Gene AqueK118 (A.queenslandica)

AqueK118

Species: A.queenslandica
Alias: AqueK118
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
AqueK118.AA Protein None 356 None Fasta, JSON
AqueK118.kin_dom Protein Kinase Domain None 289 None Fasta, JSON

Protein domain

Protein domains of AqueK118.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK118.AA ERK1 22-310 82 4.3e-224 750.75 In-house 1-289 (289) Show / Hide 
Range on Protein: 22-310
Range on HMM: 1-289/289
Sequence Identity: 82% (238 aa)

YSNLSYIGEGAYGMVCSAVDNQSLTKVAIKRITPFEHQTYCQRTLREIKILTRFRHENIIGILDILKPPSMAEMKDVYIVQTLMETDLYKLLKTQHLSND
| ||.|||||||||||||.|.   ..||||.| |||||||||||||||||||||.|||||.| ||.. ... .|.|||||| ||||||||||||||||||
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQHLSND

HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEQDHTGILTEYVATRWYRAPEIMLNSKGYSKAIDIWSVGCILAEMLSN
|||||||||||||||||||||||||||||||||||||||||||||||||||||.|||| |||||||||||||||||||||| |.||||||||||||||||
HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN

RPIFPGKHYLDQLNHILNVIGSPTEKDLSCIRNEKAKSYLKNLPFKPTVPWSRLYPKADPKALDILGKMLTFNPDERISVDAALAHPYL
||||||||||||||||| |.||| ..|| || ||||..||. ||.|| ||| ||.||||.||||.|.|||||||..|| |. |||||||
RPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase AqueK118.AA MAPK 22-310 53 3.9e-199 667.83 In-house 1-328 (328) Show / Hide 
Range on Protein: 22-310
Range on HMM: 1-328/328
Sequence Identity: 53% (177 aa)

YSNLSYIGEGAYGMVCSAVDNQ------SLTKVAIKRIT-PFEHQTYCQRTLREIKILTRF-RHENIIGILDILKP------PSMAEMKDVYIVQTLMET
| .|..||.||||.||||.|.       . .|||||.|  ||...|.|.||.||||.| .| .|||||..|||..|      .|. |..|.|||. ||||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLYKLLKTQH-LSNDHICYFLYQILRG--LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEQDHTG-----------ILTEYVATRWYRAP
||....|.|  ||.|||.||.||||||  |||||||||.||||||||.|.|. ||||||||||||..|||. | .            .||||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EIMLN--SKGYSKAIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILNVIGSPTEKDLSCIR-NEKAKSYLKNL---PFKPTVPWSRLYPK----ADPK
|||||  ...|.||.|.||||||.||||. ..|.||||.|.||.|.|..|.|.|.| ...||  .|.|..|...|   | .| .||. ..|.    |.|.
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

ALDILGKMLTFNPDERISVDAALAHPYL
|.| | |||.|.||.||.|. ||.|||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase AqueK118.AA ERK 22-310 54 1.3e-178 599.7 In-house 1-307 (307) Show / Hide 
Range on Protein: 22-310
Range on HMM: 1-307/307
Sequence Identity: 54% (168 aa)

YSNLSYIGEGAYGMVCSAVDNQ-----SLTKVAIKRI-TPFEHQTYCQRTLREIKILTRFR-HENIIGILDILKPPSMAEMKDVYIVQTLMETDLYKLLK
|. .. ||.|||| ||||.|.      . .||||| |  .|.|  || |||||||.|  |. |||||...||..| |  ...|.|.|. |||||| .  .
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

TQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEQDHT-----GILTEYVATRWYRAPEIMLNSKGYSKAIDI
.|  || ||. ||.||||.||||||||||.||||||||.|.|  ||||||||||||. |....       ...||||||||||||||||. . |.||.||
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSVGCILAEMLSNRPIFPGKHYLDQLNHILNVIGSP-TEKDLSCIRNEKAKSYLKNLPF--KPTVPWSRLYPKAD--PKALDILGKMLTFNPDERISVDA
||.|||.||||  .|.|||| |..|.|.|...||.| .| ||..| .|.|. |.||||.  .| .||. ..|.|.  |.|.| | |||.|.||.||.|. 
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

ALAHPYL
.|.|||.
CLEHPYF
Kinase AqueK118.AA CMGC 22-310 27 3.9e-147 487.09 In-house 1-513 (513) Show / Hide 
Range on Protein: 22-310
Range on HMM: 1-513/513
Sequence Identity: 27% (141 aa)

YSNLSYIGEGAYGMVCSAVD--------------NQSLTKVAIKRIT-PFEHQTYCQ----------RTLREIKILTRFR-----------------HEN
| ....||||.||.|....|              ...  .||||.|  || ... ..          |.||||||| ...                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIGILDILKPPS-------------MAEMKDVYIVQTLMETDLYKLLKTQH----------LSNDH------------ICYFL------YQILRGLK--Y
|....||....                .....|.|  .|..|||...| ..          ||  |            |.||.      ||||||||  |
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

IHSAN--VLHRDLKPSNLLLNTTCDL--------------------KICDFGLARIADPEQDH------------------TGILTEYVATRWYRAPEIM
.||..  ..||||||.|.|.| .|.|                    |||||||||. .|..||                  .  .|.||.|||||||||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LNS---------KGYSKAIDIWSVGCILAEMLSN--------RPIFP-----------GKHYLDQLNHILNVIGSP----------------TEKDLSCI
|..         ..|...||.||||||.|||. .        .|.||           ||...|||..| .|.|.|                .|.. ..|
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

R--------------------NEKAKSYLKN---LPFKPTVPWSRLYPK-----------------------------------ADPKALDILGKMLTFN
                     .|.|. |...   .| .|  ||..|.|.                                   .||.|.| | |||...
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PDERISVDAALAHPYL
||.||... ||.|||.
PDKRITAEQALQHPYF
Kinase AqueK118.AA p38 22-310 48 9.1e-145 487.24 In-house 1-289 (289) Show / Hide 
Range on Protein: 22-310
Range on HMM: 1-289/289
Sequence Identity: 48% (142 aa)

YSNLSYIGEGAYGMVCSAVDNQSLTK---VAIKRIT-PFEHQTYCQRTLREIKILTRFRHENIIGILDILKP--PSMAEMKDVYIVQTLMETDLYKLLKT
| ||...|.|||| ||.|.| .. .|   ||||..  ||.   .  || ||.. |   ||||.|..||.  |   || ...|||.| ..|..||....|.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEQDHTGILTEYVATRWYRAPEIMLNSKGYSKAIDIWSVGCIL
|.|| ||| . .|||||||||||||.. ||||||||. .|  |.|.| |||||| .| |      .|.|||||||||||||||   | ...||||||||.
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDE------MTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIM

AEMLSNRPIFPGKHYLDQLNHILNVIGSPTEKDLSCIRNEKAKSYLKNLPFKPTVPWSRLYPKADPKALDILGKMLTFNPDERISVDAALAHPYL
||... |. |||. ..|||. |..|.|.|.|  .. | .|.|..|....|  |    ......|.|.|.| | |||   || ||..  |..|||.
AELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase AqueK118.AA ERK5 22-310 51 3.8e-130 438.67 In-house 1-295 (295) Show / Hide 
Range on Protein: 22-310
Range on HMM: 1-295/295
Sequence Identity: 51% (152 aa)

YSNLSYIGEGAYGMVCSAVDNQSLTKVAIKRI-TPFEHQTYCQRTLREIKILTRFRHENIIGILDILKPPS-MAEMKDVYIVQTLMETDLYKLLK-TQHL
|  .  ||.||||.||||.  .   .||||.|   |.  |  .||.||.|||  |||.||| | |||.|   ..||||||.|  ||| || ...   | .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADP--EQDHTGILTEYVATRWYRAPEIMLNSKGYSKAIDIWSVGCILA
. .|| ||||||||||||.|||.|.|||||||||| |  |.||| |||.||       ..|   .|||||||||||||.|. |. | .|||.||||||. 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMLSNRPIFPGKHYLDQLNHILNVIGSPTEKDLSCIRNEKAKSYLKN-LPFKPTVPWSRLYPKADPKALDILGKMLTFNPDERISVDAALAHPYL
||.. | .|||| |..||. |. |.| |  . .  .  .. . |..  .| .  ..|...|||||..|||.|..|| | | |||.| .|| ||.|
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase AqueK118.AA ERK7 22-310 43 2.9e-116 392.56 In-house 1-292 (292) Show / Hide 
Range on Protein: 22-310
Range on HMM: 1-292/292
Sequence Identity: 43% (128 aa)

YSNLSYIGEGAYGMVCSAVDNQSLTKVAIKRI-TPFEHQTYCQRTLREIKILTRFR-HENIIGILDILKPPSMAEMKDVYIVQTLMETDLYKLLK-TQHL
|  .. .| ||||.|  |.| ..   ||.|.|   |  ||  ||| ||| .|  |. |.||| ......       .|.|.|   |||||    .  . |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIR---ADNDRDIYLVFEFMETDLHAVIRKGNIL

SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-IADPE--QDHTGILTEYVATRWYRAPEIMLNSKGYSKAIDIWSVGCIL
 . |  | .||.|| .||.||.||.||||||||.||.. | .|.||||||| ||. |  ......|||||||||||||||.| |. | |..| ||.||||
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL

AEMLSNRPIFPGKHYLDQLNHILNVIGSPTEKDLSCIRNEKAKSYLKNLPFKPTVPWSRLYPKADPKALDILGKMLTFNPDERISVDAALAHPYL
.||| ..|.|||   ..|.. ||..|. ||..|.  |  . | . |.... ... . . ..|.. . |.|.| ..| |||..|.... ||.||| 
GEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase AqueK118.AA ERK3 22-310 44 3.3e-109 352.62 In-house 1-300 (300) Show / Hide 
Range on Protein: 22-310
Range on HMM: 1-300/300
Sequence Identity: 44% (134 aa)

YSNLSYIGEGAYGMVCSAVDNQSLTKVAIKRITPFEHQTYCQRTLREIKILTRFRHENIIGILDILKP-----------PSMAEMKDVYIVQTLMETDLY
.  |   | |  |.| ||||..   |||||.|     .  |   ||||||. |  |.||. . ..| |            .. |.. |.||| .||||| 
FCDLRPLGCGSNGLVFSAVDSECCKKVAIKKIVLTDKKS-CKHALREIKIIRRLDHDNIVKVYEVLFPKGSDNQDDEDIGILFELRTVCIVQEYMETDLA

KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT-CDLKICDFGLARIADPEQDHTGILTEYVATRWYRAPEIMLNSKGYSKAIDIW
 ..  | ||..|.  | || ||||||||||||||||||| |.. ||    ||| |||.||| ||.  | | |.| . |.||| |. .|    | ||||.|
CVMEQQRLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTEDLVLKIGDFGMARIVDPHYSHKGYLSEGLVTKWYRSPRLLLQPNNYTKAIDMW

SVGCILAEMLSNRPIFPGKHYLDQLNHILNVIGSPTEKDLSCIRNEKAKSYLKNLPFKPTVPWSRLYPKADPKALDILGKMLTFNPDERISVDAALAHPY
. ||||||||  .. |.| | | |.  ||. |    |.|.  .      .|.||    |  |  .| .  |  |||.| .||||.| .|.    || |||
AAGCILAEMLTGKMLFAGAHELEQMMLILDSIPVVHEEDKNELLCVMPSKYIKNYMWYPHHPLKQLLCNIDCHALDFLEQMLTFDPMDRLTAEMALQHPY

L
.
M
Kinase AqueK118.AA CDK 22-310 34 1.4e-99 319.31 In-house 1-284 (284) Show / Hide 
Range on Protein: 22-310
Range on HMM: 1-284/284
Sequence Identity: 34% (110 aa)

YSNLSYIGEGAYGMVCSAVDNQSL-----TKVAIKRI-TPFE----HQTYCQR-TLREIKILTRFRHENIIGILDILKPPSMAEM------KDVYIVQTL
|  |  ||||.|| |  | | |.        ||.|.| .  |    . .     ..|||..|    |.||. ..|.    .|.        . .|.|   
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

METDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD-----LKICDFGLARIADPEQD---HTGILTEYVATRWYRAPEIM
|..||.|...        |  ...|.|||| |.|| ...||||||.|.|.| .       ||| ||||||.   . .    .  .|  | |.||||||. 
MDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELL

LNSKGYS--KAIDIWSVGCILAEMLS---NRPIFPGKHYLDQLNHILNVIGSPTEKDLS-CIRNEKAKSYLKNLPFKPTVPWSRLYPKADPKALDILGKM
| || ||   .||.||||||.|||.    ..|.|||.  .||| .| ...|.|||..   .                                 | | ||
LGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLLNKM

LTFNPDERISVDAALAHPYL
|...|. ||| ..|| |||.
LCYDPKKRISAEQALQHPYF
Kinase AqueK118.AA S_TKc 22-310 29 8.7e-98 332.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-310
Range on HMM: 1-231/231
Sequence Identity: 29% (90 aa)

YSNLSYIGEGAYGMVCSAVDNQSLTKVAIKRITPFEHQTYCQRTLREIKILTRFRHENIIGILDILKPPSMAEMKDVYIVQTLMET---DLYKLLKTQH-
|  |  ||.||.| |. .... .  .||||.|         ....|||.|| . .|.||. ..|.         ...|.|  ....   ||....| .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGR

------LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEQDHTGILTEYVATRWYRAPEIMLNSKGYSK-AIDIWS
      ..  |.....|||...|.|.|| ...||||||.|.||..   .|||||||||.           | .. |.||.|||..    ||.| ..|.||
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKCKCDWWS

VGCILAEMLSNRPIFPGKHYLDQLNHILNVIGSPTEKDLSCIRNEKAKSYLKNLPFKPTVPWSRLYPKADPKALDILGKMLTFNPDERISVDAALA----
.||||.|||. .| ||      |.. ....||                                     .| |.|.. |.|...|..|...  ||.    
CGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---HPYL
   ||..
IKCHPWF
Kinase AqueK118.AA Pkinase 22-310 28 6.8e-84 289.82 Pfam 1-293 (293) Show / Hide 
Range on Protein: 22-310
Range on HMM: 1-293/293
Sequence Identity: 28% (89 aa)

YSNLSYIGEGAYGMVCSAVDNQSLTKVAIKRITPFEHQTYCQRTLR---EIKILTRFRHENIIGILDILKPPSMAEMKDVYIVQTLMET-----DLYKLL
|  .. ||.|..| |. ...  .  .||.|.|   .    ...|.|   ||.|. |..|.||. ..|.         ...|.|. ..|      ||. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

K---TQHL--SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDL----KICDFGLARIADPEQDHTGILTEYVATRWYRAPEIMLNSKGYSK
.      .  | .... ..|||||||.|.|| ...||||||.|.|.. ....    ||||||||. .|    . . .| .. |.||.|||. . ...|..
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

AIDIWSVGCILAEMLSNRPIFPGK----HYLDQLNHILNVIGSPTEKDLSCIRNEKAKSYLKNLPFKPTVPWSRLYPKADPKALDILGKMLTFNPDERIS
..|.||.||||.|||. ||.|||.    . .||.  | .. | |.. | .  ...   . ..  . .     ... ..... ..|.. ..|...| .|..
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPT

VDAALAHPYL
 . .| ||..
AEQILQHPWF
Kinase AqueK118.AA MAPK-Unclassified 22-172 49 1e-69 237.89 In-house 1-161 (575) Show / Hide 
Range on Protein: 22-172
Range on HMM: 1-161/575
Sequence Identity: 49% (79 aa)

YSNLSYIGEGAYGMVCSAVDNQS-LTKVAIKRIT-PFEHQTYCQRTLREIKILTRFRHENIIGILDILKPPSMAE--MKDVYIVQTLMET---DLYKLLK
|    .|| |||| || |.|...   .||||...  |. .| | |.|||| ||    |.||| | ||. . .      .|.|||  .|.|   ||....|
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

-TQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-IAD
  | |..  || ||.|||||||||.|||...||||||||||.|  | ..|||||..| | |
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIED
Kinase AqueK118.AA MAPK-Unclassified 177-310 34 4.8e-57 195.82 In-house 401-575 (575) Show / Hide 
Range on Protein: 177-310
Range on HMM: 401-575/575
Sequence Identity: 34% (60 aa)

HTGILTEYVATRWYRAPEIMLNSKGYSKAIDIWSVGCILAEMLSN-----------RPIFPGKH--------------------YLDQLNHILNVIGSPT
| . .|.||.||||||||||| .. |....||||.|||.|||...           ||.|||.                     . ||.. |. . |.| 
HCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPP

EKDLSCIRNEKAKSYLKNLPFKPTVPWS-RLYPKAD---------PKALDILGKMLTFNPDERISVDAALAHPYL
| |.. |.. .|. |.. .  |. |...   ..||          . ..|.. ||| |||  ||. |.|| ||| 
EEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase AqueK118.AA TyrKc 22-310 19 2.9e-15 24.09 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-310
Range on HMM: 1-280/280
Sequence Identity: 19% (61 aa)

YSNLSYIGEGAYGMVCSAVDNQSLTKVAIKRITPFEHQTYCQRTLREIKILTRF--RHENIIGILDILKPPS---MAEMKDVYIVQTLMET-DLYKLLKT
 . .  .||||.| |. .. .   ..||.| . .       .  .||..|....  .|.||. .. .   ..   | . . ..||  .|.  || . |. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFM-YIEPLMIVMEYMPHGDLKDYLRK

QH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPE------QDHTGI----LTEY-VATRWYRAPEIMLNSKGY
 .  |.... ..| .|| .|  |.|| |. ||||   | |..     ||.||||.|  . .      .|         . . .  ||. ||| . | . .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

SKAIDIWSVGCILAEMLSNRPIFPGK-----HYLDQLNHILNVIGSPTEKDL----SCIRNEKAKSYLKNLPFKPTVPWSRLYPKADPKALDILGKMLTF
. . |.|| |  . |....    .          ... . .   . .   .     |                      .   . . ..  .|  .   .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------F---VCCPDEMYQIMKQCWHE

NPDERISVDAALAHPYL
.|..| .  .   | ..
DPEDRPTFSEI--HECF
Kinase AqueK118.AA Pkinase_Tyr 22-220 25 7.3e-13 44.18 Pfam 1-209 (270) Show / Hide 
Range on Protein: 22-220
Range on HMM: 1-209/270
Sequence Identity: 25% (55 aa)

YSNLSYIGEGAYGMVCSAVDN----QSLTKVAIKRITPFEHQTY--CQRTLREIKILTRF-RHENIIGILDILKPPSMAEMKD--VYIVQTLMET-DLYK
 . .  .||||.|.|. .. .    .  ..||.| . .  ..     .  .||.||.. . .|.||.  . .       . .   .|||  .|.  ||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT----DQGEPNQIYIVMEYMPHGDLLD

LLKTQ-----HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEQDH-TGILTEYVATRWYRAPEIMLNSKGYSKA
 |...     .|.  ... . .|| .|. | .| |  ||||   | |.. .   |||||||||   ..    .      .  .|. ||| . ..| .. .
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM-APECINYGK-FTTK

IDIWSVGCILAEMLS
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SDVWSFGVLMWEIFT