Gene AqueK351 (A.queenslandica)

AqueK351

Species: A.queenslandica
Alias: AqueK351
External Links:
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
AqueK351.AA Protein None 1168 None Fasta, JSON
AqueK351.kin_dom Protein Kinase Domain None 137 None Fasta, JSON

Protein domain

Protein domains of AqueK351.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF2368 AqueK351.AA DUF2368 1-129 43 5.7e-47 167.16 Pfam 1-131 (141) Show / Hide 
Range on Protein: 1-129
Range on HMM: 1-131/141
Sequence Identity: 43% (58 aa)

MGSFFTKPMSNVMD-ENMKKQQEFQLSAQKMQMERQMMMQVQMRNKGVAQQLSMAREAFNW--YAGFYVTATLGMIAGFAKTKNPAVLSPLIPLTFLVGY
||. |   .|. |. |||||.||| |  ..|||||.  |. ||. .  | |.. .|| |.|  .|.|| .||.|...|. |.|.|... |..||.| .||
MGQVF--SFSKSMQAENMKKCQEFMLHNYRMQMERWIQMHNQMWERQMAMQIAWHREFFHWEVFACFYCLATVGCAMGAYKHKKPLHVIPIVPLSFICGY

QADMALGNKMERILNDADKILSNETG-LLRLPG
|.||. | || ||  .| .|.  | . || .|.
QYDMCYGDKMHRIREEAEMIMEHEQEALLMWPK
FN3 AqueK351.AA FN3 389-465 17 0.015414 13.01 SMART 1-69 (69) Show / Hide 
Range on Protein: 389-465
Range on HMM: 1-69/69
Sequence Identity: 17% (16 aa)

TGSPSN---LVYSRDSLP------SVTLGWSPSAVISATPQYHVFVNNSNGIIINANTTNTELSLS-LRPD----DEYNIRLVAT--GEDLPS
 |.|.|   |. .  .        |||| |.|  ... .                         .. |.|.     ||..|..|   ... ..
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-IVGYR-----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 AqueK351.AA FN3 785-862 18 3e-07 31.34 SMART 1-69 (69) Show / Hide 
Range on Protein: 785-862
Range on HMM: 1-69/69
Sequence Identity: 18% (17 aa)

PESVNN---TMVYPISDD------SLFIDWSAPGSLCIDHYNVTIISNNTNSESITTNSTNVTIDFLITG----TDYSFIIVPVD-TGGREG
| .. |     | .....      |. . |..|    | .|                    .|.. |  |    | |.| .. |. ... ||
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----IVGYR-------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase AqueK351.AA Pkinase_Tyr 1031-1168 36 6.7e-47 159.47 Pfam 11-143 (270) Show / Hide 
Range on Protein: 1031-1168
Range on HMM: 11-143/270
Sequence Identity: 36% (53 aa)

EFGIVYKATMK-PMNKSEQEIALKTLKGEFSKSD--VNSLLEECLLMSNF-DNPNVLSLIGVCADLGSA--PGIIMPYMSKGSLLSYLQKEKSHLIVEAT
.|| |||.|.|  . . ... | |.||   ....    ....|  .|... ..||...|.||| | |    . |.|.|| .|.||.||.| .        
AFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR--------

SEESTVLINVRKELLSVCLQVANGMNYLASQRFIHRDLAARNCL
  |.   ...   ||. |.|.|.||.||.|...|||||||||||
--EDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCL
Kinase AqueK351.AA Met 1032-1168 35 3.7e-42 135.82 In-house 11-136 (271) Show / Hide 
Range on Protein: 1032-1168
Range on HMM: 11-136/271
Sequence Identity: 35% (50 aa)

FGIVYKATMKPMNKSEQEIALKTLK----GEFSKSDVNSLLEECLLMSNFDNPNVLSLIGVCADLGS-APGIIMPYMSKGSLLSYLQKEKSHLIVEATSE
|| ||.... .    |  .| |.|.    ..  .  .   |.| ..|. || ||||||||.| |  .  | .. ||| .| |...   ..  . |     
FGCVYHGMYHDNDGNEHHCACKSLHGERITDIQH--ISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNNPCV-----

ESTVLINVRKELLSVCLQVANGMNYLASQRFIHRDLAARNCL
         ..|.. |.||| ||.|.|||.|.|||||.|||.
---------RDLIEFCHQVAKGMMYMASQKFVHRDLACRNCM
Kinase AqueK351.AA TK 1031-1168 19 4.3e-36 117.94 In-house 11-272 (486) Show / Hide 
Range on Protein: 1031-1168
Range on HMM: 11-272/486
Sequence Identity: 19% (52 aa)

EFG---IVYKATMKPMN----------------------KSEQEIALKTLKGEFSKSDVNSLL-------------EECLLMSNFD-----NPNVLSLIG
.||    |||......|                      . ... | |.|| . . |.   ..             ||.. |. ..      ||...|.|
QFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYG

VCADLG-----------SAPGIIMPYMSKGS----LLSYLQKEKSHLIVEATSEE---------------------------------------------
|| . .             . |.| ||..|.    |..||.| . . . |. . .                                             
VCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPP

---STVLIN-------------VRKELLSVCLQVANGMNYLASQ------RFIHRDLAARNCL
    . |..               ..||  |.|.|.|| ||.|.      .|.||||||||||
PLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCL
Kinase AqueK351.AA UTK 1031-1168 31 1.2e-32 108.97 In-house 11-150 (296) Show / Hide 
Range on Protein: 1031-1168
Range on HMM: 11-150/296
Sequence Identity: 31% (46 aa)

EFGIVYKATMKPMN--KSEQEIALKTLK-GEFSKSDVN---SLLEECL---LMSNFD-NPNVLSLIGVCADLGSAPGIIMPYMSKGSLLSYLQKEKSHLI
.||.|.||. .. .    |.  |.|... ....  .      ..||.    .|..|.  |||| |.||| . .  . |.. ||..|.|.|||.. .  . 
AFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRSYLRRHRPTPP

VEATSEESTVLINVRKELLSVCLQVANGMNYLASQRFIHRDLAARNCL
      . ... . . ..|. ....|.||.||.|..|.||||||||||
------ACPHWLTLH-QRLCMAWDIARGMQYLHSCGFVHRDLAARNCL
Kinase AqueK351.AA TK-Unique 1021-1168 26 1.8e-29 98.87 In-house 1-165 (294) Show / Hide 
Range on Protein: 1021-1168
Range on HMM: 1-165/294
Sequence Identity: 26% (43 aa)

PLDLNSAYQSEFGIVYKATMKP--MNKSEQ-EIALKTLKGEFSKSDVNSLLEECLLMSNFD-NPNVLSLIGVCADLGSAPGIIMPYMSKGSLLSYLQKEK
.  ... .. .|| |.......  .. ..|  .|.|.|| .... |.  .| |  .|.. .  ||.....|.| . .  . |||.|...|.|..||.. .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

SH---------LIVEATSEESTVLIN-VR-KELLSVCLQVANGMNYLAS--QRFIHRDLAARNCL
           |   . ....... . .  | |.. . |.|.||.||||  ....||||.|||.|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVL
Kinase AqueK351.AA Fer 1032-1168 34 4.2e-24 79.07 In-house 12-143 (283) Show / Hide 
Range on Protein: 1032-1168
Range on HMM: 12-143/283
Sequence Identity: 34% (51 aa)

FGIVYKA--TMKPMN--KSEQ---EIALKTLKGEFSKSD-VNSLLEECLLMSN-FDNPNVLSLIGVCADLGSAPGIIMPYMSKGSLLSYLQKEKSHLIVE
||.|||.  |.| ..  ....   ... |..|.|... .  . .. |  .| | .| |||  ..|||.|   .  |.| ... |||.|||.|.|.     
FGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDE-QPIMIVMEFCNGGSLDSYLKKNKNK----

ATSEESTVLINVRK-ELLSVCLQVANGMNYLASQRFIHRDLAARNCL
          .|   |..  |.|.|.||.|| |.  ||||.||||||
----------TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCL
Kinase AqueK351.AA Axl 1031-1168 32 2.4e-23 79.4 In-house 11-145 (267) Show / Hide 
Range on Protein: 1031-1168
Range on HMM: 11-145/267
Sequence Identity: 32% (47 aa)

EFGIVYKATMKPMNKSEQEIALKTLK-GEFSKSDVNSLLEECLLMSNFDNPNVLSLIGVCADLGS-----APGIIMPYMSKGSLLSYLQKEKSHLIVEAT
||| |  . .|    | . .| |..|   ...|..   | |   | .|| |||. |||||  . .     .| .|.|.|  | | ..|        . . 
EFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFL--------LYSR

SEESTVLINVRKELLSVCLQVANGMNYLASQRFIHRDLAARNCL
 ..  . . .   |.   . .| || ||....|||||||||||.
LGDQPFYLPLQM-LVKFMVDIACGMEYLSNRNFIHRDLAARNCM
Kinase AqueK351.AA TKL 1032-1168 22 6.1e-22 75.8 In-house 6-172 (364) Show / Hide 
Range on Protein: 1032-1168
Range on HMM: 6-172/364
Sequence Identity: 22% (43 aa)

FGIVYKATMKP------MNKSEQEIALKTLKG----EFSKSDVN---------------------SLLEECL-LMSNFDNPNVLSLIGVCADLGSA----
||.|||.. .          . ...| |..|     ||.|.. .                       .|| . .||... ||.....|.| . ..     
FGEVYKGKWRGWGGKCPS-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCM

--------PGIIMPYMSKGSLLSYLQKEKSHLIVEATSEESTVLINVRKELLSVCLQVANGMNYLASQR--------FIHRDLAARNCL
        ..|.| |...||||.||.                        ... .|..| ||||| |..         |||||  .|.|
HPVGPWGQLCIVMEYCPGGSLLHYLH---------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNIL
Kinase AqueK351.AA Sev 1032-1168 34 9.4e-22 69.1 In-house 12-146 (277) Show / Hide 
Range on Protein: 1032-1168
Range on HMM: 12-146/277
Sequence Identity: 34% (48 aa)

FGIVYKATMKPMN---KSEQEIALKTLKGEFSKSDVNSLLEECLLMSNFDNPNVLSLIGVCADLGSAPGIIMPYMSKGSLLSYLQKEKSHLIVEATSEES
|| ||  ..|        || .| |||.     ..   .| |  |||.|  ||.. ..||| |  .   |||  |  | ||.|| .       .      
FGEVYEGQAKDIDGVGEEEQRVAIKTLRKGSTDQEKQEFLKEAHLMSKFKHPNIVCQMGVCLDNEPQ-YIIMEHMEGGDLLCYLRAARMTTFQNPQPTAG

TVLINVRKELLSVCLQVANGMNYLASQRFIHRDLAARNCL
  |.    .|.  |. ...|  ||    |.|||||.||||
LTLM----DLVEMCIDISKGCEYLEDMHFVHRDLACRNCL
Kinase AqueK351.AA Src 1049-1168 35 3.5e-20 65.23 In-house 25-129 (255) Show / Hide 
Range on Protein: 1049-1168
Range on HMM: 25-129/255
Sequence Identity: 35% (43 aa)

EIALKTLKGEFSKSDVNSLLEECLLMSNFDNPNVLSLIGVCADLGSAPG-IIMPYMSKGSLLSYLQKEKSHLIVEATSEESTVLINVRKELLSVCLQVAN
. | ||||      ... .|.|  .| ... .....|  || .    |  |.  |||.|||| ||.|         ..|.... ..   .|..   |||.
KVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE--PIYIVTEYMSHGSLLDYLKK---------DGEGRHLHLP---QLIDMAAQVAE

GMNYLASQRFIHRDLAARNCL
||.|| |...||||||||| |
GMAYLESMNYIHRDLAARNVL
Kinase AqueK351.AA Tec 1098-1168 42 2.8e-19 64.09 In-house 71-129 (254) Show / Hide 
Range on Protein: 1098-1168
Range on HMM: 71-129/254
Sequence Identity: 42% (30 aa)

IIMPYMSKGSLLSYLQKEKSHLIVEATSEESTVLINVRKELLSVCLQVANGMNYLASQRFIHRDLAARNCL
|.  ||..|.||.|| ..| |.. . .             ||..|..|  || || .. ||||||||||||
IVTEYMEHGCLLNYLREHKHHFQKNMAI------------LLEMCQDVCEGMAYLERHCFIHRDLAARNCL
Kinase AqueK351.AA Pkinase 1032-1162 23 3.3e-12 44.27 Pfam 12-134 (293) Show / Hide 
Range on Protein: 1032-1162
Range on HMM: 12-134/293
Sequence Identity: 23% (33 aa)

FGIVYKATMKPMNKSEQEIALKTLKGEFSKSDVNSLLE---ECLLMSNFDNPNVLSLIGVCADLGSAPGIIMPYMSKG----SLLSYLQKEKSHLIVEAT
|| |||.. |  .|   . |.|..| .  ||...  .    |. .| ... ||.. |.... | .. . ..|.|. .|    .| .|..           
FGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST----------

SEESTVLINVRKELLSVCLQVANGMNYLASQRFIHRDL
 .......   .|. ....|.. |..|. |...|||||
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDL
Kinase AqueK351.AA TyrKc 1022-1168 17 1.1e-09 -66.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 1022-1168
Range on HMM: 1-280/280
Sequence Identity: 17% (52 aa)

LDLNSAYQS-EFGIVYKATMKPMNKSEQEIALKTLKGEFSKSDVNSLLEECLLMSNF--DNPNVLSLIGVCADLG------SAPGIIMPYMSKGSLLSYL
. |.    . .||.|||.|.|      .. | |.|| .     .  ...|  .|...  ..||.. |.||| . |        . |.| ||..|.|..||
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QKEKSHLIVEATSEESTVLINVRKELLSVCLQVANGMNYLASQRFIHRDLAARNC---------------------------------------------
.| . .             ... |.||| |.|.|.||.||.|...||||||||||                                             
RKHRPK-------------LCM-KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

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IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

---L
   .
HECF
Kinase AqueK351.AA S_TKc 1028-1168 12 0.000918 -121.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 1028-1168
Range on HMM: 1-231/231
Sequence Identity: 12% (32 aa)

YQSE-------FGIVYKATMKPMNKSEQEIALKTLKGEFSKSDVNSLLEECLLMSNFDNPNVLSLIGVCADLGSAPGIIMPYMSK--GSLLSYLQKEKSH
|.         || |||.. |    . .. |.| .|        .... |  .... . ||.  |..|. |  .   ..| |..   |.|..|..| ..|
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH

L----IVEATSEESTVLINVRKELLSVCLQVANGMNYLASQRFIHRDL----------------------------------------A-----------
     . | .               ... |......|. |...|||||                                                    
GLRFPFPE-H-------------ARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCI

-----------------------------------------------A-------RNCL
                                               .          .
LYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF