Gene AqueK379 (A.queenslandica)
AqueK379
Species: A.queenslandica
Alias: AqueK379
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| AqueK379.AA | Protein | None | 135 | None | Fasta, JSON |
| AqueK379.kin_dom | Protein Kinase Domain | None | 277 | None | Fasta, JSON |
Protein domains of AqueK379.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Pkinase_Tyr | AqueK379.AA | Pkinase_Tyr | 2-130 | 45 | 5.3e-71 | 241.08 | Pfam | 123-253 (270) | Show / Hide |
Range on Protein: 2-130 Range on HMM: 123-253/270 Sequence Identity: 45% (60 aa) GMEYLSRKKFVHRDLAARNILVSDEGTGICKIADFGMSRDLQDESYY-ISQT-KKVPLKWTAPEALHYKKYSSASDVWSYGAVMYEIWSLGHKP-FENST |||||..|...||||||||.||.. ....||.|||..||.....|| ... |.| ||.|||...|.|....|||||.| .|.|| ..| .| ... . GMEYLESKNCIHRDLAARNCLVTE--NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMS NQEYVRLV-DSGYRLPPPPGCPKPMYKLMIQCW |.| .... ..|||.|.|..||...|.|| ||| NEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCW |
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| Kinase | AqueK379.AA | TK | 2-130 | 29 | 1.2e-63 | 211.93 | In-house | 246-469 (486) | Show / Hide |
Range on Protein: 2-130
Range on HMM: 246-469/486
Sequence Identity: 29% (65 aa)
GMEYLSRK------KFVHRDLAARNILVSDEGT---------GICKIADFGMS--------RDLQDESYYISQT-------------------------K
|||||..| .||||||||||.||..... .|||||||.| ||......| ...
GMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGG
KVPLKWTAPEALH---------YKKYSSASDVWSYGAVMYEIWSLGHKPFEN-STN---------QEYVRLVDSG--------------YRLPPPPGCP-
|.|..|.|||.| |.|....|||||.| .|.||...| .|. .| || .... .| .|.|.||.||
KLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPD
-------------KPMYKLMIQCW
. .| || |||
WMRYRMHPPHCPPEEYYDLMQQCW
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| Kinase | AqueK379.AA | Eph | 2-130 | 50 | 3.7e-63 | 210.98 | In-house | 117-247 (264) | Show / Hide |
Range on Protein: 2-130 Range on HMM: 117-247/264 Sequence Identity: 50% (67 aa) GMEYLSRKKFVHRDLAARNILVSDEGTGICKIADFGMSRDLQDES----YYISQTKKVPLKWTAPEALHYKKYSSASDVWSYGAVMYEIWSLGHKPFENS || ||| .||||||||||||. . .||..|||.|| |.|.. | .. |.|..||||||. |.|..||||||||| || |. | | .|. . GMKYLSDMNYVHRDLAARNILVNSN--LVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDM TNQEYVRLVDSGYRLPPPPGCPKPMYKLMIQCW .||. . .. |||||||..||.....|| .|| SNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCW |
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| Kinase | AqueK379.AA | SFK-Src | 2-130 | 49 | 5.5e-62 | 182.24 | In-house | 108-238 (259) | Show / Hide |
Range on Protein: 2-130 Range on HMM: 108-238/259 Sequence Identity: 49% (66 aa) GMEYLSRKKFVHRDLAARNILVSDEGTGICKIADFGMSRDLQDESY-YISQTK-KVPLKWTAPEALHYKKYSSASDVWSYGAVMYEIWSLGHKPFENSTN || || . ||||||||||.|| | .||..|||||| | ... | .. | | ||||||| . ..| |||||.| |.|| .| .|.. || GMAYLEAQNFVHRDLAARNVLVGDN--NVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPYPGMTN QEYVRLVDS--GYRLPPPPGCPKPMYKLMIQCW .| .. || |||.| ||.|| .||.|..|| MEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCW |
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| Kinase | AqueK379.AA | Src | 2-130 | 44 | 4.5e-59 | 199.33 | In-house | 109-238 (255) | Show / Hide |
Range on Protein: 2-130 Range on HMM: 109-238/255 Sequence Identity: 44% (59 aa) GMEYLSRKKFVHRDLAARNILVSDEGTGICKIADFGMSRDLQ--DESYYISQTKKVPLKWTAPEALHYKKYSSASDVWSYGAVMYEIWSLGHKPFENSTN ||.||......||||||||.||... .||.|||| | .. |. | .. |.| |||||||..| ... |||||.| ..|| . | | . || GMAYLESMNYIHRDLAARNVLVGENN--VCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTN QEYVRLVDSGYRLPPPPGCPKPMYK-LMIQCW .| .. |. |||.| |..||. .|. .| ||| HEVLQQVERGYRMPCPHNCPDELYEQIMLQCW |
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| Kinase | AqueK379.AA | UTK | 2-131 | 43 | 1e-58 | 199.52 | In-house | 130-280 (296) | Show / Hide |
Range on Protein: 2-131 Range on HMM: 130-280/296 Sequence Identity: 43% (65 aa) GMEYLSRKKFVHRDLAARNILVSDEG-----TGICKIADFG---MSRDLQD--------ES-YYISQ-TKKVPLKWTAPEALHYK-KYSSASDVWSYGAV ||.||....||||||||||.|| . . .||||||| |||.... || || .| ...|..|.||||| . .....|||||.| | GMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVV MYEIWSLGHKPFENSTNQEYVRLVDSG--YRLPPPPGCPKPMYKLMIQCWY ..|||. | .|... .|.. . | | ||.|.|..|| |.|.|| .||. CWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWH |
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| Kinase | AqueK379.AA | SRM | 2-130 | 46 | 1.8e-54 | 180.57 | In-house | 109-235 (253) | Show / Hide |
Range on Protein: 2-130
Range on HMM: 109-235/253
Sequence Identity: 46% (60 aa)
GMEYLSRKKFVHRDLAARNILVSDEGTGICKIADFGMSRDLQDESYYISQTKKVPLKWTAPEALHYKKYSSASDVWSYGAVMYEIWSLGHKPFENSTNQE
|| || ....||||||||.|| |. . ||..|||. | . | | | ..| |||||||. | || |||||.| ..|. . | |.. || |
GMCYLEEQNYIHRDLAARNVLVGDNNL--CKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYPGMTNHE
YVRLVDSGYRLPPPPGCPKPMYKLMIQCW
.| |||.| | || .|||..||
TFQQIDRGYRMPCPAECPPEVHKLMLECW
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| Kinase | AqueK379.AA | Fer | 2-130 | 37 | 1.7e-53 | 180.6 | In-house | 123-265 (283) | Show / Hide |
Range on Protein: 2-130
Range on HMM: 123-265/283
Sequence Identity: 37% (54 aa)
GMEYLSRKKFVHRDLAARNILVSDEGTGI-CKIADFGMSRDLQDESYYIS---QTKKVPLKWTAPEALHYKKYSSASDVWSYGAVMYEIWSLGHKPFEN-
||||| |. .|||.||||.|...... . |||.||||||.. |. | . .||| .|.|||.. .. ||...||||.| ...|| . | .|...
GMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQ
-----STNQ--EYVRL-VDSGYRLPPPPGCPKPMYKLMI-QCW
||. . .. ...||..|.|...|......| |||
PHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCW
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| Kinase | AqueK379.AA | TK-Unique | 2-130 | 41 | 3.1e-53 | 181.89 | In-house | 143-277 (294) | Show / Hide |
Range on Protein: 2-130 Range on HMM: 143-277/294 Sequence Identity: 41% (57 aa) GMEYLSR--KKFVHRDLAARNILVSDEGTGICKIADFGMSRDLQDESYYISQTK--KVPLKWTAPEALH--YKKY-SSASDVWSYGAVMYEIWSLGHKPF |||||.. ||.|||||.|||.|... ..|||.||||.||.... |..... ..|..| |||.| .. | .. |||||.| .|.|| .|| |. GMEYLASQRKKIVHRDLCARNVLLTE--DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPY ENSTNQEYVRLVDSGYRLPPPPGC-PKPMYKLMIQCW . . . .... |||.| |..| .. ||.||..|| PGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCW |
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| Kinase | AqueK379.AA | Syk | 2-130 | 48 | 1.3e-51 | 175.97 | In-house | 118-246 (257) | Show / Hide |
Range on Protein: 2-130 Range on HMM: 118-246/257 Sequence Identity: 48% (64 aa) GMEYLSRKKFVHRDLAARNILVSDEGTGICKIADFGMSRDL-QDESYYISQTK-KVPLKWTAPEALHYKKYSSASDVWSYGAVMYEIWSLGHKPFENSTN || || |.||||||||||.| .. . || |||||. | |..|| ..| | |.|| ||| | | |..|||||.| | | |.| || .. GMCYLEEKHFVHRDLAARNVLLVNR--HYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMWEMFSYGQKPYGEMKG QEYVRLVDSGYRLPPPPGCPKPMYKLMIQCW || . ....| |.. |.|||. || || .|| QEVMKFIENGHRMNCPNGCPQEMYQLMNKCW |
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| Kinase | AqueK379.AA | Tec | 2-130 | 48 | 2.7e-51 | 176.72 | In-house | 109-235 (254) | Show / Hide |
Range on Protein: 2-130 Range on HMM: 109-235/254 Sequence Identity: 48% (62 aa) GMEYLSRKKFVHRDLAARNILVSDEGTGICKIADFGMSRDLQDESYYISQTKKVPLKWTAPEALHYKKYSSASDVWSYGAVMYEIWSLGHKPFENSTNQE ||.|| |..|.|||||||| ||.|. .. |..||||.| | | | | | || .|| .|| .||| ||||..| | |..|.| |.|| .| | GMAYLERHCFIHRDLAARNCLVGDQ--CVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYENMSNSE YVRLVDSGYRLPPPPGCPKPMYKLMIQCW | | |.|| | |.. .|. | .|| VVEHVSQGHRLYRPHLCSMHIYQIMYHCW |
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| TyrKc | AqueK379.AA | TyrKc | 1-134 | 22 | 6.7e-17 | 50.56 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-134
Range on HMM: 1-280/280
Sequence Identity: 22% (64 aa)
X---------------------------------------------------------------------------------------------------
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK
-----------GMEYLSRKKFVHRDLAARNILVSDEGTGICKIADFGMSRDLQDE-------SYYISQT---KK--VPLKWTAPEALHYKKYSSASDVWS
|||||..|...||||||||.||.... ..||.|||.|||. |. .|| ... .| .|..|.|||.. |.|....|||||
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWS
YGAVMYEIWSLGHKPFEN-----STNQEYVRLVDSGYRLPPPPG--------CPKPMYKLMIQCWYV-------------FL
.| .|.|| ..| .| .. .||| ...|..|||.|.|| ||. ||..| ||| ..
FGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | AqueK379.AA | Pkinase | 2-130 | 21 | 1.5e-13 | 48.96 | Pfam | 120-274 (293) | Show / Hide |
Range on Protein: 2-130 Range on HMM: 120-274/293 Sequence Identity: 21% (35 aa) GMEYLSRKKFVHRDLAARNILVSDEGTGIC----KIADFGMSRDLQDESYYISQTKKVPLKWTAPEALH-YKKYSSASDVWSYGAVMYEIWSLGHKPFEN |.||. .....|||| |||.. .| . ||.||| .. .. .. .| . . . ||| . ...|....|.||.| ..|| . |. || . GLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPG S-------TNQEYVRLVDSGYRLPPPPGCP-------------------KPMYKLMIQCW . .| ..| . .. . | |. ... ... |. HCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL |
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| Kinase | AqueK379.AA | S_TKc | 2-134 | 13 | 0.000102 | -107.72 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 2-134
Range on HMM: 1-231/231
Sequence Identity: 13% (34 aa)
G----------------------------------------------------------------MEYLSR-----------------------------
|||..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYM
------------KKFVHRDLAARNILVSDEGTGICKIADFGMSRDLQDESYYISQTKKVPLKWTAPEALHYKKYSS-ASDVWSYGAVMYEIWSLGHKPFE
....|||| |||... ||.|||..| | | . . . ||| | .|. ..|.|| | ..|| . | ||.
YQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP
NSTNQEYVRLVDSGYRLPPPPGCPKPMYKLMIQCWY---------------------VFL
. |. ... .... .. .|. ..
--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
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