Gene AqueK347 (A.queenslandica)

AqueK347

Species: A.queenslandica
Alias: AqueK347
External Links:
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
AqueK347.AA Protein None 437 None Fasta, JSON
AqueK347.kin_dom Protein Kinase Domain None 119 None Fasta, JSON

Protein domain

Protein domains of AqueK347.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK347.AA TK 285-429 29 3.3e-58 193.37 In-house 235-462 (486) Show / Hide 
Range on Protein: 285-429
Range on HMM: 235-462/486
Sequence Identity: 29% (67 aa)

KQLLSICLQVANGMCYLASQ------RFIHRDLAARNCMIDDNGI-----------IKVADFG--------LSEDIYA-KNYFRQFKRNSNDSPSL----
.||| .|.|.|.|| ||.|.      .|.|||||||||....|..           .|.||||        |. |||  ..| |.  .  .. .      
HQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFED

----------TTVKLPVKWMAIESLHDGL---------FSEKTDVWSYGILCWEVFSLGRVPYPGLDPV----------GVVEFLDTGGR----------
          .  |||..||| |.| |.          |..|.||||.|.|.||.|..|..||.|  .            |.|.| .|||          
DPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVG

--LLAPRGEACS--------------KEIY
  .  |. . |.              .|.|
YRMRMPQPPHCPDWMRYRMHPPHCPPEEYY
Kinase AqueK347.AA Met 285-419 42 1.2e-55 180.84 In-house 104-244 (271) Show / Hide 
Range on Protein: 285-419
Range on HMM: 104-244/271
Sequence Identity: 42% (63 aa)

KQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDI-YAKNYFRQFKRNSNDSPSLTT-VKLPVKWMAIESLH--------DGL-
..|.. |.||| || |.|||.|.|||||.||||.|   ..|||||||. |. | | |  |  .        |   .||||||| |.|         .   
RDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHH--------THPARLPVKWMAPECLQQGVCLGCPTYRQ

FSEKTDVWSYGILCWEVFSLGRVPYPGLDP-VGVVEFLDTG--GRLLAP
|. |.|||| |.. || .  | .|||  |. . .  .| .|   ||. |
FTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQP
Kinase AqueK347.AA UTK 286-429 35 5.5e-51 172.67 In-house 119-272 (296) Show / Hide 
Range on Protein: 286-429
Range on HMM: 119-272/296
Sequence Identity: 35% (55 aa)

QLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNG-------IIKVADFG---LSEDIYAKNYFRQFKRNSNDSPSLTTVKLPVKWMAIESLHDG-LF
|.|. ....|.|| ||.|..|.||||||||| .....       ..|.||||   .| ....   |     .|. . .    ..|..||| |.| ..  |
QRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFH-FSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRF

SEKTDVWSYGILCWEVFSLGRVPYPGLDPVGVVEFLDTGGRLLAPRGEACSKEIY
..|.||||.|..|||... ||.||||.  . |....  |||.. |. ..|. ..|
TTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVY
Kinase AqueK347.AA TK-Unique 285-430 38 1.1e-50 172.93 In-house 131-271 (294) Show / Hide 
Range on Protein: 285-430
Range on HMM: 131-271/294
Sequence Identity: 38% (58 aa)

KQLLSICLQVANGMCYLAS--QRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYAKNYFRQFKRNSNDSPSLTTVKLPVKWMAIESLH--DGLF-SEKTD
|.|.... |.|.|| ||||  ....||||.|||... .....|..|||...|.|.         |   | . .  ..|..||| |||   .| . ..|.|
KDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT---------NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSD

VWSYGILCWEVFSLGRVPYPGLDPVGVVEFLDTGGRLLAPRGEAC-SKEIYS
|||.|.| ||.|.||  ||||...  ..| .  | |.. |  | | |.|.|.
VWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQP--EHCCSHEMYN
BING4CT AqueK347.AA BING4CT 14-92 53 1.1e-49 176.2 Pfam 1-80 (80) Show / Hide 
Range on Protein: 14-92
Range on HMM: 1-80/80
Sequence Identity: 53% (43 aa)

PYLKY-RLSGQLHKLQFCPFEDCLGLGHSNGFTSIVVPGAGEANIDGLEVNPYQSKRQRQEWEVKALLEKIPADLIMLEP
||... . ... ....|||||| || |||.||.|..|||.||.|.| .| |||..| |||||||..||||.|...|.| |
PYMTHMKPGSKICSVRFCPFEDVLGIGHSHGFSSMIVPGSGEPNFDSYEANPYETKKQRQEWEVRQLLEKLPPEMISLDP
Kinase AqueK347.AA KIN6 285-429 40 6.2e-48 156.39 In-house 144-281 (305) Show / Hide 
Range on Protein: 285-429
Range on HMM: 144-281/305
Sequence Identity: 40% (61 aa)

KQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNG---IIKVADFGLSEDIYAKNYFRQFKRNSNDSPSLTTVK-LPVKWMAIESLHDGLFSEKTDV
|.|...  |...|| ||.| ..|||||||||  ..        |. ||||   .|.     ||  .|         . ||.|||| |.|    || |.||
KDLYMFAWQICDGMEYLHSKNCIHRDLAARNVLVTEGCRMKTCKISDFGLCRYPYMD----QFQYTSK------GGRYLPIKWMAPECLKHYEFSYKSDV

WSYGILCWEVFSLGRVPYPGLD-PVGVVEFLDTGGRLLAPRGEACSKEIY
||.|.| .|.|||| ||||..  |. . |..  |.|.. |  . |..|||
WSFGVLMFEMFSLGDVPYPEMQRPTEMIEHHRSGRRPKHP--KWCPEEIY
Kinase AqueK347.AA HMTK 287-401 41 2.7e-47 163.01 In-house 130-240 (291) Show / Hide 
Range on Protein: 287-401
Range on HMM: 130-240/291
Sequence Identity: 41% (50 aa)

LLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIY-AKNYFRQFKRNSNDSPSLTTVKLPVKWMAIESLH--DGLFSEKTDVWSY
.|..| |.| || |.||||..|.|||||||.. .| ..|.|||||.  .   ..|... |.       .  ||||.||||.| .   .. ||||.|||..
QLYFCVQCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLTRRLDPGQDYWHLRKH-------M--VKLPIKWMAPEAMDGKRKIFSEKSDVWAF

GILCWEVFSLGRVPYP--GL
|...||... |..||.  ..
GVTMWEIWMYGEQPYESQQI
Kinase AqueK347.AA VEGFR 285-403 43 1.7e-45 157.46 In-house 173-283 (332) Show / Hide 
Range on Protein: 285-403
Range on HMM: 173-283/332
Sequence Identity: 43% (53 aa)

KQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSED-IYAK-NYFRQFKRNSNDSPSLTT-VKLPVKWMAIESLHDGLFSEKTDVW
. |..  .|||.|| .|||.  |||||||||  .. | ..|  ||||. . ||   .| |.           .   .|| ||||.||. |  .. . |||
EDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRK-----------GDQGRLPIKWMAPESIFDKVYTTYSDVW

SYGILCWEVFSLGRVPYPGLDP
|||.. ||.|||| .|||| ..
SYGVFLWEIFSLGGSPYPGVQI
Kinase AqueK347.AA Src 285-429 41 5.5e-45 150.75 In-house 97-230 (255) Show / Hide 
Range on Protein: 285-429
Range on HMM: 97-230/255
Sequence Identity: 41% (61 aa)

KQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIY--AKNY-FRQFKRNSNDSPSLTTVKLPVKWMAIESLHDGLFSEKTDVW
.||...  |||.||.|| |...|||||||||  ...| . |||||||   |     .|  |.              |.|.||.| | .. | |. |.|||
PQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH------------GAKFPIKWTAPEAINYGRFTIKSDVW

SYGILCWEVFSLGRVPYPGLDPVGVVEFLDTGGRLLAPRGEACSKEIY
|.||| .|... ||||||| .   |.. .. | |.  |. . | .|.|
SFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRM--PCPHNCPDELY
Kinase AqueK347.AA FGFR 285-429 43 8.8e-45 150.53 In-house 136-269 (293) Show / Hide 
Range on Protein: 285-429
Range on HMM: 136-269/293
Sequence Identity: 43% (64 aa)

KQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYAKNYFRQFKRNSNDSPSLTTVKLPVKWMAIESLHDGLFSEKTDVWSYG
|.| |.  ||| || ||||.. |||||||||  . |. ..|..||||. ||    |.|  |.        |   ||.|||| |.| |  .  . ||||||
KDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYR--KT--------TNGRLPIKWMAPEALFDRVYTHQSDVWSYG

ILCWEVFSLGRVPYPGLD-PVGVVEFLDTGGRLLAPRGEACSKEIY
.| ||.. .|  |||.        ..| .| |.  |  . ||.|||
VLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKP--HNCSQEIY
Kinase AqueK347.AA ALK 287-421 47 1e-44 152.27 In-house 113-241 (273) Show / Hide 
Range on Protein: 287-421
Range on HMM: 113-241/273
Sequence Identity: 47% (66 aa)

LLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNG---IIKVADFGLSEDI-YAKNYFRQFKRNSNDSPSLTTVKLPVKWMAIESLHDGLFSEKTDVWS
|| .|. || |  || ...||||| |||||     |   . |.|||| . || |   |.|   |         .  .|||||  | . ||.|  ||||||
LLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGR---------AM-MPVKWMPPEAFMDGIFTSKTDVWS

YGILCWEVFSLGRVPYPGLDPVGVVEFLDTGGRLLAPRG
.|.||||.||||..||||     | ||. .|||.  ||.
FGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRN
SR AqueK347.AA SR 168-272 41 5.4e-43 150.07 SMART 1-118 (118) Show / Hide 
Range on Protein: 168-272
Range on HMM: 1-118/118
Sequence Identity: 41% (49 aa)

VQLVDGDVPNVGRVEICINN----EWGTVCDDGWTHTNAEVVCRQLGYPTIDAAYLN----RAFFGPGAGPIYLDEVVCTGSEETILNCSHSGIGIND--
| ||.|. |. ||||. .|.    .|||||||.|. ..|.|||||||...  .|. .    .|.||.|.|||..|.| |||.| .. .|.|.|.| ..  
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCTGTETSLWDCPHWGWGQHNNC

CSHDAD---KERANLTVA
|||. .   .| | ..  
CSHNHHRNRQEDAGVVCS
SRCR AqueK347.AA SRCR 171-263 44 2.4e-39 133.96 Pfam 1-106 (112) Show / Hide 
Range on Protein: 171-263
Range on HMM: 1-106/112
Sequence Identity: 44% (47 aa)

VDGDVPNVGRVEICI-NNEWGTVCDD-G-WTHTNAEVVCRQLGY-PTIDAAYLNRAF--FG--PGAGPIYLDEVVCTGSEETILNCSHSGIGI--ND--C
|.|..|. ||||..  |..||||||| | |. ..|.|||||||. ..   |. ..|.  ||  || |||..|.| |.|.| .. .|.||. |   ..  |
VGGSSPCEGRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPGTGPIWMDNVRCHGNETSLWQCPHSPWGWHRHNPMC

SHD-AD
||.  |
SHSRED
Kinase AqueK347.AA Pkinase_Tyr 358-430 45 1.3e-32 111.02 Pfam 175-247 (270) Show / Hide 
Range on Protein: 358-430
Range on HMM: 175-247/270
Sequence Identity: 45% (34 aa)

KLPVKWMAIESLHDGLFSEKTDVWSYGILCWEVFSLGRVP-YPGLDPVGVVEFL-DTGGRLLAPRGEACSKEIYS
|||.|||| |....| |..|.||||.|.|.||.|..|. | |||...  |.|.. . |.|. .|..  |..|||.
KLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPEN--CPDEIYD
Kinase AqueK347.AA Pkinase_Tyr 285-340 55 1.1e-29 101.14 Pfam 111-166 (270) Show / Hide 
Range on Protein: 285-340
Range on HMM: 111-166/270
Sequence Identity: 55% (31 aa)

KQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYAKNY
|.||..|.|.|.|| ||.|...||||||||||....|...|..||||. ||| . |
KDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDY
TyrKc AqueK347.AA TyrKc 87-434 18 2.1e-25 91.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 87-434
Range on HMM: 1-280/280
Sequence Identity: 18% (77 aa)

LIMLEP---QNLTQVYTGPIEAENNTQRNDKGKKKKIVLKMKKRGRSTPGKLASRKQKILDRRARQLLK--AKLRST--------KAKGCVE--------
. ...     .  .|| |                 .   || | .                   . ...    ...         .  |..         
ITLGKKLGEGAFGEVYKGTWK-------------IQVAVKMLKEDA-----------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMY

-GDVQLVDGDVPNVGRVEICINNEWGTVCDDGWTHTNAEVVCRQLGYPTIDAAYLNRAFFGPGAGPIYLDEVVCTGSEETILNCSHSGIGINDCSHDADK
 . . .|   .|. |     . .  ..                                                                         
IEPLMIVMEYMPH-GDLKDYLRKHRPK-------------------------------------------------------------------------

ERANLTVADTSEEDIVLNVRKQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYAK-------NYFRQFKRNSNDSPSLTTV
                |.. |.|||.|.|.|.|| ||.|...||||||||||....|...|..||||| ||| .        | |. ..           
----------------LCM-KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEH--------KGG

K--LPVKWMAIESLHDGLFSEKTDVWSYGILCWEVFSLGRVPYPG-----LDPVGVVEFLDTGGRLLAPRGEA------CSKEIYS--------------
|  ||..|||.|.. .| |..|.||||.|...||.|..|  ||||     ...  |.|....|.|.  |          |..|.|.              
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

-----PDDF
      ..|
TFSEIHECF
Kinase AqueK347.AA Pkinase 285-400 29 9.5e-15 53.23 Pfam 108-214 (293) Show / Hide 
Range on Protein: 285-400
Range on HMM: 108-214/293
Sequence Identity: 29% (36 aa)

KQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGII----KVADFGLSEDIYAKNYFRQFKRNSNDSPSLTTVKLPVKWMAIESLH-DGLFSEKTD
... ....|.. |. |. |...|||||   |..||.|| |    |..||||.. ..              .. .||.     .|| | .  .   . | |
WECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VWSYGILCWEVFSLGRVPYPG
.||.|....|... || |.||
MWSCGCILYEMLC-GRPPFPG
S_TKc AqueK347.AA S_TKc 179-435 16 4.8e-09 -44.29 SMART 13-231 (231) Show / Hide 
Range on Protein: 179-435
Range on HMM: 13-231/231
Sequence Identity: 16% (47 aa)

GRVEICINNEWGTVCDDGWTHTNAEVVCRQLGYPTIDAAYLNRAFFGPGAGPIYLDEVVCTGSEETILNCSHSGIGINDCSHDADK-----ERANL---T
|.|  |....           |. .| . ..                       . |. .  .           . . |. .| |.     | ..    .
GKVYKCRHKK-----------TGRIVAIKIIK-------------------EHIRREIQILKK------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGD

VADTSEEDIV------LNVRKQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYAKNYFRQFKRNSNDSPSLTTVKLPVKWM
. |  ..         ..   .  ... |..... |. |...|||||   | ..|.   ||..||||.  .                   ||.     .|
LFDYIKKRGRHGLRFPFPE--HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------TTFCGTPWYM

AIESLHDGLFSE-KTDVWSYGILCWEVFSLGRVPYPGLDPVGV-------VEFLDTGGRLLAPRGE--ACSKEIYS---P---DDFM
| | |    ..  | |.|| |.. .| .. |. |.|    . .        |..|   ..|    |      |.         . ..
APEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF