AqueK253

Species: A.queenslandica
Alias: AqueK253
External Links:
Annotation:

Classification

Group: TK
Family: Csk

Sequence

Name Sequence Type Origin Length Description Download
AqueK253.AA Protein None 213 None Fasta, JSON
AqueK253.kin_dom Protein Kinase Domain None 248 None Fasta, JSON

Protein domain

Protein domains of AqueK253.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK253.AA Pkinase_Tyr 15-207 41 5.6e-84 285.05 Pfam 57-241 (270) Show / Hide
Range on Protein: 15-207
Range on HMM: 57-241/270
Sequence Identity: 41% (82 aa)

MMSF-DNVNVLHLIGVCI-DMGP-APYIVMPFMAKGSLLSYLKKERHNLTVAESSDDDIVLDVRKKLVSICLQVAKGMCYLASHNFIHRDLASRNCMIDD
|... .. |.. |.|||. . .|  .||||..|..|.||.||.| |         .|.  |..   |...|.|.|||| ||.|.|.|||||| |||....
MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR---------EDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE

HGIIKVADFGLTEEVYANNYFKQLKDNNASVKLPIKWMALESLHDGLFSEKSDVWSYGVLCWEVFSLGRTP-YPGLDPAGVVDLL-DTGGRLQCPHNT
 ...|..||||.  .|   |    |  ..   |||||||.|....| |..||||||.|||.||.|..|..| |||.... |.... . |.|. ||.|.
NNVVKICDFGLARDIYNDDYY-YRKRGGGK--LPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENC

Kinase AqueK253.AA TK 11-213 21 8.2e-70 232.97 In-house 90-461 (486) Show / Hide
Range on Protein: 11-213
Range on HMM: 90-461/486
Sequence Identity: 21% (81 aa)

ECIRMMS---FDNVNVLHLIGVCIDMG-----------PAPYIVMPFMAKGS----LLSYLKKERHNLTVAESSDDDIVLDVRK----------------
| . ||.   ..  |...|.||| . .           . ..||| .|..|.    |..||.| |.. .  ... |.   ...                 
EEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHE

----------------------------------------------KLVSICLQVAKGMCYLASH------NFIHRDLASRNCMIDDHGI----------
                                               |. .|.|.|.|| ||.|.      ||.||||| |||.......          
SNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGP

-IKVADFG--------LTEEVYAN-NYFKQLKDNNA-------------------SVKLPIKWMALESLHDGL---------FSEKSDVWSYGVLCWEVF
 .|.||||        |. ..| . .| ..     .                   . ||||.||| |.| |.          |..||||||.|||.||.|
VCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIF

SLGRTPYPG-LDP---------AGVVDLLDTGGR------------LQCPHNTACS--------------QEM
..|..||.| ..          . |...| .|||            ...|    |.              .|.
TYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEY

Kinase AqueK253.AA Met 11-204 39 4.1e-64 209.01 In-house 51-244 (271) Show / Hide
Range on Protein: 11-204
Range on HMM: 51-244/271
Sequence Identity: 39% (83 aa)

ECIRMMSFDNVNVLHLIGVCIDMGP-APYIVMPFMAKGSLLSYLKKERHNLTVAESSDDDIVLDVRKKLVSICLQVAKGMCYLASHNFIHRDLASRNCMI
| | |  ||  ||| |||.|.|     |..| |.|..| |... . . .|..|             . |.. |.|||||| |.||  |.||||| ||||.
EGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNNPCV-------------RDLIEFCHQVAKGMMYMASQKFVHRDLACRNCML

DDHGIIKVADFGLTEEV-YANNYFKQLKDNNASVKLPIKWMALESLH--------DGL-FSEKSDVWSYGVLCWEVFSLGRTPYPGLDP-AGVVDLLDTG
| | ..|||||||   . |   |  | ..  .  .||.||||.|.|         .   |. |||||| ||. || .  | .|||  |.   .   | .|
DEHFTVKVADFGLCRDMDYDKEYYSQ-MHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQG

--GRLQCP
   ||  |
ETRRLPQP

Kinase AqueK253.AA TK-Unique 22-213 31 3.1e-62 213.06 In-house 65-269 (294) Show / Hide
Range on Protein: 22-213
Range on HMM: 65-269/294
Sequence Identity: 31% (67 aa)

NVLHLIGVCIDMGPAPYIVMPFMAKGSLLSYLKKERHN-----------LTVAESSDDDIVLDVR-KKLVSICLQVAKGMCYLAS--HNFIHRDLASRNC
|.....|.|.. .  ..|.|.....|.|..||.. | .            ...   |..   ..  | |.... |.|.|| ||||  ....||||..||.
NIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNV

MIDDHGIIKVADFGLTEEVYANNYFKQLKDNNASVKLPIKWMALESLH--DGLF-SEKSDVWSYGVLCWEVFSLGRTPYPGLDPAGVVDLLDTGGRLQCP
.. .....|..|||....||.    ...  .  . ..||.|||.|||   .| . ..||||||.||| ||.|.|| .||||.... .....  | |.. |
LLTEDKVCKICDFGMARDVYT---NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQP

HNTAC-SQEM
 .  | |.||
EH--CCSHEM

TyrKc AqueK253.AA TyrKc 1-213 26 1.1e-58 202.25 SMART 1-280 (280) Show / Hide
Range on Protein: 1-213
Range on HMM: 1-280/280
Sequence Identity: 26% (77 aa)

TQND-----------------------------VESIVDECIRMMSF--DNVNVLHLIGVCIDMG------PAPYIVMPFMAKGSLLSYLKKERHNLTVA
 . .                             .| . .|   |...  .. |.. |.|||.. |      . ..||| .|..|.|..||.| |..    
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK----

ESSDDDIVLDVRKKLVSICLQVAKGMCYLASHNFIHRDLASRNCMIDDHGIIKVADFGLTEEVYAN-------NYFKQLKDNNASVKLPIKWMALESLHD
            |.|.|.|.|.|.|| ||.|.|.|||||| |||.... ...|..||||. ..|          | .. .  ..   |||.|||.|.. .
---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

GLFSEKSDVWSYGVLCWEVFSLGRTPYPG-----LDPAGVVDLLDTGGRLQCPHN-------------------------------TACSQEM
| |..||||||.||..||.|..| .||||     .... |. ....|.|. .|.|                               ... ...
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase AqueK253.AA UTK 15-213 34 6.7e-57 193.19 In-house 63-271 (296) Show / Hide
Range on Protein: 15-213
Range on HMM: 63-271/296
Sequence Identity: 34% (74 aa)

MMSFD-NVNVLHLIGVCIDMGPAPYIVMPFMAKGSLLSYLKKERHNLTVAESSDDDIVLDVRKK-LVSICLQVAKGMCYLASHNFIHRDLASRNCMIDDH
|. |.  .||| |.||| . .| ..||. .|..|.|.||| . |...        .  . ...  ... ....| || ||.|..|.||||| ||| ...|
MKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRSYLRRHRPTPP-------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMH

G-------IIKVADFG---LTEEVY----ANNYFKQLKDNNA-SVKLPIKWMALESLHDG-LFSEKSDVWSYGVLCWEVFSLGRTPYPGLDPAGVVDLLD
.       ..|.||||   .. .|.    .| |  ..  . .   ..||.||| |.| ..  |..||||||.||.|||... ||.||||.  . |.  . 
RMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVC

TGGRLQCPHNTACSQEM
 |||.. | . .|. ..
NGGRYRMPCPWDCPHPV

Kinase AqueK253.AA Src 22-206 39 1.5e-54 183.74 In-house 55-224 (255) Show / Hide
Range on Protein: 22-206
Range on HMM: 55-224/255
Sequence Identity: 39% (74 aa)

NVLHLIGVCIDMGPAPYIVMPFMAKGSLLSYLKKERHNLTVAESSDDDIVLDVRKKLVSICLQVAKGMCYLASHNFIHRDLASRNCMIDDHGIIKVADFG
....|  || .  |  |||  .|..|||| ||||          ...   | .. .|...  |||.||.|| | |.|||||| ||  .... . ||||||
KLVQLYAVCSQEEPI-YIVTEYMSHGSLLDYLKK----------DGEGRHLHLP-QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFG

LTEEVY--ANNYFKQLKDNNASVKLPIKWMALESLHDGLFSEKSDVWSYGVLCWEVFSLGRTPYPGLDPAGVVDLLDTGGRLQCPHN
|   .    ..|  .        |.||||.| | .. | |. ||||||.|.| .|... ||.|||| . . |.. .. | |. ||||
LARLIKEDDDEYCARH-----GAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHN

Kinase AqueK253.AA Axl 1-206 40 2.7e-51 176.74 In-house 41-239 (267) Show / Hide
Range on Protein: 1-206
Range on HMM: 41-239/267
Sequence Identity: 40% (85 aa)

TQNDVESIVDECIRMMSFDNVNVLHLIGVCIDMG-----PAPYIVMPFMAKGSLLSYLKKERHNLTVAESSDDDIVLDVRKKLVSICLQVAKGMCYLASH
|| ..|  . | . |  ||  ||..|||||| |      |.| ...|||  | | ..|   | .       |. . | . . ||   . .| || ||...
TQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLYSRLG-------DQPFYLPL-QMLVKFMVDIACGMEYLSNR

NFIHRDLASRNCMIDDHGIIKVADFGLTEEVYANNYFKQLKDNNASVKLPIKWMALESLHDGLFSEKSDVWSYGVLCWEVFSLGRTPYPGLDPAGVVDLL
|||||||| ||||. .   . ||||||   .|.  |..|        |.|.||.|.||| | ..  |||||..||  ||.   |.|||||.. . . | |
NFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQ----GCIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIMTRGQTPYPGVENHEMYDYL

DTGGRLQCPHN
  | ||. |..
IHGHRLKQPED

Kinase AqueK253.AA FGFR 20-213 35 1.2e-50 170.86 In-house 64-268 (293) Show / Hide
Range on Protein: 20-213
Range on HMM: 64-268/293
Sequence Identity: 35% (76 aa)

NVNVLHLIGVCIDMGPAPYIVMPFMAKGSLLSYLKKERHNLTVAESSDD-------DIVLDV----------RKKLVSICLQVAKGMCYLASHNFIHRDL
. |.. |.|.|   || .|..  . ..| |  .|.. |     .... .        .  ..           |.|||.  |||.|| ||||   |||||
HKNIINLLGCCTQEGP-LYVIVEYCHHGNLRDFLRARRPPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDL

ASRNCMIDDHGIIKVADFGLTEEVYANNYFKQLKDNNASVKLPIKWMALESLHDGLFSEKSDVWSYGVLCWEVFSLGRTPYPGLD-PAGVVDLLDTGGRL
| ||  . |  ..|..||||   .  . |..  |  |    |||||||.|.| |  .  .||||||||| ||.. .| .|||.        ..| .| |.
AARNVLVTDDYVMKICDFGLARDIHCIDYYR--KTTNG--RLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRM

QCPHNTACSQEM
  |||  ||||.
EKPHN--CSQEI

Kinase AqueK253.AA Fer 15-185 39 6.3e-50 168.25 In-house 62-221 (283) Show / Hide
Range on Protein: 15-185
Range on HMM: 62-221/283
Sequence Identity: 39% (69 aa)

MMS-FDNVNVLHLIGVCIDMGPAPYIVMPFMAKGSLLSYLKKERH-NLTVAESSDDDIVLDVRKKLVSICLQVAKGMCYLASHNFIHRDLASRNCMIDDH
|.. .|  ||  ..||| |  |  .||| |.  |||.|||||. . .....|             .. .|.|.|.|| || |.| ||||.|.||| ....
MRNNYDHPNVVKFYGVCVDEQPI-MIVMEFCNGGSLDSYLKKNKNKTVSDNE-------------KIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKD

GIIK---VADFGLTEEVYANNYFKQLKDNNASVKLPIKWMALESLHDGLFSEKSDVWSYGVLCWEVFSLGRTPYPG
.. |   ..|||.  .   . | ...|.  .. |.||.|.| |.. .|..|.|.||||.||.|||.|. | .||||
KVKKKCKISDFGMSRQCSDYGYDYKMKE--KACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPG

Kinase AqueK253.AA InsR 15-186 37 2.3e-49 163.93 In-house 58-225 (278) Show / Hide
Range on Protein: 15-186
Range on HMM: 58-225/278
Sequence Identity: 37% (66 aa)

MMSFDNVNVLHLIGVCIDMGPAPYIVMPFMAKGSLLSYLKKERHNLTVAESSDDDIVLD------VRKKLVSICLQVAKGMCYLASHNFIHRDLASRNCM
|  |.  .|  | |||    |. |.|| .|..| | |||   |.          ....        . ....   ... || |||. .|.||||| ||||
MKEFNCHHVVRLLGVCSRGQPM-YVVMEMMTYGDLKSYLRSRRPEEEF-----NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCM

IDDHGIIKVADFGLTEEVYANNYFKQLKDNNASVKLPIKWMALESLHDGLFSEKSDVWSYGVLCWEVFSLGRTPYPGL
... . .|..|||.|  .|   | .  .      .||. ||| ||| || |. .|||||.||. ||. .||  || ||
VNHDFTVKIGDFGMTRDIYEHDYYRKGGKG----MLPVRWMAPESLKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGL

Kinase AqueK253.AA Tec 28-205 40 4.9e-49 169.23 In-house 61-221 (254) Show / Hide
Range on Protein: 28-205
Range on HMM: 61-221/254
Sequence Identity: 40% (73 aa)

GVCIDMGPAPYIVMPFMAKGSLLSYLKKERHNLTVAESSDDDIVLDVRKK--LVSICLQVAKGMCYLASHNFIHRDLASRNCMIDDHGIIKVADFGLTEE
|||.   |  |||  .|..|.||.||....| .              ..   | ..|..| .|| || .|.||||||| ||| ..| ...||.|||.|  
GVCSQQRPI-YIVTEYMEHGCLLNYLREHKHHFQ-------------KNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRY

VYANNYFKQLKDNNASV--KLPIKWMALESLHDGLFSEKSDVWSYGVLCWEVFSLGRTPYPGLDPAGVVDLLDTGGRLQCPH
|    |         ||  | |.|| . | .|   .| |||||..||| |||||.|. ||. ..   ||.   .| ||  ||
VLDDQYT-------SSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYENMSNSEVVEHVSQGHRLYRPH

Kinase AqueK253.AA Pkinase 22-122 24 3.8e-13 47.55 Pfam 61-158 (293) Show / Hide
Range on Protein: 22-122
Range on HMM: 61-158/293
Sequence Identity: 24% (28 aa)

NVLHLIGVCIDMGPAPYIVMPFMAKG----SLLSYLKKERHNLTVAESSDDDIVLDVRKKL-------VSICLQVAKGMCYLASHNFIHRDLASRNCMID
|.. |.... | .. .|.||... .|    .| .|..                  . ....        ....|...|. |. |...||||| . |..||
NIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST-----------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID

DHGII----KVADFGL
..| |    |..||||
NNGHIDACVKICDFGL

Kinase AqueK253.AA S_TKc 2-213 19 2.6e-11 -11.0 SMART 19-231 (231) Show / Hide
Range on Protein: 2-213
Range on HMM: 19-231/231
Sequence Identity: 19% (48 aa)

QNDV-----------ESIVDECIRMMSFDNVNVLHLIGVCIDMGPAPYIVMPFMAK--GSLLSYLKKERHN-----LTVAESSDDDIVLDVRKKLVSICL
..             |.|  |   ... .  |. .|..|. |     |.|| ..    |.|..|.|| ...     ..  .               ... 
RHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H-------------ARFYMY

QVAKGMCYLASHNFIHRDLASRNCMIDDHGIIKVADFGLTEEVYANNYFKQLKDNNASVKLPIKWMALESLHDGLFSE-KSDVWSYGVLCWEVFSLGRTP
|..... |. ||..|||||   | ..|.   ||..||||  ..              ..     .|| | |    ..  |.|.|| |.. .| .. |..|
QICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPP

YPGLDPAGVVDLL---------------DTGGRLQCPHNTA------CSQEM
.|  ... . ...               |   |. .    .      | . .
FP--QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase AqueK253.AA Pkinase 160-185 42 0.00065 14.92 Pfam 190-214 (293) Show / Hide
Range on Protein: 160-185
Range on HMM: 190-214/293
Sequence Identity: 42% (11 aa)

SEKSDVWSYGVLCWEVFSLGRTPYPG
. |.|.||.|....|... ||.|.||
GPKVDMWSCGCILYEMLC-GRPPFPG