AqueK181

Species: A.queenslandica
Alias: AqueK181
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK8

Sequence

Name Sequence Type Origin Length Description Download
AqueK181.AA Protein None 111 None Fasta, JSON
AqueK181.kin_dom Protein Kinase Domain None 108 None Fasta, JSON

Protein domain

Protein domains of AqueK181.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK181.AA NEK8 1-109 55 3.5e-82 234.41 In-house 144-256 (278) Show / Hide
Range on Protein: 1-109
Range on HMM: 144-256/278
Sequence Identity: 55% (63 aa)

DLKTANIFLTRH-GIVKLGDFGISKVLSGTHQAADS--IVGTPYYISPEICEGKQYNSKSDIWSLGCILHEMMCLSRPFDGTNLPALVHKIVEG-SFDPI
||||.|||.||| ..||.|||||||...    .. .  .||||||.|||.||||.|| |||.|.|||.| || || | |...|||||| ||. .  . ||
DLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPI

KGKYSDELKQLVS
...|| |...||.
SDHYSNEMRMLVH

Kinase AqueK181.AA NEK 1-109 50 9.3e-65 221.46 In-house 144-264 (286) Show / Hide
Range on Protein: 1-109
Range on HMM: 144-264/286
Sequence Identity: 50% (61 aa)

DLKTANIFLTRHGI----VKLGDFGISKVLSGTHQAADS-IVGTPYYISPEICEGKQYNSKSDIWSLGCILHEMMCL--SRPFDGT--NLPALVHKIVEG
|.|..|||||. ..    ||.|||||||||. | ..| .  ||||||.|||.|..| ||.|||||||||.| ||..|   .||...  |.|.|. ||..|
DIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKG

-SFDPIKGK--YSDELKQLVS
  ..||  .  ||..|..|.|
PQYPPIPSHRMYSQDLQNLIS

Kinase AqueK181.AA NEK1 1-109 48 1.9e-53 183.73 In-house 129-254 (276) Show / Hide
Range on Protein: 1-109
Range on HMM: 129-254/276
Sequence Identity: 48% (61 aa)

DLKTANIFLT--RHG---------------IVKLGDFGISKVLSGTHQAADSIVGTPYYISPEICEGKQYNSKSDIWSLGCILHEMMCLSRPFDGTNLPA
|.|. |||||  . |               .||||||||...|. |   |   .|||||.|||||. | || |||||||||.| | . |..||.. |...
DIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKN

LVHKIVEGSFDPIKGKYSDELKQLVS
|| ||..|.. ||   || ||. |||
LVLKICQGTYPPIPPHYSYELQSLVS

Kinase AqueK181.AA NEK4 1-108 48 8.8e-42 145.13 In-house 127-234 (257) Show / Hide
Range on Protein: 1-108
Range on HMM: 127-234/257
Sequence Identity: 48% (52 aa)

DLKTANIFLTRHGIVKLGDFGISKVLSGTHQAADSIVGTPYYISPEICEGKQYNSKSDIWSLGCILHEMMCLSRPFDGTNLPALVHKIVEGSFDPIKGKY
|||| |||||.  |.|.||||||.||    . |  ..|||||.|||.   . |. ||||||||| . ||. |   ||  ... |...|..|   |.  .|
DLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNY

SDELKQLV
| .|..||
SQDLQNLV

Kinase AqueK181.AA NEK2 1-109 35 3.1e-38 126.26 In-house 150-297 (319) Show / Hide
Range on Protein: 1-109
Range on HMM: 150-297/319
Sequence Identity: 35% (52 aa)

DLKTANIFLTRHGI---------------------------------------VKLGDFGISKVLSGTHQAADSIVGTPYYISPEICEGKQYNSKSDIWS
|.| |||||   .                                        |||||||  ..|    . | . |||||| |||  .|  || ||||||
DIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWS

LGCILHEMMCLSRPFDGTNLPALVHKIVEGSFDPIKGKYSDELKQLVS
.||.. ||  |. || .||  .|  || .| |..|   ||..|  ...
VGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIH

Kinase AqueK181.AA NEK6 1-109 50 5.7e-35 112.35 In-house 128-239 (252) Show / Hide
Range on Protein: 1-109
Range on HMM: 128-239/252
Sequence Identity: 50% (57 aa)

DLKTANIFLTRHGIVKLGDFGISKVLSGTHQAADSIVGTPYYISPEICEGKQYNSKSDIWSLGCILHEMMCLSRPF--DGTNLPALVHKIVEGSFDPIKG
|.| ||.|.| .||||||| |. .  |    || |.||||||.|||  . . || |||||||||.| ||  |  ||  |  || .| .|| .  . |. .
DIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPA

-KYSDELKQLVS
  ||..|.|||.
DHYSEQLRQLVC

Kinase AqueK181.AA NEK-Unclassified 1-108 40 6.6e-34 109.42 In-house 122-235 (258) Show / Hide
Range on Protein: 1-108
Range on HMM: 122-235/258
Sequence Identity: 40% (46 aa)

DLKTANIFLTRHGIVKLGDFGISKVLSGTHQAADSIVGTPYYISPEICEGKQYNSKSDIWSLGCILHEMMCLSRPFDGTNLPALVHKIVEGSF------D
|||. |||||   .| .||||||...  |   |   |||. ..|||.|. . || .||.||||||. ||      ||  |.  .  ||. .        .
DLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDTHNMGEVYMKIKQDDNRLEEALE

PIKGKYSDELKQLV
|.   ||  | |..
PVSKTYSTDLQQVI

Kinase AqueK181.AA Pkinase 1-110 25 4.4e-30 107.45 Pfam 133-272 (293) Show / Hide
Range on Protein: 1-110
Range on HMM: 133-272/293
Sequence Identity: 25% (36 aa)

DLKTANIFLTRHGIV----KLGDFGISKVL-SGTHQAADSIVGTPYYISPEICE-GKQYNSKSDIWSLGCILHEMMCLSRPFDGT------NLPALVHKI
||| .||.. ..| .    |..|||..|..     . .....|||.|..||..  |. | .|.|.||.||||.||.|   ||.|       .  ... .|
DLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRI

VEGSFDPIKGKYS--------------------DELKQLVSG
 .. ..    . .                    .|.|.....
MGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

Kinase AqueK181.AA ULK 1-110 25 4.1e-29 98.81 In-house 155-308 (329) Show / Hide
Range on Protein: 1-110
Range on HMM: 155-308/329
Sequence Identity: 25% (39 aa)

DLKTANIFLTRH------------GIVKLGDFGISKVLSGT---HQAADSIV------GTPYYISPEICE----GKQYN-SKSDIWSLGCILHEMMCLSR
|.| .|| .. .            |..|..||| .|...      | . . |      |||.| .|.| .    .|.|. .|.||||||||..||     
DIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKP

PFDGTNLPALVHKIVEGSFD------------PIK-------GKYSDELKQLVSG
|| .     ....|..  ..            |..        . |.|.|.| ..
PFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRR

Kinase AqueK181.AA NEK11 1-104 46 2.9e-27 96.31 In-house 130-232 (259) Show / Hide
Range on Protein: 1-104
Range on HMM: 130-232/259
Sequence Identity: 46% (48 aa)

DLKTANIFLTRHGIVKLGDFGISKVLSGTHQAADSIVGTPYYISPEICEGKQYNSKSDIWSLGCILHEMMCLSRPFDGTNLPALVHKIVEGSFDPIKGKY
|||  |||| .  ..|.||||.|..| |  . |  . ||| |.|||    . | .||||||| ||| || |.   | | |  ..| .||||    .  .|
DLKSKNIFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMDHAFAGSNFLSIVLNIVEGDTPSLPDRY

SDEL
  ||
PREL

Kinase AqueK181.AA ULK 1-110 25 1.6e-26 91.17 In-house 151-303 (324) Show / Hide
Range on Protein: 1-110
Range on HMM: 151-303/324
Sequence Identity: 25% (40 aa)

DLKTANIFLTR------------HGIVKLGDFGISKVLSGT---HQAADSIV------GTPYYISPEICE----GKQYN-SKSDIWSLGCILHEMMCLSR
|.| .|| ..             .|..|..||| .|..       |   ..|      |||.| .|.| .    .|.|. .|.||||||||..||   . 
DIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKY

PFDGTNLPALVHK--------------IVEGSFDPIKG----KYSDELKQLVSG
|| .     ....              |    ... |.    | |.|.|.| ..
PFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRR

Kinase AqueK181.AA Pkinase_Tyr 6-78 22 6e-06 20.82 Pfam 141-218 (270) Show / Hide
Range on Protein: 6-78
Range on HMM: 141-218/270
Sequence Identity: 22% (18 aa)

NIFLTRHGIVKLGDFGISKVL-----SGTHQAADSIVGTPYYISPEICEGKQYNSKSDIWSLGCILHEMMCLS-RP-FDG
|. .|. ..|| .||| .. .       .... .. .  . . .||    . ...|||.|| |  . |.. .   | . |
NCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPG

Kinase AqueK181.AA S_TKc 1-111 14 2.3e-05 -98.23 SMART 1-220 (231) Show / Hide
Range on Protein: 1-111
Range on HMM: 1-220/231
Sequence Identity: 14% (35 aa)

D---------------------------------------------------------------------------------------------------
                                                                                                    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYM

-------------------LKTANIFLTRHGIVKLGDFGISKVLSGTHQAADSIVGTPYYISPEICEGKQYNS-KSDIWSLGCILHEMMCLSRPFDGTNL
                   || .||.|..   .|..|||....|       ....|||.|..||..   .|.  |.|.||.|||| ||.|   ||.  ..
YQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QM

PALVHKIVEGSFDPIKGKYSDELKQLVSG---------------E
 .. .||.           |.|.|.....               .
QMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTAEALQ