Gene AqueK371 (A.queenslandica)

AqueK371

Species: A.queenslandica
Alias: AqueK371
External Links:
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
AqueK371.AA Protein None 859 None Fasta, JSON
AqueK371.kin_dom Protein Kinase Domain None 274 None Fasta, JSON

Protein domain

Protein domains of AqueK371.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IGc2 AqueK371.AA IGc2 69-155 13 0.000116 19.57 SMART 1-56 (56) Show / Hide 
Range on Protein: 69-155
Range on HMM: 1-56/56
Sequence Identity: 13% (12 aa)

LDYKTVYVNCSVYGESPFEVSWLYSTDEISNRSSDYTIISGSKVSNIVYNPNSDDEGYVWWNSSLLLNPINNSTAGYYYCRVNTSFG
.   .|  .| . |    ...|..   ...                              ||..| . ..  . .||| |..  . |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG AqueK371.AA IG 63-167 11 0.001609 18.94 SMART 1-58 (58) Show / Hide 
Range on Protein: 63-167
Range on HMM: 1-58/58
Sequence Identity: 11% (13 aa)

NPFLYYLDYKTVYVNCSVYGESPFEVSWLYSTDEISNRSSDYTIISGSKVSNIVYNPNSDDEGYVWWNSSLLLNPINNSTA---GYYYCRVNTSFGLNYS
 | ..     ||  .| |      ...|.                                         | . ..  . .   | |||...   |  .|
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWS

-KPVYVRST
 ...... .
IQGTTLTVQ
I-set AqueK371.AA I-set 263-343 21 8.1e-10 35.82 Pfam 1-81 (92) Show / Hide 
Range on Protein: 263-343
Range on HMM: 1-81/92
Sequence Identity: 21% (18 aa)

SSISSKVTNITINETKRMYLWCCATGAPQPTIIWYHNNTQLHS-NSYLTITYPSVQESAVIILQTRYERDKGTYTCEAKNGV
 ... | ......| ..  . | .|| |.|.. |.... .|.. ...  .||      .  . .    .| |.||| |.| .
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDG-DGTYTLTISNVQPDDEGKYTCVATNSF
IGc2 AqueK371.AA IGc2 275-344 28 6e-06 27.1 SMART 1-56 (56) Show / Hide 
Range on Protein: 275-344
Range on HMM: 1-56/56
Sequence Identity: 28% (20 aa)

NETKRMYLWCCATGAPQPTIIWYHNNTQLHSNSYLTITYPSVQESAVIILQTRYERDKGTYTCEAKNGVT
.|     | | |||.| |.| ||. ...|              .. . |   . . | |.|||.| | . 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVT-PEDSGYYTCYARNPWG
IG AqueK371.AA IG 269-358 17 3.7e-05 24.38 SMART 1-58 (58) Show / Hide 
Range on Protein: 269-358
Range on HMM: 1-58/58
Sequence Identity: 17% (16 aa)

VTNITINETKRMYLWCCATGAPQPTIIWYHNNTQLHSNSYLTITYPSVQESAVIILQTRYERD--KGTYTCEAKNGVTNLINAKQ--SHNITVN
   .| .|  .  | | ..     .| ||                        .| . ..|    .|||.|.|.       ....  . ..|| 
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT-----HGQYWSIQGTTLTVQ
V-set AqueK371.AA V-set 331-357 33 0.426215 5.61 Pfam 104-128 (128) Show / Hide 
Range on Protein: 331-357
Range on HMM: 104-128/128
Sequence Identity: 33% (9 aa)

DKGTYTCEAKNGVTNLINAKQSHNITV
| |||.| ..|.  | ..  .. . ||
DSGTYYCAVWNC--NEDYFGHGTRLTV
IG AqueK371.AA IG 368-465 16 2.5e-09 38.26 SMART 1-58 (58) Show / Hide 
Range on Protein: 368-465
Range on HMM: 1-58/58
Sequence Identity: 16% (17 aa)

PQKITAYENENITITVKVIRAHPPVLPDHISWTCTTSNGSARAMNQSIVEGYDSRFNISEDNRSLYISDLTSDDE---GYYQVLIWHPAGYKNK--TTYL
|. .|. | |..|.|  |          .|.|.                               | | ... .|.   | |.   .  .| . .  .|.|
PP-VTVKEGETVTLTC-VS---------QIWWY-------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTL

KIN
.. 
TVQ
V-set AqueK371.AA V-set 364-464 15 3.9e-05 19.54 Pfam 1-128 (128) Show / Hide 
Range on Protein: 364-464
Range on HMM: 1-128/128
Sequence Identity: 15% (20 aa)

EIELPQ--------KITAYENENITITVKVI-RAHPPVLPDHISWTC-TTS------------NGSARAMNQSIVEGYDSRFNISEDNR----SLYISDL
 ... |         .|. | ...|.. ..    ...  . .|.|    ..            . ...  ..   . .  |. .| ...    || ||.|
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

TSDDEGYYQVLIWHP-AGYKNKTTYLKI
...|.| |   .|..  .|  . | | .
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set AqueK371.AA I-set 420-447 32 0.300313 6.75 Pfam 45-75 (92) Show / Hide 
Range on Protein: 420-447
Range on HMM: 45-75/92
Sequence Identity: 32% (10 aa)

DSRFNISEDN---RSLYISDLTSDDEGYYQV
..|.....|.    .| ||. ..|||| | .
SDRHQMTYDGDGTYTLTISNVQPDDEGKYTC
TyrKc AqueK371.AA TyrKc 567-844 35 1.7e-112 380.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 567-844
Range on HMM: 1-280/280
Sequence Identity: 35% (110 aa)

LKILDCVGQGEFAKVYKGHYYIDSQCITVAVKALKGTLDRYSSESMKELIEESLVMKDL--QHPNVMGLIGICLDAG------PSPLIVLPYMEGGSLLK
.. ..  | |.| .||||...     |.|||| ||          ......|  .|. |  .|||.  |.|.|.. |      . ..||. ||..|.|..
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLIKNRENLMACTSTDDDEINQLRSQLLSVCLQIGKGMQYLAGKGLIHRDLAARNCMIDEHGNIKVADFGLSKDVSGN-------VYFRQGMSSGVK--L
|| |.|..                ..||| |.|| .||.||. |..||||||||||...| . .|..|||||.|.           | |.  ..| |  |
YLRKHRPK-------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML

PIKWMAIESIEDGIFTEKTDIWSFGITVWEVFNGGKTPYGG-----FSPTCVKTMISDGYKLEAPSNSA------CNDDIYQKTMLKCWERDPNERPTFA
||.|||.|.| .|.||.|.|.||||.. ||.|  |..|| |      |.. |   . .|| .. | |        | |..||  |..||..||..||||.
PIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFS

QVVTDI
... ..
EIHECF
Pkinase_Tyr AqueK371.AA Pkinase_Tyr 567-844 39 5e-111 376.64 Pfam 1-270 (270) Show / Hide 
Range on Protein: 567-844
Range on HMM: 1-270/270
Sequence Identity: 39% (115 aa)

LKILDCVGQGEFAKVYKGHYY--IDSQCITVAVKALKGTLDRYSSES--MKELIEESLVMKDL-QHPNVMGLIGICL-DAGP-SPLIVLPYMEGGSLLKY
....   |.|.| .||||...   |...|.|||| ||   . ...|   ......|  .|| | .|||.  |.|.|. . .| ...||..||..|.||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK---EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LIKNRENLMACTSTDDDEINQLRSQLLSVCLQIGKGMQYLAGKGLIHRDLAARNCMIDEHGNIKVADFGLSKDV-SGNVYFRQGMSSGVKLPIKWMAIES
| |.|          .|. .   ..||. |.|| |||.||. |..||||||||||...| . .|..||||..|. .   |  .  ..|  ||||||| |.
LRKHR----------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGK-LPIKWMAPEC

IEDGIFTEKTDIWSFGITVWEVFNGGKTP-YGGFSPTCVKTMI-SDGYKLEAPSNSACNDDIYQKTMLKCWERDPNERPTFAQVVTDI
| .|.||.|.|.||||.. ||.|  |..| | | |.. |. .|  ||| ...| |  | |.||.  |..||. ||..||||.... ..
INYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPEN--CPDEIYDL-MKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK371.AA TK 567-844 23 2.8e-99 333.53 In-house 1-486 (486) Show / Hide 
Range on Protein: 567-844
Range on HMM: 1-486/486
Sequence Identity: 23% (113 aa)

LKILDCVGQGEFA---KVYKGHYYIDS-----------------------QCITVAVKALKGTLDRYSSESMK-------------ELIEESLVMKD--L
.....  |.|.|    .|||| .. ..                       ....|||| || . .  . | .              |. ||  .|.   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHPNVMGLIGICLDAGPS-----------PLIVLPYMEGGS----LLKYLIKNRENLMA----------------------------------CTSTDDD
.|||.  |.|.|.. .|.           ..||. ||..|.    |..|| |.|.. .                                   | . ..|
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

EIN-------------QLRS----------------QLLSVCLQIGKGMQYLAGK------GLIHRDLAARNCMIDEHGN-----------IKVADFG--
 ..             .| .                |||  |.|| .||.||. |      ...|||||||||...|...           .|.||||  
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LSKDV-SGNVYFRQG---------------------MSSGVKLPIKWMAIESIEDGI---------FTEKTDIWSFGITVWEVFNGG-KTPYGG
      |..|. |.  | |..                     ..|| ||||.||| |...|..         ||.|.|.||||...||.|  | ...|||
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

FSP---------TCVKTMISD------------GYKLEAPSNSACND-------------DIYQKTMLKCWERDPNERPTFAQVVTDI
 |          . |  .. .            ||... |    | |             ..|.  |..||..||..||||.|..  .
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK371.AA UTK 567-844 31 3.9e-86 292.46 In-house 1-296 (296) Show / Hide 
Range on Protein: 567-844
Range on HMM: 1-296/296
Sequence Identity: 31% (96 aa)

LKILDCVGQGEFAKVYKGHYYIDS---QCITVAVKALKGTLDRYSSESMK---ELIEESL---VMKDLQ-HPNVMGLIGICLDAGPSPLIVLPYMEGGSL
...... |||.|  |.|...  .|   .   ||||...   .  .  ..    ...||.    .|| .. ||||..|.|.|.. .| ..||. |||.|.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ--HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDL

LKYLIKNRENLMACTSTDDDEINQLRSQ-LLSVCLQIGKGMQYLAGKGLIHRDLAARNCMIDEHG-------NIKVADFG---LSKDVS---------GN
..|| ..|....       ..  .|..  .|. ...|  |||||...|..||||||||| ...|.        .|.||||   .|..|.         . 
RSYLRRHRPTPP-------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWES

VYFRQGMSSGVKLPIKWMAIESIEDG-IFTEKTDIWSFGITVWEVFNGGKTPYGGFSPTCVKTMISDGYKLEAPSNSACNDDIYQKTMLKCWERDPNERP
 |..  ...  ..||.||| |.. ..  ||.|.|.||||...||.. .|..||.| |   | . ...|. .  |.. .| ...|.  |..||. || |||
YYYM--AQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYR-LMHRCWHYDPQERP

TFAQVVTDI
.| ..|  .
DFEDLVQQM
Kinase AqueK371.AA Met 568-838 35 7e-84 274.86 In-house 1-271 (271) Show / Hide 
Range on Protein: 568-838
Range on HMM: 1-271/271
Sequence Identity: 35% (103 aa)

KILDCVGQGEFAKVYKGHYYI-DSQCITVAVKALK----GTLDRYSSESMKELIEESLVMKDLQHPNVMGLIGICLDAGP-SPLIVLPYMEGGSLLKYLI
  .| .||| |  ||.| |   |.. . .|.| |.    ...   |     .  .| ..||...||||  |||||||    .|..|||||..| |... |
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHIS-----QFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTF-I

KNRENLMACTSTDDDEINQLRSQLLSVCLQIGKGMQYLAGKGLIHRDLAARNCMIDEHGNIKVADFGLSKDV-SGNVYFRQGMSSG-VKLPIKWMAIESI
.| .| .               .|.. |.|. |||.|.|..  .|||||.||||.|||  .|||||||. |.     |  |    .  .||.|||| |. 
RNPQNNPCVR------------DLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECL

E--------DGI-FTEKTDIWSFGITVWEVFNGGKTPYGGFSP-TCVKTMISDG--YKLEAPSNSACNDDIYQKTMLKCWERDPNERPTFA
.        . . || |.|.||||.  || .  | .||.  .. . . .    |    |  |    | | .|   ||.||. .| .||.| 
QQGVCLGCPTYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEY--CPDHLYTDVMLCCWHANPEDRPQFS
Kinase AqueK371.AA TK-Unique 567-844 31 3.1e-76 259.59 In-house 1-294 (294) Show / Hide 
Range on Protein: 567-844
Range on HMM: 1-294/294
Sequence Identity: 31% (96 aa)

LKILDCVGQGEFAKVYKGHYYIDS--QCIT--VAVKALKGTLDRYSSESMKELIEESLVMKDLQ-HPNVMGLIGICLDAGPSPLIVLPYMEGGSLLKYLI
|...| .|.|.|  |..| .  ..  .. .  ||||.||   |. . .. ...  |  .|| |  |||.  ..|.| . . ...|...|...|.|..|| 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLK---DNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR

KNREN-----------LMACTSTDDDEINQLR-SQLLSVCLQIGKGMQYLAG--KGLIHRDLAARNCMIDEHGNIKVADFGLSKDVS-GNVYFRQGMSSG
..| .             . . .|... . .   .|.. . || .||.|||.  |. .||||.|||... |....|..|||...||. ..||  . | | 
TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVY--SMMCSQ

VKLPIKWMAIESIE--DGIF-TEKTDIWSFGITVWEVFNGGKTPYGGFSPTCVKTMISDGYKLEAPSNSACNDDIYQKTMLKCWERDPNERPTFAQVVTD
 ..||.||| ||.   .|.. |.|.|.||||.. ||.|  |..||.| ... . ..| ||| .. |... |....|.  |  || ..| |||.|.|..  
GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHC-CSHEMYN-LMKSCWQWEPEERPSFRQIKHR

I
.
L
Kinase AqueK371.AA EGFR 567-845 32 2.9e-71 235.84 In-house 1-258 (258) Show / Hide 
Range on Protein: 567-845
Range on HMM: 1-258/258
Sequence Identity: 32% (91 aa)

LKILDCVGQGEFAKVYKGHYYIDSQCITVAVKALKGTLDRYSSESMKELIEESLVMKDLQHPNVMGLIGICLDAGPSPLIVLPYMEGGSLLKYLIKNREN
|| .   | | | .|||| .. . . . . | | |   .  . .. .|...| .||  ..||... |.|.|.       .|  ||  |.|| |. ....|
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPV-AIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ--MQLVTQYMPYGCLLDYVRQHKDN

LMACTSTDDDEINQLRSQLLSVCLQIGKGMQYLAGKGLIHRDLAARNCMIDEHGNIKVADFGLSKDVSGNVYFRQGMSSGVKLPIKWMAIESIEDGIFTE
. .              .||  |.|| ||||||  . ..|||||||| ..     .|..||||.|  . .    .   .| |.||||||.|.|. ...| 
IGS-------------QHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDE--KEYHAQGGKMPIKWMALECIHHRCYTH

KTDIWSFGITVWEVFNGGKTPYGGFSPTCVKTMISDGYKLEAPSNSACNDDIYQKTMLKCWERDPNERPTFAQVVTDID
. |.||.|.|.||.   |. || | .   .  .. .| .|. | .  |  |.|. .|.|||  |.. |||| . ..  .
QSDVWSYGVTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPI--CTIDVYM-VMVKCWMIDEDMRPTFKELYEEFK
Kinase AqueK371.AA Axl 567-842 36 1.6e-70 240.6 In-house 1-267 (267) Show / Hide 
Range on Protein: 567-842
Range on HMM: 1-267/267
Sequence Identity: 36% (103 aa)

LKILDCVGQGEFAKVYKGHYYIDS-QCITVAVKALKGTLDRYSSESMKELIEESLVMKDLQHPNVMGLIGICLDAG-----PSPLIVLPYMEGGSLLKYL
. .   .|.|||  |  |.   .    . |||| .|  .|  ..  . | . |   ||. .||||| |||.|. .      | |...||.|  | |  .|
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMK--IDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFL

IKNRENLMACTSTDDDEINQLRSQLLSVCLQIGKGMQYLAGKGLIHRDLAARNCMIDEHGNIKVADFGLSKDVSGNVYFRQGMSSGVKLPIKWMAIESIE
.  |         .|. ..     |.   . |  || ||. .  |||||||||||. |   . |||||||| .    |.|||  .  |.|.||.||||. 
LYSR--------LGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQGCIA--KMPVKWIAIESLA

DGIFTEKTDIWSFGITVWEVFNGGKTPYGGFSPTCVKTMISDGYKLEAPSNSACNDDIYQKTMLKCWERDPNERPTFAQVVT
| ..| | |.|.||.|.||.   |.||| |     .   . .| .|  | .  | |..|.  | .||| || .||.|...  
DRVYTSKSDVWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPED--CMDELYD-LMYQCWEADPKDRPSFSVLRE
Kinase AqueK371.AA Src 567-844 36 4.5e-70 237.25 In-house 1-255 (255) Show / Hide 
Range on Protein: 567-844
Range on HMM: 1-255/255
Sequence Identity: 36% (101 aa)

LKILDCVGQGEFAKVYKGHYYIDSQCITVAVKALKGTLDRYSSESMKELIEESLVMKDLQHPNVMGLIGICLDAGPSPLIVLPYMEGGSLLKYLIKNREN
.| ..  ||| |  |..| .    . . |||| ||         | . . .|  .|| |.|...  |  .| .  |  .||  ||. ||||.|| |    
IKLCRKLGQGQFGEVWMGYW---NGNTKVAVKTLKPGT-----MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPI-YIVTEYMSHGSLLDYLKK----

LMACTSTDDDEINQLRSQLLSVCLQIGKGMQYLAGKGLIHRDLAARNCMIDEHGNIKVADFGLSKDVS--GNVYFRQGMSSGVKLPIKWMAIESIEDGIF
       |... .    ||..   |. .||.||  . .|||||||||  ..|.   ||||||| . .    ..|    ...| |.||||.| | |  | |
-------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYC---ARHGAKFPIKWTAPEAINYGRF

TEKTDIWSFGITVWEVFNGGKTPYGGFSPTCVKTMISDGYKLEAPSNSACNDDIYQKTMLKCWERDPNERPTFAQVVTDI
| |.| |||||  .|..  |..|| | .   | .... ||..  |.|  | | .|.. ||.||..|| .||||.      
TIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHN--CPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK371.AA Fer 567-845 32 3.4e-68 231.32 In-house 1-283 (283) Show / Hide 
Range on Protein: 567-845
Range on HMM: 1-283/283
Sequence Identity: 32% (98 aa)

LKILDCVGQGEFAKVYKG----HYYIDSQCIT--VAVKALKGTLDRYSSESMKELIEESLVMKD-LQHPNVMGLIGICLDAGPSPLIVLPYMEGGSLLKY
 .. .  | | | .||||    . . . .. .  ||||  |   .  . | .||.  |  .|.  ..||||  ..|.| |  |  .||. .. ||||..|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPI-MIVMEFCNGGSLDSY

LIKNRE-NLMACTSTDDDEINQLRSQLLSVCLQIGKGMQYLAGKGLIHRDLAARNCMIDEHGNIK---VADFGLSKDVSGNVYFRQGMS-SGVKLPIKWM
| || . ..                ...  |.|. .||.|| .|. ||||.||||| ...... |   ..|||.|.. |...| .  |     |.||.|.
LKKNKNKTVSD-------------NEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGY-DYKMKEKACKVPIRWL

AIESIEDGIFTEKTDIWSFGITVWEVFNGGKTPYGG----FSPTCV-----KTMISDGYKLEAPSNSACNDDIYQKTMLKCWERDPNERPTFAQVVTDID
| |....||...|||.||||.. ||.|. |..||.|    . .|.|     |  | .|| .  |..  . ..|.|  | .||..||..|||.....  . 
APETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNH--MPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase AqueK371.AA TKL 573-844 21 2.3e-60 206.87 In-house 1-364 (364) Show / Hide 
Range on Protein: 573-844
Range on HMM: 1-364/364
Sequence Identity: 21% (82 aa)

VGQGEFAKVYKGHYYIDS------QCITVAVKALKGTL-----------------------DRYSSESMKELIEESLVMKDLQHPNVMGLIGICLDAGP-
.|.| |..||||..   .       . .|||| .| .                        |. .|  .....|| ..|. |.|||.  ..|.|.. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------SPLIVLPYMEGGSLLKYLIKNRENLMACTSTDDDEINQLRSQLLSVCLQIGKGMQYLAG--------KGLIHRDLAARNCMIDEHGN--
            . ||  |..||||| ||.                     .|... .|.| .||.||          ...|||||  .|...||...  
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNV

------------IKVADFGLSKDVSGNVYFRQGM---------------SSGVKLPIKWMAIESIEDG----------------IFTEKTDIWSFGITVW
            .|..|||||...|..     .|               .. .   . ||| | ...                  ..||.|..||||  |
SNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLW

EVFNGGKTPYGGFSPTCV---------KTMISDGYKLEAPSNSAC------NDDI---YQKTMLKCWERDPNERPTFAQVVTDI
|.. . .  |.  ... .         .  ...|.... |.   .      ..|.   . | | .||. ||..||.| ...  .
EILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK371.AA Tec 567-846 35 9.9e-60 204.75 In-house 1-254 (254) Show / Hide 
Range on Protein: 567-846
Range on HMM: 1-254/254
Sequence Identity: 35% (99 aa)

LKILDCVGQGEFAKVYKGHYYIDSQCITVAVKALK-GTLDRYSSESMKELIEESLVMKDLQHPNVMGLIGICLDAGPSPLIVLPYMEGGSLLKYLIKNRE
|...  .|.| |  |  | .      . ||.|..| |.       |  . |||  ||. |.||.   | |.|.   |   ||  ||| |.|| || ... 
LTFMKELGSGQFGVVHLGKWRH---QYDVAIKMIKEGSM------SEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPI-YIVTEYMEHGCLLNYLREHKH

NLMACTSTDDDEINQLRSQLLSVCLQIGKGMQYLAGKGLIHRDLAARNCMIDEHGNIKVADFGLSKDVSGNVYFRQGMSSGVKLPIKWMAIESIEDGIFT
 . ....            ||..|... .|| ||  .. |||||||||| ... . .||.|||..  |    |     |.| | |.|| . |      . 
HFQKNMAI-----------LLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYT---SSVGTKFPVKWCPPEVFHYSRYS

EKTDIWSFGITVWEVFNGGKTPYGGFSPTCVKTMISDGYKLEAPSNSACNDDIYQKTMLKCWERDPNERPTFAQVVTDIDT
 | |.|.||.  |||| .|| ||. .| . | ...| |..|. |    | . |||  | .||.  | |||||.|    |  
SKSDVWAFGVLMWEVFSCGKMPYENMSNSEVVEHVSQGHRLYRP--HLCSMHIYQ-IMYHCWHEKPEERPTFQQLLRQITE
Kinase AqueK371.AA S_TKc 567-848 22 2.6e-38 134.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 567-848
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

LKILDCVGQGEFAKVYKGHYYIDSQCITVAVKALKGTLDRYSSESMKELIEESLVMKDLQHPNVMGLIGICLDAGPSPLIVLPYMEG--GSLLKYLIKNR
 .||. .|.| |.||||..         ||.| .|           . .. |  ..|  .|||.  |.... |   .  .|. |..|  |.|..|. |..
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRG

EN-----LMACTSTDDDEINQLRSQLLSVCLQIGKGMQYLAGKGLIHRDLAARNCMIDEHGNIKVADFGLSKDVSGNVYFRQGMSSGVKLPIKWMAIESI
 .     .                .  ... || ....|.  .| |||||   | ..||  .||..||||.. .           . .     .|| | .
RHGLRFPFP-------------E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL

EDGIFTE-KTDIWSFGITVWEVFNGGKTPYGGFSPTCVKTMISDGYKLEAPSNSACNDDIYQKTMLKCWERDPNERPTFAQVVTDI-----DTLL
    ..  | |.||.|....| .  |..|.    .  .  .|               ..  .  . ||...||..|||  .. .|      .  .
---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK371.AA Pkinase 567-844 23 3.8e-38 135.97 Pfam 1-293 (293) Show / Hide 
Range on Protein: 567-844
Range on HMM: 1-293/293
Sequence Identity: 23% (75 aa)

LKILDCVGQGEFAKVYKGHYYIDSQCITVAVKALKGTLDRYSSESMKELIE-----ESLVMKDLQHPNVMGLIGICLDAGPSPLIVLPYMEGG----SLL
..|. ..|.| |..|||.|   ...  .|||| .|     ...|.......     |  .|| |.|||.  |.... | .... .|..|.|||    .| 
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIK-----KRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLF

KYLIKNRENLMACTSTDDDEINQL---RSQLLSVCLQIGKGMQYLAGKGLIHRDLAARNCMIDEHGNI----KVADFGLSKDVSGNVYFRQGMSSGVKLP
 |.               .. . .     .. ....|| .|..|.  .| |||||   |..||..|.|    |..||||.| ..   | ...  ...   
DYIST-------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGT

IKWMAIESIE-DGIFTEKTDIWSFGITVWEVFNGGKTPYGGF----SPTCVKTMISDGYKLEAPSNSACNDDIY--------------------QKTMLK
. .|| | |  .   . | |.||.|....|... |..|. |     .  . . ||    . . ....   ..|.                    .. . .
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

CWERDPNERPTFAQVVTD--I
|...||..|||..|.. .  .
CLCKDPKKRPTAEQILQHPWF