Gene AqueK116 (A.queenslandica)

AqueK116

Species: A.queenslandica
Alias: AqueK116
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: PRP4

Sequence

Name Sequence Type Origin Length Description Download
AqueK116.AA Protein None 428 None Fasta, JSON
AqueK116.kin_dom Protein Kinase Domain None 317 None Fasta, JSON

Protein domain

Protein domains of AqueK116.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK116.AA PRP4 107-423 66 2.6e-223 748.15 In-house 1-320 (320) Show / Hide 
Range on Protein: 107-423
Range on HMM: 1-320/320
Sequence Identity: 66% (214 aa)

YMVYGYTGHGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMAELEILKKLNAT--DPDDKFHCIRLFSNFFHKNHLCLVFESMSMNIREVLRKYGKN
| ||||.| ||||||.|.||. |  ..||||||||||.|||||. |||||.||| .  |..|||||.|.|  |.|..|.||||| |||| |||| ||||.
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

IGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNESKLMLKLCDFGSASFIQDNEITPYLVSRFYRAPEIIIGCKYDYGIDMWSVGATLYELYT
.|||.||||||.|||.||||..|.| |||||||||||||||||. ||.||||||| |..|||||||||||||||||||| .|||.||||||| |||||||
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYT

GQILFPGKSNNEMLKLNMELKGKMSHKMVRKGMFRENHFDSSFNFLYHTVDKVTQKEKVVVMSSFSPQRDLLADLVGS-QSPSEAHLRKIHHFKDFLDKI
| |.||||.||.|||| |..||||..||.||| |..||||  .||.|  |||||..|||.||.   | .|....|..  |. .|   .|.| |||.|||.
GKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHFDQNCNFMYQEVDKVTEREKVTVMTYIKPTKDIYQELIECNQRIPEDQMKKVHQFKDLLDKC

FILDPTKRLSINQALQHPFI
..||| || ..|.||.||||
LMLDPKKRITCNEALKHPFI
Kinase AqueK116.AA DYRK 107-423 38 1.4e-154 519.8 In-house 1-320 (320) Show / Hide 
Range on Protein: 107-423
Range on HMM: 1-320/320
Sequence Identity: 38% (126 aa)

YMVYGYTGHGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMAELEILKKLNATDPDDKFHCIRLFSNFFHKNHLCLVFESMSMNIREVLRKYGKNIG
| ...|.| |.|..||...|. .  . |||||||||. .|.... |..||..||  |||||.||....  | |.||||.||| .||| .|.|...... .
YEILEYIGKGSFGQVVKCWDH-KTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

LHIKAVRSYSQQLLLALKLMKRC-TILHADIKPDNILVNE--SKLMLKLCDFGSASFIQDNEITPYLVSRFYRAPEIIIGCKYDYGIDMWSVGATLYELY
.....||.. ||.|..||.....  |.|.|.||.||....  .|  .|..||||..|. . .|..|..||||||||.|.||.|.| |||||.| .|.||.
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELF

TGQILFPGKSNNEMLKLNMELKGKMSHKMVRKG--MFRENHFDSSFNFLYHTVDKVTQKEKVVVMSSF---SPQRDLLADLVGSQSP--SEAHLRKIHHF
|| .||||......|.. ||..|.....|..||   .....||.   | | ..|..|...|. ...      | ..    .......  .. . .. | |
TGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQF

KDFLDKIFILDPTKRLSINQALQHPFI
|||..| ...||.||.. .||||||..
KDFIKKCLQWDPHKRITPSQALQHPWF
Kinase AqueK116.AA CMGC 107-423 21 6.2e-99 325.76 In-house 1-513 (513) Show / Hide 
Range on Protein: 107-423
Range on HMM: 1-513/513
Sequence Identity: 21% (109 aa)

YMVYGYTGHGVFSNVVRARDTS-------------RSSQEVAIKIIRNNEMMHKTGM-------------AELEILKKLNAT---------DPDDKFH--
| . .. |.| ...|...||.              .. ..||||.|.|.. .. ..               |..|||.|| .         |||.| |  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

CIRLFSNFFHKN-----------------HLCLVFESMSMNIREVLRKYGK-------------------------NIGLHIKAVRSYSQQLLLALK--L
...|.  | |||                 ||.|||| | ..  ...... .                            . | ..| |..|.| .||   
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

MKRCT--ILHADIKPDNILVNESK-------------------LMLKLCDFGSASFIQDN-----------------------EITPYLVSRFYRAPEII
. .    |.| |.|| |||.|. .                     ||.||||.| .. ..                        .|.| |.|.||||||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

IGCK----------YDYGIDMWSVGATLYELYTG--------QILFPGKSN-----------NEMLKLNMELKGKMSHKMVRKGMFRE-NHFDSSFNFLY
.|.|          |...|||||||  ..|.|||        ..||||.|.            ..|.. ... |. . .| .||. |. | |..  .  .
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGK-RHFN-FCKHEEEWP

HTVDKVTQKEKVVVMS-------SFSPQRDLLADLVGSQSPSEAHLRKI----------------------------------------HHFKDFLDKIF
  ... . . .  ...         . .|  .      . .   .....                                        . . |.|.|..
NMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKML

ILDPTKRLSINQALQHPFI
..||.||... ||||||..
QYDPDKRITAEQALQHPYF
Kinase AqueK116.AA S_TKc 107-423 22 2.8e-71 244.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 107-423
Range on HMM: 1-231/231
Sequence Identity: 22% (76 aa)

YMVYGYTGHGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMAELEILKKLNATDPDDKFHCIRLFSNFFHKNHLCLVFESMSM---NIREVLRKYGK
| .    |.| |. | ..|... . ..||||||.      .. . |..||||       .  . ..|.  | . .||..|.| ..    . .....|.|.
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

---NIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNESKLMLKLCDFGSASFIQDNEITPYLVSRFYRAPEIIIGCKYDY-GIDMWSVGATL
   . ...   .|.| .|...||. . .  |.| |.||.|||..|    .|.||||.| ..     | . ....|.|||..   .|..  .|.||.| .|
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

YELYTGQILFPGKSNNEMLKLNMELKGKMSHKMVRKGMFRENHFDSSFNFLYHTVDKVTQKEKVVVMSSFSPQRDLLADLVGSQSPSEAHLRKIHHFKDF
||...|. .||    ..|.|. .                                                                       . .|||
YEMLCGYPPFP--QMQMMFKKIG----------------------------------------------------------------------SPEAKDF

LDKIFILDPTKRLSINQALQ-------HPFI
..|..  ||.||... .|||       ||..
IRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK116.AA DYRK2 107-343 36 2.8e-61 197.92 In-house 1-240 (318) Show / Hide 
Range on Protein: 107-343
Range on HMM: 1-240/318
Sequence Identity: 36% (89 aa)

YMVYGYTGHGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMAELEILKKLNATDPDDKFHCIRLFSNFFHKNHLCLVFESMSMNIREVLRKYGKNIG
| .    | | |  ||.. |     | ||||.|||    |..   |..||...   |.|  . |....  |   ||.|..|| .|||. | ..|  .. |
YEILEVIGKGSFGQVVKCYDH-KTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQ-G

LHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNES-KLMLKLCDFGSASFIQDNEITPYLVSRFYRAPEIIIGCKYDYGIDMWSVGATLYELYTG
.  . ||   ...| .|.. ..  | |.| || ||| ..  .  .|. ||||  |     |  |  ||||||||.|.|.||.  ||||| | .. |||||
FSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTG

QILFPGKSNNEMLKLNMELKGKMSHKMVRKG----MFRENHF
..||||   |. . . ||. |. . |.. .      || . |
YPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYF
Kinase AqueK116.AA HIPK 107-423 30 3.2e-54 168.92 In-house 1-329 (329) Show / Hide 
Range on Protein: 107-423
Range on HMM: 1-329/329
Sequence Identity: 30% (103 aa)

YMVYGYTGHGVFSNVVRARDTSRSSQE-VAIKIIRNNEMMHKTGMAELEILKKLNATDPDDKFHCIRLFSNFFHKNHLCLVFESMSMNIREVLRKYGKNI
| |  . | | |  ||..    |. .| |||||..|.    . |  |..||..|   ..|. .| .| .  | |||| ||||| .  |. . . |  |  
YEVLEFLGRGTFGQVVKCWK--RGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADE-YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQ-KQNKFM

GLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNI-LVNESK--LMLKLCDFGSASFIQDNEITPYLVSRFYRAPEIIIGCKYDYGIDMWSVGATLYEL
 | .|..|   || | ||. .|   ..|||.||.|| || ...     |  |||||| . .    .|| ||.|||||||.| ..   .|||| |  . ||
PLPLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAEL

YTGQILFPGKSNNEMLKLNMELKGKMSHKMVRKGMFRENHF--DSSFNFLYHTVDKVTQKEKVVVMSSFS------------PQRDLLADLVGSQSPSEA
. |  |.|| .. .      .  ..    .. ...  .  |  |   .| .    .. ..|. . . |              |.  .| |...  ..  .
FLGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKFRPWRLKHIEEHEQQTSVKSKEARKYIFNCLDDMPEVNMLVDPER--QDYRV

HLRKIHHFKDFLDKIFILDPTKRLSINQALQHPFI
       | . | |.  .|. ||..  .||.|||.
EKIDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase AqueK116.AA DYRK1 107-423 30 2.1e-49 170.42 In-house 1-321 (321) Show / Hide 
Range on Protein: 107-423
Range on HMM: 1-321/321
Sequence Identity: 30% (99 aa)

YMVYGYTGHGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMAELEILKKLNATDPDDKFHCIRLFSNFFHKNHLCLVFESMSMNIREVLRKYGKNIG
| .    | | |  ||.| |.    ..||||||.|          |. .|  .|. |...|.. ..|   | ..|||||||| .| |. ..||   .  |
YEIDSLIGKGSFGQVVKAYDH-QEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRN-THFRG

LHIKAVRSYSQQLLLALKLMK--RCTILHADIKPDNI-LVNESKLMLKLCDFGSASFIQDNEITPYLVSRFYRAPEIIIGCKYDYGIDMWSVGATLYELY
  .  .| . ||.. ||  |      |.| |.||.|| |.|  .  .|. |||| |   .. |  |. |||||.||...| .||  |||||.|  | |. 
VSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGS-SCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMH

TGQILFPGKSNNEMLKLNMELKGKMSHKMVRKGMFRENHFDSSFNFLYHTVDKVTQKEKVVVMSSFSPQRDLLADLVGSQSPSEAH----LRKIHHFKDF
||  || |..  . ..  .|  |   ..|. ..   . .|.   .  .    .  .| . . .     .  |  .  | ..  .      .   ..||| 
TGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYLKFKDL

LDKIFILDPTKRLSINQALQHPFI
. .. . || .|..  .||||.|.
IKRMLQYDPKQRITPYYALQHSFF
Kinase AqueK116.AA DyrkP 107-423 31 1.3e-45 147.79 In-house 1-323 (323) Show / Hide 
Range on Protein: 107-423
Range on HMM: 1-323/323
Sequence Identity: 31% (103 aa)

YMVYGYTGHGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMAELEILKKLNATDPDDKFHCIRLFSNFFHKNHLCLVFESMSMNIREVL---RKYGK
| .  | |   ||  .   |     | . .||| ||       . |. .|. .|     |    .| .  |.|| || .. | .  |. |     |   .
YQIMEYLGSAAFSKAIQCQDK-QTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQ

NIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVN-ESKLMLKLCDFGSASFIQDNEITPYLVSRFYRAPEIIIGCKYDYGIDMWSVGATLYEL
     .  .    ||.|.||  .    ..| |.||.|||.   .|   |. ||||. || |  .  |  || |||||.|||||||| |||||.|  | ||
QRYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHD-HLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAEL

YTGQILFPGKSNNEMLKLNMELKGKMSHKMVRKGMFRENHFDSSFNFLYHTVDKVTQKEKVVVMSSFSPQRDLLAD----LVGSQSPSEAHLRKIHH-FK
.|| .||       .|   . . | .   |.. |   .| |      ||  |   ... . .   .  ...   .     ||  .|   | ||   | | 
WTGNVLFQNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFFTRK-RLLYMDVFEEADQSQNINDQQDMQRQRQKTGKIQILVPKHSNLRARLRTDDHMFI

DFLDKIFILDPTKRLSINQALQHPFI
||  ..  .| |.| .   |||||..
DFVRQCLQIDFTRRPTAKEALQHPWF
Kinase AqueK116.AA GSK 184-320 39 6.3e-39 116.12 In-house 89-230 (328) Show / Hide 
Range on Protein: 184-320
Range on HMM: 89-230/328
Sequence Identity: 39% (57 aa)

CLVFESMSMNIREVLRKY---GKNIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNESKLMLKLCDFGSASFIQDNE---ITPYLVSRFYRA
|||.| | ..  .|.|.|   ....   |. .. |. |.. .|.      | | ||||.||||....  ||.||||||  ...|.    ..| .||.|||
CLVMEYMPQTLYQVIRHYVKNKQQM--PIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRA

PEIIIGCK-YDYGIDMWSVGATLYELYTGQILFPGKSNNEMLKL
|| |.||. |.  ||.||.|  . |. .||.||||.| . .|..
PELIFGCTNYTCQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVE
Kinase AqueK116.AA Pkinase 114-327 26 1.4e-37 133.91 Pfam 8-233 (293) Show / Hide 
Range on Protein: 114-327
Range on HMM: 8-233/293
Sequence Identity: 26% (63 aa)

GHGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMA-----ELEILKKLNATDPDDKFHC--IRLFSNFFHKNHLCLVFESMSM-----NIREVLR--
| | |. | .... . .  .||.|||.  .  ..  ..     |..|.|.||        |.  .||.  |  |.|...|.| . .        ....  
GSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

KYGKNIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNESKLML----KLCDFGSASF--IQDNEITPYLVSRFYRAPEIII-GCKYDYGIDM
..|. . .  . ...|  |.| .|. . .. |.| |.||.|||.. ..  .    |.||||.| .  .  |. | . ....|.|||.|  | .|.. .||
RHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSVGATLYELYTGQILFPGK----SNNEMLKLNMELKGK
||.| .|||...|. .|||.    . ......  . .|.
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGP
Kinase AqueK116.AA YAK 134-343 34 8.1e-36 118.89 In-house 27-239 (347) Show / Hide 
Range on Protein: 134-343
Range on HMM: 27-239/347
Sequence Identity: 34% (75 aa)

VAIKIIRNNEMMHKTGMAELEILKKLNA-TDPDDKF---HCIRLFSNFFHKNHLCLVFESMSMNIREVLRKYGKNIGLHIKAVRSYSQQLLLALKLMKRC
.|.|.| |       .  |  ||. ||   ||..|    | .|.   | ||||.|||||  |.|  | | |  |  |. .  .| .  | | ..   .  
FAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYL-KQNKFCGFSFQLIRQWTKQILDGMCVLENK

TILHADIKPDNILVNE-SKLMLKLCDFGSASFIQDNEITPYLVSRFYRAPEIIIGCKYDYGIDMWSVGATLYELYTGQILFPGKSNNEMLKLNMELKGKM
 | | | || ||.     |  .|. ||||.       .. |  .|.||.||||..  |   ||||| |  . ||. |  .||| |  . .|   .  |. 
QIIHCDLKPENIMLCKPNKPEIKIIDFGSSC-QEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFLGLPIFPGNSEYNQIKRIIDMLGYP

SHKMVRKGMFRENHF
   |. .| |.   |
PSWMIDQGRFKNKYF
Kinase AqueK116.AA CLK 107-248 30 1.2e-35 103.82 In-house 1-152 (350) Show / Hide 
Range on Protein: 107-248
Range on HMM: 1-152/350
Sequence Identity: 30% (46 aa)

YMVYGYTGHGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMAELE-ILKKLNAT-DPDDKFH--CIRLFSNFFH-KNHLCLVFESMSMNIREVLRKY
| ..   | |.|. ||. .|.... . ||.||||| |       .|.. |.||.|.. ||. |.   |..... | . ..| |.||| .  .| ..... 
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

G-----KNIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNESKL
.     | |.. | ..|. . ||. |.| .    . | | || ||.   |..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRF
Kinase AqueK116.AA CLK 251-334 38 1.9e-18 51.25 In-house 187-277 (350) Show / Hide 
Range on Protein: 251-334
Range on HMM: 187-277/350
Sequence Identity: 38% (35 aa)

KLCDFGSAS-FIQDNEITPYLVS-RFYRAPEIIIGCKYDYGIDMWSVGATLYELYTGQILFPGKSNNEMLKLNMELKG-----KMSHKMVR
.. |||||    .|.|  . .|| | |||||.| |. . .  | ||.|  |.|||||  ||.. .| | | .  .. |      |.....|
CVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRR
Kinase AqueK116.AA TyrKc 107-354 20 8.9e-11 -48.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 107-354
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

YMVYGYTGHGVFSNVVRARDTSRSSQEVAIKIIRNNEMMHKTGMAELEILKKL--NATDPDDKFHCIRLFSNFFHK-------NHLCLVFESMSM-NIRE
       |.| |  |.... .    ..||.| ....   ..  | |..|..||  .        . .||.    ..         |..|.| |.  . ..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHHP------NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

VLRKYGKNIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNESKLMLKLCDFGSASFIQDN----EITPYLV------SR-----FYRAPEII
 |||....  |  |   |.. |         .  . | |.   |.||.| .   | .||| . .| |     | . | .      ..        ||| |
YLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

IGCKYDYGIDMWSVGATLYELYT-GQILFPG-----KSNNEMLKLNMEL----KGKM--------SHKMVRKGMFRENHFDS----SFNFLYHTV
  .|.    | || | ...|..| ||   ||     .|| |.... ..     . .          .. . . | .  |.|     .|. ...  
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK116.AA Pkinase 396-423 42 3.3e-09 33.63 Pfam 266-293 (293) Show / Hide 
Range on Protein: 396-423
Range on HMM: 266-293/293
Sequence Identity: 42% (12 aa)

FKDFLDKIFILDPTKRLSINQALQHPFI
.|||..... .||.||... |.||||..
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK116.AA GSK 398-423 46 4.4e-09 23.25 In-house 303-328 (328) Show / Hide 
Range on Protein: 398-423
Range on HMM: 303-328/328
Sequence Identity: 46% (12 aa)

DFLDKIFILDPTKRLSINQALQHPFI
|.. |... ||.||||  .|..||| 
DLISKCLVYDPKKRLSPLEACAHPFF
Kinase AqueK116.AA CLK 394-423 40 4.8e-09 22.5 In-house 321-350 (350) Show / Hide 
Range on Protein: 394-423
Range on HMM: 321-350/350
Sequence Identity: 40% (12 aa)

HHFKDFLDKIFILDPTKRLSINQALQHPFI
. . | . |... ||.||..  .|||||| 
RQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase AqueK116.AA DYRK2 396-423 46 1.8e-08 23.33 In-house 291-318 (318) Show / Hide 
Range on Protein: 396-423
Range on HMM: 291-318/318
Sequence Identity: 46% (13 aa)

FKDFLDKIFILDPTKRLSINQALQHPFI
| ||. . |  ||..|..  |||.||.|
FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase AqueK116.AA YAK 396-423 46 1.9e-07 20.97 In-house 320-347 (347) Show / Hide 
Range on Protein: 396-423
Range on HMM: 320-347/347
Sequence Identity: 46% (13 aa)

FKDFLDKIFILDPTKRLSINQALQHPFI
| ||.  .  |.| .| .  || |||||
FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase AqueK116.AA GSK 107-137 31 2e-06 15.25 In-house 1-38 (328) Show / Hide 
Range on Protein: 107-137
Range on HMM: 1-38/328
Sequence Identity: 31% (12 aa)

YMVYGYTGHGVFSNVVRARDTSR--SSQEV-----AIK
|  .   |||.|..|..| ..|    ..|.     |||
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIK
Kinase AqueK116.AA Pkinase_Tyr 240-320 32 9.7e-05 16.68 Pfam 141-227 (270) Show / Hide 
Range on Protein: 240-320
Range on HMM: 141-227/270
Sequence Identity: 32% (29 aa)

NILVNESKLMLKLCDFGSASFIQDNEITPYLVSR------FYRAPEIIIGCKYDYGIDMWSVGATLYELYT-GQIL-FPGKSNNEMLKL
|.||.|..   | |||| |  |.. .   | ..       .  ||| |  .|.    | || | ...|..| |..  .|| ||.|....
NCLVTENN-VVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEY