Gene AqueK097 (A.queenslandica)

AqueK097

Species: A.queenslandica
Alias: AqueK097
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK5

Sequence

Name Sequence Type Origin Length Description Download
AqueK097.AA Protein None 294 None Fasta, JSON
AqueK097.kin_dom Protein Kinase Domain None 282 None Fasta, JSON

Protein domain

Protein domains of AqueK097.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK097.AA CDK5 4-285 66 2.6e-211 674.61 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-287/287
Sequence Identity: 66% (191 aa)

YERLEKIGEGTYGTVFKAKEKESGEIVALKIVRLDEDDEGVPSAALREICLLKELKHKNIVRLTDVLHKNLKLTMVFEYIDQDLKKYFDVSGGIISPQVV
||..|||||||||||.||..||..|||||| ||||..||||||.|.||||||||||||||||| ||.| . |||.|||..|||||||.|  .| ......
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

QSFFFQLLQGLAFCHYNNILHRDLKPQNILISKKGDLKLADFGLARAFGIPVRLFSAEVVTLWYRPPDVLMGAQVYNTSIDMWSAGTIFAELANAGRPLF
.|| .|||.|||||| ...||||||||| ||.|.| ||||||||||||||||| .|.|||||||||||||||...|.|||||||.| ||||.||||||||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGSDVDEQLKRIFKLVGTPTERSWPGLTKLPEFK----EFPPYPPAC-IESVVPALNDAGVDLLQRHLICHPTERISAEEAMRHEYF
||.||..|||||||..|||.| .||..||||..|    ..|.||.    ...|| |.  | ||||. |.| | .||||..|..| ||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase AqueK097.AA CDK 4-285 47 5.6e-172 554.68 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-284/284
Sequence Identity: 47% (151 aa)

YERLEKIGEGTYGTVFKAKEKESG-----EIVALKIVRLDE-----DDEGVPSAALREICLLKELKHKNIVRLTDVLHKN-----------LKLTMVFEY
||.||||||||||.|.||. |..|     .||||| .|..      ..||.|. |.|||.||||| |.|||.| || | .            ||.|||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

IDQDLKKYFDVSGGIISPQVVQSFFFQLLQGLAFCHYNNILHRDLKPQNILISKKGD-----LKLADFGLARAFGI------PVRLFSAEVVTLWYRPPD
.|.||||| |          ......|||.||..|| |.|.|||||||||||...|      ||.|||||||||||      |.| .. ||||||||.|.
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

VLMGAQVYN--TSIDMWSAGTIFAELAN--AGRPLFPGSDVDEQLKRIFKLVGTPTERSWPGLTKLPEFKEFPPYPPACIESVVPALNDAGVDLLQRHLI
.|.|.. |.  |.|||||.| ||||...  ...|||||.   .||..||.. ||||| .|||.||||..                       |||.. | 
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------------DLLNKMLC

CHPTERISAEEAMRHEYF
. |. |||||.|. |.||
YDPKKRISAEQALQHPYF
Kinase AqueK097.AA CDC2 4-285 52 1.4e-164 510.2 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-301/301
Sequence Identity: 52% (160 aa)

YERLEKIGEGTYGTVFKAKEKESGEIVALKIVRLDEDDEG--VPSAALREICLLKELK-HKNIVRLTDVLHKNLKLTMVFEYIDQDLKKYFD---VSGGI
|...||||||||| |.|.|......||||| .||. .|||  ||| |.|||..||||| |.|||.| ||.|.  || |||||.|.||||| |   ...  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

ISPQVVQSFFFQLLQGLAFCHYNNILHRDLKPQNILISKKGDLKLADFGLARAFGIPVRLFS--AEVVTLWYRPPDVLMGAQVYNTSIDMWSAGTIFAEL
..||.|.|...|.|||..||| . |.|||||||||||.|||..|.||||||||||||.|      ||||||||.| .|.|.. |.|..|||| | ||||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

-AN-AGRPLFPG-SDVDEQLKRIFKLVGTPTERSWPGLTKLPEFKE-FPPYPPACIESVVPA---------LNDAGVDLLQRHLICHPTERISAEEAMRH
  .   .|||.| |  | || .||. .|||.| .|||.|.||..|. || ..|  .....|          |.. |.|||.. |.  |  ||||.||..|
FMDVTKKPLFHGDSEID-QLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQH

EYF
 ||
PYF
Kinase AqueK097.AA PCTAIRE 4-285 52 1.8e-137 462.99 In-house 1-291 (291) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-291/291
Sequence Identity: 52% (153 aa)

YERLEKIGEGTYGTVFKAKEKESGEIVALKIVRLDEDDEGVPSAALREICLLKELKHKNIVRLTDVLHKNLKLTMVFEYIDQDLKKYFDVSGGIISPQVV
| .|.| ||||| ||.| . |  . .|||| .|| | .|| |  | ||. |||.||| ||| | |..| .  ||.||||.|.|||.| |  | |..   |
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRL-EHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNV

QSFFFQLLQGLAFCHYNNILHRDLKPQNILISKKGDLKLADFGLARAFGIPVRLFSAEVVTLWYRPPDVLMGAQVYNTSIDMWSAGTIFAELANAGRPLF
  | |||| |||.||   |||||||||| ||  .| |||||||||||  .| . .| |||||||||||||||   | |.||||  | ||.|.. .|||||
KLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMC-TGRPLF

PGSD------VDEQLKRIFKLVGTPTERSWPGLTKLPEFK--EFPPYPPACIESVVPALN---DAGVDLLQRHLICHPTERISAEEAMRHEYF
|||       | .||  ||.. |||.|..||| . ..||.   || |..  . .. | |      . |||.  |   . .|.|||.||.| ||
PGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase AqueK097.AA CMGC 4-285 25 3e-136 450.66 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-513/513
Sequence Identity: 25% (132 aa)

YERLEKIGEGTYGTVFKAKE--------------KESGEIVALKIVRLDEDDE----------GVPSAALREICLLKELK-----------------HKN
|| ..||||||||.|.|..               .|..||||.|...... .|          |.|. ||||| .||.|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVRLTDVLHKNL-----------------KLTMVFEYIDQDLKKYFDVSGG--------IISPQV------------VQSFF------FQLLQGLA--FC
||.| |... .                  .| .||||.|.||..| .   .          |. .            ...|.      .|.|.||.  .|
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HYNN--ILHRDLKPQNILISKKGDL--------------------KLADFGLARAFGIP---------------------VRLFSAEVVTLWYRPPDVLM
| ..  |.||||||.||||.....|                    |..||||||.....                     .| .. .|||.|||.| .|.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GA---------QVYNTSIDMWSAGTIFAELANA-------GRPLFPGSDV-----------DEQLKRIFKLVGTPT---------------ERSWPGLTK
|.         . |.|.|||||.| ||||. .        |.|||||..             .||..|||. ||||               |. ||. .|
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

LPEFKE---------------------------FPPYPPACIESVVPA-----------------------------------LNDAGVDLLQRHLICHP
||...                            ||..||  .....|                                    ... ..|||.. |.. |
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

TERISAEEAMRHEYF
..||.||.|..|.||
DKRITAEQALQHPYF
Kinase AqueK097.AA PFTAIRE 4-285 50 1.2e-131 443.67 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-287/287
Sequence Identity: 50% (147 aa)

YERLEKIGEGTYGTVFKAKEKESGEIVALKIVRLDEDDEGVPSAALREICLLKELKHKNIVRLTDVLHKNLKLTMVFEYIDQDLKKYFDVSGGIISPQVV
||.||| |||.| ||.|.. .  . .|||| .||.. .||.|  | ||  |||.||| ||| | |. |    ||.||||.. ||..| |   | . |. |
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQ-EEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNV

QSFFFQLLQGLAFCHYNNILHRDLKPQNILISKKGDLKLADFGLARAFGIPVRLFSAEVVTLWYRPPDVLMGAQVYNTSIDMWSAGTIFAELANAGRPLF
. | |||| ||..||   .||||||||| |||..| |||||||||||  .| . .| |||||||||||||.|.  | |..||| .| || |.  .|.|.|
RLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMM-WGQPAF

PGS-DVDEQLKRIFKLVGTPTERSWPGLTKLPEFK--EFP--PYPPACIESVVPALN--DAGVDLLQRHLICHPTERISAEEAMRHEYF
||  |. .|| .|||. |||||  ||| ..||..|   |.   | |   . ..| .     . ||..  | | | .|.||.||| |.||
PGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase AqueK097.AA CDK7 4-285 39 6.30000000001e-129 345.63 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-288/288
Sequence Identity: 39% (114 aa)

YERLEKIGEGTYGTVFKAKEKESGEIVALKIVR----LDEDDEGVPSAALREICLLKELKHKNIVRLTDVLHKNLKLTMVFEYIDQDLKKYFDVSGGIIS
|| ...||||...||.|| ....|.||| | ..     .| . |.   |.||| .|.|..| |.. | |.. .   . .||...| ||      .  |  
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

PQVVQSFFFQLLQGLAFCHYNNILHRDLKPQNILISKKGDLKLADFGLARAFGIPVRLFSAEVVTLWYRPPDVLMGAQVYNTSIDMWSAGTIFAELANAG
|  . ..  ..|||| .|| | |||||||| | |... |.||.|||||||..| | | ..  ||| ||| |  | ||  | |..|||| | |||||    
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELM-LR

RPLFPG-SDVDEQLKRIFKLVGTPTERSWPGLTKLPEFKEFPPYPP---ACIESVVPALNDAGVDLLQRHLICHPTERISAEEAMRHEYF
 | .|| ||.| ||.|||.  |||||. ||........ .| ..|.      . .  |  |  .||... .   | .|... ..  ..||
VPYLPGDSDID-QLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase AqueK097.AA PITSLRE 4-285 41 6.8e-109 368.08 In-house 1-295 (295) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-295/295
Sequence Identity: 41% (124 aa)

YERLEKIGEGTYGTVFKAKEKESGEIVALKIVRLD--EDDEGVPSAALREIC-LLKELKHKNIVRLTDVLH-KNL-KLTMVFEYIDQDLKKYFDVSG---
.. | .|.||||| |..||.|. .|||||| . ..   . || |  .||||  .|..|.| ||| .  ..  .|. |  ||.||.. |||   ..     
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

GIISPQVVQSFFFQLLQGLAFCHYNNILHRDLKPQNILISKKGDLKLADFGLARAFGIPVRLFSAEVVTLWYRPPDVLMGAQVYNTSIDMWSAGTIFAEL
   .|  . ..  ||| | .. | | |.|||||  |.|.| || ||..|||||| .| |.. ..  ||||||| | .| |...| | .|||| | ||||.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

ANAGRPLFPGSDVDEQLKRIFKLVGTPTERSWPGLTKLPEFKEFP---PYPPACIESVVP---ALNDAGVDLLQRHLICHPTERISAEEAMRHEYF
   ..|||.|.   .|...|||. |||||..||| |.|| .| .    .||.    . .|    ..| | |||.. |   |..||.|..|. |..|
I-TMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase AqueK097.AA CDK4 4-285 42 1.5e-103 350.34 In-house 1-290 (290) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-290/290
Sequence Identity: 42% (126 aa)

YERLEKIGEGTYGTVFKAKEKESGEIVALKIVRLDEDDE--GVPSAALREICLLKELK---HKNIVRLTDVLH-----K-NLKLTMVFEYIDQDLKKYFD
|. .  |||| ||||..|   ..| .|||| ||    .|  |.|   .||| ... |.   | |||.| || |        .|.||||| .|.||. | |
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

VSGG-IISPQVVQSFFFQLLQGLAFCHYNNILHRDLKPQNILISKKGDLKLADFGLARAFGIPVRLFSAEVVTLWYRPPDVLMGAQVYNTSIDMWSAGTI
      ..|. ..   .||| |. | | . | ||||||||||..  | .||||||||| ..    | .  ||||||| | ||  .. ||| .||||.| |
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPV-VVTLWYRAPEVLL-QSYYNTPVDMWSVGCI

FAELANAGRPLFPGSDVDEQLKRIFKLVGTPTERSWPGLTKLPEFKEFPPYPPACIESVVPALNDAGVDLLQRHLICHPTERISAEEAMRHEYF
|||. .  ||||.|.   .|| .||...|.|.|  ||    ||    ||.. |  .....| .   | ||||. |   .  |.||...  | ||
FAEMYCR-RPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP-WDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase AqueK097.AA S_TKc 4-285 30 5.2e-95 322.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-231/231
Sequence Identity: 30% (90 aa)

YERLEKIGEGTYGTVFKAKEKESGEIVALKIVRLDEDDEGVPSAALREICLLKELKHKNIVRLTDVLHKNLKLTMVFEYIDQ---DLKKYFDVSGGI---
|| |.|||.|..|.|.|...|..|.|||.||..           ..||| .||. .|.|||.| || .   .| ||.||.|.   ||..| .  |.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--ISPQVVQSFFFQLLQGLAFCHYNNILHRDLKPQNILISKKGDLKLADFGLARAFGIPVRLFSAEVVTLWYRPPDVLMGAQVYNT-SIDMWSAGTIFAE
  ... ...... |....|..|| ..|.||||||.|||...   .|..|||||| .       .  ..|.||..| ||     |.. ..|.|| | |..|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LANAGRPLFPGSDVDEQLKRIFKLVGTPTERSWPGLTKLPEFKEFPPYPPACIESVVPALNDAGVDLLQRHLICHPTERISAEEAMR-------HEYF
..  |.|.||      |....||..|                                   . . |.... |   |..|..| ||..       |..|
MLC-GYPPFP------QMQMMFKKIG----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK097.AA CRK7 4-285 36 1.4e-94 320.49 In-house 1-343 (343) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-343/343
Sequence Identity: 36% (125 aa)

YERLEKIGEGTYGTVFKAKEKESGEIVALKIVRLDED---DEGVPSAALREICLLKELKHKNIVRLTD-VLHK-------NLK--LTMVFEYIDQDLKKY
||... ||||||| | ||| |. ||.|||| ||.| .    || |  | ||| .|..|.|.|||.| . |. |       . |    |||||.| ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

FDVSG--GIISPQVVQSFFFQLLQGLAFCHYNNILHRDLKPQNILISKKGDLKLADFGLARAFGIPV--RLFSAEVVTLWYRPPDVLMGAQVY-------
 . |.    .|.| . .|. ||| |.. ||..|.||||.|  |||.  .| .|.||||||| .      | .   |.|||||||  | |.. |       
LE-SKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILK

-------------------------------NTSIDMWSAGTIFAELANAGRPLFPGSDVDEQLKRIFKLVGTPTERSWPGLTKLPEFKEFPP---YPPA
                               ...||||| | |..||.. ..|.|.|.   .||  |.|. |.|.  .|| ..||| .. . |   |   
ELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFT-KKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRR

CIESVVP-----ALNDAGVDLLQRHLICHPTERISAEEAMRHEYF
  | ..       .  . .|||   |   |. |..|||. .|..|
LREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase AqueK097.AA Pkinase 4-285 32 7.7e-93 319.54 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

YERLEKIGEGTYGTVFKAKEKESGEIVALKIVRLDEDDEGVPSAALR--EICLLKELKHKNIVRLTDVLHKNLKLTMVFEYIDQDLKKYFDVS-------
|....|||.|..|.|.|...| .|.|||.||........... ...|  ||...|.|.|.||||| |. . . .. ||.|| . .|.  .| .       
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

GGII--SPQVVQSFFFQLLQGLAFCHYNNILHRDLKPQNILISKKGDL----KLADFGLARAF-GIPVRLFSAEVVTLWYRPPDVLMGAQVYNTSIDMWS
.| .  |........ |.|.||..|| ..|.||||||.||||...|..    |..|||||. |   . . ..  ..|.||..| |..|.| | ...||||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

AGTIFAELANAGRPLFPGS----DVDEQLKRIFKLVGTPTERSWPGLTKLPEFKEFPPYPPACIESVVPALNDAGVDLLQRHLICHPTERISAEEAMRHE
.| |..|... |||.|||.    . ..|...|..  |.|....|| .   . |. |.. . .  ........... |.. . |   |..|..||... |.
CGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

YF
.|
WF
Kinase AqueK097.AA Pkinase_Tyr 4-150 27 1.6e-15 53.22 Pfam 1-160 (270) Show / Hide 
Range on Protein: 4-150
Range on HMM: 1-160/270
Sequence Identity: 27% (44 aa)

YERLEKIGEGTYGTVFKAKEK----ESGEIVALKIVRLDEDDEGV--PSAALREICLLKEL-KHKNIVRLTDVLH-KNLK--LTMVFEYIDQ-DLKKYFD
 . ..|.||| .|.|.|.. |    . .  || |..  .  ..      . .||. ..|.| .|.|||||  |   .     . .|.||    ||..|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

VS---GGIISPQVVQSFFFQLLQGLAFCHYNNILHRDLKPQNILISKKGDLKLADFGLARA
     .. ....   .. .|  .|... . .|. ||||   |.|.....  | .||||||.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase AqueK097.AA TyrKc 4-216 20 5.5e-12 -28.86 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-216
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

YERLEKIGEGTYGTVFKAKEKESGEIVALKIVRLDEDDEGVPSAALREICLLKEL--KHKNIVRLTDVLHKN-------LKLTMVFEYIDQ-DLKKYFDV
 . ..|.||| .|.|.|.. |   . || | .. |        . .||. ....|  .|.|||||  |  .          | .|.|| .  |||.|   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SGGIISPQVVQSFFFQLLQGLAFCHYNNILHRDLKPQNILISKKGDLKLADFGLARAF--------------------G---IPVRLFSAEVV-------
... ....   || .|  .| .. | .|. ||||   |.|.....  | .||||.|.                     |   .|.|  . |.        
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

---------TLWYRPPDVLMGAQVYNTS---IDMWSAGTIFAELANAGRPLFPGS--------DVDE--------------------QLKRIF
         ..|     ..   |          | |.  ... . . .|.  | .          ||                    .....|
KSDVWSFGVCMW----EIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF