/268
Sequence Identity: 22% (24 aa)

YDIKEDMLLGYGSYSRCVRCIHR-ATNQEFAVKIISKEKSTRDVDEEIEILLRYAPQ-HE-N--IIKLRDVYDDGTYIYMVMELMRGGELLDKIISQKFF
...    .|| | ... . . ..  ... .| |.|.|.|  .   ... |. |.  . .  .  |.|| .   . .... .|| ..||||.. . ..|.|
FHV--YKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKF

SEKEA
||..|
SEEQA
Kinase AqueK025.AA Akt 666-699 35 3.5e-05 12.41 In-house 226-264 (264) Show / Hide 
Range on Protein: 666-699
Range on HMM: 226-264/264
Sequence Identity: 35% (14 aa)

DTVSAAAKDLVLRMLHVDPQQRC-----TAAQILQHPWI
|..| ..|||. ..|. || .|      .| .| .||| 
DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase AqueK025.AA Pkinase_Tyr 439-523 28 0.000281 15.11 Pfam 1-96 (270) Show / Hide 
Range on Protein: 439-523
Range on HMM: 1-96/270
Sequence Identity: 28% (28 aa)

IKEDMLLGYGSYSRCVRCIHR----ATNQEFAVKIISKEKSTRD------VDEEIEILLRYAPQHENIIKLRDVYD-DGTY--IYMVMELMRGGELLD
|. .  || |.. . .... .     |... |||.. ||... .        .|..|.  . ..|.||..|  |   .|    ||.|||.| .| |||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQL-GHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD