Gene AqueK366 (A.queenslandica)

AqueK366

Species: A.queenslandica
Alias: AqueK366
External Links:
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
AqueK366.AA Protein None 650 None Fasta, JSON
AqueK366.kin_dom Protein Kinase Domain None 232 None Fasta, JSON

Protein domain

Protein domains of AqueK366.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK366.AA Pkinase_Tyr 6-90 45 5.8e-35 119.03 Pfam 186-270 (270) Show / Hide 
Range on Protein: 6-90
Range on HMM: 186-270/270
Sequence Identity: 45% (40 aa)

LHDGLFSEKSDVWSYGVLCWKIFSLGKVP-YPGLDPIGVVELL-DTGGRLQCPLNGACSQEIYSLMMLCWCESPIDRPVFSDLVSLI
...| |..||||||.|||.| ||..|. | |||...  |.|.. . |.|. || |  |..|||.||..|| . | ||| ||.... .
INYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPEN--CPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK366.AA TK 1-90 31 9.2e-32 103.16 In-house 352-486 (486) Show / Hide 
Range on Protein: 1-90
Range on HMM: 352-486/486
Sequence Identity: 31% (42 aa)

MALKTLHDGL---------FSEKSDVWSYGVLCWKIFSLGKVPYPGLDPI----------GVVELLDTGGR------------LQCPLNGACS-------
||  .| |.          |..||||||.|||.| ||..|..||.|  .            |.|.| .|||            ...|    |.       
MAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM

-------QEIYSLMMLCWCESPIDRPVFSDLVSLI
       .|.| ||. || . | ||| ||.|.. .
HPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK366.AA ALK 8-92 48 1.7e-29 99.02 In-house 191-273 (273) Show / Hide 
Range on Protein: 8-92
Range on HMM: 191-273/273
Sequence Identity: 48% (41 aa)

DGLFSEKSDVWSYGVLCWKIFSLGKVPYPGLDPIGVVELLDTGGRLQCPLNGACSQEIYSLMMLCWCESPIDRPVFSDLVSLIDN
||.|  |.||||.||||| ||||| .||||     | |.. .|||.  | |  | | .| .|  ||   | ||| | ...  |  
DGIFTSKTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRN--CPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase AqueK366.AA Tec 11-92 45 3.6e-28 95.57 In-house 175-254 (254) Show / Hide 
Range on Protein: 11-92
Range on HMM: 175-254/254
Sequence Identity: 45% (37 aa)

FSEKSDVWSYGVLCWKIFSLGKVPYPGLDPIGVVELLDTGGRLQCPLNGACSQEIYSLMMLCWCESPIDRPVFSDLVSLIDN
.| |||||..||| | .||.||.||. .. . |||   .| ||  |    ||..||  |  || |.| .|| |..| . | .
YSSKSDVWAFGVLMWEVFSCGKMPYENMSNSEVVEHVSQGHRLYRPH--LCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase AqueK366.AA Src 9-90 40 1.1e-27 91.14 In-house 175-255 (255) Show / Hide 
Range on Protein: 9-90
Range on HMM: 175-255/255
Sequence Identity: 40% (34 aa)

GLFSEKSDVWSYGVLCWKIFSLGKVPYPGLDPIGVVELLDTGGRLQCPLNGACSQEIYS-LMMLCWCESPIDRPVFSDLVSLI
| |. ||||||.|.| . |.. |.||||| .   |.. .. | |. || |  | .|.|  .|. ||...| .|| |  | .  
GRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHN--CPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK366.AA TK-Unique 1-90 40 4e-27 90.65 In-house 203-294 (294) Show / Hide 
Range on Protein: 1-90
Range on HMM: 203-294/294
Sequence Identity: 40% (38 aa)

MALKTLH--DGLF-SEKSDVWSYGVLCWKIFSLGKVPYPGLDPIGVVELLDTGGRLQCPLNGACSQEIYSLMMLCWCESPIDRPVFSDLVSLI
||.  |   .| . ..||||||.||| | ||.||. ||||...  ..|..  | |.. | .. ||.|.|.||  ||...| .|| |..... .
MAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQP-EHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK366.AA FGFR 1-90 42 2e-26 87.01 In-house 205-293 (293) Show / Hide 
Range on Protein: 1-90
Range on HMM: 205-293/293
Sequence Identity: 42% (39 aa)

MALKTLHDGLFSEKSDVWSYGVLCWKIFSLGKVPYPGLD-PIGVVELLDTGGRLQCPLNGACSQEIYSLMMLCWCESPIDRPVFSDLVSLI
||.  | |  .  .||||||||| | |. .|  |||.        ..| .| |.  | |  |||||| .|  || ..| .|| |  ||  .
MAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHN--CSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase AqueK366.AA UTK 1-90 41 3.4e-24 79.69 In-house 206-296 (296) Show / Hide 
Range on Protein: 1-90
Range on HMM: 206-296/296
Sequence Identity: 41% (38 aa)

MALKTLHDG-LFSEKSDVWSYGVLCWKIFSLGKVPYPGLDPIGVVELLDTGGRLQCPLNGACSQEIYSLMMLCWCESPIDRPVFSDLVSLI
||   | ..  |..||||||.||.|| |.. |..||||.    |.. .  |||.. | . .|. ..| ||. ||  .| .|| | |||. .
MAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase AqueK366.AA Axl 1-88 40 8.4e-22 73.84 In-house 182-267 (267) Show / Hide 
Range on Protein: 1-88
Range on HMM: 182-267/267
Sequence Identity: 40% (36 aa)

MALKTLHDGLFSEKSDVWSYGVLCWKIFSLGKVPYPGLDPIGVVELLDTGGRLQCPLNGACSQEIYSLMMLCWCESPIDRPVFSDLVS
.|.  | | ..  |||||..||  | |   |. ||||..   . . |  | ||. | .  | .|.| ||  ||   | ||| || |  
IAIESLADRVYTSKSDVWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPED--CMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase AqueK366.AA InsR 6-92 38 7e-20 63.37 In-house 193-278 (278) Show / Hide 
Range on Protein: 6-92
Range on HMM: 193-278/278
Sequence Identity: 38% (34 aa)

LHDGLFSEKSDVWSYGVLCWKIFSLGKVPYPGLDPIGVVELL-DTGGRLQCPLNGACSQEIYSLMMLCWCESPIDRPVFSDLVSLIDN
| || |. .|||||.||. | . .||  || ||    | .     |. |. | |  |..  . ||| ||  .| .|| | |..... .
LKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPEN--CPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase AqueK366.AA Met 1-84 35 8.3e-20 61.36 In-house 177-271 (271) Show / Hide 
Range on Protein: 1-84
Range on HMM: 177-271/271
Sequence Identity: 35% (34 aa)

MALKTLH--------DGL-FSEKSDVWSYGVLCWKIFSLGKVPYPGLDP-IGVVELLDTG--GRLQCPLNGACSQEIY-SLMMLCWCESPIDRPVFS
||.  |         .   |. |||||| ||. |  .  | .|||  |. . .   | .|   ||  |    |   .|  .|  ||  .|.||| ||
MAPECLQQGVCLGCPTYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEY--CPDHLYTDVMLCCWHANPEDRPQFS
Kinase AqueK366.AA Pkinase 12-90 16 0.011783 10.47 Pfam 190-293 (293) Show / Hide 
Range on Protein: 12-90
Range on HMM: 190-293/293
Sequence Identity: 16% (18 aa)

SEKSDVWSYGVLCWKIFSLGKVPYPGL------DPIGVVELLDTGGRLQCPLNGACS-----------------------QEIYSLMMLCWCESPIDRPV
. |.|.||.|....  .. |. |.||       |.. ....     ....||   ..                       .|  ...  |.|  | .|| 
GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICR-----IMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT

FSDLVSL--I
. ...    .
AEQILQHPWF
SR AqueK366.AA SR 169-242 28 1.2e-19 72.56 SMART 1-118 (118) Show / Hide 
Range on Protein: 169-242
Range on HMM: 1-118/118
Sequence Identity: 28% (34 aa)

IRLVDGNGPNEGRLEICNSR------------------------------AVFLEK------AFFGAGNGSILLDEVECSGSEDTILQCMHNSFGSHD--
.|||.||.|.|||.|.  .                               ||   .      |.||.|.| |..|.| |.|.|... .|.|...|.|.  
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCTGTETSLWDCPHWGWGQHNNC

CGH------HEDVGIHCS
|.|      .||.|..||
CSHNHHRNRQEDAGVVCS
SRCR AqueK366.AA SRCR 195-242 40 1.3e-15 54.3 Pfam 56-112 (112) Show / Hide 
Range on Protein: 195-242
Range on HMM: 56-112/112
Sequence Identity: 40% (23 aa)

AF--FG--AGNGSILLDEVECSGSEDTILQCMHNSFGS--HD--CGHH-EDVGIHCS
|.  ||  .|.| |..|.|.|.|.|... || | . |   |.  |.|. ||.|. ||
AYAWFGNCPGTGPIWMDNVRCHGNETSLWQCPHSPWGWHRHNPMCSHSREDAGVICS
SRCR AqueK366.AA SRCR 172-184 53 0.021987 9.82 Pfam 1-13 (112) Show / Hide 
Range on Protein: 172-184
Range on HMM: 1-13/112
Sequence Identity: 53% (7 aa)

VDGNGPNEGRLEI
|.|..|.|||.|.
VGGSSPCEGRVEV
Pkinase_Tyr AqueK366.AA Pkinase_Tyr 394-643 38 1.3e-102 348.15 Pfam 1-240 (270) Show / Hide 
Range on Protein: 394-643
Range on HMM: 1-240/270
Sequence Identity: 38% (99 aa)

IEIQETVGQGEFGIVYRGVMT-SNTQLPKAVAVKTLKGFYKESD--IDSLLDECIIMMSF-DNLNVLPLIGVCLDLGPA--PYIIMPFMSRGSLLSYLKK
|.. .. |.|.|| ||.|... .  .    ||||.||  . ...  ..... |  ||... .. |.. |.|||.| |    .||.|..|  |.||.||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

ERPNFTVADTSEEDIILNVRKQLLSICLQVANGMSYLASQKFIHRDLAARNCMIDDNGVIKVADFGLSEDIYACNYFRQLKGSDN-NSGSSTVKLPVKWM
 |         |..  |..   ||..|.|.|.||.||.|...||||||||||....|.|.|..||||. ||         . .    .....  ||.|||
HR---------EDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--------YNDDYYYRKRGGGK-LPIKWM

ALESLHDGLFSEKSDVWSYGVLCWEVFSLGKVP-YPGLDPIGVVELL-DTGGRLQCPHN
|.|....| |..||||||.|||.||.|..|. | |||...  |.|.. . |.|. ||.|
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPEN
TyrKc AqueK366.AA TyrKc 394-650 31 1.3e-91 311.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 394-650
Range on HMM: 1-280/280
Sequence Identity: 31% (99 aa)

IEIQETVGQGEFGIVYRGVMTSNTQLPKAVAVKTLKGFYKESDIDSLLDECIIMMSF--DNLNVLPLIGVCLDLG------PAPYIIMPFMSRGSLLSYL
|.  .. | |.||.||.|...        ||||.||       .  ...|  ||...  .. |.. |.|||.. |      . ..|.| .|. |.|..||
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKERPNFTVADTSEEDIILNVRKQLLSICLQVANGMSYLASQKFIHRDLAARNCMIDDNGVIKVADFGLSEDIYAC-------NYFRQLKGSDNNSGSST
.| ||.            |.. |.|||.|.|.|.||.||.|...||||||||||....|...|..||||| |||          | |. ..       . 
RKHRPK------------LCM-KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEH-------KG

VK--LPVKWMALESLHDGLFSEKSDVWSYGVLCWEVFSLGKVPYPG-----LDPIGVVELLDTGGRLQCPHN----------------------------
 |  ||..|||.|.. .| |..||||||.||..||.|..|. ||||     .... |.|....|.|. .|.|                            
GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR

---GACSQEM
    .. ...
PTFSEIHECF
Kinase AqueK366.AA TK 394-650 21 2.4e-84 282.58 In-house 1-461 (486) Show / Hide 
Range on Protein: 394-650
Range on HMM: 1-461/486
Sequence Identity: 21% (101 aa)

IEIQETVGQGEFG---IVYRGVMTSN----------------------TQLPKAVAVKTLKGFYKESDIDSLL---------------DECIIMMS---F
|.. .. |.|.||    ||.| . .                       .. .  ||||.||    .|. . ..                | . ||.   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DNLNVLPLIGVCLDLG-----------PAPYIIMPFMSRGS----LLSYLKKERPNFTV----------------------------ADTSEEDIILNV-
.  |.. |.|||.. .           . ..|.| .|. |.    |..||.| ||.|.                             .. .... . .  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

--------------RKQLLS-------------------ICLQVANGMSYLASQ------KFIHRDLAARNCMIDDNGV-----------IKVADFG---
               |.||.                   .|.|.|.||.||.|.      .|.|||||||||....|.|           .|.||||   
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSEDIY-------------ACNYFRQLKGSDNNSGSS--------------TVKLPVKWMALESLHDGL---------FSEKSDVWSYGVLCWEV
     |. |||             .... .           .                |||..||| |.| |.          |..||||||.|||.||.
QGSGVLARDIYSDDDYYRKSSYGTGRPM-W-----------PFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI

FSLGKVPYPGLDPI----------GVVELLDTGGR------------LQCPHNGACS--------------QEM
|..|..||.|  .            |.|.| .|||            ...|    |.              .|.
FTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEY
Kinase AqueK366.AA Met 395-641 37 7.7e-81 264.73 In-house 1-244 (271) Show / Hide 
Range on Protein: 395-641
Range on HMM: 1-244/271
Sequence Identity: 37% (100 aa)

EIQETVGQGEFGIVYRGVMTSNTQLPKAVAVKTLK--GFYKESDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGP-APYIIMPFMSRGSLLSYLKKERPN
   . .||| || ||.| .. | ..   .|.|.|.      .  |   | | |.|  ||  ||| |||.|||     |... |.|  | |... . .  |
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNN

FTVADTSEEDIILNVRKQLLSICLQVANGMSYLASQKFIHRDLAARNCMIDDNGVIKVADFGLSEDI-YACNYFRQLKGSDNNSGSSTV--KLPVKWMAL
 .|             ..|.. |.||| ||.|.|||||.|||||.||||.|   ..|||||||. |. |   |  |         . |   .|||||||.
PCV-------------RDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQM--------HHTHPARLPVKWMAP

ESLH--------DGL-FSEKSDVWSYGVLCWEVFSLGKVPYPGLDP-IGVVELLDTG--GRLQCP
|.|         .   |. |||||| ||. || .  | .|||  |. . .   | .|   ||  |
ECLQQGVCLGCPTYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQP
Kinase AqueK366.AA TK-Unique 394-650 32 3.7e-78 265.95 In-house 1-269 (294) Show / Hide 
Range on Protein: 394-650
Range on HMM: 1-269/294
Sequence Identity: 32% (91 aa)

IEIQETVGQGEFGIVYRGVMTSNT---QLPKAVAVKTLKGFYKESDIDSLLDECIIMMSFD-NLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKER
.|.....|.|.|| |.|| .....     .| ||||.||    . | . .|.|  .|.. .   |.. ..|.| . .  ..|||.....|.|..||.. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PN-FTV---------ADTSEEDIILN-VR-KQLLSICLQVANGMSYLAS--QKFIHRDLAARNCMIDDNGVIKVADFGLSEDIYACNYFRQLKGSDNNSG
|. ...         ... ...  .. .  |.|.... |.|.||.||||  .|..||||.|||... ...|.|..|||...|.|.        . .... 
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT--------NGVYSMM

SSTVKLPVKWMALESLH--DGLF-SEKSDVWSYGVLCWEVFSLGKVPYPGLDPIGVVELLDTGGRLQCPHNGAC-SQEM
 |  ..|..|||.|||   .| . ..||||||.||| ||.|.||. ||||...  ..|..  | |.. | .  | |.||
CSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEH--CCSHEM
Kinase AqueK366.AA UTK 394-623 31 1.3e-73 250.87 In-house 1-244 (296) Show / Hide 
Range on Protein: 394-623
Range on HMM: 1-244/296
Sequence Identity: 31% (81 aa)

IEIQETVGQGEFGIVYRGVMTSNT-QLPK-AVAVKTLK-GFYKESDID---SLLDECI---IMMSFD-NLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLS
... .. |||.||.|...  |  . . .. .||||... .  .. . .    .. |.    .|. |.   ||| |.|||.. .| ..|.. .|..|.|.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

YLKKERPNFTVADTSEEDIILNVRKQLLSICLQVANGMSYLASQKFIHRDLAARNCMIDDNG-------VIKVADFG---LSEDIY----ACNYFRQLKG
|| . ||..      ... .|. . |.|. ....|.||.||.|..|.||||||||| .....       |.|.||||   .| ...    .     . ..
YLRRHRPTPP-----ACPHWLTLH-QRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSN----RYWE

SDNNSGSSTVKLPVKWMALESLHDG-LFSEKSDVWSYGVLCWEVFSLGKVPYPGL
|.    ..  ..|..||| |.| ..  |..||||||.||.|||... |..||||.
SYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGM
Kinase AqueK366.AA InsR 394-623 35 1e-60 202.66 In-house 1-225 (278) Show / Hide 
Range on Protein: 394-623
Range on HMM: 1-225/278
Sequence Identity: 35% (85 aa)

IEIQETVGQGEFGIVYRG----VMTSNTQLPKAVAVKTLKGFYKESDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKER
|..    ||| || || |    ..  .     ..|.||..      .    | |  .|  |.  .|  | |||    |. |..| .| .| | |||   |
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPM-YVVMEMMTYGDLKSYLRSRR

PNFTVADTSEEDII----LNVRKQLLSICLQVANGMSYLASQKFIHRDLAARNCMIDDNGVIKVADFGLSEDIYACNYFRQLKGSDNNSGSSTVKLPVKW
|        . ...       . |...   ... ||.|||. ||.|||||.||||... . .|..|||.  |||   | |  ...         .||| |
PEEEF---NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKG---------MLPVRW

MALESLHDGLFSEKSDVWSYGVLCWEVFSLGKVPYPGL
|| ||| || |. .|||||.||. ||. .||  || ||
MAPESLKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGL
Kinase AqueK366.AA ALK 394-643 38 1.4e-60 207.62 In-house 1-241 (273) Show / Hide 
Range on Protein: 394-643
Range on HMM: 1-241/273
Sequence Identity: 38% (100 aa)

IEIQETVGQGEFGIVYRGVMTS--NTQLPKAVAVKTLKGFYKESDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKERPN
|.     |.| || || |  .   .   | .||.|||.   .. |    . |  ||  |.  ||  .||.|..  |  .|.  .|. | ..|.|.  ||.
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPY-MIVLEYMEGGDMKSFLRECRPH

FTVADTSEE--DIILNVRKQLLSICLQVANGMSYLASQKFIHRDLAARNCMIDDNG---VIKVADFGLSEDI-YACNYFRQLKGSDNNSGSSTVKLPVKW
       .|     . . | || .|. || |  || ...||||| |||||     |   | |.|||| . || |   |.|         |  .  .||||
-------PESLQPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRK--------GGRAM-MPVKW

MALESLHDGLFSEKSDVWSYGVLCWEVFSLGKVPYPGLDPIGVVELLDTGGRLQCPHN
|  | . ||.|  |.||||.||||||.|||| .||||     | |.. .|||.  | |
MPPEAFMDGIFTSKTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRN
Kinase AqueK366.AA Src 394-643 39 2e-60 203.95 In-house 1-224 (255) Show / Hide 
Range on Protein: 394-643
Range on HMM: 1-224/255
Sequence Identity: 39% (100 aa)

IEIQETVGQGEFGIVYRGVMTSNTQLPKAVAVKTLKGFYKESDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKERPNFT
|   .  ||| || |. |.   ||.    |||||||      . . .| |  || ...  ... |  || .  |  ||.  .||.|||| ||||      
IKLCRKLGQGQFGEVWMGYWNGNTK----VAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPI-YIVTEYMSHGSLLDYLKK------

VADTSEEDIILNVRKQLLSICLQVANGMSYLASQKFIHRDLAARNCMIDDNGVIKVADFGLSEDIYACNYFRQLK-GSDNNSGSSTVKLPVKWMALESLH
    ..|   |... ||...  |||.||.|| |...|||||||||  ...| | |||||||          | .| . |. . ..  |.|.||.| | ..
----DGEGRHLHLP-QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLA---------RLIKEDDDEYCARHGAKFPIKWTAPEAIN

DGLFSEKSDVWSYGVLCWEVFSLGKVPYPGLDPIGVVELLDTGGRLQCPHN
 | |. ||||||.|.| .|... |.||||| .   |.. .. | |. ||||
YGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHN
Kinase AqueK366.AA Axl 394-643 37 9.1e-60 204.88 In-house 1-239 (267) Show / Hide 
Range on Protein: 394-643
Range on HMM: 1-239/267
Sequence Identity: 37% (96 aa)

IEIQETVGQGEFGIVYRGVMTSNTQLPKAVAVKTLK-GFYKESDIDSLLDECIIMMSFDNLNVLPLIGVCLDLG-----PAPYIIMPFMSRGSLLSYLKK
. .  ..|.|||| |  | .  .      ||||..|     .|.|.  | | . |  ||  ||. |||||. .      |.| .|.|||  | | ..|  
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY

ERPNFTVADTSEEDIILNVRKQLLSICLQVANGMSYLASQKFIHRDLAARNCMIDDNGVIKVADFGLSEDIYACNYFRQLKGSDNNSGSSTVKLPVKWMA
 |         .. . | . . |.   . .| || ||....||||||||||||. ..  . |||||||  ||.  |.|| .           |.||||.|
SR-------LGDQPFYLPL-QMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQGC---------IAKMPVKWIA

LESLHDGLFSEKSDVWSYGVLCWEVFSLGKVPYPGLDPIGVVELLDTGGRLQCPHN
.||| | ..  |||||..||  ||.   |. ||||..   . . |  | ||. |..
IESLADRVYTSKSDVWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPED
Kinase AqueK366.AA FGFR 394-650 34 3.3e-58 196.98 In-house 1-268 (293) Show / Hide 
Range on Protein: 394-650
Range on HMM: 1-268/293
Sequence Identity: 34% (97 aa)

IEIQETVGQGEFGIVYRGVMT----SNTQLPKAVAVKTLKGFYKESDIDSLLDECIIM-MSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKE
  . .. | | || | ..       . ..   .|||| ||    . |. .|  |  .| |   . |.. |.|.|   || .|.|  . ..| |  .|.. 
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGP-LYVIVEYCHHGNLRDFLRAR

RPNFTVADTSEE-------DIILNV----------RKQLLSICLQVANGMSYLASQKFIHRDLAARNCMIDDNGVIKVADFGLSEDIYACNYFRQLKGSD
||    .. . .        .   .           |.| |.  ||| || ||||.| |||||||||  . |. |.|..||||. ||    |.|      
RPPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRK-----

NNSGSSTVKLPVKWMALESLHDGLFSEKSDVWSYGVLCWEVFSLGKVPYPGLD-PIGVVELLDTGGRLQCPHNGACSQEM
.  |     ||.||||.|.| |  .  .||||||||| ||.. .|  |||.        ..| .| |.  |||  ||||.
TTNG----RLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHN--CSQEI
Kinase AqueK366.AA Tec 394-555 33 3.3e-33 113.41 In-house 1-144 (254) Show / Hide 
Range on Protein: 394-555
Range on HMM: 1-144/254
Sequence Identity: 33% (56 aa)

IEIQETVGQGEFGIVYRGVMTSNTQLPKAVAVKTLK-GFYKESDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKERPNF
. . . .|.| ||.| .|  ... .    ||.|..| |   | |    ..|  .||     .   | |||.   |  ||.  .|..|.||.||....  |
LTFMKELGSGQFGVVHLGKWRHQYD----VAIKMIKEGSMSEED---FIEEAKVMMKLSHPKLVQLYGVCSQQRPI-YIVTEYMEHGCLLNYLREHKHHF

TVADTSEEDIILNVRKQ--LLSICLQVANGMSYLASQKFIHRDLAARNCMIDDNGVIKVADFGLS
              ...  ||..|..|  || || ...||||||||||| ..|..|.||.|||..
Q-------------KNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMT
Kinase AqueK366.AA Pkinase 394-631 24 3.3e-27 97.29 Pfam 1-229 (293) Show / Hide 
Range on Protein: 394-631
Range on HMM: 1-229/293
Sequence Identity: 24% (63 aa)

IEIQETVGQGEFGIVYRGVMTSNTQLPKAVAVKTLKGFYKESDID--SLL-DECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRG----SLLSYLK
..| ...|.| || ||...  .. .    ||||..|   ..|. |   ..  |. || ...  |.. |.... | .. .|..|...  |    .| .|..
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIS

KERPNFTVADTSEEDIIL--NVRKQLLSICLQVANGMSYLASQKFIHRDLAARNCMIDDNGVI----KVADFGLSEDIYACNYFRQLKGSDNNSGSSTVK
            ...  .     ... ....|.. |. |. |...|||||   |..||.||.|    |..||||.. ..            |||  .|. 
T-----------WRHGCFYFS-EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----------Y-NNS-MTTFC

LPVKWMALESLH-DGLFSEKSDVWSYGVLCWEVFSLGKVPYPGL------DPIGVVEL
    .|| | .  .   . |.|.||.|....|... |. |.||       |.. ....
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICR
Kinase AqueK366.AA Tec 576-650 48 2.8e-21 71.15 In-house 154-227 (254) Show / Hide 
Range on Protein: 576-650
Range on HMM: 154-227/254
Sequence Identity: 48% (37 aa)

SST-VKLPVKWMALESLHDGLFSEKSDVWSYGVLCWEVFSLGKVPYPGLDPIGVVELLDTGGRLQCPHNGACSQEM
||.  | |||| . | .|   .| |||||..||| |||||.||.||. .. . |||   .| ||  ||   ||...
SSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYENMSNSEVVEHVSQGHRLYRPH--LCSMHI
Kinase AqueK366.AA S_TKc 394-650 20 3.6e-21 77.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 394-650
Range on HMM: 1-231/231
Sequence Identity: 20% (59 aa)

IEIQETVGQGEFGIVYRGVMTSNTQLPKAVAVKTLKGFYKESDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSR--GSLLSYLKKERPN
 || ...|.| || ||... ..     . ||.| .|        .... |  |... .  |.  |..|. |     |..| ...   |.|..|.|| ...
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FTVADTSEEDIILNVRKQLLSICLQVANGMSYLASQKFIHRDLAARNCMIDDNGVIKVADFGLSEDIYACNYFRQLKGSDNNSGSSTVKLPVKWM
     |.  ..              ... |..... |. |...|||||   | ..|.  .||..||||.  .                  .|.     .|
GLRFPFPE-HAR-------------FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------------TTFCGTPWYM

ALESLHDGLFSE-KSDVWSYGVLCWEVFSLGKVPYPGLDPIGVVELL---------------DTGGRLQCPHNGA------CSQEM
| | |    ..  |.|.|| |.. .| .. |. |.|  ..  . ...               |   |. .    .      | . .
APEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF