Gene AqueK358 (A.queenslandica)

AqueK358

Species: A.queenslandica
Alias: AqueK358
External Links:
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
AqueK358.AA Protein None 610 None Fasta, JSON
AqueK358.kin_dom Protein Kinase Domain None 178 None Fasta, JSON

Protein domain

Protein domains of AqueK358.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SR AqueK358.AA SR 20-121 31 2.3e-36 128.07 SMART 1-118 (118) Show / Hide 
Range on Protein: 20-121
Range on HMM: 1-118/118
Sequence Identity: 31% (37 aa)

IRLVNGGGPNVGRLEICRNN----IWELVCNNDWSYTNAQVVCRQLGHPTDGATVLN----ETYFGAGNGSILLGDIVCSGSESTILQCTHSSVGSHN--
.|||.|..|. ||.|.  |.     |  || ..|. ..|.||||||| ..  ... .      .||.|.| |.. .. |.|.|... .|.|...|.||  
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCTGTETSLWDCPHWGWGQHNNC

CGP------NDTVGIQCA
|.       .  .|. | 
CSHNHHRNRQEDAGVVCS
SRCR AqueK358.AA SRCR 23-121 33 2.5e-32 110.4 Pfam 1-112 (112) Show / Hide 
Range on Protein: 23-121
Range on HMM: 1-112/112
Sequence Identity: 33% (38 aa)

VNGGGPNVGRLEICR-NNIWELVCNN-D-WSYTNAQVVCRQLGHPTDGATV-LNETY--FG--AGNGSILLGDIVCSGSESTILQCTHSSVGS--HN--C
|.| .|. ||.|... |. |  ||.. . |. ..|.||||||| . ... .  ...|  ||  .|.| |.. .. |.|.|... || ||. |   ||  |
VGGSSPCEGRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPGTGPIWMDNVRCHGNETSLWQCPHSPWGWHRHNPMC

GPN-DTVGIQCA
. .   .|..|.
SHSREDAGVICS
Kinase AqueK358.AA Pkinase_Tyr 307-462 38 1.4e-59 202.41 Pfam 11-162 (270) Show / Hide 
Range on Protein: 307-462
Range on HMM: 11-162/270
Sequence Identity: 38% (62 aa)

EFGIVYRGVMT-IENKIPEPVAIKTLKGFYKESD--IDSLLDECIIMMSF-DNLNVLPLIGVCLDLGPA--PYIIMPFMSRGSLLSYLKKERPNLTVADT
.|| ||.|...  . .   |||.|.||  . ...  ..... |  ||... .. |.. |.|||.| |    .||.|..|  |.||.||.| |        
AFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR--------

SEEDIILNVRKQLLSICLQVANGMSYLASQRFIHRDLAARNCMIDDNGIIKVADFGISEDIY
 |..  |..   ||..|.|.|.||.||.|...||||||||||....|...|..||| . |||
-EDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIY
Kinase AqueK358.AA Met 308-462 38 1.1e-50 164.28 In-house 11-156 (271) Show / Hide 
Range on Protein: 308-462
Range on HMM: 11-156/271
Sequence Identity: 38% (61 aa)

FGIVYRGVMTIENKIPEPVAIKTLK--GFYKESDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGP-APYIIMPFMSRGSLLSYLKKERPNLTVADTSEED
|| ||.| .. .    ...|.|.|.      .  |   | | |.|  ||  ||| |||.|||     |... |.|  | |... . .  |..|       
FGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNNPCV-------

IILNVRKQLLSICLQVANGMSYLASQRFIHRDLAARNCMIDDNGIIKVADFGISEDI-Y
      ..|.. |.||| ||.|.|||.|.|||||.||||.|   ..|||||| . |. |
------RDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDY
Kinase AqueK358.AA TK 297-462 20 2.8e-46 152.7 In-house 1-310 (486) Show / Hide 
Range on Protein: 297-462
Range on HMM: 1-310/486
Sequence Identity: 20% (63 aa)

ILPSSTIITSEFG---IVYRGVMTIEN----------------------KIPEPVAIKTLKGFYKESDIDSLL---------------DECIIMMS---F
|    ..   .||    ||.| .  .|                      . ..|||.|.||    .|. . ..                | . ||.   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DNLNVLPLIGVCLDLG-----------PAPYIIMPFMSRGS----LLSYLKKERP-----------------------------NLTVADTSEEDIILNV
.  |.. |.|||.. .           . ..|.| .|. |.    |..||.| ||                             ..  .. .... . . 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY-SHESNSPC-PEEQ

---------------RKQLLS-------------------ICLQVANGMSYLASQ------RFIHRDLAARNCMIDDNGI-----------IKVADFGIS
                |.||.                   .|.|.|.||.||.|.      .|.|||||||||....|..           .|.|||| |
DYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

--------EDIY
         |||
RQGSGVLARDIY
Kinase AqueK358.AA Pkinase_Tyr 474-610 37 9.3e-46 155.6 Pfam 11-143 (270) Show / Hide 
Range on Protein: 474-610
Range on HMM: 11-143/270
Sequence Identity: 37% (54 aa)

EFGIVYRGVMT-NNPQLPKAVAVKTLKGFYKESD--IDSLLDECLIMMSF-DDLNVLPLIGVCLDLGPA--PYIIMPFMSRGSLLSYLKKERPNLTVADT
.|| ||.|...    .    ||||.||  . ...  ..... |  ||... .  |.. |.|||.| |    .||.|..|  |.||.||.| |        
AFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR--------

SEEDIILNVRKQLLSICLQVANGMSYLASQRFIHRDLAARNCM
 |..  |..   ||..|.|.|.||.||.|...||||||||||.
-EDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCL
Kinase AqueK358.AA Met 475-610 37 1.6e-42 137.07 In-house 11-136 (271) Show / Hide 
Range on Protein: 475-610
Range on HMM: 11-136/271
Sequence Identity: 37% (52 aa)

FGIVYRGVMTNNPQLPKAVAVKTLK--GFYKESDIDSLLDECLIMMSFDDLNVLPLIGVCLDLGP-APYIIMPFMSRGSLLSYLKKERPNLTVADTSEED
|| ||.| .. | ..   .|.|.|.      .  |   | | ..|  ||  ||| |||.|||     |... |.|  | |... . .  |..|       
FGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNNPCV-------

IILNVRKQLLSICLQVANGMSYLASQRFIHRDLAARNCM
      ..|.. |.||| ||.|.|||.|.|||||.||||
------RDLIEFCHQVAKGMMYMASQKFVHRDLACRNCM
Kinase AqueK358.AA TK-Unique 297-463 28 7.8e-41 138.56 In-house 1-185 (294) Show / Hide 
Range on Protein: 297-463
Range on HMM: 1-185/294
Sequence Identity: 28% (52 aa)

ILPSSTIITSEFGIVYRGVMTIEN---KIPEPVAIKTLKGFYKESDIDSLLDECIIMMSFD-NLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKER
.   ..| . .|| |.|| ..  .     .  ||.|.||    . | . .|.|  .|.. .   |.. ..|.| . .  ..|||.....|.|..||.. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

P---------NLT-VADTSEEDIILN-VR-KQLLSICLQVANGMSYLAS--QRFIHRDLAARNCMIDDNGIIKVADFGISEDIYA
|         ||   ... ...  .. .  |.|.... |.|.||.||||  ....||||.|||... .....|..|||...|.|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT
Kinase AqueK358.AA UTK 297-458 29 1.3e-40 136.6 In-house 1-175 (296) Show / Hide 
Range on Protein: 297-458
Range on HMM: 1-175/296
Sequence Identity: 29% (53 aa)

ILPSSTIITSEFGIVYRGVMT-IENKIPE-PVAIKTLK-GFYKESDID---SLLDECI---IMMSFD-NLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLS
. .. ..   .||.|...  | . .  .|  ||.|... .  .. . .    .. |.    .|. |.   ||| |.|||.. .| ..|.. .|..|.|.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

YLKKERPNLTVADTSEEDIILNVRKQLLSICLQVANGMSYLASQRFIHRDLAARNCMIDDNG-------IIKVADFG---IS
|| . ||..      ... .|. . |.|. ....|.||.||.|..|.||||||||| .....       ..|.||||    |
YLRRHRPTPP-----ACPHWLTLH-QRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMS
Kinase AqueK358.AA TK 464-610 18 1.5e-38 126.31 In-house 1-272 (486) Show / Hide 
Range on Protein: 464-610
Range on HMM: 1-272/486
Sequence Identity: 18% (51 aa)

CNYFRQLKGSEFG---IVYRGVMTNNP----------------------QLPKAVAVKTLKGFYKESDIDSLL-------------DECLIMMSFD----
  . ..|   .||    ||.| . . .                      . .  ||||.||    .|. . ..              |...|. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-DLNVLPLIGVCLDLG-----------PAPYIIMPFMSRGS----LLSYLKKERP-----------------------------NLTVADTSEEDIILNV
   |.. |.|||.. .           . ..|.| .|. |.    |..||.| ||                             ..  .. .... . . 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY-SHESNSPC-PEEQ

---------------RKQLLS-------------------ICLQVANGMSYLASQ------RFIHRDLAARNCM
                |.||.                   .|.|.|.||.||.|.      .|.|||||||||.
DYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCL
Kinase AqueK358.AA UTK 474-609 32 1.5e-35 119.11 In-house 11-149 (296) Show / Hide 
Range on Protein: 474-609
Range on HMM: 11-149/296
Sequence Identity: 32% (47 aa)

EFGIVYRGVMTN-NPQLPK-AVAVKTLK-GFYKESDID---SLLDECL---IMMSFD-DLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKERPNLT
.||.|...  |. ... .. .||||... .  .. . .    .. |.    .|. |.   ||| |.|||.. .| ..|.. .|..|.|.||| . ||.. 
AFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRSYLRRHRPTPP

VADTSEEDIILNVRKQLLSICLQVANGMSYLASQRFIHRDLAARNC
     ... .|. . |.|. ....|.||.||.|..|.|||||||||
-----ACPHWLTLH-QRLCMAWDIARGMQYLHSCGFVHRDLAARNC
Kinase AqueK358.AA Axl 296-469 36 1.8e-33 115.86 In-house 1-171 (267) Show / Hide 
Range on Protein: 296-469
Range on HMM: 1-171/267
Sequence Identity: 36% (65 aa)

VILPSSTIITSEFGIVYRGVMTIENKIPEPVAIKTLK-GFYKESDIDSLLDECIIMMSFDNLNVLPLIGVCLDLG-----PAPYIIMPFMSRGSLLSYLK
..|   ..   ||| |  | .  |      ||.|..|     .|.|.  | | . |  ||  ||. |||||. .      |.| .|.|||  | | ..| 
FVL-GKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLL

KERPNLTVADTSEEDIILNVRKQLLSICLQVANGMSYLASQRFIHRDLAARNCMIDDNGIIKVADFGISEDIYACNYFRQ
  |         .. . | . . |.   . .| || ||....||||||||||||. ..  . |||||.|  ||.  |.||
YSR-------LGDQPFYLPL-QMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQ
Kinase AqueK358.AA InsR 308-468 32 4.5e-33 108.35 In-house 12-176 (278) Show / Hide 
Range on Protein: 308-468
Range on HMM: 12-176/278
Sequence Identity: 32% (55 aa)

FGIVYRG----VMTIENKIPEPVAIKTLKGFYKESDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKERPNLTVADTSEE
|| || |    ..  |  .  ..||||..      .    | |  .|  |.  .|  | |||    |. |..| .| .| | |||   ||        . 
FGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPM-YVVMEMMTYGDLKSYLRSRRPEEEF---NNP

DII----LNVRKQLLSICLQVANGMSYLASQRFIHRDLAARNCMIDDNGIIKVADFGISEDIYACNYFR
...       . |...   ... ||.|||.  |.|||||.||||... . .|..|||   |||   | |
GCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYR
Kinase AqueK358.AA TK-Unique 464-610 29 1.8e-31 105.82 In-house 1-165 (294) Show / Hide 
Range on Protein: 464-610
Range on HMM: 1-165/294
Sequence Identity: 29% (48 aa)

CNYFRQLKGSEFGIVYRGVMTNNP---QLPKAVAVKTLKGFYKESDIDSLLDECLIMMSFDDL-NVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKER
 . ....   .|| |.|| .....     .| ||||.||    . | . .|.|  .|.. .|  |.. ..|.| . .  ..|||.....|.|..||.. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

P---------NLT-VADTSEEDIILN-VR-KQLLSICLQVANGMSYLAS--QRFIHRDLAARNCM
|         ||   ... ...  .. .  |.|.... |.|.||.||||  ....||||.|||..
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVL
Kinase AqueK358.AA Src 325-456 40 9.7e-31 101.62 In-house 25-142 (255) Show / Hide 
Range on Protein: 325-456
Range on HMM: 25-142/255
Sequence Identity: 40% (54 aa)

PVAIKTLKGFYKESDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKERPNLTVADTSEEDIILNVRKQLLSICLQVANGM
.||.||||      . . .| |  || ...  ... |  || .  |  ||.  .||.|||| ||||          ..|   |... ||...  |||.||
KVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPI-YIVTEYMSHGSLLDYLKK----------DGEGRHLHLP-QLIDMAAQVAEGM

SYLASQRFIHRDLAARNCMIDDNGIIKVADFG
.|| |...|||||||||  ...| . ||||||
AYLESMNYIHRDLAARNVLVGENNVCKVADFG
Kinase AqueK358.AA Abl 297-458 37 9e-30 96.1 In-house 1-144 (252) Show / Hide 
Range on Protein: 297-458
Range on HMM: 1-144/252
Sequence Identity: 37% (61 aa)

ILPSSTIITSEFGIVYRGVMTIENKIPEPVAIKTLKGFYKESDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKERPNLT
|     .    .| || ||    ...   ||.||||      ...  | |  ||      |.  |.|||    |  |||  ||. | || ||..      
IMMKHKLGGGQYGEVYEGVWKRHDCT---VAVKTLK--EDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPF-YIITEFMCYGNLLDYLRE------

VADTSEEDIILNVRKQLLSICLQVANGMSYLASQRFIHRDLAARNCMIDDNGIIKVADFGIS
 .| .| . .      || .  |.| ||||| .. |||||||||||.. .. |.||||||..
-CDREELPAVV-----LLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLA
Kinase AqueK358.AA TKL 303-458 21 9.6e-29 100.63 In-house 1-201 (364) Show / Hide 
Range on Protein: 303-458
Range on HMM: 1-201/364
Sequence Identity: 21% (48 aa)

IITSEFGIVYRGVMTIEN--KIP----EPVAIKTLKG----FYKESDID---------------------SLLDECIIMMS-FDNLNVLPLIGVCLDLGP
|    ||.||.|.   ..  . |    ..||.|..|     .  ... .                       . | | ||| ..  |.....|.|.. ..
IGSGGFGEVYKGKWRGWGGKC-PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

A------------PYIIMPFMSRGSLLSYLKKERPNLTVADTSEEDIILNVRKQLLSICLQVANGMSYLASQR--------FIHRDLAARNCMIDDNGI-
             ..|.| ....||||.||                       |.....|..| ||.|| |..         |||||  .|...|.|.  
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTN

-------------IKVADFGIS
             .|..|||.|
VSNYMYNPNADWCCKICDFGLS
Kinase AqueK358.AA TyrKc 297-528 24 9.8e-29 102.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 297-528
Range on HMM: 1-280/280
Sequence Identity: 24% (74 aa)

ILPSSTIITSEFGIVYRGVMTIENKIPEPVAIKTLKGFYKESDIDSLLDECIIMMSF--DNLNVLPLIGVCLDLG------PAPYIIMPFMSRGSLLSYL
|    ..   .||.||.|...      ..||.|.||       .  ...|  ||...  .. |.. |.|||.. |      . ..|.| .|. |.|..||
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKERPNLTVADTSEEDIILNVRKQLLSICLQVANGMSYLASQRFIHRDLAARNCMIDDNGIIKVADFGISEDIYAC-------NYFRQLK--GSE-----
.| ||.            |.. |.|||.|.|.|.||.||.|...||||||||||....|...|..||| | |||          | |. .  |.      
RKHRPK------------LCM-KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

---------------------FGIV-----------YRGV---MTNNPQLPKAVAVK--TLKGFY--------KESDIDSLLDECLIM-----MSFDDLN
                     ||..           | |.   | .| .. . |       .  .          ... ..  .|         .| .. 
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-

VLPL
.  .
HECF
Kinase AqueK358.AA ALK 308-468 35 1.9e-27 91.81 In-house 12-172 (273) Show / Hide 
Range on Protein: 308-468
Range on HMM: 12-172/273
Sequence Identity: 35% (60 aa)

FGIVYRGVMTI--ENKIPEPVAIKTLKGFYKESDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKERPNLTVADTSEE--
|| || |  .       | .||.|||.   .. |    . |  ||  |.  ||  .||.|..  |  .|.  .|. | ..|.|.  ||.       .|  
FGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPY-MIVLEYMEGGDMKSFLRECRPH-------PESL

DIILNVRKQLLSICLQVANGMSYLASQRFIHRDLAARNCMIDDNG---IIKVADFGISEDI-YACNYFR
   . . | || .|. || |  || ...||||| |||||     |   . |.|||| . || |   |.|
QPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYR
Kinase AqueK358.AA InsR 475-610 30 5.1e-24 77.47 In-house 12-151 (278) Show / Hide 
Range on Protein: 475-610
Range on HMM: 12-151/278
Sequence Identity: 30% (44 aa)

FGIVYRG----VMTNNPQLPKAVAVKTLKGFYKESDIDSLLDECLIMMSFDDLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKERPNLTVADTSEE
|| || |    .. ...    ..|.||..      .    | |  .|  |.  .|  | |||    |. |..| .| .| | |||   ||        . 
FGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPM-YVVMEMMTYGDLKSYLRSRRPEEEF---NNP

DII----LNVRKQLLSICLQVANGMSYLASQRFIHRDLAARNCM
...       . |...   ... ||.|||.  |.|||||.||||
GCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCM
Kinase AqueK358.AA ALK 475-609 35 9.9e-24 78.8 In-house 12-142 (273) Show / Hide 
Range on Protein: 475-609
Range on HMM: 12-142/273
Sequence Identity: 35% (50 aa)

FGIVYRGVMTN--NPQLPKAVAVKTLKGFYKESDIDSLLDECLIMMSFDDLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKERPNLTVADTSEE--
|| || |  .   .   | .||.|||.   .. |    . | |||  |.. ||  .||.|..  |  .|.  .|. | ..|.|.  ||.       .|  
FGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPY-MIVLEYMEGGDMKSFLRECRPH-------PESL

DIILNVRKQLLSICLQVANGMSYLASQRFIHRDLAARNC
   . . | || .|. || |  || ...||||| |||||
QPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNC
Kinase AqueK358.AA Src 493-608 41 1.7e-23 76.66 In-house 26-127 (255) Show / Hide 
Range on Protein: 493-608
Range on HMM: 26-127/255
Sequence Identity: 41% (48 aa)

VAVKTLKGFYKESDIDSLLDECLIMMSFDDLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKERPNLTVADTSEEDIILNVRKQLLSICLQVANGMS
|||||||      . . .| |  || ...  ... |  || .  |  ||.  .||.|||| ||||          ..|   |... ||...  |||.||.
VAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPI-YIVTEYMSHGSLLDYLKK----------DGEGRHLHLP-QLIDMAAQVAEGMA

YLASQRFIHRDLAARN
|| |...|||||||||
YLESMNYIHRDLAARN
Kinase AqueK358.AA Abl 465-610 38 3.7e-23 73.68 In-house 2-129 (252) Show / Hide 
Range on Protein: 465-610
Range on HMM: 2-129/252
Sequence Identity: 38% (56 aa)

NYFRQLKGSEFGIVYRGVMTNNPQLPKAVAVKTLKGFYKESDIDSLLDECLIMMSFDDLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKERPNLTV
    .| |  .| || ||     .  . |||||||      ...  | |  ||      |.  |.|||    |  |||  ||. | || ||..       
MMKHKLGGGQYGEVYEGVWK---RHDCTVAVKTLK--EDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPF-YIITEFMCYGNLLDYLRE-------

ADTSEEDIILNVRKQLLSICLQVANGMSYLASQRFIHRDLAARNCM
.| .| . .      || .  |.| ||||| .. |||||||||||.
CDREELPAVV-----LLYMATQIASGMSYLEKRHFIHRDLAARNCL
Kinase AqueK358.AA Axl 474-610 37 1.1e-22 77.05 In-house 11-145 (267) Show / Hide 
Range on Protein: 474-610
Range on HMM: 11-145/267
Sequence Identity: 37% (53 aa)

EFGIVYRGVMTNNPQLPKAVAVKTLK-GFYKESDIDSLLDECLIMMSFDDLNVLPLIGVCLDLG-----PAPYIIMPFMSRGSLLSYLKKERPNLTVADT
||| |  | .  .      ||||..|     .|.|.  | |   |  ||  ||. |||||. .      |.| .|.|||  | | ..|   |        
EFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLYSR-------L

SEEDIILNVRKQLLSICLQVANGMSYLASQRFIHRDLAARNCM
 .. . | . . |.   . .| || ||....||||||||||||
GDQPFYLPL-QMLVKFMVDIACGMEYLSNRNFIHRDLAARNCM
Kinase AqueK358.AA TKL 470-604 20 4.3e-21 72.71 In-house 1-166 (364) Show / Hide 
Range on Protein: 470-604
Range on HMM: 1-166/364
Sequence Identity: 20% (39 aa)

LKGSEFGIVYRGVMTNNPQLP------KAVAVKTLKG----FYKESDID---------------------SLLDECLIMMS-FDDLNVLPLIGVCLDLGP
.    ||.||.|.  ...         | ||||..|     .  ... .                       . | . ||| ..  |.....|.|.. ..
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

A------------PYIIMPFMSRGSLLSYLKKERPNLTVADTSEEDIILNVRKQLLSICLQVANGMSYLASQR--------FIHRDL
             ..|.| ....||||.||                       |.....|..| ||.|| |..         |||||
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDL
Kinase AqueK358.AA Pkinase 308-459 24 4.9e-15 54.25 Pfam 12-160 (293) Show / Hide 
Range on Protein: 308-459
Range on HMM: 12-160/293
Sequence Identity: 24% (41 aa)

FGIVYRGVMTIENKIPEPVAIKTLKGFYKESDID--SLL-DECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRG----SLLSYLKKERPNLTVADT
|| ||...   ..|    ||.|..|   ..|. |   ..  |. || ...  |.. |.... | .. .|..|...  |    .| .|..           
FGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST----------

SEEDIIL--NVRKQLLSICLQVANGMSYLASQRFIHRDLAARNCMIDDNGII----KVADFGISE
 ...  .     ... ....|.. |. |. |...|||||   |..||.|| |    |..|||...
-WRHGCFYFS-EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAK
Kinase AqueK358.AA S_TKc 297-573 18 1.4e-11 -6.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 297-573
Range on HMM: 1-231/231
Sequence Identity: 18% (55 aa)

ILPSSTIITSEFGIVYRGVMTIENKIPEPVAIKTLKGFYKESDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSR--GSLLSYLKKERPN
     .|    || ||... .      . |||| .|        .... |  |... .  |.  |..|. |     |..| ...   |.|..|.|| ...
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LTVADTSEEDIILNVRKQLLSICLQVANGMSYLASQRFIHRDLAARNCMIDDNGIIKVADFGISEDIYACNYFRQLKGSEFGIVYRGVMTNNPQL
     ..  ..              ... |..... |. |...|||||   | ..|.   ||..|||..  .                            
GLRFPFPE-HAR-------------FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------------------

PKAVAVKT--------LKGFYK-ESDIDSL---LDECLI-MMSFDDLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKERPNLTVADTSE-----ED
     . |        | |. | ..|. |.   | |.|     |.  ..  .. ...     |  .  |...  .| .  ..||    | ..|       
--TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----SPEAKD-FIRK--CLQKDPEKRPTA-EALQDEWDIKCHP

II
 .
WF
Kinase AqueK358.AA Pkinase 475-604 22 3.6e-08 29.97 Pfam 12-134 (293) Show / Hide 
Range on Protein: 475-604
Range on HMM: 12-134/293
Sequence Identity: 22% (31 aa)

FGIVYRGVMTNNPQLPKAVAVKTLKGFYKESDID--SLL-DECLIMMSFDDLNVLPLIGVCLDLGPAPYIIMPFMSRG----SLLSYLKKERPNLTVADT
|| ||...  ....    ||||..|   ..|. |   ..  |. || ...  |.. |.... | .. .|..|...  |    .| .|..           
FGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST----------

SEEDIIL--NVRKQLLSICLQVANGMSYLASQRFIHRDL
 ...  .     ... ....|.. |. |. |...|||||
-WRHGCFYFS-EWECKFYMYQILRGLEYCHSMGIIHRDL