Gene AqueK111 (A.queenslandica)

AqueK111

Species: A.queenslandica
Alias: AqueK111
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK1

Sequence

Name Sequence Type Origin Length Description Download
AqueK111.AA Protein None 683 None Fasta, JSON
AqueK111.kin_dom Protein Kinase Domain None 322 None Fasta, JSON

Protein domain

Protein domains of AqueK111.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK111.AA DYRK1 96-417 69 4.5e-208 697.54 In-house 1-321 (321) Show / Hide 
Range on Protein: 96-417
Range on HMM: 1-321/321
Sequence Identity: 69% (225 aa)

YEIDSLIGKGSFGQVVKAFDLEEREWVAIKVIKNKRAFYQQALIEKRLLELLNSRDPEGKYYIVSLKRSFTFRGHLCFVFELLSYNLYELLRNTNFRGVS
||||||||||||||||||.| .|.|.||||.||||..||.||.|| |||||.| .|.| ||||| ||| | || ||| ||||||||||.|||||.|||||
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LNLTRKFAQQLCTALLFLSTHDINVIHCDLKPENILLCNPKRSAIRIVDFGSSCQVGSRMFQYIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVEMHTGE
||||||||||.||||||.|| ....||||||||||||||||||||.|.|||||||.| |..|||||||||||||||||.||.||||||||||||||||||
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFSGKDEIDQMSKIVEVLGIPPPHVLERSARRDRFFERESGGTWVLKRQRDGRKDHHRRPGSRSLYEILGGDKGGPGGLRKGDSGHTPNDYYKFRDLVL
|||||..|.|||.|||||||.|| |..... .  ..||..  .||..|..||..|. .. |. | | |||| . ||||| |||..||...|| ||.||..
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKH-YKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYLKFKDLIK

QMLDYDPETRIKPLAALKHPFF
.||.|||..||.|. ||.|.||
RMLQYDPKQRITPYYALQHSFF
Kinase AqueK111.AA DYRK 96-417 47 4.1e-181 607.99 In-house 1-320 (320) Show / Hide 
Range on Protein: 96-417
Range on HMM: 1-320/320
Sequence Identity: 47% (156 aa)

YEIDSLIGKGSFGQVVKAFDLEEREWVAIKVIKNKRAFYQQALIEKRLLELLNSRDPEGKYYIVSLKRSFTFRGHLCFVFELLSYNLYELLRNTNFRGV-
|||.. |||||||||||..|    |.||||.|.|. .|..||.|| ..||.||  ||. ||..| ....|..|.||| ||||||.||||.|.|..|.|. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SLNLTRKFAQQLCTALLFLSTHDINVIHCDLKPENILLCNP-KRSAIRIVDFGSSCQVGSRMFQYIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVEMHT
||||.||||||..|.|.||...  | ||||||||||.|..| ..|.| ..||||||... |...||||||||.|||.||.||. |||||||||||.|..|
SLNLVRKFAQQILTCLKFLHKNE-NIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFT

GEPLFSGKDEIDQMSKIVEVLGIPPPHVLERS--ARRDRFFERESGGTWVLKRQRDGRKDHHRRPGSRSLYEILGGDKGGPGGLRKGDSGHTPNDYYKFR
|.|||.|..| ||. .|.||||.||..... .   |...||..    ..  .. ......   ... ... .... ....|.| |..|..|.  |. .| 
GWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFK

DLVLQMLDYDPETRIKPLAALKHPFF
|.....|..||. ||.|  ||.||.|
DFIKKCLQWDPHKRITPSQALQHPWF
Kinase AqueK111.AA DYRK2 96-417 41 2.5e-134 439.42 In-house 1-318 (318) Show / Hide 
Range on Protein: 96-417
Range on HMM: 1-318/318
Sequence Identity: 41% (140 aa)

YEIDSLIGKGSFGQVVKAFDLEEREWVAIKVIKNKRAFYQQALIEKRLLELLNSRDPEGKYYIVSLKRSFTFRGHLCFVFELLSYNLYELLRNTNFRGVS
|||.. |||||||||||..|   .. ||||.| ||  | .||..| | |. . . |. . . .| .. .|.||.|.| .||||| ||||.... .| | |
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LNLTRKFAQQLCTALLFLSTHDINVIHCDLKPENILLCNPKRSAIRIVDFGSSCQVGS-RMFQYIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVEMHTG
|.| |.||... ..| ||. ..|  ||||||||||||  . || | ..|||||| .   |.. ||||||||.||| ||..|. ||||||.|||..|. ||
LQLVRRFAHSILQCLRFLHKNNI--IHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTG

EPLFSGKDEIDQMSKIVEVLGIPPPHVLERS-----ARRDRFFER---------ESGGTWVLKRQRDGRKDHHRRPGSRSLYEILGGDKGGPGGLRKGDS
 ||| | .| ||.  . ||||.||..... .      ||. ||..          . .. ......  |... | |||.|. ..| |             
YPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKG-------------

GHTPNDYYKFRDLVLQMLDYDPETRIKPLAALKHPFF
     . . | | ... .. ||..|..|  |||||..
----CEDENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase AqueK111.AA CMGC 96-417 21 1e-111 368.58 In-house 1-513 (513) Show / Hide 
Range on Protein: 96-417
Range on HMM: 1-513/513
Sequence Identity: 21% (115 aa)

YEIDSLIGKGSFGQVVKAFD--------------LEEREWVAIKVIKNKRAFYQQAL-------------IEKRLLELLN-SRDPEG-----------KY
|||.. ||.|..|.|.|..|               |  | |||| |||.  .  ||.              | ..|. ||   || .           . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

YIVSLKRSFTFRG-----------------HLCFVFELLSYNLYELLRNTN--------------------------FRGVSLNLTRKFAQQLCTALL--
.||.|. .|....                 ||..|||.. ..||....|..                           .  .. . | ...|....|   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

FLSTHDINVIHCDLKPENILLCNPKRS------------------AIRIVDFGSSCQVGSR------------------------MFQYIQSRFYRSPEV
..  |. |.||.||||||||... ...                   ..| |||........                        . .|...|.||.||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

LLGIP----------YDLAIDMWSLGCILVEMHTG--------EPLFSGKDE-----------IDQMSKIVEVLGIPPPHVLERS------ARRDRFFER
||| .          |. .|||||.|||. || ||        .||| |..|           |||. ||..||| |. ......      ..... .  
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

ESGGTWVLK---------------------RQRDGRKDHHRRPGSRSLYEI---------------------LGGDKGGPGGLRKGDSGHTPN-------
 ..  |  |                     .|. .|.  ....  ..|.                        ...|               |       
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHK-------------F-NHQFKRKC

DYYKFRDLVLQMLDYDPETRIKPLAALKHPFF
.  ...||. .|| |||. ||..  ||.||.|
CDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase AqueK111.AA YAK 96-337 41 7.6e-104 351.29 In-house 1-244 (347) Show / Hide 
Range on Protein: 96-337
Range on HMM: 1-244/347
Sequence Identity: 41% (103 aa)

YEIDSLIGKGSFGQVVKAFDLEEREWVAIKVIKNKRAFYQQALIEKRLLELLNSR-DPEGKY---YIVSLKRSFTFRGHLCFVFELLSYNLYELLRNTNF
| .    |.| ||||||   .   | .|.|||||. |. |||  | ..|..|| . ||..|     |. .  .| .. |.| |||.|| ||||.| ...|
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

RGVSLNLTRKFAQQLCTALLFLSTHDINVIHCDLKPENILLCNPKRSAIRIVDFGSSCQVGSRMFQYIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVEM
.| | .| | .  |   ..  |   . ..||||||||||.||.| . .|.|.|||||||  . .  |||.|.|||||......|  .|||||||||..| 
CGFSFQLIRQWTKQILDGMCVL--ENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAEL

HTGEPLFSGKDEIDQMSKIVEVLGIPPPHVLERSARRDRFFERESG
  | |.| |  | .|.. |...||.||  ....   . ..| .  |
FLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYFHCHDG
Kinase AqueK111.AA S_TKc 96-417 24 3.8e-81 276.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 96-417
Range on HMM: 1-231/231
Sequence Identity: 24% (84 aa)

YEIDSLIGKGSFGQVVKAFDLEEREWVAIKVIKNKRAFYQQALIEKRLLELLNSRDPEGKYYIVSLKRSFTFRGHLCFVFELLSY---NLYELLRNTNFR
|||  .||||.||.| |. . .  . ||||.||      .... | ..|.        .  .|| |. .|   .||..|.|...    .|...... . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----VSLNLTRKFAQQLCTALLFLSTHDINVIHCDLKPENILLCNPKRSAIRIVDFGSSCQVGSRMFQYIQSRFYRSPEVLLGIPYDL-AIDMWSLGCI
|     .   .|....|.| || ..  |. ..||.|||||||||..     | | |||...|.      .. ...|..||||   .|.  ..|.||.|||
GLRFPFPE-HARFYMYQICCALEYC--HSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LVEMHTGEPLFSGKDEIDQMSKIVEVLGIPPPHVLERSARRDRFFERESGGTWVLKRQRDGRKDHHRRPGSRSLYEILGGDKGGPGGLRKGDSGHTPNDY
| || .|.|.|.      || .. ...|                                                                        
LYEMLCGYPPFP------QMQMMFKKIG-----------------------------------------------------------------------S

YKFRDLVLQMLDYDPETRIKPLAALK-------HPFF
  ..|.. ..|..||| |.    ||.       ||.|
PEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK111.AA HIPK 96-347 37 1e-66 208.97 In-house 1-255 (329) Show / Hide 
Range on Protein: 96-347
Range on HMM: 1-255/329
Sequence Identity: 37% (98 aa)

YEIDSLIGKGSFGQVVKAFDLEEREWVAIKVIKNKRAFYQQALIEKRLLELLNSRDPEGKYYIVSLKRSFTFRGHLCFVFELLSYNLYELLRNTNFRGVS
||.  ..|.| ||||||.      | ||||..||   .  |  || ..|. | . ...  | .|     |  . | | |||.|  |||. ... .|    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENAD-EYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

LNLTRKFAQQLCTALLFLSTHDINVIHCDLKPENILLCNPKRSAIR--IVDFGSSCQVGSRMFQ-YIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVEMH
|.  |   ||  |||. |   .. .|| |||||||.|  |.|   |  ..||||   |     . |.|||.|| ||..||.|.  ..|||||||.. | .
LKHIRPILQQVLTALMKL--KELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELF

TGEPLFSGKDEIDQMSKIVEVLGIPPPHVLERSARRDRFF---ERESGGTWVLKRQRD
 | ||. | || ||   | .  . | .| |.   .  |||   .  .   | ||  ..
LGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKFRPWRLKHIEE
Kinase AqueK111.AA Pkinase 96-417 24 2.8e-63 221.35 Pfam 1-293 (293) Show / Hide 
Range on Protein: 96-417
Range on HMM: 1-293/293
Sequence Identity: 24% (86 aa)

YEIDSLIGKGSFGQVVKAFDLEEREWVAIKVIKNKRAFYQQ---ALI--EKRLLELLNSRDPEGKYYIVSLKRSFTFRGHLCFVFELLSY-----NLYEL
|.| . ||.||||.| |. .  ... ||.|.|| ...  ..   ..   | ...  ||      .. || |...|. ..|...|.|..        |...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-----HPN-IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LR---NTNFRGVSLNLTRKFAQQLCTALLFLSTHDINVIHCDLKPENILLCNPKRSAI----RIVDFGSSCQ---VGSRMFQYIQSRFYRSPEVLL-GIP
..   ...|   | .  .... |.. .| ..  |. ..||.||||||||.   ..  |    .| |||...|    .| |  .  ...|..|||.. | .
ISTWRHGCFY-FSEWECKFYMYQILRGLEYC--HSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQY

YDLAIDMWSLGCILVEMHTGEPLFSGK----DEIDQMSKIVEVLG-IPPPHVLERSARRDRFFERESGGTWVLKRQRDGRKDHHRRPGSRSLYEILGGDK
|. ..||||.|||| || .|.|.|.|.    . .||| .|....| ... .  . . ....|  |    .                              
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------------------------------

GGPGGLRKGDSGHTPNDYYKFRDLVLQMLDYDPETRIKPLAALKHPFF
       .  .   .|    ..|..  .|..||. |. .  .|.||.|
-------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK111.AA PRP4 96-301 38 3.3e-57 196.38 In-house 1-208 (320) Show / Hide 
Range on Protein: 96-301
Range on HMM: 1-208/320
Sequence Identity: 38% (82 aa)

YEIDSLIGKGSFGQVVKAFDLEERE-WVAIKVIKNKRAFYQQALIEKRLLELLNSR--DPEGKYYIVSLKRSFTFRGHLCFVFELLSYNLYELLRN-TNF
|.. . .|.| |. |... |.      ||||.| |.   ..  | |.  |  ||    |.. |. .| ..|.| .| |.| ||| .| || |.|      
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

RGVSLNLTRKFAQQLCTALLFLSTHDINVIHCDLKPENILLCNPKRSAIRIVDFGSSCQVG-SRMFQYIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVE
 | .|.  | .||||  ||  |     | .| |.|| |||  |  .. . ..||||  ..  . .  | .|||||.||...|.||| .||||| || | |
VGLHLKAVRSYAQQLFLALKHL--KKCNILHADIKPDNILV-NESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYE

MHTGEPLFSGK
. ||  .|.||
LYTGKIMFPGK
Kinase AqueK111.AA CDK 96-417 25 2.6e-54 172.11 In-house 1-284 (284) Show / Hide 
Range on Protein: 96-417
Range on HMM: 1-284/284
Sequence Identity: 25% (92 aa)

YEIDSLIGKGSFGQVVKAFDLEER-----EWVAIKVIKNKR--------AFYQQALIEKRLLELLNSRDPEGKYYIVSLKRSFTFR-----------GHL
||.   || |..|.| || |..       . ||.| |.            | . |. |  ||  |    |    .||.|.  ..               |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL---HP----NIVKLHDVCHTKNMDRNNKDKHENKL

CFVFELLSYNLYELLRNTNFRGVSLNLTRKFAQQLCTALLFLSTHDINVIHCDLKPENILLCNPK---RSAIRIVDFGSSCQVGS------RMFQY---I
 .||| . . |.....            . . .||  .| ..  |. ...| |||| |||. |     .  . | ||| ..  |.       .  |   .
YMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYC--HSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEV

QSRFYRSPEVLL-GIPYD--LAIDMWSLGCILVEMHT---GEPLFSGKDEIDQMSKIVEVLGIPPPHVLERSARRDRFFERESGGTWVLKRQRDGRKDHH
  . ||.||.||    |.   .|||||.|||..|| |   ..||| |. ||||. || ...| | . .         .                      
VTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------------

RRPGSRSLYEILGGDKGGPGGLRKGDSGHTPNDYYKFRDLVLQMLDYDPETRIKPLAALKHPFF
                                      ||  .|| |||. ||.  .||.||.|
--------------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase AqueK111.AA CLK 96-235 32 1.1e-46 137.61 In-house 1-150 (350) Show / Hide 
Range on Protein: 96-235
Range on HMM: 1-150/350
Sequence Identity: 32% (50 aa)

YEIDSLIGKGSFGQVVKAFDLEE-REWVAIKVIKNKRAFYQQALIEKR-LLELLNSR-DPEGKYY--IVSLKRSFTF-RGHLCFVFELLSYNLYELLRNT
||| .  | | || ||.  | .     ||.|.|.|   .  .| .| .  .. .|   ||..||   .. .  .| .  || | ||||.  ..|.... .
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

N------FRGVSLNLTRKFAQQLCTALLFLSTHDINVIHCDLKPENILLCNP
|      ...  .. .|..| |||.|. ||  ||.  .| |||||||.....
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFL--HDMKLTHTDLKPENICFVDS
Kinase AqueK111.AA MAPK 219-324 39 5.8e-35 118.23 In-house 137-261 (328) Show / Hide 
Range on Protein: 219-324
Range on HMM: 137-261/328
Sequence Identity: 39% (50 aa)

NVIHCDLKPENILLCNPKRSAIRIVDFGSSCQVGSR-----------------MFQYIQSRFYRSPEVLLG---IPYDLAIDMWSLGCILVEMHT-GEPL
||||.||||.|||.   .    .| ||| .... .                  | .|.  |.||.||..|.     |. |.||||.|||. || | . ||
NVIHRDLKPSNILV--NENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPL

FSGKDEIDQMSKIVEVLGIPPPHVLER
| ||| |||. .|.|||| |.......
FPGKDYIDQWNLIMEVLGTPSEEFIQC
Kinase AqueK111.AA CLK 240-350 29 1.7e-18 51.39 In-house 186-301 (350) Show / Hide 
Range on Protein: 240-350
Range on HMM: 186-301/350
Sequence Identity: 29% (35 aa)

IRIVDFGSSC---QVGSRMFQYIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVEMHTGEPLFSGKDEIDQMSKIVEVLGIPPPHVLERSAR----RDRFF
|...||||     .        ...| || ||| || ..    | || ||||.|  ||. || . |... .  . ...|.| |    .. |     ...|
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYF

ERESGGTWVLKRQRDGRK
 .  .  |.    .|||.
YHN-RLDWDW-HNSDGRY
Kinase AqueK111.AA MAPK 96-129 35 9.4e-11 33.18 In-house 1-40 (328) Show / Hide 
Range on Protein: 96-129
Range on HMM: 1-40/328
Sequence Identity: 35% (14 aa)

YEIDSLIGKGSFGQVVKAFDLE------EREWVAIKVIKN
|.|.. ||.|..|.|..|.| .      . . |||| | .
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISR
Kinase AqueK111.AA CLK 389-417 51 3.3e-09 23.0 In-house 322-350 (350) Show / Hide 
Range on Protein: 389-417
Range on HMM: 322-350/350
Sequence Identity: 51% (15 aa)

KFRDLVLQMLDYDPETRIKPLAALKHPFF
.. ||. .|| |||  ||.   ||.||||
QLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase AqueK111.AA TyrKc 96-417 16 4.2e-09 -75.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 96-417
Range on HMM: 1-280/280
Sequence Identity: 16% (60 aa)

YEIDSLIGKGSFGQVVKAFDLEEREWVAIKVIKNKRAFYQQALI-EKRLLELL--NSRDPEGKYYIVSLKRSFTFR-------GHLCFVFELLSY-NLYE
 . .  .| | ||.|.|.      . ||.|..|.     ..... | |..  |  .         || |    |         . |. |.|. .. .| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHP------NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

LLRNTNFRGVSLNLTRKFAQQLCTALLFLSTHDINVIHCDLKPENILLCNPKRSAIRIVDFGSSCQVGSR-MF----QYI------QSR-----FYRSPE
 ||..  . ...    .|. | .    .|. .  |.|| ||   |.|. ...   ..| ||| |  ...  .     .|.      ...        .||
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

VLLGIPYDLAIDMWSLGCILVEMHT-GEPLFSG-----KDEIDQMSKIVEVLGIPPPHV----LERSARRDRFFERESGGTWVLKRQRDGRKDHHRRPGS
..    .  . | || |  . |. | |..  .|     .. .. . .. .    |.|.                                          
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------------

RSLYEILGGDKGGPGGLRKGDSGHTPNDYYKFRDLVLQMLDYDPETRIKPLAALKHPFF
                     . . | . |   .. .|  ..||| |    .   | .|
---------------------FVCCPDEMY---QIMKQCWHEDPEDRPTFSEI--HECF
Kinase AqueK111.AA PRP4 390-417 50 2.5e-07 22.96 In-house 293-320 (320) Show / Hide 
Range on Protein: 390-417
Range on HMM: 293-320/320
Sequence Identity: 50% (14 aa)

FRDLVLQMLDYDPETRIKPLAALKHPFF
|.||  ..|  ||. || .  ||||||.
FKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase AqueK111.AA HIPK 386-417 37 6.2e-07 17.35 In-house 298-329 (329) Show / Hide 
Range on Protein: 386-417
Range on HMM: 298-329/329
Sequence Identity: 37% (12 aa)

DYYKFRDLVLQMLDYDPETRIKPLAALKHPFF
|.  | ..  .|.  |.. || |..||.||| 
DRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase AqueK111.AA YAK 390-417 42 1e-05 15.01 In-house 320-347 (347) Show / Hide 
Range on Protein: 390-417
Range on HMM: 320-347/347
Sequence Identity: 42% (12 aa)

FRDLVLQMLDYDPETRIKPLAALKHPFF
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FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase AqueK111.AA MAPK 391-417 48 0.000132 11.59 In-house 302-328 (328) Show / Hide 
Range on Protein: 391-417
Range on HMM: 302-328/328
Sequence Identity: 48% (13 aa)

RDLVLQMLDYDPETRIKPLAALKHPFF
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IDLLEKMLVFDPDKRITVEEALQHPYF