Gene AqueK219 (A.queenslandica)

AqueK219

Species: A.queenslandica
Alias: AqueK219
External Links:
Annotation:

Classification

Group: Other
Family: WNK

Sequence

Name Sequence Type Origin Length Description Download
AqueK219.AA Protein None 1765 None Fasta, JSON
AqueK219.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of AqueK219.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK219.AA WNK 157-192 69 3.3e-24 75.0 In-house 1-36 (261) Show / Hide 
Range on Protein: 157-192
Range on HMM: 1-36/261
Sequence Identity: 69% (25 aa)

VKYEQEIGRGSFKTVYKGLDTETGVAVAWCELLDSQ
 |...|.|||||||||.||||||.|.|||||| |..
MKFDEEVGRGSFKTVYRGLDTETWVEVAWCELQDQK
Kinase AqueK219.AA Dicty4 157-174 61 0.000175 11.06 In-house 1-18 (277) Show / Hide 
Range on Protein: 157-174
Range on HMM: 1-18/277
Sequence Identity: 61% (11 aa)

VKYEQEIGRGSFKTVYKG
 . ||.||.||| .||||
INIEQRIGKGSFGEVYKG
Kinase AqueK219.AA STE11 157-184 39 0.000192 12.31 In-house 1-28 (303) Show / Hide 
Range on Protein: 157-184
Range on HMM: 1-28/303
Sequence Identity: 39% (11 aa)

VKYEQEIGRGSFKTVYKGLDTETGVAVA
 .  . ||.|.| ||||.... ||. .|
WQKGEIIGKGAFGTVYKCMNVDTGELMA
Kinase AqueK219.AA STE 157-184 25 0.000271 11.21 In-house 1-43 (359) Show / Hide 
Range on Protein: 157-184
Range on HMM: 1-43/359
Sequence Identity: 25% (11 aa)

VKYEQEIGRGSFKTVYKGLDTE---------------TGVAVA
 .  ..||.|.| ||||... .               ||. .|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMA
Kinase AqueK219.AA CAMK 162-183 25 0.000308 8.77 In-house 1-36 (425) Show / Hide 
Range on Protein: 162-183
Range on HMM: 1-36/425
Sequence Identity: 25% (9 aa)

EIGRGSFKTVYKGLDTETG--------------VAV
..||||| .|... ...|.              ||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAI
Kinase AqueK219.AA ULK 157-184 34 0.004093 6.82 In-house 1-32 (329) Show / Hide 
Range on Protein: 157-184
Range on HMM: 1-32/329
Sequence Identity: 34% (11 aa)

VKYEQEIGRGSFKTVYKGLDTET----GVAVA
    ...| ||| .|||| . .|    ...||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVA
Kinase AqueK219.AA Pkinase 157-183 44 0.008508 10.97 Pfam 1-29 (293) Show / Hide 
Range on Protein: 157-183
Range on HMM: 1-29/293
Sequence Identity: 44% (13 aa)

VKYEQEIGRGSFKTVYKGLDTETG--VAV
 . .. ||.||| .|||. .  ||  |||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAV
Kinase AqueK219.AA Ciliate-E2 157-180 33 0.017026 4.36 In-house 1-24 (365) Show / Hide 
Range on Protein: 157-180
Range on HMM: 1-24/365
Sequence Identity: 33% (8 aa)

VKYEQEIGRGSFKTVYKGLDTETG
 |  . ||.|.| .|||. . ...
YKFIKKIGQGNFGSVYKCKVWKVQ
Kinase AqueK219.AA TKL 163-174 66 0.169641 1.17 In-house 1-12 (364) Show / Hide 
Range on Protein: 163-174
Range on HMM: 1-12/364
Sequence Identity: 66% (8 aa)

IGRGSFKTVYKG
||.|.| .||||
IGSGGFGEVYKG
Kinase AqueK219.AA NRBP 161-188 39 0.240909 0.11 In-house 1-27 (261) Show / Hide 
Range on Protein: 161-188
Range on HMM: 1-27/261
Sequence Identity: 39% (11 aa)

QEIGRGSFKTVYKGLDTETGVAVAWCEL
|    |  ...|  .|||.|| | | |.
QRDVPG-IDCAYLAMDTEEGVEVVWNEV
Kinase AqueK219.AA Pkinase_Tyr 157-174 38 0.335541 4.69 Pfam 1-18 (270) Show / Hide 
Range on Protein: 157-174
Range on HMM: 1-18/270
Sequence Identity: 38% (7 aa)

VKYEQEIGRGSFKTVYKG
..  ...|.|.| .||||
ITFGKKLGEGAFGEVYKG
Kinase AqueK219.AA WNK 219-478 66 3.8e-184 599.83 In-house 1-261 (261) Show / Hide 
Range on Protein: 219-478
Range on HMM: 1-261/261
Sequence Identity: 66% (174 aa)

VKYEQEIGRGSFKTVYKGLDTETGVAVAWCELLEHKFNKEEQSRFKEEVAILKTLNHPYILRLFDSWEFVRQSDKKRVLVLITELMTSGTLKSYMRRFKS
 |...|.|||||||||.||||||.|.|||||| . | .| |. |||||. .|| | || |.|..|.||.|    ||   ||.||||||||||.|..||| 
MKFDEEVGRGSFKTVYRGLDTETWVEVAWCELQDQKLSKNERQRFKEEAEMLKKLQHPNIVRFYDYWESV-LCGKK-CIVLVTELMTSGTLKTYLKRFKK

IKPRVIRSWGRQILRGLSFLHTRTP-PIIHRDLKCDNVFINGTTGLVKIGDLGLA-TLK-RSDVKTVIGTPEFMAPEMYDEVYDESVDVYAFGMCLLEMC
.||.| ||| ||||.||.|||||.| |||||||||||.||.|||| ||||||||| ||| .|  | ||||||||||||| | |||||||||||||.||| 
MKPKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIGDLGLAVTLKNSSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMA

TLEYPYQECSNPAQIYKKVTSGVMPNSLNKVNDPMLKEIIVACTKLSKSARYTVEMLLNHEFF
|.||||.||.|.||||.|||.|. |||..|...| .||||  |.. .|. |.... ||||.||
TSEYPYSECQNAAQIYRKVTQGIKPNSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF
Kinase AqueK219.AA S_TKc 219-478 25 1.1e-62 215.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 219-478
Range on HMM: 1-231/231
Sequence Identity: 25% (70 aa)

VKYEQEIGRGSFKTVYKGLDTETGVAVAWCELLEHKFNKEEQSRFKEEVAILKTLNHPYILRLFDSWEFVRQSDKKRVLVLITELMTS--GTLKSYMRRF
 .  ..||.|.| .|||. ...||  ||  ..           ... |..|||  .||.| .|.|...          | ...|..    |.|..|... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

KS------IKPRVIRSWGRQILRGLSFLHTRTPPIIHRDLKCDNVFINGTTGLVKIGDLGLATLKRSDVKTVIGTPEFMAPEMYDEVYDE-SVDVYAFGM
..      . . ..|.. .||...| ..| .   ||||||| .|....     .||.| |||..     .|..|||..||||.    |.  ..|....| 
GRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGC

CLLEMCTLEYPYQECSNPAQIYKKVTSGVMPNSLNKVNDPMLKEIIVACTKLSKSARYTVEMLLN-------HEFF
.| ||.. . |..   ......||.             .| .|..|  | .   . |.|.  .|.       |..|
ILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK219.AA Pkinase 219-478 26 4.4e-54 190.8 Pfam 1-293 (293) Show / Hide 
Range on Protein: 219-478
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

VKYEQEIGRGSFKTVYKGLDTETGVAVAWCELLEHKFNKEEQSRFKE--EVAILKTLNHPYILRLFDSWEFVRQSDKKRVLVLITELMTSG----TLKSY
 . .. ||.||| .|||. .  ||  ||  ..  .. ..... .     |..|.| ||||.|.||.|..|       |. . ...|..  |     |..|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

MR--RFKSI--KPRVIRSWGRQILRGLSFLHTRTPPIIHRDLKCDNVFINGTTGL---VKIGDLGLA----TLKRSDVKTVIGTPEFMAPEM--YDEVYD
..  | ...   ....... .|||||| ..| .   ||||||| .|..|. .  .   |||.| |||    . . |  .|. |||..||||    .. |.
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

ESVDVYAFGMCLLEMCTLEYPYQEC-----SNPAQIYKKVTSGVMPNSLNKVND-------------------PMLKEIIVACTKLSKSARYTVEMLLNH
 .||....|  | ||.. . |....      .. |..... ..  . .  . ..                   . .|..|  | ..  . |.| | .|.|
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

EFF
..|
PWF
Kinase AqueK219.AA STE 219-478 20 5.3e-50 172.44 In-house 1-359 (359) Show / Hide 
Range on Protein: 219-478
Range on HMM: 1-359/359
Sequence Identity: 20% (77 aa)

VKYEQEIGRGSFKTVYKGLDTE---------------TGVAVAWCELLEHKFNK---------------EEQSRFKEEVAILKTLN--HPYILRLFDSWE
 .  ..||.|.| ||||... .               ||. .|  ..   . |.               ||. ....|. |.| .|  ||.| . ... .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

FVRQSDKKRV-LVLITELMTSGTLKSYMR-RFKSIKP-------------RVIRSWGRQILRG-LSFLHTRTPPIIHRDLKCDNVFINGTTGLVKIGDLG
     .| .  | .. |.|  |.| . .. ...  ||              .|.   ||||.| |..||     |||||.|..|...      ||. | |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------VKLCDFG

LATLKRSDVK-------------------TVIGTPEFMAPEMYDE-------VYDESVDVYAFGMCLLEMCTLEYPYQECSNPAQIYKKVTS--------
...   ...                    |..||| .||||. .         ||...|.. .| ...||.| ..|. . ...  .. . ..        
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE

------GVMPNSLNKVND------------------PMLKEIIVACTKLSKSARYTVEMLLN--HEFF
      |  |   ... .                  | .|. |  | .   . | |.. ||.  |.|.
QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase AqueK219.AA CAMK 224-478 16 4e-45 142.91 In-house 1-425 (425) Show / Hide 
Range on Protein: 224-478
Range on HMM: 1-425/425
Sequence Identity: 16% (72 aa)

EIGRGSFKTVYKGLDTETG--------------VAVAW-------------------CELLEHKF-----NKEEQSRFKEEVAILKT-------LNHPYI
..||||| .|... ...|.              ||.                      .  . |      . . . ... |..|.|.       |.|| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LRLFDSWE----------------FVRQSDKKRVLVL-ITELMTSG----TLKSYMRRFKS---------------IKPRVIRSWGRQILRGLSFLHTRT
..|.. .|                 .  .||. ..|. |.|... |     | .| .. ..               .. |  | . |||. .. ..| . 
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

PPIIHRDLKCDNVFINGTT----------------GLVKIGDLGLATLKRS--------------------------DVKTVIGTPEFMA-PEMYD----
  |.|||||..|. ..                   . .|| | |.|. ...                            ||. ||||.|| ||.      
--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-----------EVYDESVDVYAFGMCLLEMCTLEYPYQECS------------NPAQIYKKVTSGVMPNSLNKVNDPM----------------------
           . |....|. . |  |  | . ..|... .            |. ....|...|       .. ..                       
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

LKEIIVACTKLSKSARYTVEMLLNHEFF
 |  |  . .   . |.|.|  |||...
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase AqueK219.AA Ciliate-E2 219-478 19 5.8e-43 145.31 In-house 1-365 (365) Show / Hide 
Range on Protein: 219-478
Range on HMM: 1-365/365
Sequence Identity: 19% (75 aa)

VKYEQEIGRGSFKTVYKGLDTETGVAVAWCELLEHK-------------------FNKEEQSRFKEEVAILK----------------TLNHPYILRLFD
 |  . ||.|.| .|||. . ...  .|      .|                   ..| .   .| |  |..                .||||.|.....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

SWEFVRQSD-KKRVLVLITELMTSGTLKSYMR------------RFKSIKPRVIRSWGRQILR---------------GLSFLHTRTPPIIHRDLKCDNV
...     . ..  . |..|.   |.|..|..              |... . |.   .|||.               .| .|| . . |||||.| .|.
CFQ-----EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENI

FINGTTGLVKIGDLGLATLKRSD----------------------------------VKTVIGTPEFMAPEMYD----------EVYDESVDVYAFGMCL
..      .|| |.||..    |                                  ..|..|||..||||..           . ||...|....|..|
LF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

LEMCTLEYPYQECSNPAQIYKK-VTSGVMPN-------------SLNKVNDP-----------MLKEIIVACTKLSKSARYT-VEMLLNHEFF
 ||.. ..|.       |. |.   .   |.             | .|. .            ||.           . |.|  | .|||..|
YEMLFGKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDP--------EKRITGWEQILNHPWF
Kinase AqueK219.AA TKL 225-466 19 2.3e-40 140.42 In-house 1-354 (364) Show / Hide 
Range on Protein: 225-466
Range on HMM: 1-354/364
Sequence Identity: 19% (70 aa)

IGRGSFKTVYKG-LDTET-------GVAVAWCELLEHKFNKEEQ-------------------------SRFKEEVAILKTLNHPYILRLFDSWEFVRQS
||.|.| .|||| .  ..       |  ||   . .|  ....                           ...||. ... |.|| |...  .    .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------DKKRVLVLITELMTSGTLKSYMRRFKSIKPRVIRSWGRQILRGLSFLHTRT------PPIIHRDLKCDNVFING-------------TTGLVK
       . .  | ...|..  |.| .|.       . .. .| ..| ||...||...      ||||||||| .|....               .. .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

IGDLGLAT-LKRSD---------------------VKTVIGTPEFMAPEMYD-----------------EVYDESVDVYAFGMCLLEMCTLEYPYQECSN
|.|.||.. ...|                        |..||| .||||. .                 . |.|..|||.||..| |..| . ||..  .
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

P------------AQIYKKVTSGVMPNSLN-----KVNDPM---LKEIIVACTKLSKSAR
.            .....|     .|.  .       ....   .|...  | .   ..|
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKR
Kinase AqueK219.AA STE11 219-478 24 5.1e-40 139.28 In-house 1-303 (303) Show / Hide 
Range on Protein: 219-478
Range on HMM: 1-303/303
Sequence Identity: 24% (77 aa)

VKYEQEIGRGSFKTVYKGLDTETGVAVAWCELLEHKFN-------KEEQS-----RFKEEVAILKTLNHPYILRLFDSWEFVRQSD-KKRVLVLITELMT
 .  . ||.|.| ||||.... ||. .|  .  ... |       || ||      ..||....|.|||. | | ..    . ..| ..  .  . | . 
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYG----CCLHDNQNDHVNIFMEYCP

SGTLKSYMR-RFKS--IKPRVIRSWGRQILRGLSFLHTRTPPIIHRDLKCDNVFINGTTGLVKIGDLGLATLKRSDV-------------KTVIGTPE--
 |.|.|  | ..        |||   .|||.||..||     |||||.| .|.... . ...|..| | |.   ..              |.. |||   
GGSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHG--IIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNS

------FMAPEMYD-EV---YDESVDVYAFGMCLLEMCTLEYPYQECSN--PAQIYKKVTS-GVMPNSLNKVND-----PMLKEIIVACTKLSKSARYTV
      .||||... |    |. ..|. ..| . .||.|   |. ....   |...| ... . .|.   ..       . .....  | .  .. |.|.
MMGTPMWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTA

EMLLNHEFF
  ||.| |.
NQLLQHPFI
Kinase AqueK219.AA NRBP 223-479 32 8.2e-37 126.87 In-house 1-261 (261) Show / Hide 
Range on Protein: 223-479
Range on HMM: 1-261/261
Sequence Identity: 32% (89 aa)

QEIGRGSFKTVYKGLDTETGVAVAWCELL--EHKFNKEEQSRFKEEVAILKTLNHPYILRLFDSWEFVRQSDKKRVLVLITELMTSGTLKSYMRRFK---
|    |  ...|  .|||.|| | | |.   | |  | .  . ..    |  |.|. | ..   |  ...  | || . ||| | || .| .... |   
QRDVPG-IDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEE-KPRV-IFITEYMSSGSMKQFLKKTKKNH

-SIKPRVIRSWGRQILRGLSFLHTRTPPIIHRDLKCDNVFINGTTGLVKIGDLGLATLKRSDVKTV---IGTPEFMAPEMYD--EVYDE--SVDVYAFGM
 ... .  . |  |||  ||.||.  |||||  | || .||    ||.|||     .. ...|.|         |.||| |.  || |    ||.|.|||
KNMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQ-HNGLIKIGCVWPDAI-HHHVRTCREEMRNMHFFAPE-YGILEVTDLTTAVDIYSFGM

CLLEMCTLEYPYQECSNPAQIYKKVTSGVMPNSLNKVNDPMLKEIIVACTKLSKSARYTVEMLLNHEFFA
| |||  ||   . |.|    |  ||  ..  . . ..||| ...|  | .     | . . || |.   
CALEMAVLEI-QSGCQNGESEY--VTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF
Kinase AqueK219.AA Ciliate-E2-Unclassified 220-478 20 2e-34 116.79 In-house 2-352 (352) Show / Hide 
Range on Protein: 220-478
Range on HMM: 2-352/352
Sequence Identity: 20% (72 aa)

KYEQEIGRGSFKTVYKGLDTETGVAVAWCELLEHKFNKEEQSRFK-------EEVA----------------ILKTLNHPYILRLFDSWEFVRQSDKKRV
|  . ||.|.| .|||  . ... . |  ..  .. .|  | ..|       .|.                 ||. ..||.|...|    .. |....  
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMF----YCFQDKQN--

LVLITELMTSGTLKSYMRRFKS-----------------IKPRVIR-----SWGRQILRGLSFLHTRTPPIIHRDLKCDNVFINGTTG--LVKIGDLGLA
. ...|..  |.|. |.. .|.                 .  . ..      . .||| ||..||     |||||.|..|....   .   .|| |.|..
IYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGIS

TLKRSD------------------VKTVIGTPEFM----APEMYDE-VYDES----VDVYAFGMCLLEMCTLEYPYQ-ECSNP---------------AQ
    ..                   .|..|||..|    |||....  ||.|    .|....|..| ||.. .||.. ....                 .
KKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQL

IYKKVTSGVMPNSLNK-----VNDPMLKEIIV----ACTKLSKSARYTVEMLLNHEFF
. ..    .  .. ..       .|  |..|      . |   . |.| | .||| .|
YQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase AqueK219.AA ULK 219-478 22 6.3e-33 112.32 In-house 1-329 (329) Show / Hide 
Range on Protein: 219-478
Range on HMM: 1-329/329
Sequence Identity: 22% (75 aa)

VKYEQEIGRGSFKTVYKGLDTET----GVAVAWCELLEHKFNKEEQSR--------FKEEVAILKTLN--------HPYILRLFDSWEFVRQSDKKRVLV
    ...| ||| .|||| . .|    ...||   ..  |.|.... .        .| |. |.|.|.        ||.| .|.|    . ....   . 
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYD----WFETSNHNNIY

LITELMTSGTLKSYMR----------RFKSIKPRVIRSWGRQILRGLSFLHTRTPPIIHRDLKCDNVFINGTT-----------GLVKIGDLGLATLKRS
.|.|.   |.|..|.           . | .    ...  .||| |. .|| .   |||||.| .|. |.  .           | .||.| |.|    .
IIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKH--NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDN

D------VKTVI------GTPEFMAPEMYDEV-----YDES-VDVYAFGMCLLEMCTLEYPYQECSNPAQI----YKKVTSG------VMPNSLN-----
|       .|        ||| .|||.   .      |... .|.. .|. . || . ..|.... .  |.    .| .  .      .  . |.     
DNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDG

--KVNDPMLKEIIVACTKLSKSARYTVEMLLNHEFF
  ..  | .|..|  . .   . | . | |.||..|
NDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase AqueK219.AA Dicty4 301-431 34 4.2e-27 87.56 In-house 81-228 (277) Show / Hide 
Range on Protein: 301-431
Range on HMM: 81-228/277
Sequence Identity: 34% (52 aa)

TELMTSGTLKSYMRR-----FKSIKPR--VIRS---WGRQILRGLSFLHTRTPPIIHRDLKCDNVFINGTTGLVKIGDLGLAT-----LKRSD-VKTVIG
||.| .|.| |  .       .|||.    |..    .. . ||.  ||...| ||||||| .|  .      ||..|.||..        .|  .|..|
TEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNW-RVKVCDFGLSQYMKKHEDHKDNQMTACG

TPEFMAPE-MYDEVYDESVDVYAFGMCLLEMCTLEYPYQ-ECSNPAQIY
||  |||| |  . |.|..||| ||. | |. | . ||| . ... |..
TPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFV
Kinase AqueK219.AA TyrKc 219-478 24 2.5e-17 57.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 219-478
Range on HMM: 1-280/280
Sequence Identity: 24% (74 aa)

VKYEQEIGRGSFKTVYKGLDTETGVAVAWCELLEHKFNKEEQSRFKEEVAILKTL--NHPYILRLFDSWEFVRQSDKK----RVLVLITELMTSGTLKSY
.. ....|.| | .||||  .   . ||   | |..     .  | .|  |.. |  .|| |.||.     ..|.  .      | ...|.|  | ||.|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYG---VCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

MRRFKS-IKPRVIRSWGRQILRGLSFLHTRTPPIIHRDLKCDNVFINGTTGLVKIGDLGLATLKRSD--------VKTV---IGTPE-----FMAPEMY-
 |. .  ....   |.  || .| ..|| .  ..||||| . |. ..     |||.| ||.    .|        ....    |.        ||||   
LRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

DEVYDESVDVYAFGMCLLEMCTLEYPYQEC-----SNPAQIYKKVTSG-VMPNSLN-------KVNDPMLKEIIVACTKLSKSARYTVEMLLNHEFF
. .. .  ||..|| |. |..|.  .  .       ........| .|  ||   |          | | . |.  | .   . | | . .  ||.|
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase AqueK219.AA Pkinase_Tyr 299-437 25 3.5e-15 52.05 Pfam 84-232 (270) Show / Hide 
Range on Protein: 299-437
Range on HMM: 84-232/270
Sequence Identity: 25% (39 aa)

LITELMTSGTLKSYMRR----FKSIKPRVIRSWGRQILRGLSFLHTRTPPIIHRDLKCDNVFINGTTGLVKIGDLGLATLK-------RSDVKTVIGTPE
...|.|  | |..| |.     .....  . .. .|| .|...|. .   .||||| . |. .. .   |||.| ||| .        |.  ..      
IVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENN-VVKICDFGLARDIYNDDYYYRKRGGGK-LPIK

FMAPE--MYDEVYDESVDVYAFGMCLLEMCTLE-YP-YQECSNPAQIYKKV-TSG
 ||||  .| . . .  ||..|| .. |..|.   | |...  ....|...  .|
WMAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDG
Kinase AqueK219.AA Dicty4 219-279 36 2.4e-07 20.72 In-house 1-61 (277) Show / Hide 
Range on Protein: 219-279
Range on HMM: 1-61/277
Sequence Identity: 36% (22 aa)

VKYEQEIGRGSFKTVYKGLDTETGVAVAWCELLEHKFNKEEQSRFKEEVAILKTLNHPYIL
 . ||.||.||| .||||    . |||    ..  .|  .. . |. ||.|.. . || |.
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNIC
Kinase AqueK219.AA Pkinase_Tyr 219-281 31 2e-06 22.18 Pfam 1-69 (270) Show / Hide 
Range on Protein: 219-281
Range on HMM: 1-69/270
Sequence Identity: 31% (22 aa)

VKYEQEIGRGSFKTVYKGLDT----ETGVAVAWCELLEHKFNKEE--QSRFKEEVAILKTL-NHPYILRL
..  ...|.|.| .||||  .    .|.. ||   |  ..  .|.  .  | .|..|.|.| .|| |.||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL
FRWNK_Wnk1 AqueK219.AA FRWNK_Wnk1 495-567 27 8.2e-11 36.51 In-house 19-92 (92) Show / Hide 
Range on Protein: 495-567
Range on HMM: 19-92/92
Sequence Identity: 27% (20 aa)

DSVMVRLVVPRTSK-ENKKNEQESIEFAYNLQTDIPEDIVNDMVKSGILREEDKKNAIRSVRELTDPLTDPAKQ
...  .|..  . |   |  ..| ||| ..|..|.||... .||.||.. |.| |   .|.|.         ..
SAIKLWLWMEDPKKLKGKYKDNEAIEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER
OSR1_C AqueK219.AA OSR1_C 497-533 26 0.001054 17.19 Pfam 1-38 (38) Show / Hide 
Range on Protein: 497-533
Range on HMM: 1-38/38
Sequence Identity: 26% (10 aa)

VMVRLVVPRTSK-ENKKNEQESIEFAYNLQTDIPEDIV
.  .| .  . | ..|  | | |.|......| ||...
INLWLRMRDPKKRKGKHKENEAIQFEFDIEKDTPEEVA
FRWNK_Wnk2.hmm AqueK219.AA FRWNK_Wnk2.hmm 520-565 23 0.008186 6.93 In-house 18-63 (63) Show / Hide 
Range on Protein: 520-565
Range on HMM: 18-63/63
Sequence Identity: 23% (11 aa)

FAYNLQTDIPEDIVNDMVKSGILREEDKKNAIRSVRELTDPLTDPA
| . |  | ||.| . ||..  . |....  |. .|.  .   .  
FKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM
FRWNK_Wnk2.hmm AqueK219.AA FRWNK_Wnk2.hmm 929-991 28 6.8e-14 44.22 In-house 1-63 (63) Show / Hide 
Range on Protein: 929-991
Range on HMM: 1-63/63
Sequence Identity: 28% (18 aa)

DNVISCSLQTSAGQVINFKFSLDYDKPNEIFNNLVKTGHLSQLEGTDFISQFQKVVDTVRSKS
|... | |.|   ... ||| || |.|.|| . .|.   . . |   || | ..... . .. 
DRMVECQLETHNHKMVTFKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM
OSR1_C AqueK219.AA OSR1_C 944-959 37 12.495883 2.43 Pfam 23-38 (38) Show / Hide 
Range on Protein: 944-959
Range on HMM: 23-38/38
Sequence Identity: 37% (6 aa)

INFKFSLDYDKPNEIF
| |.| .  |.| |. 
IQFEFDIEKDTPEEVA