Gene AqueK134 (A.queenslandica)

AqueK134

Species: A.queenslandica
Alias: AqueK134
External Links:
Annotation:

Classification

Group: CMGC
Family: SRPK

Sequence

Name Sequence Type Origin Length Description Download
AqueK134.AA Protein None 518 None Fasta, JSON
AqueK134.kin_dom Protein Kinase Domain None 428 None Fasta, JSON

Protein domain

Protein domains of AqueK134.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK134.AA SRPK 356-516 67 5.2e-155 402.76 In-house 394-554 (554) Show / Hide 
Range on Protein: 356-516
Range on HMM: 394-554/554
Sequence Identity: 67% (109 aa)

VKIADLGNACWINHHFTDDIQTRQYRSLEVIIGIEYGPPADIWSLACMTFELLTGDFLFEPHSGDTYSRDEDHIAHICELLGTIPPTLAVSGRYSREFFS
.||||||||||..||||.|||||||||.|||||..|..||||||.||| |||.|||.|||||||..||||.|||||| ||.| ||. .|.||.|||||| 
IKIADLGNACWVHHHFTEDIQTRQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFEPHSGEDYSRDDDHIAHIIELCGKIPWHFALSGKYSREFFN

HSGKLKRIHHLRPWSLHDVLVDKYHWCDDEAKLLASFLLPMLNYNQKERATAKECLDHPWL
..|.|..|. | ||.| .||. ||.|  .|||  ..||.|||.||.  |||||||| ||||
KKGELRHIPKLKPWPLMNVLIEKYEWSHEEAKQFEDFLMPMLHYNPEKRATAKECLQHPWL
Kinase AqueK134.AA SRPK 89-339 40 1.6e-135 351.38 In-house 1-282 (554) Show / Hide 
Range on Protein: 89-339
Range on HMM: 1-282/554
Sequence Identity: 40% (113 aa)

YQIIRKLGWGHFSTVWLCKDLKCGRFVALKVVKSAKQYMEASLDEIELLRKVATANRA---------------------NPGLKHVVEMYDSFRISGPHG
|..|||||||||||||||.|..  |.||.|.||||. | |. .|||.|| .|. ..                       .|. .||| ..|.|...||.|
YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNG

NHMVMVFEVLGCNLLRPIIKYNYKGLPPSFVKLVTKQVLLGLDYLHTECGIIHTDIKPENILFCVSDEHVKSL---------ARNRVSSKSAVCNAPSSL
|| .|||||||.|||  |..|||.|.| . ||  ..||| ||||||..||||||||||||.| ||... .|..         .     |.|.|  ||. .
NHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLCVNQDYIKRMAAEWTEWQKMGMQMPSSSMVQTAPQHQ

SKSGGGPMTKNQKKRLKKKLKKHQELMVKEESMISDVDAVTTET-DSVSMTIDNHTILPESVEEEDTMETEETDQSTTNGSS
..  .. |.||.|| .||| |. ||.  |.   .      ...  |    . ||    . ....|. || |......||...
TQCQQQKMSKNKKKKMKKKQKQQQEQQEKNQQQKQQMEDDQNDNEDNNQEDNDNEQDNKNNQNQENNMENEQEEKENTNKQK
Kinase AqueK134.AA CMGC 89-516 16 5.6e-105 346.01 In-house 1-513 (513) Show / Hide 
Range on Protein: 89-516
Range on HMM: 1-513/513
Sequence Identity: 16% (101 aa)

YQIIRKLGWGHFSTVWLCKD--------------LKCGRFVALKVVKSAKQYMEASL-------------DEIELLRKVA-TANRAN---------PGLK
|.||.|.|.|....|. |.|               . ...||.| .|... | |  .             .||..|...  . .  |         .  .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

HVVEMYDSFRISGPHGN-------------HMVMVFEVLGCNLLRPIIKYN--YKG-----LPPSF------------VKLVT------KQVLLGLD--Y
..| .||.|. ....||             |. .||| ....|.. | ...  |.|     |..              .|  .      .|.| ||.  |
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHTECG-IIHTDIKPENILFCVSDEHVKSLARNRVSSKSAVCNAPSSLSKSGGGPMTKNQKKRLKKKLKKHQELMVKEESMISDVDAVTTETDSVSMTID
.|  .| |||.|.||||||..   | ....    . .                                                               
CHSHWGNIIHRDLKPENILINHNCELITRM-M--W-K---------------------------------------------------------------

NHTILPESVEEEDTMETEETDQSTTNGSSAGSSCTDSFDLLGPVS----------VKIADLGNACWINHH------------------------FTDDIQ
                                    |       .          .||.| |.|.|...|                        .|....
------------------------------------S-------EDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVV

TRQYRSLEVIIGIE----------YGPPADIWSLACMTFELLTG--------DFLFEPHSGD-----TYSRDEDHIAHICELLGTIPPTLAVSGR-----
|| ||. |...| .          |..| |.||..|. .|..||        . || .||..     ..... |....|...|||..  .. .|.     
TRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNF

--YSREFFSHSGKLKRIHHL-------------------------RPWSLHDVLVDKYHWCDD--------------------------------EAKLL
  ...|........ .. ..                          ||     . ... | ..                                . ...
CKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQA

ASFLLPMLNYNQKERATAKECLDHPWL
  .|  || |. ..| ||...|.||..
IDLLKKMLQYDPDKRITAEQALQHPYF
Kinase AqueK134.AA S_TKc 89-516 17 1.2e-56 195.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 89-516
Range on HMM: 1-231/231
Sequence Identity: 17% (80 aa)

YQIIRKLGWGHFSTVWLCKDLKCGRFVALKVVKSAKQYMEASLDEIELLRKVATANRANPGLKHVVEMYDSFRISGPHGNHMVMVFEVLGC---NLLRPI
|.|.||.| | |..|..|.. | || ||.|..|      |  . ||..|.|         . ...| .||.|.      .|. ||.| ..    .|.. |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK---------HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYI

IKYNYKG----LPPSFVKLVTKQVLLGLDYLHTECGIIHTDIKPENILFCVSDEHVK----SLARNRVSSKSAVCNAPSSLSKSGGGPMTKNQKKRLKKK
 |....|    .|.  .. ...|....|.|.|   |||| |.||||||..    |.|     |||                                   
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE---HIKICDFGLARQL---------------------------------

LKKHQELMVKEESMISDVDAVTTETDSVSMTIDNHTILPESVEEEDTMETEETDQSTTNGSSAGSSCTDSFDLLGPVSVKIADLGNACWINHHFTDDIQT
                                                                                              |  . |
----------------------------------------------------------------------------------------------TTFCGT

RQYRSLEVIIGIEYGP-PADIWSLACMTFELLTGDFLFEPHSGDTYSRDEDHIAHICELLGTIPPTLAVSGRYSREFFSHSGKLKRIHHLRPWSLHDVLV
. |.. ||.    ||. ..|.||. |. .|.|.|  .|.            ... . ...|                                       
PWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------------QMQMMFKKIG---------------------------------------

DKYHWCDDEAKLLASFLLPMLNYNQKERATAKECLD-------HPWL
          . . .|.  .|... ..| || |.|        |||.
---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK134.AA CLK 89-458 21 3.7e-55 163.46 In-house 1-289 (350) Show / Hide 
Range on Protein: 89-458
Range on HMM: 1-289/350
Sequence Identity: 21% (84 aa)

YQIIRKLGWGHFSTVWLCKDLKCG-RFVALKVVKSAKQYMEASLDEIE-LLRKVATA-NRANPGLKHVVEMYDSFRISGPH-GNHMVMVFEVLGCNLLRP
| |. .|| | |..|  |.| | | ..||||.......| ||.  ||.  ..|.... .  |  ..|.. |.|.|    .. ..|. .||| .| ..   
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWF----DYGHGHICIVFELYGLSIYDF

IIKYN------YKGLPPSFVKLVTKQVLLGLDYLHTECGIIHTDIKPENILFCVS-----DEHVKSLARNRVSSKSAVCNAPSSLSKSGGGPMTKNQKKR
. . |      |...| . ..  ..| .  .  || . ...||| |||||.|. |     |  .|   .. ..                           
MKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH-DMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKIN---------------------------

LKKKLKKHQELMVKEESMISDVDAVTTETDSVSMTIDNHTILPESVEEEDTMETEETDQSTTNGSSAGSSCTDSFDLLGPV---SVKIADLGNAC---WI
                                                                     |  .... . .|    ... | |.|      
-------------------------------------------------------------------KKS-NNCVCHYWHVKNTHICVIDFGSATKIRFD

NHHFTDDIQTRQYRSLEVIIGIEYGPPADIWSLACMTFELLTGDFLFEPHSGDTYSRDEDHIAHICELLG-TIPPTLAVSGR---YSREFFSHSG
. | .. ..||.||  ||| |  .  | |.|| .|  ||| ||. ||  |.        .| | . ...|  ||   . . |    ....| | .
HEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHD------NREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNR
Kinase AqueK134.AA Pkinase 89-441 19 2.2e-42 150.94 Pfam 1-236 (293) Show / Hide 
Range on Protein: 89-441
Range on HMM: 1-236/293
Sequence Identity: 19% (73 aa)

YQIIRKLGWGHFSTVWLCKDLKCGRFVALKVVKSAKQYMEA---SLD--EIELLRKVATANRANPGLKHVVEMYDSFRISGPHGNHMVMVFEVLGCN---
|.|.||.| | |..|..|.. . |. ||.|..|  .. ..     .   ||......          ...|..||.|.     ..|. ||.| ...    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N-------HPNIVRLYDWFED----KDHIYMVMEYCEGGLYV

-LLRPIIK-YNYKGL--PPSFVKLVTKQVLLGLDYLHTECGIIHTDIKPENILFCVSDEHVKSLARNRVSSKSAVCNAPSSLSKSGGGPMTKNQKKRLKK
  |  .|.  .....  ..  .| . .|.| ||.|.|  .|||| |.||||||.  .. |...                                     
MDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILID-NNGHIDA-------------------------------------

KLKKHQELMVKEESMISDVDAVTTETDSVSMTIDNHTILPESVEEEDTMETEETDQSTTNGSSAGSSCTDSFDLLGPVSVKIADLGNAC---WINHHFTD
                                                                              .|||.| | |.   . | . ..
------------------------------------------------------------------------------CVKICDFGLAKQFDY-NNS-MT

DIQ-TRQYRSLEVII-GIEYGPPADIWSLACMTFELLTGDFLFEPHSGDTYSRDEDHIAHICELLGTIPP
..  |. |.. |||  | .|||..|.||. |. .|.|.| ..|  ... .  .  |... ||. .|....
TFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPLH
Kinase AqueK134.AA DYRK 89-229 33 1.7e-30 107.64 In-house 1-136 (320) Show / Hide 
Range on Protein: 89-229
Range on HMM: 1-136/320
Sequence Identity: 33% (47 aa)

YQIIRKLGWGHFSTVWLCKDLKCGRFVALKVVKSAKQYMEASLDEIELLRKVATANRANPGLKHVVEMYDSFRISGPHGNHMVMVFEVLGCNLLRPIIKY
|.|.  .| | |. |  |.| | .  ||.|.... | .   ...||..|..  .... .   .|.| |||.|     | ||. .||| |  ||   . ..
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDD--KYHCVHMYDYFY----HRNHLCIVFELLSMNLYEFLKNN

NYKGL-PPSFVKLVTKQVLLGLDYLHTECGIIHTDIKPENIL
. .|. . . |. ...|.|..|..||..  ||| |.|||||.
HFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIM
Kinase AqueK134.AA Ciliate-E2 89-516 14 2.5e-28 94.32 In-house 1-365 (365) Show / Hide 
Range on Protein: 89-516
Range on HMM: 1-365/365
Sequence Identity: 14% (79 aa)

YQIIRKLGWGHFSTVWLCKDLKCGRFVALKV-------------VKSAKQYMEAS-LDEIELLRKVATANRANP-------------GLKH--VVEMYDS
| .|.|.| | |..|..||. | .. .|.|.             ||. . .|.    ..|| . ..   .|                 |.|  ...||..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FR-ISGPHGNHMVMVFEVLGCNLLRPIIKYN---YKGLPP-------SFVKLVTKQVLL---------------GLDYLHTECGIIHTDIKPENILFCVS
|  .     |.. .|.| .  . |. .|| |    .  ..         .| ..||.|                .| ||| .  ||| |||||||||   
FQEK---DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

DEHVKSLARNRVSSKSAVCNAPSSLSKSGGGPMTKNQKKRLKKKLKKHQELMVKEESMISDVDAVTTETDSVSMTIDNHTILPESVEEEDTMETEETDQS
                                                                                                    
----------------------------------------------------------------------------------------------------

TTNGSSAGSSCTDSFDLLGPVSVKIADLGNA-----------------CWINHH------------------FTDDIQTRQYRSLEVIIGIE--------
                      .||.|.|..                  ... .                  |   . |  | . |.. | .        
----------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQK

-YGPPADIWSLACMTFELLTGDFLFEPHSGDTYSRDEDHIAHICELLGTIPPTLAVSGRYSREFFSHSGKLKRIHHLRPWSLHDVL--VDKYHWCDDEAK
 |.  .||||| .. .|.|.| . |                                               ....  ....       | .  |. . .
GYDYKCDIWSLGVILYEMLFGKPPF----------------------------------------------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-C

LL----------ASFLLP----MLNYNQKERAT-AKECLDHPWL
              ..      ||......| | ....|.|||.
KWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase AqueK134.AA DYRK 352-516 25 5.6e-25 89.3 In-house 142-320 (320) Show / Hide 
Range on Protein: 352-516
Range on HMM: 142-320/320
Sequence Identity: 25% (49 aa)

GPVSVKIADLGNACWINHHFTDDIQTRQYRSLEVIIGIEYGPPADIWSLACMTFELLTGDFLFEPHSGDTYSRDEDHIAHICELLGTIPPTLAVSG--RY
..  .|..| | .| ......  || | ||. |||.|. |. . |.||| |   ||.||  ||   .|...    | .| |.|.|| .|. .  .|  |.
NKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF---PGENE---YDQLACIMEVLGMPPKWMIDKGRCRR

SREFFSHSGKLKRIHHLRPWSLHDV-------------------------LVDKYHWCDDEAKLLASFLLPMLNYNQKERATAKECLDHPWL
 ..||      ..  ... |. ...                         . .. . |||.  ..  |.. .|... ..| |... |.|||.
KHKFFDC----FMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQ-CDDH--QFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase AqueK134.AA Ciliate-E2-Unclassified 89-415 15 1.2e-24 82.42 In-house 1-271 (352) Show / Hide 
Range on Protein: 89-415
Range on HMM: 1-271/352
Sequence Identity: 15% (63 aa)

YQIIRKLGWGHFSTVWLCKDLKCGRFV-----ALKVVKSAKQYMEASLDEIELLRKVATANR---------------ANPGLKHVVEMYDSFRISGPHGN
| ||...| | |..|..|.. | . ..     . |. . ...... .  || .  |    .                 |    ..| |.. |.      .
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDK----Q

HMVMVFEVLGCNLLRPIIK----------------YNYKGLPPSFVK-----LVTKQVLLGLDYLHTECGIIHTDIKPENILFCVSDEHVKSLARNRVSS
.. .| | .  . |. .||                .. | ..   .|       ..|.|.||.||| . .||| |||||||||  . .            
NIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK------------

KSAVCNAPSSLSKSGGGPMTKNQKKRLKKKLKKHQELMVKEESMISDVDAVTTETDSVSMTIDNHTILPESVEEEDTMETEETDQSTTNGSSAGSSCTDS
                                                                                                    
----------------------------------------------------------------------------------------------------

FDLLGPVSVKIADLGNA------------------CWINHHFTDDIQTRQYR----SLEVIIGIEYGPP----ADIWSLACMTFELLTGDFLFE
        .||.|.|..                   |....... ..| .|     . ||. | .|. .    .||||| .  .|.|.| . |.
-----NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFY
Kinase AqueK134.AA DYRK2 89-229 32 1e-22 70.38 In-house 1-134 (318) Show / Hide 
Range on Protein: 89-229
Range on HMM: 1-134/318
Sequence Identity: 32% (47 aa)

YQIIRKLGWGHFSTVWLCKDLKCGRFVALKVVKSAKQYMEASLDEIELLRKVATANRANPGLKHVVEM--YDSFRISGPHGNHMVMVFEVLGCNLLRPII
| |   .| | |  |  | | | . .||.|..   | . .  . ||. | .  . .. |     .| |  |. ||      ||. ..|| |. ||   | 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDN--TMNCVHMLDYFYFR------NHHCITFELLSMNLYEYIK

KYNYKGLPPSFVKLVTKQVLLGLDYLHTECGIIHTDIKPENIL
| ...|. .. |   ....| .|. || .  ||| | ||||||
KNHFQGFSLQLVRRFAHSILQCLRFLHKNN-IIHCDLKPENIL
Kinase AqueK134.AA DYRK2 352-516 25 2.2e-20 62.72 In-house 139-318 (318) Show / Hide 
Range on Protein: 352-516
Range on HMM: 139-318/318
Sequence Identity: 25% (49 aa)

GPVSVKIADLGNACWINH-HFTDDIQTRQYRSLEVIIGIEYGPPADIWSLACMTFELLTGDFLFEPHSGDTYSRDEDHIAHICELLGTIPPTLAVSG---
.. ..|..| |  |  .  ..  .||.| ||. |||.|. || . |.||. |   ||.||  ||    |. .    | .| . |.|| .||   ..    
NRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF---PGENE---NDQFACMMEVLG-MPPKKFFDTWFY

---RYSREFFS-----------------HSGKLKRIHHLRPWSLHDVLVDKYHWCDDEAKLLASFLLPMLNYNQKERATAKECLDHPWL
   .. . ||                   ..  |. |  |       .... . |.||  ... |..  .    .|| |... |.|||.
IHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDE--NFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase AqueK134.AA DyrkP 89-229 32 2.6e-19 59.65 In-house 1-138 (323) Show / Hide 
Range on Protein: 89-229
Range on HMM: 1-138/323
Sequence Identity: 32% (48 aa)

YQIIRKLGWGHFSTVWLCKDLKCGRFVALKVVKSAKQYMEASLDEIELLRKVATANRANPGLKHVVEMYDSFRISGPHGNHMVMVFEVLGCNLLRPIIKY
|||.  ||   ||    |.|.. .. . .|..   | | . |.||| ||| .          | |. .|| |     |  |. .. |.|  ||     |.
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVD--EKNVLRYYDYFY----HKEHLFIITELLKDNLYE-FYKF

NYKGLPPSFVKL-----VTKQVLLGLDYLHTECGIIHTDIKPENIL
|       .  .     .|.|.|..|||.|    .|| |.||||||
NRENEQQRYFTVGRLQKITQQILIALDYIHS-LRLIHCDLKPENIL
Kinase AqueK134.AA STE 89-238 23 6.8e-18 59.87 In-house 1-187 (359) Show / Hide 
Range on Protein: 89-238
Range on HMM: 1-187/359
Sequence Identity: 23% (47 aa)

YQIIRKLGWGHFSTVWLCKDLK---------------CGRFVALKVVKSAK------------------QYMEASLDEIELLRKVATANRANPGLKH--V
...|.|.| | | || .... |                |...| |...  .                  . |.  | ||....|            |  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNH-------M-HPNI

VEMYDSFRISGPH---GNHMVMVFEVLGCNLLRPIIKYNYKGLPP-------------SFVKLVTKQVLLG-LDYLHTECGIIHTDIKPENILFCVSDEH
|. |...   |.    ...  .. | ..   |. ||| .|. . |             | .. ...|.| | |.|||    ||| |||| |||.      
VKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL------

VK
||
VK
Kinase AqueK134.AA DyrkP 356-414 49 2.5e-16 49.61 In-house 147-205 (323) Show / Hide 
Range on Protein: 356-414
Range on HMM: 147-205/323
Sequence Identity: 49% (29 aa)

VKIADLGNACWINHHFTDDIQTRQYRSLEVIIGIEYGPPADIWSLACMTFELLTGDFLF
||| | | .|.|  |    .| | ||  |||||  |    |.||| |.  || ||  ||
VKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLF
Kinase AqueK134.AA DYRK1 89-231 29 9.6e-15 47.75 In-house 1-138 (321) Show / Hide 
Range on Protein: 89-231
Range on HMM: 1-138/321
Sequence Identity: 29% (42 aa)

YQIIRKLGWGHFSTVWLCKDLKCGRFVALKVVKSAKQYMEASLDEIELLRKVATANRANPGLKHVVEMYDSFRISGPHGNHMVMVFEVLGCNLLRPIIKY
|.|.  .| | |  |    | .   .||.|..|  | ...  . || ||  .  . . .    ..|..   |     . ||. .|||.|  ||   .   
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEM--KYYIVHLKRHFM----FRNHLCLVFELLSYNLYDLLRNT

NYKGLPPSFVKLVTKQVLLGLDYLHT-ECGIIHTDIKPENILFC
...|     ..   .|..  | .. | |  ||| |.|||||| |
HFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLC
Kinase AqueK134.AA DYRK1 356-456 36 2e-14 46.61 In-house 145-239 (321) Show / Hide 
Range on Protein: 356-456
Range on HMM: 145-239/321
Sequence Identity: 36% (37 aa)

VKIADLGNACWINHHFTDDIQTRQYRSLEVIIGIEYGPPADIWSLACMTFELLTGDFLFEPHSGDTYSRDEDHIAHICELLGTIPPTLAVSGRYSREFFS
.|| | | .|  ..     || | ||| ||..||||    |.||| |.  |. ||. ||   ||   | . | . .| | ||  |  .  ..  .. .| 
IKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF---SG---SNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE

H
.
K
Kinase AqueK134.AA STE 350-410 23 8.6e-09 27.31 In-house 184-264 (359) Show / Hide 
Range on Protein: 350-410
Range on HMM: 184-264/359
Sequence Identity: 23% (20 aa)

LLGPVSVKIADLGNACWINH-------------------HFTDDIQTRQYRSLEVIIG------IEYGPPADIWSLACMTFELLTG
||    ||..| | .  ...                   . . .. |  . . ||| .       .|.  .||||| |.  |..||
LL----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATG
Kinase AqueK134.AA Ciliate-E2-Unclassified 483-516 37 2e-06 18.02 In-house 318-352 (352) Show / Hide 
Range on Protein: 483-516
Range on HMM: 318-352/352
Sequence Identity: 37% (13 aa)

DDEAKLLAS-FLLPMLNYNQKERATAKECLDHPWL
..||| . . .|  ||..|...| |... | |||.
SPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase AqueK134.AA Pkinase 489-516 35 4e-06 22.63 Pfam 266-293 (293) Show / Hide 
Range on Protein: 489-516
Range on HMM: 266-293/293
Sequence Identity: 35% (10 aa)

LASFLLPMLNYNQKERATAKECLDHPWL
. .|.  .|... |.| ||...| |||.
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK134.AA STE 497-516 31 8e-06 16.67 In-house 338-359 (359) Show / Hide 
Range on Protein: 497-516
Range on HMM: 338-359/359
Sequence Identity: 31% (7 aa)

LNYNQKERATAKECLD--HPWL
|... ..|.||.. |   ||..
LQKDPNKRPTASQLLKSEHPFI
Kinase AqueK134.AA DyrkP 504-516 69 5.2e-05 11.7 In-house 311-323 (323) Show / Hide 
Range on Protein: 504-516
Range on HMM: 311-323/323
Sequence Identity: 69% (9 aa)

RATAKECLDHPWL
| |||| |.|||.
RPTAKEALQHPWF
Kinase AqueK134.AA TyrKc 89-371 13 8e-05 -144.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 89-371
Range on HMM: 1-280/280
Sequence Identity: 13% (48 aa)

YQIIRKLGWGHFSTVWLCKDLKCGRFVALKVVKSAKQYMEASLDEIELLRKV--ATANRANPGLKHVVEMYDSFRIS-------GPHGNHMVMVFE-VLG
 . ..||| |.| .|....     . || |..|. .  .|. ..|.....|.            ...| .|   . .       .|    . .|.| . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHH--------PNIVRLYGVCTQQGRNFMYIEP----LMIVMEYMPH

CNLLRPIIKYNYKGLPPSFVKLVTKQVLLGLDYLHTECGIIHTDIKPENILFCVSDEH-VK----SLARNRVSS---------KSA----VCN-------
 .|.  . |.  | |...       |.  | .|||   ..|| |.   |.|  |...| ||     |.|.  .          ...     ..       
GDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCL--VGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

-APSSLSKS---------------------GGGPMTK-----NQKKRLKKKLKKHQELMVKEE----SMISDVDAVTTETDSVSMTIDNHTILPESVEEE
 || .. ..                     |. |           ... ...|.   ..  ..    |                                
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------

DTMETEETDQSTTNGSSAGSSCTDSFDLLGPVSVKIADLGNACWIN------------HHF
                         |      . .. ..   ||              . |
-------------------------F---VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK134.AA CLK 483-516 35 0.000284 7.92 In-house 317-350 (350) Show / Hide 
Range on Protein: 483-516
Range on HMM: 317-350/350
Sequence Identity: 35% (12 aa)

DDEAKLLASFLLPMLNYNQKERATAKECLDHPWL
|.|.  |   .  || |    | |.|. |.||. 
DPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase AqueK134.AA DYRK1 496-516 38 0.052405 2.26 In-house 301-321 (321) Show / Hide 
Range on Protein: 496-516
Range on HMM: 301-321/321
Sequence Identity: 38% (8 aa)

MLNYNQKERATAKECLDHPWL
||.|. |.| |  . | |...
MLQYDPKQRITPYYALQHSFF