Gene AqueK373 (A.queenslandica)

AqueK373

Species: A.queenslandica
Alias: AqueK373
External Links:
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
AqueK373.AA Protein None 2336 None Fasta, JSON
AqueK373.kin_dom Protein Kinase Domain None 274 None Fasta, JSON

Protein domain

Protein domains of AqueK373.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SRCR AqueK373.AA SRCR 23-116 27 9.7e-14 47.96 Pfam 9-112 (112) Show / Hide 
Range on Protein: 23-116
Range on HMM: 9-112/112
Sequence Identity: 27% (29 aa)

GLLLI-YYNGSYGTVCDD-E-FSMNEVQVLCTEQGFSSDNGIAVSSEKF-VFI--QDEFQVYLDTVRCRSYIDTTIGRCLNDGFHS--TN--CDTI-ESV
| . . |.||. ||||||   ..|.. .| | . |. ..   |.|.. .  |   ..  ....| |||.    |..  |  ..     .|  |.   | .
GRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPGTGPIWMDNVRCHG-NETSLWQCPHSPWGWHRHNPMCSHSREDA

GIICQ
|.||.
GVICS
SR AqueK373.AA SR 7-116 20 6.1e-09 34.79 SMART 4-118 (118) Show / Hide 
Range on Protein: 7-116
Range on HMM: 4-118/118
Sequence Identity: 20% (26 aa)

ANGDMALLSFLSASNLGLLLIYYNG----SYGTVCDDEFSMNEVQVLCTEQGFSSDNGIAVS----SEKFVFIQDEFQVYLDTVRCRSYIDTTIGRCLND
..|.         .. | . .|.||    . |||||| ..... .| | . |...      .    .  |   ..  . ..| |||.   . ..  | ..
VGGNN--------PCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSG--PIWMDNVRCTGTET-SLWDCPHW

GFHSTN--CDT------IESVGIICQ
|....|  |.        | .|..|.
GWGQHNNCCSHNHHRNRQEDAGVVCS
SRCR AqueK373.AA SRCR 130-217 30 9.2e-21 71.55 Pfam 1-112 (112) Show / Hide 
Range on Protein: 130-217
Range on HMM: 1-112/112
Sequence Identity: 30% (34 aa)

MGGTRA-AGRVELCI-GGQWGTICNK-G-WNDKSANRVCNQLEY-KKGSDTLTCCVT----------------PRQDLDPPGLLDCLWPLPIGSTPN--C
.||.   .||||..  .|||||.|.  | |... |. || || .   .. .. ||                  .|   .   | .| ..    .. |  |
VGGSSPCEGRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPGTGPIWMDNVRCHGNETSLWQCPHSPWGWHRHNPMC

THS-NDAGVICT
.|| .||||||.
SHSREDAGVICS
SR AqueK373.AA SR 127-217 27 1.9e-19 71.83 SMART 1-118 (118) Show / Hide 
Range on Protein: 127-217
Range on HMM: 1-118/118
Sequence Identity: 27% (33 aa)

IRLMGGTR-AAGRVELCIGG----QWGTICNKGWNDKSANRVCNQLEYKKGSDTLT-----CCVTPR-------QDLDPPGLL----DCLWPLPIGSTPN
.||.||..  .||||  ..|    ||||.| ..|. . || || || .  .. . .      .  ..        . .  |      || .  ..|.. |
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCTGTETSLWDCPH-WGWGQHNN

-CTH------SNDAGVICT
 | |      ..||||.|.
CCSHNHHRNRQEDAGVVCS
SRCR AqueK373.AA SRCR 239-279 32 3.9e-08 29.13 Pfam 1-43 (112) Show / Hide 
Range on Protein: 239-279
Range on HMM: 1-43/112
Sequence Identity: 32% (14 aa)

FNGTNPSSGRIGICGSDGQLHNICDF-M-FSDQAATVICRELG
 .|..|..||. ..  .|| . .||    .....| |.||.||
VGGSSPCEGRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLG
SRCR AqueK373.AA SRCR 1195-1299 24 2.8e-10 36.35 Pfam 1-112 (112) Show / Hide 
Range on Protein: 1195-1299
Range on HMM: 1-112/112
Sequence Identity: 24% (29 aa)

FGSTREYEGLVSVCY-NGTWSVLCGGTDSRWNVDTATIVCRSLNY-KGAGII-LKDHGWSNG--TSSSLPAVQFTSSQCIGGTANIITDC---ASLESIT
 |..  .|| | |.| ||.|   |.  .  |.   |  ||| |..  ||       ...  |   . . | .   . .| | .   ...|   .. .. .
VGGSSPCEGRVEVRYHNGQWGTVCDDDG-NWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPG-TGP-IWMDNVRCHG-NETSLWQCPHSPWGWHRH

Y--CPTH--QYSGVLCS
.  | .|  .. || ||
NPMC-SHSREDAGVICS
SR AqueK373.AA SR 1192-1299 23 4.9e-09 35.88 SMART 1-118 (118) Show / Hide 
Range on Protein: 1192-1299
Range on HMM: 1-118/118
Sequence Identity: 23% (29 aa)

ITLFGSTREYEGLVSVCYNG----TWSVLCGGTDSRWNVDTATIVCRSLNYKGAGIILK----DHGWSNGTSSSLPAVQFTSSQCIGGTANIITDCA-SL
. | | ....|| | | .||    .|   |   |..|.   |  ||| | . ||    .    ....  . |           .| |  .  ..||. . 
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVC---DDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSG---PIWMDNVRCTGTET-SLWDCPHWG

ESITY--CPT------HQYSGVLCS
   ..  |.       ..  || ||
WGQHNNCCSHNHHRNRQEDAGVVCS
SRCR AqueK373.AA SRCR 1323-1416 27 1.9e-15 53.67 Pfam 9-112 (112) Show / Hide 
Range on Protein: 1323-1416
Range on HMM: 9-112/112
Sequence Identity: 27% (29 aa)

GLLLI-YYNGSYGTVCDD-E-FSMNEVQVLCTELGYSPDNGIAVSSEKF-VFI--QDEFQVYLDTVHCRSNIDTTIGRCLNDGFRS--TN--CDTI-ESV
| . . |.||. ||||||   ..|.. .| | .||. ..   |.|.. .  |   ..  ....| |.|.    |..  |  .. .   .|  |.   | .
GRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPGTGPIWMDNVRCHG-NETSLWQCPHSPWGWHRHNPMCSHSREDA

GIICQ
|.||.
GVICS
SR AqueK373.AA SR 1307-1416 20 4.3e-13 50.75 SMART 4-118 (118) Show / Hide 
Range on Protein: 1307-1416
Range on HMM: 4-118/118
Sequence Identity: 20% (26 aa)

ANGDTALLSFLSASNLGLLLIYYNG----SYGTVCDDEFSMNEVQVLCTELGYSPDNGIAVS----SEKFVFIQDEFQVYLDTVHCRSNIDTTIGRCLND
..|..        .. | . .|.||    . |||||| ..... .| | .||..       .    .  |   ..  . ..| |.|. . . ..  | ..
VGGNN--------PCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSG--PIWMDNVRCTGTET-SLWDCPHW

GFRSTN--CDT------IESVGIICQ
|....|  |.        | .|..|.
GWGQHNNCCSHNHHRNRQEDAGVVCS
SR AqueK373.AA SR 1427-1536 33 1.4e-26 95.57 SMART 1-118 (118) Show / Hide 
Range on Protein: 1427-1536
Range on HMM: 1-118/118
Sequence Identity: 33% (43 aa)

VRLMGGTR-AAGRVELCIGG----QWGTICNKGWNDKSANRVCNQLGYKKGIPSLAG------QFPAGIGPIWGSEINCTTLASLLGSDLDPPGLLDCLW
|||.||..  .||||  ..|    ||||.| ..|. . || || |||.  ..    .       |..| |||| ....||          . . | || .
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCT---------GTETSLWDCPH

PLPIGSTPN-CTH------SNDAGVICT
  ..|.. | | |      ..||||.|.
-WGWGQHNNCCSHNHHRNRQEDAGVVCS
SRCR AqueK373.AA SRCR 1430-1495 37 4.8e-20 69.16 Pfam 1-77 (112) Show / Hide 
Range on Protein: 1430-1495
Range on HMM: 1-77/112
Sequence Identity: 37% (29 aa)

MGGTRA-AGRVELCI-GGQWGTICNK-G-WNDKSANRVCNQLGYKKG---IPSLAGQ--FP--AGIGPIWGSEINCT
.||.   .||||..  .|||||.|.  | |... |. || |||.. |    .|  .   |.  .| |||| ....|.
VGGSSPCEGRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPGTGPIWMDNVRCH
SRCR AqueK373.AA SRCR 1510-1536 40 2e-05 20.02 Pfam 83-112 (112) Show / Hide 
Range on Protein: 1510-1536
Range on HMM: 83-112/112
Sequence Identity: 40% (12 aa)

LLDCLWPLPIGSTPN--CTHS-NDAGVICT
| .| ..    .. |  |.|| .||||||.
LWQCPHSPWGWHRHNPMCSHSREDAGVICS
SRCR AqueK373.AA SRCR 1558-1655 26 1.3e-18 64.31 Pfam 1-112 (112) Show / Hide 
Range on Protein: 1558-1655
Range on HMM: 1-112/112
Sequence Identity: 26% (30 aa)

FNGTNPSSGRIGICGSDGQLHNICDF-I-FSDQAATVICRELGL-KTPGYA-VHGLF--FG--TSGTTPLYTNSRCSGEETAYSECNRLMTSR------C
 .|..|..||. ..  .|| . .||    .....| |.||.||   .   |  .. .  ||   ..   .. | ||.| ||. ..|.. ....      |
VGGSSPCEGRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPGTGPIWMDNVRCHGNETSLWQCPHSPWGWHRHNPMC

TPGR-GDVGVVCS
   .  |.||.||
-SHSREDAGVICS
SR AqueK373.AA SR 1555-1655 27 3.4e-11 44.45 SMART 1-118 (118) Show / Hide 
Range on Protein: 1555-1655
Range on HMM: 1-118/118
Sequence Identity: 27% (33 aa)

LFLFNGTNPSSGRIGICGSD---GQLHNICDFIFSDQAATVICRELGLKTPGYAVH-----GLFFGTSGTTPLYTNSRCSGEETAYSECN-RLMTSR---
. | .|.||..||  .  ..   || . .||  .. ..| |.||.||. ..  |..     . .||  ..  .  | ||.| ||. ..|  .   .    
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCTGTETSLWDCPHWGWGQHNNC

CTPG-----RGDVGVVCS
|  .     . |.|||||
CSHNHHRNRQEDAGVVCS
SRCR AqueK373.AA SRCR 1685-1774 30 3e-20 69.84 Pfam 13-112 (112) Show / Hide 
Range on Protein: 1685-1774
Range on HMM: 13-112/112
Sequence Identity: 30% (31 aa)

VCF-GNSWGYICPE-D-WDNNDAKVICRQLGL-SLTWTGGKGIDAEY----ENLNDWLWMNEVQCTGNETRLLECGRRRLGTLRSN--CDDG-GFAAVAC
|.. ...|| .| . . ||..|| |.|||||  .  .   ..    .    .  .   ||..|.|.||||.| .| .. .|  |.|  |...   |.| |
VRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPG-TGPIWMDNVRCHGNETSLWQCPHSPWGWHRHNPMCSHSREDAGVIC

L
 
S
SR AqueK373.AA SR 1677-1774 25 3.6e-09 37.27 SMART 1-118 (118) Show / Hide 
Range on Protein: 1677-1774
Range on HMM: 1-118/118
Sequence Identity: 25% (31 aa)

EKVYKKVG-------VCFGN----SWGYICPEDWDNNDAKVICRQLGLSLTWTGGKG---IDAEYENLNDWLWMNEVQCTGNETRLLECGRRRLGTLRSN
    .  .       | ...    .|| .|  .|| .|| |.|||||..   .  ..    .| .   ..  || .|.|||.||.| .| .   |  ..|
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCTGTETSLWDCPH--WGWGQHN

--CDD------GGFAAVACL
  |.       .  | | |.
NCCSHNHHRNRQEDAGVVCS
SRCR AqueK373.AA SRCR 1880-1893 41 8.148556 1.19 Pfam 96-112 (112) Show / Hide 
Range on Protein: 1880-1893
Range on HMM: 96-112/112
Sequence Identity: 41% (7 aa)

SS--CSHS-DDIGIDCN
..  ||||  | |. |.
HNPMCSHSREDAGVICS
Pkinase_Tyr AqueK373.AA Pkinase_Tyr 2015-2288 37 1.4e-110 375.18 Pfam 1-270 (270) Show / Hide 
Range on Protein: 2015-2288
Range on HMM: 1-270/270
Sequence Identity: 37% (107 aa)

LKLMETIGKGEYGLVHKGQLM--MKSKSRIVAVKTLKGQFEQSD--VDSLLEESIKMFRF-NHPNVLGLLGVCL-DAGP-SPYIILPYMENGSLLNWLKR
.......|.|..| |.|| .   ....   ||||.|| .  ...   .....|   |  . .|||.. |.|||. . .| ..||...||..|.||. |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

ERNRIVIEETSAEDEVVDVKRELLSACHQIAKGMEYLSTRKFIHRDLAARNCMMDEYNLLKVSDFGLSQEIYGKTYFRQAEGEETKLPIKWMAIESMTDG
 |          ... ...|. ||. |.|||||||||. ...||||||||||. .| |  |..||||.  || . |     ....|||||||| |.. .|
HR---------EDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYG

LFSEKTDVWSFGVTCWEIFSGGKMP-YGGVSPMSLPSLL-EAGDRLQKPLNAACTSDVFDVLTRCWLTNPKDRPTFTDLVSTF
 |..|.|||||||..||||. |..| | |.|.  .  .. | | |. .| |  |. .. |....||  .|.|||||..... .
KFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPEN--CPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
TyrKc AqueK373.AA TyrKc 2015-2288 34 2e-110 374.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 2015-2288
Range on HMM: 1-280/280
Sequence Identity: 34% (106 aa)

LKLMETIGKGEYGLVHKGQLMMKSKSRIVAVKTLK-GQFEQSDVDSLLEESIKMFRF--NHPNVLGLLGVCLDAG------PSPYIILPYMENGSLLNWL
..| ...| |..| |.||..      . ||||.|| .      .  ...|   | ..  .|||.. |.|||.. |      . ..|.. ||..|.|.. |
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KRERNRIVIEETSAEDEVVDVKRELLSACHQIAKGMEYLSTRKFIHRDLAARNCMMDEYNLLKVSDFGLSQEIYGK-------TYFRQAEGEETK--LPI
.. |..                ..||| |.|||.|||||. ...||||||||||. .| .  |.|||||| .|| .        | |..|.. .|  |||
RKHRPK-------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

KWMAIESMTDGLFSEKTDVWSFGVTCWEIFSGGKMPYGG-----VSPMSLPSLLEAGDRLQKPLNAA------CTSDVFDVLTRCWLTNPKDRPTFTDLV
.|||.|.. .| |..|.|||||||..||||. |..|| |     .|.  .  ....|.|. .| |.       |....... ..||  .|.|||||....
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

STF
. |
ECF
Kinase AqueK373.AA TK 2015-2288 22 2.2e-102 344.07 In-house 1-486 (486) Show / Hide 
Range on Protein: 2015-2288
Range on HMM: 1-486/486
Sequence Identity: 22% (108 aa)

LKLMETIGKGEYG---LVHKGQLMMKS-----------------------KSRIVAVKTLKGQFEQSDVDSLL---------------EESIKMFR---F
..| ...|.|..|    |.||.. ...                       .   ||||.||   ..|. . ..                | .||..   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NHPNVLGLLGVCLDAGPS-----------PYIILPYMENGS----LLNWLKRERN---------------------------------RIVIEETSAEDE
.|||.. |.|||.. .|.           ..|.. ||..|.    |...|.. |.                                 . . .. . |..
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

VVDV------------------------------KRELLSACHQIAKGMEYLSTR------KFIHRDLAARNCMMDEYNL-----------LKVSDFG--
..|                                ..||  |.|||.|||||. .      .|.|||||||||. .| |             |..|||  
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LSQEIY-GKTYFRQAEGE---------------------ETKLPIKWMAIESMTDGL---------FSEKTDVWSFGVTCWEIFSGG-KMPYGG
      |. .|| .. | |. ..                       .||||.||| |...|.          |..|.|||||||..||||. | ...|||
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

VSP---------MSLPSLLEA------------GDRLQKPLNAACT--------------SDVFDVLTRCWLTNPKDRPTFTDLVSTF
.|            .  .|..            |.|...|  . |.               ...|....||  .|.|||||..|.. .
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK373.AA UTK 2015-2288 33 3e-89 302.81 In-house 1-296 (296) Show / Hide 
Range on Protein: 2015-2288
Range on HMM: 1-296/296
Sequence Identity: 33% (101 aa)

LKLMETIGKGEYGLVHKGQLMMKS---KSRIVAVKTLK-GQFEQSDVD---SLLEESI---KMFRFN-HPNVLGLLGVCLDAGPSPYIILPYMENGSLLN
..|....|.|..| |||. .   |   .  .||||... . . | . .    ..||.     | .|. |||||.|.|||.. .| ..|.. |||||.|..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

WLKRERNRIVIEETSAEDEVVDVK-RELLSACHQIAKGMEYLSTRKFIHRDLAARNCMMDEY-------NLLKVSDFG---LSQEIY---------GKTY
 | | |           .. . .. ...|. . .|| ||.||....|.|||||||||  ..        .. |..|||   .| ...         .  |
YLRRHRPTPP-------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYY

FRQAEGEETKLPIKWMAIESMTDG-LFSEKTDVWSFGVTCWEIFSGGKMPYGGVSPMSLPSLLEAGDRLQKPLNAACTSDVFDVLTRCWLTNPKDRPTFT
.....   ...||.||| |..|..  |..|.|||||||.||||...|..||.| | | .   ...|.|.. | ...|  .|.....||| ..| .||.| 
YMAQH--QDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFE

DLVSTF
|||...
DLVQQM
Kinase AqueK373.AA Met 2016-2282 36 8.2e-89 291.3 In-house 1-271 (271) Show / Hide 
Range on Protein: 2016-2282
Range on HMM: 1-271/271
Sequence Identity: 36% (103 aa)

KLMETIGKGEYGLVHKGQLMM-KSKSRIVAVKTLK--GQFEQSDVDSLLEESIKMFRFNHPNVLGLLGVCLDAGP-SPYIILPYMENGSLLNWLKRERNR
 . . ||.| .| | .|..   ...   .|.|.|.   . .   .   |.| | |  |.||||| |.|.|||    .|...||||..| |... . . | 
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNN

IVIEETSAEDEVVDVKRELLSACHQIAKGMEYLSTRKFIHRDLAARNCMMDEYNLLKVSDFGLSQEI-YGKTYFRQAEGEE-TKLPIKWMAIESMT----
. .             |.|.. |||.||||.|.  .||.|||||.||||.||    || ||||.  . | | |  | .     .||.|||| |.      
PCV-------------RDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVC

----DGL-FSEKTDVWSFGVTCWEIFSGGKMPYGGVSP-MSLPSLLEAG--DRLQKPLNAACTSDVF-DVLTRCWLTNPKDRPTFT
    .   |. |.|||||||  || .  |  ||. |..   .   |. |   || .|    |   .  ||  .||  || |||.| 
LGCPTYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQP--EYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase AqueK373.AA Axl 2015-2286 40 5.3e-80 272.1 In-house 1-267 (267) Show / Hide 
Range on Protein: 2015-2286
Range on HMM: 1-267/267
Sequence Identity: 40% (114 aa)

LKLMETIGKGEYGLVHKGQLMMKS-KSRIVAVKTLK-GQFEQSDVDSLLEESIKMFRFNHPNVLGLLGVCLDAG-----PSPYIILPYMENGSLLNWLKR
. |  ..|.||.| |  |||      .  ||||..|   . ||...  | | . |  |.||||. |.|||. .      | | .|||.|  | |  .|  
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY

ERNRIVIEETSAEDEVVDVKRELLSACHQIAKGMEYLSTRKFIHRDLAARNCMMDEYNLLKVSDFGLSQEIYGKTYFRQAEGEETKLPIKWMAIESMTDG
 |    ...      .      |.     || ||||||.|.||||||||||||. |     | |||||. ||   |.||  |  .|.|.||.||||. | 
SR----LGDQPFYLPL----QMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQ--GCIAKMPVKWIAIESLADR

LFSEKTDVWSFGVTCWEIFSGGKMPYGGVSPMSLPSLLEAGDRLQKPLNAACTSDVFDVLTRCWLTNPKDRPTFTDLVS
..  | |||.|||| |||   |. || ||    .   |  |.||..|  . |  ...|.. .|| ..|||||.|. |  
VYTSKSDVWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQP--EDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase AqueK373.AA TK-Unique 2015-2288 29 8.7e-80 271.37 In-house 1-294 (294) Show / Hide 
Range on Protein: 2015-2288
Range on HMM: 1-294/294
Sequence Identity: 29% (89 aa)

LKLMETIGKGEYGLVHKGQLMMKS----KSRIVAVKTLKGQFEQSDVDSLLEESIKMFRFN-HPNVLGLLGVCLDAGPSPYIILPYMENGSLLNWLKRER
|.. ..||.|..| |..|..  ..    | ..||||.||  . . |.. .| |   |     |||.. .||.| . . ...||..|...|.|.. |.. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

NR-----------IVIEETSAEDEVVDVK-RELLSACHQIAKGMEYLST--RKFIHRDLAARNCMMDEYNLLKVSDFGLSQEIY-GKTYFRQAEGEETKL
             .  .   ....  ... . |.. . |||.|||||.   .|..||||.|||... |.. .|..|||.. ..| .. |  . .... ..
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVY--SMMCSQGRI

PIKWMAIESMT--DGLF-SEKTDVWSFGVTCWEIFSGGKMPYGGVSPMSLPSLLEAGDRLQKPLNAAC-TSDVFDVLTRCWLTNPKDRPTFTDLVSTF
||.||| ||.   .| . ..|.|||||||. ||||. |..||.|... ..  ....|.|...|  . | . ... .. .||  .|..||.|..... .
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQP--EHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK373.AA EGFR 2015-2289 35 2.1e-75 249.82 In-house 1-258 (258) Show / Hide 
Range on Protein: 2015-2289
Range on HMM: 1-258/258
Sequence Identity: 35% (98 aa)

LKLMETIGKGEYGLVHKGQLMMKSKS-RI-VAVKTLKGQFEQSDVDSLLEESIKMFRFNHPNVLGLLGVCLDAGPSPYIILPYMENGSLLNWLKRERNRI
||..   | | .| |.||  . . .. .| ||.| |. | ...  . .|.|   |.. .||... |||||.       ..  ||  |.||....  ...|
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ--MQLVTQYMPYGCLLDYVRQHKDNI

VIEETSAEDEVVDVKRELLSACHQIAKGMEYLSTRKFIHRDLAARNCMMDEYNLLKVSDFGLSQEIYGKTYFRQAEGEETKLPIKWMAIESMTDGLFSEK
               ..||  | ||||||.||  .. .|||||||| ..   |  |. ||||..    .    . . .. |.||||||.|..  . .  .
-------------GSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLL--EHDEKEYHAQGGKMPIKWMALECIHHRCYTHQ

TDVWSFGVTCWEIFSGGKMPYGGVSPMSLPSLLEAGDRLQKPLNAACTSDVFDVLTRCWLTNPKDRPTFTDLVSTFD
 ||||.||||||.   |. || |..  . |.||| |.||. | .  || ||. |. .||.  .. ||||  |.. |.
SDVWSYGVTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPI--CTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase AqueK373.AA Abl 2015-2288 39 4.3e-66 219.31 In-house 1-252 (252) Show / Hide 
Range on Protein: 2015-2288
Range on HMM: 1-252/252
Sequence Identity: 39% (108 aa)

LKLMETIGKGEYGLVHKGQLMMKSKSRIVAVKTLKGQFEQSDVDSLLEESIKMFRFNHPNVLGLLGVCLDAGPSPYIILPYMENGSLLNWLKRERNRIVI
. . . .| | || | .|  . |  . .|||||||   .. .|.  |.|   |    |||.  |||||    |  |||  .| .| ||..| || .|  .
IMMKHKLGGGQYGEVYEG--VWKRHDCTVAVKTLKE--DTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPF-YIITEFMCYGNLLDYL-RECDREEL

EETSAEDEVVDVKRELLSACHQIAKGMEYLSTRKFIHRDLAARNCMMDEYNLLKVSDFGLSQEIYGKTYFRQAEGEETKLPIKWMAIESMTDGLFSEKTD
      . ||     ||    ||| ||.||  |.|||||||||||.. | ...|| ||||.  . . ||  .|     | |||| | ||.    || | |
------PAVV-----LLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHA---GAKFPIKWTAPESLAYNKFSSKSD

VWSFGVTCWEIFSGGKMPYGGVSPMSLPSLLEAGDRLQKPLNAACTSDVFDVLTRCWLTNPKDRPTFTDLVSTF
|| |||  |||   |  || |.       .|| | |...|    |  .|.... .||  .. |||.|...  ..
VWAFGVLLWEIATYGMSPYPGIDLSHVYHKLEKGYRMERP--EGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase AqueK373.AA FGFR 2015-2288 32 5.6e-65 220.41 In-house 1-293 (293) Show / Hide 
Range on Protein: 2015-2288
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

LKLMETIGKGEYGLVHKGQLM-MKSK----SRIVAVKTLKGQFEQSDVDSLLEESIKMFRF--NHPNVLGLLGVCLDAGPSPYIILPYMENGSLLNWLKR
| | ...| | .| | ..    .. .      .|||| ||      |  .|  | . |.     |.|.. |||.|  .|| .|.|  | . | |  .|. 
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSE-MEMMKMIGKHKNIINLLGCCTQEGP-LYVIVEYCHHGNLRDFLRA

ERNRIVIEETSAE-------DEVVDV----------KRELLSACHQIAKGMEYLSTRKFIHRDLAARNCMMDEYNLLKVSDFGLSQEIYGKTYFR-QAEG
 |      . ...           ..          ...| |  .|.|.|||||  || |||||||||    . . .|..||||.  |    |.|   .|
RRPPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNG

EETKLPIKWMAIESMTDGLFSEKTDVWSFGVTCWEIFSGGKMPYGGVS-PMSLPSLLEAGDRLQKPLNAACTSDVFDVLTRCWLTNPKDRPTFTDLVSTF
    ||||||| |.  |  .  . ||||.||  |||.  |  || ..     | ..|  | |. ||  . |..... ..  || ..|..||||. ||  .
---RLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKP--HNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase AqueK373.AA Src 2015-2288 34 6.9e-65 219.38 In-house 1-255 (255) Show / Hide 
Range on Protein: 2015-2288
Range on HMM: 1-255/255
Sequence Identity: 34% (95 aa)

LKLMETIGKGEYGLVHKGQLMMKSKSRIVAVKTLKGQFEQSDVDSLLEESIKMFRFNHPNVLGLLGVCLDAGPSPYIILPYMENGSLLNWLKRERNRIVI
.|| . .|.| .| | .|    . |   |||||||      ... .|.|   |  . |.... |. || .  |  ||.  ||..|||| .||.       
IKLCRKLGQGQFGEVWMGYWNGNTK---VAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPI-YIVTEYMSHGSLLDYLKK-------

EETSAEDEVVDVKRELLSACHQIAKGMEYLSTRKFIHRDLAARNCMMDEYNLLKVSDFGLSQEIY--GKTYFRQAEGEETKLPIKWMAIESMTDGLFSEK
     ...     ..|..   |.|.||.||. ...|||||||||   .| |. || |||| . |      |  .    . |.||||.| |  . | |. |
----DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH---GAKFPIKWTAPEAINYGRFTIK

TDVWSFGVTCWEIFSGGKMPYGGVSPMSLPSLLEAGDRLQKPLNAACTSDVFD-VLTRCWLTNPKDRPTFTDLVSTF
.||||||.  .||.. |..|| | . .     .|.| |. .| |  |   ... ....||   |..||||  | . .
SDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHN--CPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK373.AA Fer 2134-2289 34 7.8e-56 188.65 In-house 117-283 (283) Show / Hide 
Range on Protein: 2134-2289
Range on HMM: 117-283/283
Sequence Identity: 34% (59 aa)

CHQIAKGMEYLSTRKFIHRDLAARNCMMDE-YNLLK--VSDFGLSQE--IYGKTYF-RQAEGEETKLPIKWMAIESMTDGLFSEKTDVWSFGVTCWEIFS
|.|.|.|||||  .. ||||.||||| ...  . .|  .||||.| .   ||..|  .    ...|.||.|.| |....|..|.|||||||||.|||||.
CYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKE---KACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFT

GGKMPYGG----VSPMSLP-SLLEAGDRLQKPLNAA--CTSDVFDVLT-RCWLTNPKDRPTFTDLVSTFD
 |. ||.|    . .. .. .. ..  .  ...     . ...  ... .||  .|.||||..... .. 
NGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase AqueK373.AA S_TKc 2015-2292 21 1.6e-34 121.93 SMART 1-231 (231) Show / Hide 
Range on Protein: 2015-2292
Range on HMM: 1-231/231
Sequence Identity: 21% (63 aa)

LKLMETIGKGEYGLVHKGQLMMKSKSRIVAVKTLKGQFEQSDVDSLLEESIKMFRFNHPNVLGLLGVCLDAGPSPYIILPYMEN--GSLLNWLKRERN--
 .....|||| .| |.|..       ||||.| .|        . . | .| .   .|||.  |..|. |   . |... |...  |.|.  .|. .   
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHG

-RIVIEETSAEDEVVDVKRELLSACHQIAKGMEYLSTRKFIHRDLAARNCMMDEYNLLKVSDFGLSQEIYGKTYFRQAEGEETKLPIKWMAIESMTDGLF
 | .. |  |            . ..||....||.  ...|||||   | ..||   .|..||||. ..                   .|| | .    .
LRFPFPE-HA-----------RFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GY

SE-KTDVWSFGVTCWEIFSGGKMPYGGVSPMSLPSLLEAGDRLQKPLNAACTSDVFDVLTRCWLTNPKDRPTFTDLVSTF-----DDLL
.  | |.||.|.. .| .. |. |.          . .  ...        .... | . .|.  .|..|||  ..         .  .
GKCKCDWWSCGCILYEMLC-GYPPFP--------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK373.AA Pkinase 2015-2175 26 4e-20 72.25 Pfam 1-159 (293) Show / Hide 
Range on Protein: 2015-2175
Range on HMM: 1-159/293
Sequence Identity: 26% (46 aa)

LKLMETIGKGEYGLVHKGQLMMKSKSRI-VAVKTLKGQFEQSDVD--SLL--EESIKMFRFNHPNVLGLLGVCLDAGPSPYIILPYMENG----SLLNWL
... ..||.| .| |    . .. .... ||||..| . | |..|   ..  | .| | |.||||.. |.... | ....|....|.|.|    .|  ..
YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQI-MKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYI

KRERNRIVIEETSAEDEVVD--VKRELLSACHQIAKGMEYLSTRKFIHRDLAARNCMMD-EYNL---LKVSDFGLS
..            ... .     .|. . . ||..|.||.  ...|||||   |...| ....   .|..||||.
ST------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
Kinase AqueK373.AA Fer 2015-2116 28 1.5e-10 32.31 In-house 1-112 (283) Show / Hide 
Range on Protein: 2015-2116
Range on HMM: 1-112/283
Sequence Identity: 28% (32 aa)

LKLMETIGKGEYGLVHKG--QLMMKSKSRIV------AVKTLKGQFEQSD-VDSLLEESIKMFR-FNHPNVLGLLGVCLDAGPSPYIILPYMENGSLLNW
 .| . .|.| .| |.||   |..| . ..|      .||..|. . . .    .. |   |   ..||||  . ||| |  |  .|.. .. .|||.. 
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPI-MIVMEFCNGGSLDSY

LKRERNR-IVIEE
|| . |. . . |
LKKNKNKTVSDNE
Kinase AqueK373.AA Pkinase 2210-2288 17 1.9e-08 30.93 Pfam 190-293 (293) Show / Hide 
Range on Protein: 2210-2288
Range on HMM: 190-293/293
Sequence Identity: 17% (19 aa)

SEKTDVWSFGVTCWEIFSGGKMPYGGV----SPMSLPSLLEAGDRLQKPLNAACT-----------------------SDVFDVLTRCWLTNPKDRPTFT
. | |.||.|....| .. |. |. |     . ..   ...   ....||   .                        ..  |....|.  .||.|||..
GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICR--IMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

DLVST--F
...    |
QILQHPWF