Gene AqueK157 (A.queenslandica)

AqueK157

Species: A.queenslandica
Alias: AqueK157
External Links:
Annotation:

Classification

Group: Other
Family: IKK

Sequence

Name Sequence Type Origin Length Description Download
AqueK157.AA Protein None 548 None Fasta, JSON
AqueK157.kin_dom Protein Kinase Domain None 284 None Fasta, JSON

Protein domain

Protein domains of AqueK157.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK157.AA IKK 7-289 25 5.1e-63 215.68 In-house 1-297 (297) Show / Hide 
Range on Protein: 7-289
Range on HMM: 1-297/297
Sequence Identity: 25% (78 aa)

W-RRAPIGRGSFGDVSLFTSN-DGEQIALKEMKLEPLRNLDSHERDKMIVRLRNEIKIMWEHNHP-------NLIKALGPPPDIPYH---PPEDVMHVWM
| .. . | |.|| | .      |...| |... . .         ..  .   |. .| . ||.       |.....    ||.      . ..  . |
WEMCDRLGQGAFGNVYHWRHKKTGRKVAVKHCNHMSWM--------RCRWVWCREFEWMKRLNHQRQFVWFPNIWCLC----DIEEDMQWQICKQPVIVM

EFCNGGDLRNGVLKKIENCCGVEE-KQFRKICGDINNGIRFLH-KISVIHRDLKPENILIKHTDANTVVYKLTDFGYAKTYALSSKAQSLVGTPQYVAPE
|.|.||||.. .| . .||||  | ..|. .|.|.  |...||    ..|||.||.|| .   ..   .||.||||||.     .. .|..||..|..|.
EYCTGGDLYK-YLNSPWNCCGLKEGHEFLQVCRDCCAGMHHLHSQNGIVHRDIKPGNIMCQKGEDGKTIYKITDFGYAREWDDDEMFMSFYGTEEYLHPD

IID--------QDSHGRPVDFWSFGVVAFELVTGIRPFLHKSRRPLEWIGPTRNKRD-----NCIYITFN-NGQLEYYDSIPSPHQLSSAFAGELTKWLQ
           | . .  ||.||||| .....|| .||..    | .|.   . .        ||    . ||..|.  ..| . .|..  . ....|..
MYERAVLRKPHQKPYCATVDYWSFGVTFYHCATGELPFMPH-WQPRRWHEKMKHITTEKPSGVCIGVQEEMNGPVEWSSHLPQYCHLCQIIHEQMEPWCI

VVLHQESEKRG
 .|  . ....
MMLEWHQDQCW
S_TKc AqueK157.AA S_TKc 6-300 23 9.6e-50 172.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 6-300
Range on HMM: 1-231/231
Sequence Identity: 23% (73 aa)

NWRRAPIGRGSFGDVSLFTSND-GEQIALKEMKLEPLRNLDSHERDKMIVRLRNEIKIMWEHNHPNLIKALGPPPDIPYHPPEDVMHVWMEFCNG--GDL
     .||.|.|| | . . .. |.. |.|..|                 ..|.||.|. . .|||..| ..   |       | ... ||.|.|  |||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDL

RNGVLKKIE--NCCGVEEKQFRKICGDINNGIRFLHKISVIHRDLKPENILIKHTDANTVVYKLTDFGYAKTYALSSKAQSLVGTPQYVAPEIIDQDSHG
.    |.    ....  | . |...  | ... ..|.  .|||||||||||. .      . |..||| |. .       ...||| |.|||..   ..|
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYG

R-PVDFWSFGVVAFELVTGIRPFLHKSRRPLEWIGPTRNKRDNCIYITFNNGQLEYYDSIPSPHQLSSAFAGELTKWLQVVLHQESEKRGVAHNGDE---
. ..| ||.|.. .|...|  ||     . .. ||                                     |.   ..  |. . |||  |    .   
KCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEW

----APCL
     | .
DIKCHPWF
Kinase AqueK157.AA AGC 131-227 24 2e-43 108.93 In-house 165-310 (395) Show / Hide 
Range on Protein: 131-227
Range on HMM: 165-310/395
Sequence Identity: 24% (38 aa)

GIRFLHK-ISVIHRD-LKPENILIKHTDANTVVYKLTDFGYAKT-------------------------------------------------YALSS--
.. .||.   .|||| |||||||. .        |||||| .|                                                  ..  .  
ALEYLHSHMGIIHRDYLKPENILLDED----GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTR-KKR

-KAQSLVG--TPQYVAPEIIDQDSHGRPVDFWS--FGVVAFELVTGIRPFLHKSR
 ......|  ||.|.||||.    .|...| ||  .|.. .|..||. || ....
DRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNP
Kinase AqueK157.AA CAMK 11-226 19 2.8e-43 136.86 In-house 1-338 (425) Show / Hide 
Range on Protein: 11-226
Range on HMM: 1-338/425
Sequence Identity: 19% (67 aa)

PIGRGSFGDVSLFTSN-DG------------EQIALKEMKLEPLRN-----------LDSHE--------RDKMIVRLRNEIKIMWE-------HNHPNL
 .|||||| | | .   ..            .. | | .. . |..           .|  .        |.|.  ..|.||.||.         .|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKALG---------------PPPDIPYHPPEDVMHVWM---EFCNGGDL--R-NGVLKKIENC------------CGVEEKQFRKICGDINNGIRFLHKI
|| .                   .  .  ... |.  |   |.| ||.|  .    ... ...              ..|.. |..   |  .....|. 
IKLYEVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

SVIHRDLKPENILIKHTDANTV-------------VYKLTDFGYAKTYALSS------------------------KAQSLVGTPQYVA-PEIIDQ----
 ..||||||||||. . . ..                |..||| |. .  ..                        | .  .||| |.| ||.. .    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------DSHGRPVDFWSFGVVAFELVTGIRPFLHKS
          . .|...| || ||. . ...|  || ...
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDC
Kinase AqueK157.AA Pkinase 11-228 30 4.6e-42 149.81 Pfam 6-221 (293) Show / Hide 
Range on Protein: 11-228
Range on HMM: 6-221/293
Sequence Identity: 30% (73 aa)

PIGRGSFGDVSLFTSNDGEQ-IALKEMKLEPLRNLDSHERDKMIVRLRN--EIKIMWEHNHPNLIKALGPPPDIPYHPPEDVMHVWMEFCNGG----DLR
.||.|||| | . .  . ..  |.|..|.       .||.... ...|.  ||.|| . |||| .. ..   |      .| ... ||.|.||    || 
KIGSGSFGCVYKCHHKGTGKIVAVKIIKK-------RHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLF

NGVLKKIE--NCCGV--EEKQFRKICGDINNGIRFLHKISVIHRDLKPENILIKHTDANTVVYKLTDFGYAKT--YALSSKAQSLVGTPQYVAPEIID-Q
      |.  . ...  .|.. ....  |  |. ..|. ..||||||||||||.... .    |..||| ||   |  .| .....||| |.|||.|  .
----DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGG

DSHGRPVDFWSFGVVAFELVTGIRPFLHK----SRR
  .|..|| ||.|.. .|...|  || ..    . .
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-H
Kinase AqueK157.AA TKL 12-233 20 3.5e-38 133.17 In-house 1-307 (364) Show / Hide 
Range on Protein: 12-233
Range on HMM: 1-307/364
Sequence Identity: 20% (64 aa)

IGRGSFGDVSLFTSND---------GEQIALKEMKLEPLRNLDSHERD------------------KMIVRLRNEIKIMWEHNHPNLIKALG----PPPD
||.|.|| |   . .          |. .| | .| .   . ......                  ..  ....||..|   .|||... .|    ||..
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-IPYHP---PEDVMHVWMEFCNGGDLRNGVLKKIENCCGVEEKQFRKICGDINNGIRFLHKIS--------VIHRDLKPENILIKHTDA----------N
 . .||   . . . | ||.| ||.|.. ..            |. ... ||  |. .||           .||||||..|||..              .
CVCMHPVGPWGQLCIV-MEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

TVVYKLTDFGYAKTYALSS--------------------KAQSLVGTPQYVAPEIIDQD----------------SHGRPVDFWSFGVVAFELVTGIRPF
... |..||| ...   |.                    .  . .|||.. |||.....                .    .| .|||.| .|..|. ||.
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY

L-HKSRRPL------EWI
  .... ..      |..
YDYPYMPMIFQDPFEEMF
Kinase AqueK157.AA STE 7-222 26 5.6e-36 124.55 In-house 1-268 (359) Show / Hide 
Range on Protein: 7-222
Range on HMM: 1-268/359
Sequence Identity: 26% (76 aa)

WRR-APIGRGSFGDVSLFTSND----------------GEQIALKEMKLEPLRNLDSH-------ERD--KMIVRLRNEIKIMWEHN--HPNLIKALGPP
|..   ||.|.|| | .   ..                || .| |.|.||. .| | .       | .  . . .. .||||| . |  ||| .| .|  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYG--

PDIPYHPPE-------DVMHVWMEFCNGGDLRNGVLKKIENCCG----------VEEKQFRKICGDINNG-IRFLHKISVIHRDLKPENILIKHTDANTV
    ..  |       |  .. ||...|| |.  . .| .  ..          ..|.| ..|| .|  |   .||.  .||||.|| |||.        
----CYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------

VYKLTDFGYAKTYAL-----------------SSKAQSLVGTPQYVAPEIIDQ------DSHGRPVDFWSFGVVAFELVTGIRPF
  ||.||| ..  .                  ..| ...|||| . |||.|.|      . ... .| ||.| .. |..||  |.
-VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW
Kinase AqueK157.AA Ciliate-E2 94-233 21 2.8e-35 118.54 In-house 113-300 (365) Show / Hide 
Range on Protein: 94-233
Range on HMM: 113-300/365
Sequence Identity: 21% (44 aa)

MEFCNGGDLRNGVLKK---------------IENCCGVEEKQFR-------KICGDINNGIRFLHKIS-VIHRDLKPENILIKHTDANTVVYKLTDFGYA
||.|.||||.    ..               .. .. . .....        ... |  ....||.   .||||.||||||.          |..|||..
MEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLS

KTYALSSKAQS--------------------------------LVGTPQYVAPEIIDQDS---------HGRPVDFWSFGVVAFELVTGIRPFLHKSRRP
| |  ... ..                                ..||| |.||||.   .         ..  .|.||.||. .|...| .||       
KKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------

LEWI
.. |
QQQI
Kinase AqueK157.AA Ciliate-E2-Unclassified 94-227 25 7e-35 118.43 In-house 100-275 (352) Show / Hide 
Range on Protein: 94-227
Range on HMM: 100-275/352
Sequence Identity: 25% (46 aa)

MEFCNGGDLRNGVLKKIE------------NC-CGVEEKQFR-----KICGDINNGIRFLHKIS-VIHRDLKPENILIKHTDANTVVYKLTDFGYAKTYA
||.|.||||..   |.              .. . ..|.| .     ...  | .|. .||.   .||||.||||||..         |..||| .| | 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQ

L----------------SSKAQSLVGTPQYV----APEIIDQDSHGRP----VDFWSFGVVAFELVTGIRPFLHKSR
                 . .... .|||.|     |||....  .. .    .|.||.||...|...| .||  ...
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNC
Kinase AqueK157.AA ULK 94-222 32 2.4e-34 117.31 In-house 99-256 (329) Show / Hide 
Range on Protein: 94-222
Range on HMM: 99-256/329
Sequence Identity: 32% (51 aa)

MEFCNGGDLRNGVLKKIE------NCCGVEEKQFRKICGDINNGIRFLHKISVIHRDLKPENILIKHTDANT--------VVYKLTDFGYAKTYALS---
||.||||||..   |. .      .    .|.. .... .| || ..|||  .||||.||.||||.  .. |        .|.|..||| ||.   .   
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

-SKAQSLV------GTPQYVAPEIID----QDSHG-RPVDFWSFGVVAFELVTGIRPF
   ... |      ||| | ||.|.     |  ..   .| ||.|.. .|...|  ||
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPF
Kinase AqueK157.AA ULK 94-222 33 4.2e-33 114.83 In-house 96-252 (324) Show / Hide 
Range on Protein: 94-222
Range on HMM: 96-252/324
Sequence Identity: 33% (52 aa)

MEFCNGGDLRNGVLKKIE-----NCCGVEEKQFRKICGDINNGIRFLHKISVIHRDLKPENILIKHTDANT--------VVYKLTDFGYAKT--Y--ALS
||.||||||..   |. .     .    .|.. .... .| || ..|||  .||||.||.||||.. .. |        .|.|..||| ||.  .     
MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQ

SKAQSLV------GTPQYVAPEIID----QDSHG-RPVDFWSFGVVAFELVTGIRPF
 . |..|      ||| | ||.|.     |  ..   .| ||.|.. .|...|  ||
QMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPF
Kinase AqueK157.AA RSK 94-222 34 3.1e-32 113.41 In-house 80-212 (278) Show / Hide 
Range on Protein: 94-222
Range on HMM: 80-212/278
Sequence Identity: 34% (47 aa)

MEFCNGGDLRNGVLKKIE--NCCG-VEEKQFRKICGDINNGIRFLHKISVIHRDLKPENILIKHTDANTVVYKLTDFGYAKTYALS--SKAQSLVGTPQY
||.|.||.|    .....   . |   |.  . .   |   ...||.  .|||||||||||  . . |    |||||| .|   ..  ..... ..| .|
MEYCRGGEL----FTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEY

VAPEIID---QDS-HGRPVDFWSFGVVAFELVTGIRPF
.|||..    |.. |.. .| ||.||. .|. || .||
MAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPF
Kinase AqueK157.AA TyrKc 8-269 20 1.1e-11 -33.98 SMART 3-280 (280) Show / Hide 
Range on Protein: 8-269
Range on HMM: 3-280/280
Sequence Identity: 20% (63 aa)

RRAPIGRGSFGDVSLFTSNDGEQIALKEMKLEPLRNLDSHERDKMIVRLRNEIKIMWEH--NHPNLIKALGPPPDIPYHPPE-----DVMHVWMEFCNGG
    .|.| || | . | .  .| | | .| .             .  ...|..|| .   .|||... .|    .  .. .     . . . ||.. .|
LGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYG----VCTQQGRNFMYIEPLMIVMEYMPHG

DLRNGVLKKIENCCGVEEKQFRKICGDINNGIRFLHKISVIHRDLKPENILIKHTDANTVVYKLTDFGYAKTYALS--------SKAQSL-VGTPQ----
||..   |. ..   .  |.. ..| .| .| ..||.  .|||||   |.|...      . | .||| ..              . ..   |.      
DLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

-YVAPEIIDQDSHGRPVDFWSFGVVAFELVT-GIRPFLH------KSRRPLEWIGPTRNKRDNCIYITFNN-------GQLEYYDSI------------P
   ||| |.        | |||||. .|. | |  |         . .. .|..     |. .   .  |.          | |. |            |
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV-----KQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRP

SPHQLSSAF
.  .. . |
TFSEIHECF
Kinase AqueK157.AA Ciliate-E2 12-73 21 0.00011 11.99 In-house 7-96 (365) Show / Hide 
Range on Protein: 12-73
Range on HMM: 7-96/365
Sequence Identity: 21% (20 aa)

IGRGSFGDVSLF-TSNDGEQIA--------------------LKEMKLEPLRNLDSHERDKMIV--------RLRNEIKIMWEHNHPNLIK
||.|.||.| .    ....|.|                    ...||    ... . .. . |         .. || .|. . ||||.||
IGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIK
Kinase AqueK157.AA AGC 11-73 20 0.000936 4.0 In-house 6-94 (395) Show / Hide 
Range on Protein: 11-73
Range on HMM: 6-94/395
Sequence Identity: 20% (18 aa)

PIGRGSFGDVSLFTSN------DGEQI-ALKEMKLEP-LRNLDSHERDKMIVR--------LRNEIKIMWEHN----------HPNLIK
.||.|||| | |   .      | ... |.| .| .     .. .. .. ..         ...| .|. . |          ||...|
VIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVK
Kinase AqueK157.AA ULK 12-73 26 0.02107 4.41 In-house 7-79 (324) Show / Hide 
Range on Protein: 12-73
Range on HMM: 7-79/324
Sequence Identity: 26% (20 aa)

IGRGSFGDVSLFTS----ND--GEQIALKEMK---LEPLRNLDSHERDKMIVRLRNEIKIMWEHN---HPN--LIK
.| |||| |  .      ..  ....| | .    .    |..  . . |.  |.|||.|| . .   |||   .|
LGKGSFG-VKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQE-G-QYMWQLLKNEIQIMKKLKELKHPNHHIVK
Kinase AqueK157.AA ULK 12-73 26 0.070307 2.45 In-house 7-82 (329) Show / Hide 
Range on Protein: 12-73
Range on HMM: 7-82/329
Sequence Identity: 26% (21 aa)

IGRGSFGDVSLFTS----ND---GEQIALKEMK---LEPLRNLDSHERDKMIVRLRNEIKIMWEHN--------HPNLIK
.| ||||    .      ..   .|..| | .    .    |..  . . |.  |.|||||| . .        ||| .|
LGKGSFG--KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQE-G-QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVK