Gene AqueK277 (A.queenslandica)
AqueK277
Species: A.queenslandica
Alias: AqueK277
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| AqueK277.AA | Protein | None | 687 | None | Fasta, JSON |
| AqueK277.kin_dom | Protein Kinase Domain | None | 192 | None | Fasta, JSON |
Protein domains of AqueK277.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Pkinase_Tyr | AqueK277.AA | Pkinase_Tyr | 444-647 | 38 | 5e-93 | 315.69 | Pfam | 82-270 (270) | Show / Hide |
Range on Protein: 444-647 Range on HMM: 82-270/270 Sequence Identity: 38% (80 aa) MMIVLELIPHGDMRQYLHTLQPKYVLSVDYVINIVYYRPGELVASTVPGLLLSFCRQIASGMEYLSKKGFVHRDLAARNILIADHGMCKIADFGMSRDL- ..||.|. ||||.. ||.. | . . ||..|.|||.|||||. |...||||||||.|... . .||.|||..||. IYIVMEYMPHGDLLDYLRKHR-------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIY HDENY-YVSTAKMIPIKWTAPEALAYKRYSSASDVWSYGVVMYEIWSLGHKP-FENYTNQEYMKLI-DTGFRLPPPPGCPRSIYEMMIQCWHPKTSGRPV .|..| .... ..||||.|||...|......|||||.||.|.|| ..| .| ... .|.| ...| . | |.|.|..|| ||..| ||||.. . || NDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPT FADIVSKF |..|.... FSEIHEQL |
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| Kinase | AqueK277.AA | TK | 444-647 | 25 | 7.6e-85 | 284.27 | In-house | 130-486 (486) | Show / Hide |
Range on Protein: 444-647
Range on HMM: 130-486/486
Sequence Identity: 25% (91 aa)
MMIVLELIPHGD----MRQYLHTLQPKYVLSVDYVI-------------------------NIVYYRPGELVAS--------------------------
.|||.|. |||| |.||.. || . | | . ... . .
WMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTC
---TVPGLLLSFCRQIASGMEYLSKK------GFVHRDLAARNILIADHGM-----------CKIADFGMS--------RDL-HDENYYVST--------
. || .|.|||.|||||..| .||||||||||.|..... |||||||.| ||. .|..||...
KHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPM
----------------AKMIPIKWTAPEALA---------YKRYSSASDVWSYGVVMYEIWSLGHKPFEN-YTN---------QEYMKLIDTG-------
..||.|.|||.|. |......|||||.||.|.||...| .|. .| || |... .|
WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSG
-------FRLPPPPGCP--------------RSIYEMMIQCWHPKTSGRPVFADIVSKF
.|.|.||.|| .|..| ||||.. . || |.......
LNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | AqueK277.AA | Eph | 501-647 | 50 | 4.3e-77 | 258.5 | In-house | 114-264 (264) | Show / Hide |
Range on Protein: 501-647 Range on HMM: 114-264/264 Sequence Identity: 50% (76 aa) IASGMEYLSKKGFVHRDLAARNILIADHGMCKIADFGMSRDLHDEN----YYVSTAKMIPIKWTAPEALAYKRYSSASDVWSYGVVMYEIWSLGHKPFEN ||||| ||| ..|||||||||||. . .||..|||.|| | |. | .. |||.||||||.||....|||||||||.|| |. | | .|. . IASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWD YTNQEYMKLIDTGFRLPPPPGCPRSIYEMMIQCWHPKTSGRPVFADIVSKF .||. .| |. |.|||||..||......| .||. . || |..||| . MSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL |
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| Kinase | AqueK277.AA | UTK | 444-647 | 35 | 1.4e-76 | 260.73 | In-house | 85-296 (296) | Show / Hide |
Range on Protein: 444-647 Range on HMM: 85-296/296 Sequence Identity: 35% (81 aa) MMIVLELIPHGDMRQYLHTLQPKYVLSVDYVINIVYYRPGELVASTVPGLLLSFCRQIASGMEYLSKKGFVHRDLAARNILIADHG-------MCKIADF .|||.|. . ||.|.|| . |. . .. .|.....||.||.||. .|||||||||||.|...|. |||||| WMIVTEYMENGDLRSYLRRHRPTPP---------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADF G---MSRDLH---------DENYYVST-AKMIPIKWTAPEALAYK-RYSSASDVWSYGVVMYEIWSLGHKPFENYTNQEYMKLIDTG--FRLPPPPGCPR | |||... . .|| .. ....||.|.|||||.. |....|||||.|||..|||. | .|.....|.. . . | |.|.|..||. GRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPH SIYEMMIQCWHPKTSGRPVFADIVSKF ..|..| .|||. . || | |.|... PVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | AqueK277.AA | Src | 494-647 | 41 | 4.9e-70 | 237.13 | In-house | 99-255 (255) | Show / Hide |
Range on Protein: 494-647 Range on HMM: 99-255/255 Sequence Identity: 41% (65 aa) LLSFCRQIASGMEYLSKKGFVHRDLAARNILIADHGMCKIADFGMSRDLH--DENYYVSTAKMIPIKWTAPEALAYKRYSSASDVWSYGVVMYEIWSLGH |... |.|.||.||... ..||||||||.|. .. .||.|||| | . |..| .. ..|||||||||. | |.. |||||.|. ..|| . | LIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGR KPFENYTNQEYMKLIDTGFRLPPPPGCPRSIYE-MMIQCWHPKTSGRPVFADIVSKF | . ||.| .. .. |.|.| |..|| ..|| | |||| . || |. . ... VPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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| Kinase | AqueK277.AA | TK-Unique | 444-647 | 35 | 1.9e-69 | 237.07 | In-house | 80-294 (294) | Show / Hide |
Range on Protein: 444-647 Range on HMM: 80-294/294 Sequence Identity: 35% (77 aa) MMIVLELIPHGDMRQYLHTLQPKYVLS-----VDYVINIVYYRPGELVASTVP-GLLLSFCRQIASGMEYLSK--KGFVHRDLAARNILIADHGMCKIAD .||..| .| |. . ||.| .|. . . .. ... ..| . ... ..|..|. |||.|||||.. |..|||||.|||.|......|||.| WMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLK---FDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICD FGMSRDLHDENYYVSTAK--MIPIKWTAPEALA--YKRY-SSASDVWSYGVVMYEIWSLGHKPFENYTNQEYMKLIDTGFRLPPPPGC-PRSIYEMMIQC |||.||..... |... . .|||.| |||.| .. | .. |||||.||.|.|| .|| |. .. . . |..| |.|.| |..| .. .|. |..| FGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSC WHPKTSGRPVFADIVSKF |. . . || |..|.... WQWEPEERPSFRQIKHRL |
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| Kinase | AqueK277.AA | Tec | 492-649 | 42 | 1.3e-64 | 220.94 | In-house | 97-254 (254) | Show / Hide |
Range on Protein: 492-649 Range on HMM: 97-254/254 Sequence Identity: 42% (68 aa) GLLLSFCRQIASGMEYLSKKGFVHRDLAARNILIADHGMCKIADFGMSRDLHDENYYVST-AKMIPIKWTAPEALAYKRYSSASDVWSYGVVMYEIWSLG ..||. | .. ||.|| ...|.|||||||| |. | . |..||||.| | | |. .| |.|| .|| . | |||| ||||..|| | |..|.| AILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKF-PVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCG HKPFENYTNQEYMKLIDTGFRLPPPPGCPRSIYEMMIQCWHPKTSGRPVFADIVSKFGS |.||..| | . . .|.|| | |. .||. | .||| | .|| |.. .. KMPYENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE |
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| Kinase | AqueK277.AA | Ack | 492-647 | 42 | 2.5e-63 | 212.46 | In-house | 105-266 (266) | Show / Hide |
Range on Protein: 492-647 Range on HMM: 105-266/266 Sequence Identity: 42% (69 aa) GLLLSFCRQIASGMEYLSKKGFVHRDLAARNILIADH-GMCKIADFGMSRDL-HDENYYVSTAKM---IPIKWTAPEALAYKRYSSASDVWSYGVVMYEI ..|. ||.|||.|| || |...|||||||||| . . ||.||| .| | |.||.. . .|. | |||.| ... |.|||||..|| . | HTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVTLWEM WSLGHKPFENYTNQEYMKLID-TGFRLPPPPGCPRSIYEMMIQCWHPKTSGRPVFADIVSKF | | .|. .. . ...|| | ||| |. ||. ||.|| ||| .. || |..|. .. FSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL |
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| Kinase | AqueK277.AA | HMTK | 494-646 | 42 | 4.9e-62 | 212.4 | In-house | 130-291 (291) | Show / Hide |
Range on Protein: 494-646 Range on HMM: 130-291/291 Sequence Identity: 42% (69 aa) LLSFCRQIASGMEYLSKKGFVHRDLAARNILIADHGMCKIADFGMSRDLH-DENYYVSTAKM--IPIKWTAPEALA--YKRYSSASDVWSYGVVMYEIWS .|.||.|.||||.|......||.||||||.|... .|||||| .| | ...|.... | |||| ||||.. .|. | .||||..||.| |||. QLYFCVQCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLTRRLDPGQDYWHLRKHMVKLPIKWMAPEAMDGKRKIFSEKSDVWAFGVTMWEIWM LGHKPFE--NYTNQEYMKLIDTGFRLP-PPPG-CPRSIYEMMIQCWHPKTSGRPVFADIVSK | |.| |.|... . | || |||. || .....| .||| . || ||. . YGEQPYESQQIKNKEVQRHVREGRRLTQPPPDDCPDDFWDLMCTCWHKDPHQRPTFAQLQKM |
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| Kinase | AqueK277.AA | Fer | 497-648 | 36 | 9.3e-61 | 205.65 | In-house | 116-283 (283) | Show / Hide |
Range on Protein: 497-648 Range on HMM: 116-283/283 Sequence Identity: 36% (61 aa) FCRQIASGMEYLSKKGFVHRDLAARNILIADHGM---CKIADFGMSRDLHDENYYVS---TAKMIPIKWTAPEALAYKRYSSASDVWSYGVVMYEIWSLG .| |.|.||||| .|. .|||.||||.|. ... |||.||||||.. |. | . .|...||.|.|||.. .. ||...||||.||...|| . | MCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNG HKPFEN----YTNQEY-----MKLIDTGFRLPPPPGCPRSIYEMMI-QCWHPKTSGRPVFADIVSKFG .|... .. . .. |. | ..|.|...| |.. | |||. ... || ...|. |. AEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
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| Kinase | AqueK277.AA | Syk | 500-641 | 48 | 2.8e-60 | 206.19 | In-house | 114-257 (257) | Show / Hide |
Range on Protein: 500-641 Range on HMM: 114-257/257 Sequence Identity: 48% (70 aa) QIASGMEYLSKKGFVHRDLAARNILIADHGMCKIADFGMSRDL-HDENYYVS-TAKMIPIKWTAPEALAYKRYSSASDVWSYGVVMYEIWSLGHKPFENY |.|.|| || | ||||||||||.| . . || |||||. | |..||.. |. |.|| ||| | |..|||||.|| | | |.| || QVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMWEMFSYGQKPYGEM TNQEYMKLIDTGFRLPPPPGCPRSIYEMMIQCWHPKTSGRPVFA ..|| ||.|. | |.. |.|||. .|. | .|| | || | KGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV |
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| Kinase | AqueK277.AA | TyrKc | 444-647 | 28 | 1.4e-58 | 201.89 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 444-647
Range on HMM: 1-280/280
Sequence Identity: 28% (87 aa)
M-------------------------------------------------------------------------MIVLELIPHGDMRQYLHTLQPKYVLS
|||.|. |||| ..||. .||
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK----
VDYVINIVYYRPGELVASTVPGLLLSFCRQIASGMEYLSKKGFVHRDLAARNILIADHGMCKIADFGMSRDLHDE-------NYYVS----TAKM-IPIK
. ||||| |||.|||||..|...||||||||.|... . .||.|||.|||..|. ||.. .|. .||.
------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR
WTAPEALAYKRYSSASDVWSYGVVMYEIWSLGHKPFEN-----YTNQEYMKLIDTGFRLPPPPG--------CPRSIYEMMIQCWHPKTSGRPVFADIVS
|.|||.. |......|||||.||.|.|| ..| .| .. .||| ......|.|.|.|| || .|..| |||| . . || |..|..
WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE
KF
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CF
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| Kinase | AqueK277.AA | Pkinase | 496-647 | 22 | 2e-19 | 69.77 | Pfam | 112-293 (293) | Show / Hide |
Range on Protein: 496-647 Range on HMM: 112-293/293 Sequence Identity: 22% (42 aa) SFCRQIASGMEYLSKKGFVHRDLAARNILIADHGMC----KIADFGMSRDLHDENYYVSTAKMIP---IKWTAPEALA-YKRYSSASDVWSYGVVMYEIW ....||..|.||. ..|..|||| |||| ..| . ||.||| .. . | .. . . . . ||| . .. |....|.||.|...|| FYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEML SLGHKPFENY-------TNQEYMKLIDTGFRLPPPPGCP-------------------RSIYEMMIQCWHPKTSGRPVFADIVSK--F . |. || . .| . . .. .. . | |. .. . . |.... . || ...|. | C-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | AqueK277.AA | S_TKc | 445-648 | 18 | 7.4e-12 | -3.04 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 445-648 Range on HMM: 1-231/231 Sequence Identity: 18% (48 aa) MIVLELIPHGDM---------------------------RQYLHTLQPKYVLSVDYVIN-IVYYRPGELVAS--------------------TVPGLLLS .|..| .| . .| |. . ... .|. .| |.. . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF FCRQIASGMEYLSKKGFVHRDLAARNILIADHGMCKIADFGMSRDLHDENYYVSTAKMIPIKWTAPEALAYKRYSS-ASDVWSYGVVMYEIWSLGHKPFE ...||....||. ..|..|||| |||. . ||.|||..| | | . ||| | |. ..|.|| |...|| . | ||. YMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP NYTNQEYMKLIDTGFRLPPPPGCPRSIYEMMIQCWHPKTSGRPVFADIVS--------KFG . |. .|.| ... ... .|.. . || .. . --QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | AqueK277.AA | Syk | 444-460 | 47 | 0.035225 | 3.28 | In-house | 79-95 (257) | Show / Hide |
Range on Protein: 444-460 Range on HMM: 79-95/257 Sequence Identity: 47% (8 aa) MMIVLELIPHGDMRQYL || |.|. . | | .|| MMMVMEMAELGPMHKYL |
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| Kinase | AqueK277.AA | Fer | 445-460 | 43 | 0.0928 | 1.9 | In-house | 85-100 (283) | Show / Hide |
Range on Protein: 445-460 Range on HMM: 85-100/283 Sequence Identity: 43% (7 aa) MIVLELIPHGDMRQYL |||.|....|. . || MIVMEFCNGGSLDSYL |
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