Gene AqueK099 (A.queenslandica)

AqueK099

Species: A.queenslandica
Alias: AqueK099
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK8

Sequence

Name Sequence Type Origin Length Description Download
AqueK099.AA Protein None 265 None Fasta, JSON
AqueK099.kin_dom Protein Kinase Domain None 249 None Fasta, JSON

Protein domain

Protein domains of AqueK099.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK099.AA CDK8 25-263 72 9.1e-205 648.72 In-house 1-255 (329) Show / Hide 
Range on Protein: 25-263
Range on HMM: 1-255/329
Sequence Identity: 72% (185 aa)

KKIGRGTYGHVYKAKKRSG--DDPKEYALKQI----------EGTGISMSACREIALLRELKHSNVISLQRVFLSHADRKVWLLFDYAEHDLWHIIKYHR
| |||||||||||||.. .   . |||||||.          |||||||||||||||.|||.| |||.||||||.|.|..||.||||||||||||||.||
KYIGRGTYGHVYKAKRKKQKKKPNKEYALKQFRTEKDGVEQLEGTGISMSACREIALCRELHHPNVICLQRVFLNHKDKCVWMLFDYAEHDLWHIIKFHR

AVKGGKKPQVQVPKTMVKSLMYQILSGIHYLHSNWVLHRDLKPANILVMGDGPE--RGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGAK
. |  .|....||. ||||.|.|||.||||||||||||||||||||.|||||||  .|.||||||||||.|..|||||.||||||||||||||||||||.
HNKAHMKDPTMVPRNMVKSIMWQILDGIHYLHSNWVLHRDLKPANIMVMGDGPEDMCGCVKIADMGFARIFHNPLKPLYDLDPVVVTFWYRAPELLLGAR

HYTKAIDIWAIGCIFAELLTFEPIFHCRQE--DVEASSPYHREQLERIFLVMGFP
||||||||||||||||||.| ||||||..|  |  ...||| .||.||| |||||
HYTKAIDIWAIGCIFAELITSEPIFHCKEEKLDIKTQNPYHHDQLDRIFHVMGFP
Kinase AqueK099.AA CDK 22-263 38 1.4e-122 394.1 In-house 1-244 (284) Show / Hide 
Range on Protein: 22-263
Range on HMM: 1-244/284
Sequence Identity: 38% (105 aa)

YEG-KKIGRGTYGHVYKAKKRSGD---DPKEYALKQI---------EGTGISMSACREIALLRELKHSNVISLQRVFLSHA---------DRKVWLLFDY
||  .|||.||||.||||. .  .     . .|||.|         |..|....|.|||.||.|| | |...|  |.....         ..|... |.|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

AEHDLWHIIKYHRAVKGGKKPQVQVPKTMVKSLMYQILSGIHYLHSNWVLHRDLKPANILVMGDGPE-RGRVKIADMGFARLFNAPLK---PLADLDPVV
..|||.....                   .|..|.|.|.|.||.||||..||||||.|||.. .| . .||.||||.|.||.|. |..   |.  ....|
MDHDLKKYMD-------------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEV

VTFWYRAPELLLGAKHYT--KAIDIWAIGCIFAELLT---FEPIFHCRQEDVEASSPYHREQLERIFLVMGFP
|| ||||||||||.|||.   .||.|..||||||..|    .|.|....|          .||..|| ..| |
VTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE---------IDQLFKIFRICGTP
Kinase AqueK099.AA CMGC 22-263 26 1.3e-95 314.64 In-house 1-373 (513) Show / Hide 
Range on Protein: 22-263
Range on HMM: 1-373/513
Sequence Identity: 26% (101 aa)

YEGKK-IGRGTYGHVYKAKKRSGDDP------------KEYALKQIE-------------GTGISMSACREIALLRELK-----------------HSNV
||  | ||.|||| |||.. .  . .            ...|.| |              ..|....|.||| .|..|.                 | |.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

ISLQRVFLSHA---------------DRKVWLLFDYAEHDLWHIIKYHRA-VKGGKKPQVQVPK----------TMVKSLM------YQILSGIH--YLH
..|. .| ..                .... | |.| .|||...|| ..   .|...      .           ..|..|      |||| |..  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SNW--VLHRDLKPANILVMGDGPE----------------RGRVKIADMGFARLFNAPLKP------------------LADLDPVVVTFWYRAPELLLG
|.|  ..||||||.|||.  ..                  .||.||.| |.|| .. . ..                  .  . . ||| ||||||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

AKHYT---------KAIDIWAIGCIFAELLT--------FEPIFHCRQE----DVEASSPYHREQLERIFLVMGFP
.||||         ..||.|..||||||..|         .|.|. . |    |   .   | .||..|| |.| |
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDD-K-NGKSHIDQLFKIFKVLGTP
Kinase AqueK099.AA CDC2 25-236 41 4.6e-79 242.53 In-house 5-210 (301) Show / Hide 
Range on Protein: 25-236
Range on HMM: 5-210/301
Sequence Identity: 41% (93 aa)

KKIGRGTYGHVYKAKKRSGDDPKEYALKQI------EGTGISMSACREIALLRELK-HSNVISLQRVFLSHADRKVWLLFDYAEHDLWHIIK-YHRAVKG
.||| ||||.|||.| .  ..    |||.|      || |.  .| ||| .| ||| | |...|. |. .   .|. . |.| ..||    . .   .  
EKIGEGTYGVVYKCKDMQTNQ--IVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN--

GKKPQVQVPKTMVKSLMYQILSGIHYLHSNWVLHRDLKPANILVMGDGPERGRVKIADMGFARLFNAPLKPLADLDPV--VVTFWYRAPELLLGAKHYTK
      ..|   |||.|||||.|.|..|.. ..|||||| |||.  .|     .||||.| || |. |....    .   ||| ||||||.|||.|.|. 
-----KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN----IKIADFGLARAFGIPIRTYT---TEHEVVTLWYRAPEILLGCKRYST

AIDIWAIGCIFAEL---LTFEPIFH
..|.|.|||||||.    |..|.||
PVDMWSIGCIFAEMFMDVTKKPLFH
Kinase AqueK099.AA CDK7 20-229 38 1.5e-76 203.23 In-house 1-197 (288) Show / Hide 
Range on Protein: 20-229
Range on HMM: 1-197/288
Sequence Identity: 38% (84 aa)

FEYEGKKIGRGTYGHVYKAKKRSGDDPKEYALKQIE--------GTGISMSACREIALLRELKHSNVISLQRVFLSHADRKVWLLFDYAEHDLWHIIKYH
.|.. |.|| |... ||||   . .  .  | | |           || ..| ||| .|.|..| ||| |  .|       . | ||. . || ..||  
YEKI-KHIGEGQFATVYKACDHQTG--QIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSN--IQLVFDFMDWDLEVVIKDK

RAVKGGKKPQVQVPKTMVKSLMYQILSGIHYLHSNWVLHRDLKPANILVMGDGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGAKH
  .              .|. | ..| |. |.| ||.||||||| | |.     | |..|||| | || . .| . .    . ||| |||||||| ||.|
SII---------LTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMN----ENGQLKIADFGLARFYGSPNRIYT---HQVVTRWYRAPELLFGARH

YTKAIDIWAIGCIFAELL
|. ..|.|..|||||||.
YGTGVDMWSVGCIFAELM
Kinase AqueK099.AA CDK5 22-263 39 3.1e-67 211.35 In-house 1-219 (287) Show / Hide 
Range on Protein: 22-263
Range on HMM: 1-219/287
Sequence Identity: 39% (98 aa)

YEG-KKIGRGTYGHVYKAKKRSGDDPKEYALKQI----EGTGISMSACREIALLRELKHSNVISLQRVFLSHADRKVWLLFDYAEHDLWHIIKYHRAVKG
||   ||| |||| ||||. .       .|||..    |  |.  .| |||.||.|||| |.. |  |   |...|  | | .   ||    ||   ..|
YEKMEKIGEGTYGTVYKARNKETHE--IVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVI--HSEKKLTLVFEFCDQDL---KKYMDSCNG

GKKPQVQVPKTMVKSLMYQILSGIHYLHSNWVLHRDLKPANILVMGDGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGAKHYTKAI
      .. . ..||.||| | |. . |.. |||||||| | |.      .|  | || | || |  | .        ||| |||.|  |.|.|||.  |
------EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLIN----KNGELKLADFGLARAFGIPVRCYSH---EVVTLWYRPPDVLMGSKHYSTSI

DIWAIGCIFAELL-TFEPIFHCRQEDVEASSPYHREQLERIFLVMGFP
|.| .||||||.  .  | |   ...         .|| ||| .|| |
DMWSCGCIFAEMANAGRPLFPGNDVE---------DQLKRIFKIMGTP
Kinase AqueK099.AA Pkinase 21-235 29 6.6e-63 220.11 Pfam 1-212 (293) Show / Hide 
Range on Protein: 21-235
Range on HMM: 1-212/293
Sequence Identity: 29% (68 aa)

EYEGKKIGRGTYGHVYKAKKRSGDDPKEYALKQIEGTGISMSACR------EIALLRELKHSNVISLQRVFLSHADRKVWLLFDYAEH-----DLWHIIK
   |.|||.|..| |||.....  .  ..|.|.|.  ..... ..      ||.....|.| |.. | ..| .  ...... ..|.|.     ||...|.
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIS

YHRAVKGGKKPQVQV--PKTMVKSLMYQILSGIHYLHSNWVLHRDLKPANILVMGDGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLL
         . .  .  .   .|. |||||.|. |.||....||||||.|||.  .|    .|||.| |.|..|.  . .   .. ...| ||.|||...
T--------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIR

GAKHYTKAIDIWAIGCIFAELLTFEPIF
|...|....|.|..|||..|.|. .|.|
GGQYYGPKVDMWSCGCILYEMLCGRPPF
Kinase AqueK099.AA PITSLRE 25-263 35 2.5e-58 200.12 In-house 5-226 (295) Show / Hide 
Range on Protein: 25-263
Range on HMM: 5-226/295
Sequence Identity: 35% (88 aa)

KKIGRGTYGHVYKAKKRSGDDPKEYALKQIEGT------GISMSACREIA-LLRELKHSNVISLQRVFLSHADRKVWLLFDYAEHDLWHIIKYHR-AVKG
 .|. |||| ||.|| .  |.    ||| .         |.   . |||  .|..|.| |.... .. .     |... ..| ||||  ..  ..   . 
NRIHEGTYGVVYRAKDKRTDE--IVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRNQP

GKKPQVQVPKTMVKSLMYQILSGIHYLHSNWVLHRDLKPANILVMGDGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGAKHYTKAI
 | ..       .|.|| | |.|....|.||..||||| .|.|        |  ||.| | || .  |.||.    |.||| ||||||||||.| |. ..
FKPGE-------IKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYS----HKGILKICDFGLAREYGSPIKPYT---PCVVTLWYRAPELLLGCKKYSTPV

DIWAIGCIFAELLTFEPIFHCRQEDVEASSPYHREQLERIFLVMGFP
|.| .||||||..| .|.|  . |          .|...||  || |
DMWSVGCIFAEFITMKPLFQGKSE---------IDQINCIFKEMGTP
Kinase AqueK099.AA S_TKc 21-258 27 7.9e-57 196.03 SMART 1-231 (231) Show / Hide 
Range on Protein: 21-258
Range on HMM: 1-231/231
Sequence Identity: 27% (73 aa)

EYEGKKIGRGTYGHVYKAKKRSGDDPKEYALKQIEGTGISMSACREIALLRELKHSNVISLQRVFLSHADRKVWLLFDYAEH---DLWHIIKYHRAVKGG
   ..|||.|..| |||.....  . ...|.|.|       ...|||..|.. .| |.. |  || .    .... ..|...   || ..|| ..  .. 
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL-

KKPQVQVPKTMVKSLMYQILSGIHYLHSNWVLHRDLKPANILVMGDGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGAKHYTK-AI
   ... |  .....||||.... |.||....||||||.|||.        ..||.| |.||..          . ...| ||.|||.|    .|.| ..
---RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKCKC

DIWAIGCIFAELLTFEPIFHCRQEDV--------EAS---------SPYHR---EQLE-------RIFL
|.|..|||..|.|. .| |.  |...        ||           | .|   | |.         ..
DWWSCGCILYEMLCGYPPFP--QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK099.AA CDK4 22-263 38 7.9e-54 182.98 In-house 1-228 (290) Show / Hide 
Range on Protein: 22-263
Range on HMM: 1-228/290
Sequence Identity: 38% (98 aa)

YEG-KKIGRGTYGHVYKAKKRSGDDPKEYALKQI------EGTGISMSACREIALLRELK---HSNVISLQRVF-LSHADR---KVWLLFDYAEHDLWHI
|.    || | || ||.|  |.  . . .||||.      || |. ||  |||...| |.   | |...|  |.  .  ||   |. . |   . ||   
YQCVAEIGEGAYGTVYRA--RDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTY

IKYHRAVKGGKKPQVQVPKTMVKSLMYQILSGIHYLHSNWVLHRDLKPANILVMGDGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLL
.         | |.  .|.  .| .| |.|.|. .|||. . |||||| ||||  |    |.||.|| | || .    .    | ||||| |||||| ||
LD--------KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSD----GHVKLADFGLARIYSFQMA----LTPVVVTLWYRAPEVLL

GAKHYTKAIDIWAIGCIFAELLTFEPIFHCRQEDVEASSPYHREQLERIFLVMGFP
 .  |   .|.|..||||||.    | |    |          .||..|| ||| |
-QSYYNTPVDMWSVGCIFAEMYCRRPLFCGQSE---------KDQLHKIFDVMGLP
Kinase AqueK099.AA CDK10 20-235 38 6.3e-50 171.74 In-house 1-201 (285) Show / Hide 
Range on Protein: 20-235
Range on HMM: 1-201/285
Sequence Identity: 38% (85 aa)

FEYEGKKIGRGTYGHVYKAKKRSGDDPKEYALKQI----EGTGISMSACREIALLRELKHSNVISLQRVFLSHADRKVWLLFDYAEHDLWHIIKYHRAVK
||    ..| |||| ||.|.    |.    |||..    |  |. .|. ||| || ...| |.. |. |   .    ..|  .| | ||  ..       
FE-KLNRVGEGTYGIVYRARDMRSDE--IVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQP-

GGKKPQVQVPKTMVKSLMYQILSGIHYLHSNWVLHRDLKPANILVMGDGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGAKHYTKA
           | || .| |.| |..|||.|...||||| .|.|.     ..| .|.|| | || .  | ||.    | .|| ||||||||||..  | |
--------FTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMT----DKGCIKVADFGLARMYGVPVKPMT---PKMVTLWYRAPELLLGCRTQTTA

IDIWAIGCIFAELLTFEPIF
||.||.||| .|||   |..
IDMWAVGCILGELLVHKPLM
Kinase AqueK099.AA CRK7 129-263 33 1.1e-41 141.48 In-house 114-272 (343) Show / Hide 
Range on Protein: 129-263
Range on HMM: 114-272/343
Sequence Identity: 33% (58 aa)

VKSLMYQILSGIHYLHSNWVLHRDLKPANILVMGDGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGAKHY----------------
.|..| |.| |. |.| . .||||.| .|||.      .| ||||| | |||.|.  |  ...   |.| |||.||||||...|                
CKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMN----NQGEVKIADFGLARLYNSEEK-RRPYTNRVITLWYRPPELLLGEERYTEQHILKELIRNIKSI

----------------------TKAIDIWAIGCIFAELLTFEPIFHCRQEDVEASSPYHREQLERIFLVMGFP
                      ...||.|  |||..||.| .|||  ..|          .||| |. ..| |
QLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNE---------MAQLEKIYKICGSP
Kinase AqueK099.AA CRK7 22-104 31 2.2e-13 42.29 In-house 1-97 (343) Show / Hide 
Range on Protein: 22-104
Range on HMM: 1-97/343
Sequence Identity: 31% (31 aa)

YEG-KKIGRGTYGHVYKAKKRSGDDPKEYALKQIEGTGI-------SMSACREIALLRELKHSNVISLQRVFLSH-------ADR-KVWLLFDYAEHDL
||  . || |||| |||||  .  .    ||| ..  .           | ||| .||.|.| |.. |  . ..         ..  ... |.|. |||
YEMIMQIGEGTYGQVYKAKNKHTGE--MVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDL
Kinase AqueK099.AA TyrKc 21-257 19 1.5e-10 -52.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 21-257
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)

EYEGKKIGRGTYGHVYKAKKRSGDDPKEYALKQIEGTGISMSACREIALLREL--KHSNVISLQRVFLSH-----ADRKVWLLFDYAEH-DLWHIIKYHR
   |||.|.| .| |||.. .      . | | .      .  .||. ....|  .| |.. |  | ...      .  ..... |..| || . ...||
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

AVKGGKKPQVQVPKTMVKSLMYQILSGIHYLHSNWVLHRDLKPANILVMGDGPERGRVKIADMGFARLFNAP--------LKPLA---DLDPVVVTFWYR
           ..     | ..|| .|  ||||. . ||||   |.||  ..    .|||.| | .|              .  .   . . ..   |. 
PK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-

APELLLGAKHYTKAIDIWA----------------IG-----CIFAELLTF-------EPIFH--------CRQEDVE------ASSPYHR---EQLERI
||| .   . .| . |.|.                 |     .  .|.. .       ..  .        | .|  .      .  |  |   ... ..
APECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

F
|
F
Kinase AqueK099.AA Pkinase_Tyr 20-174 26 9e-06 20.25 Pfam 1-154 (270) Show / Hide 
Range on Protein: 20-174
Range on HMM: 1-154/270
Sequence Identity: 26% (43 aa)

FEYEGKKIGRGTYGHVYKAKKR--SGDDPKEYALKQI-EGTGIS----MSACREIALLREL-KHSNVISLQRVFLSHADR-KVWLLFDYAEH-DLWHIIK
 .   ||.|.| .|.|||.. .   ...  . | | . ||.  .     .  ||......| .| |...|  | ... .  .... . |..| || .  .
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

YHRAVKGGKKPQVQVPKTMVKSLMYQILSGIHYLHSNWVLHRDLKPANILVMGDGPERGRVKIAD
 ||       .. ...  .  .  .|| .|  ||.|.   ||||   |.||     | . |||.|
KHR------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT----ENNVVKICD