Gene AqueK388 (A.queenslandica)

AqueK388

Species: A.queenslandica
Alias: AqueK388
External Links:
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
AqueK388.AA Protein None 1820 None Fasta, JSON
AqueK388.kin_dom Protein Kinase Domain None 283 None Fasta, JSON

Protein domain

Protein domains of AqueK388.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
WD40 AqueK388.AA WD40 15-54 12 0.93307 0.55 SMART 1-46 (46) Show / Hide 
Range on Protein: 15-54
Range on HMM: 1-46/46
Sequence Identity: 12% (6 aa)

IGQFISRHYTKMG--PLRALSSNPHN------GVVTLGHHNGTVSMWT
  . ..      |  . .... .|..       ..  |  .||. .| 
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 AqueK388.AA WD40 58-96 30 2.3e-10 32.46 Pfam 1-39 (39) Show / Hide 
Range on Protein: 58-96
Range on HMM: 1-39/39
Sequence Identity: 30% (12 aa)

SKPAVKMLCHRGRVSDIAIDRE-GRYMVTGGFDAKIRVWD
.|.  .   | . |...|.. . |.|...|. | .||.||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 AqueK388.AA WD40 57-96 25 2.1e-08 35.16 SMART 1-46 (46) Show / Hide 
Range on Protein: 57-96
Range on HMM: 1-46/46
Sequence Identity: 25% (12 aa)

MSKPAVKMLCHRG--RVSDIAIDREG------RYMVTGGFDAKIRVWD
  |.  .. .|.|  .|......  |      .|...|. | .||.||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 AqueK388.AA WD40 99-135 18 0.440198 2.61 SMART 1-46 (46) Show / Hide 
Range on Protein: 99-135
Range on HMM: 1-46/46
Sequence Identity: 18% (9 aa)

QYKPVNCFP-IAS--PPSSLDISQRG-------LLAFGYGSR-CEIWK
. |.|  |.   .  . ....... |       .|| |   . . ||.
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
BING4CT AqueK388.AA BING4CT 146-224 53 1.1e-49 176.2 Pfam 1-80 (80) Show / Hide 
Range on Protein: 146-224
Range on HMM: 1-80/80
Sequence Identity: 53% (43 aa)

PYLKY-RLSGQLHKLQFCPFEDCLGLGHSNGFTSIVVPGAGEANIDGLEVNPYQSKRQRQEWEVKALLEKIPADLIMLEP
||... . ... ....|||||| || |||.||.|..|||.||.|.| .| |||..| |||||||..||||.|...|.| |
PYMTHMKPGSKICSVRFCPFEDVLGIGHSHGFSSMIVPGSGEPNFDSYEANPYETKKQRQEWEVRQLLEKLPPEMISLDP
SR AqueK388.AA SR 300-401 41 4.5e-48 166.94 SMART 1-118 (118) Show / Hide 
Range on Protein: 300-401
Range on HMM: 1-118/118
Sequence Identity: 41% (49 aa)

VQLVDGDVPNVGRVEICINN----EWGTVCDDGWTHTNAEVVCRQLGYPTYGAAYLN----RAFFGPGAGPIHLDEVVCTGSEETILNCSHSGIGIND--
| ||.|. |. ||||. .|.    .|||||||.|. ..|.|||||||...  .|. .    .|.||.|.|||..|.| |||.| .. .|.|.|.| ..  
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCTGTETSLWDCPHWGWGQHNNC

CNH------DADVSVHCQ
|.|      . |..|.|.
CSHNHHRNRQEDAGVVCS
SRCR AqueK388.AA SRCR 303-401 42 8.7e-42 142.18 Pfam 1-112 (112) Show / Hide 
Range on Protein: 303-401
Range on HMM: 1-112/112
Sequence Identity: 42% (48 aa)

VDGDVPNVGRVEICI-NNEWGTVCDD-G-WTHTNAEVVCRQLGY-PTYGAAYLNRAF--FG--PGAGPIHLDEVVCTGSEETILNCSHSGIGI--ND--C
|.|..|. ||||..  |..||||||| | |. ..|.|||||||. ..   |. ..|.  ||  || |||..|.| |.|.| .. .|.||. |   ..  |
VGGSSPCEGRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPGTGPIWMDNVRCHGNETSLWQCPHSPWGWHRHNPMC

NHD-ADVSVHCQ
.|.  |..| |.
SHSREDAGVICS
TyrKc AqueK388.AA TyrKc 675-957 34 9.90000000001e-108 365.12 SMART 1-280 (280) Show / Hide 
Range on Protein: 675-957
Range on HMM: 1-280/280
Sequence Identity: 34% (107 aa)

LTIQESVGQGEFGIVYRGLISVKNDIPQAIAAKTLKGFYSKSDIDSLLEECIIMMSF--DNLNVLPLIGVCLDLG------PAPYIIMPFMSRGSLLSYL
.|  .  | |.||.||.|  .      .  | |.||       .  ...|  ||...  .. |.. |.|||.. |      . ..|.| .|. |.|..||
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKERPNLTVADTSEEDIVLNVRKQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYAK-------NYFRQFKRNSNDSPSLT
.| ||.            |.. |.|||.|.|.|.|| ||.|...||||||||||....|...|..||||| ||| .        | |. ..         
RKHRPK------------LCM-KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEH--------K

TVK--LPVKWMAIESLHDGLFSKKTDVWSYGILCWEVFSLGRAPYPG-----LDPVGVVEFLDTGGRLLAPRGEA------CSKEIYSLMTSCWSESPDD
  |  ||..|||.|.. .| |. |.||||.|...||.|..|  ||||     ...  |.|....|.|.  |          |..|.|..|..|| | |.|
GGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPED

RPVFSDLVSSI
|| ||.... .
RPTFSEIHECF
Kinase AqueK388.AA TK 675-957 22 5e-98 329.22 In-house 1-486 (486) Show / Hide 
Range on Protein: 675-957
Range on HMM: 1-486/486
Sequence Identity: 22% (112 aa)

LTIQESVGQGEFG---IVYRGLISV----------------------KNDIPQAIAAKTLKGFYSKSDIDSLL-------------EECIIMMSFD----
.|. .  |.|.||    ||.|.                         |.. ..  | |.||   . |. . ..             ||. .|. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-NLNVLPLIGVCLDLG-----------PAPYIIMPFMSRGS----LLSYLKKERPNLTVA---------------------------------DTSEEDI
   |.. |.|||.. .           . ..|.| .|. |.    |..||.| ||. .                                   . .||. 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

VLNV----------RKQLLS-------------------ICLQVANGMCYLASQ------RFIHRDLAARNCMIDDNGI-----------IKVADFG---
...            |.||.                   .|.|.|.|| ||.|.      .|.|||||||||....|..           .|.||||   
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSEDIYA-KNYFRQFKRNSNDSPSL--------------TTVKLPVKWMAIESLHDGL---------FSKKTDVWSYGILCWEVFSLGRAPYPGL
     |. |||  ..| |.  .  .. .                .  |||..||| |.| |.          |. |.||||.|.|.||.|..|..||.| 
QGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

DPV----------GVVEFLDTGGR------------LLAPRGEACS--------------KEIYSLMTSCWSESPDDRPVFSDLVSSI
 .            |.|.| .|||            .  |. . |.              .|.| ||..||.. |.||| ||.|.. .
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK388.AA Met 676-951 37 2.7e-86 282.93 In-house 1-271 (271) Show / Hide 
Range on Protein: 676-951
Range on HMM: 1-271/271
Sequence Identity: 37% (109 aa)

TIQESVGQGEFGIVYRGLISVKNDIPQAIAAKTLK--GFYSKSDIDSLLEECIIMMSFDNLNVLPLIGVCLDLGP-APYIIMPFMSRGSLLSYLKKERPN
   . .||| || ||.|  . .      .| |.|.         |   |.| |.|  ||  ||| |||.|||     |... |.|  | |... . .  |
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNN

LTVADTSEEDIVLNVRKQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDI-YAKNYFRQFKRNSNDSPSLTT-VKLPVKWMAI
..|             ..|.. |.||| || |.|||.|.|||||.||||.|   ..|||||||. |. | | |  |  .        |   .||||||| 
PCV-------------RDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHH--------THPARLPVKWMAP

ESLH--------DGL-FSKKTDVWSYGILCWEVFSLGRAPYPGLDP-VGVVEFLDTG--GRLLAPRGEACSKEIY-SLMTSCWSESPDDRPVFS
|.|         .   |. |.|||| |.. || .  |  |||  |. . .  .| .|   ||. |  | |   .|  .| .||. .| ||| ||
ECLQQGVCLGCPTYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQP--EYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase AqueK388.AA TK-Unique 675-957 32 1.3e-84 287.39 In-house 1-294 (294) Show / Hide 
Range on Protein: 675-957
Range on HMM: 1-294/294
Sequence Identity: 32% (99 aa)

LTIQESVGQGEFGIVYRGLISVKN---DIPQAIAAKTLKGFYSKSDIDSLLEECIIMMSFD-NLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKER
|......|.|.|| |.|| .. ..   | .. .| |.||   .. | . .| |  .|.. .   |.. ..|.| . .  ..|||.....|.|..||.. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

P---------NLTVADTSEEDIVLN--VR-KQLLSICLQVANGMCYLAS--QRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYAKNYFRQFKRNSNDSP
|         ||     ...|....  .  |.|.... |.|.|| ||||  ....||||.|||... .....|..|||...|.|.         |   | 
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT---------NGVYSM

SLTTVKLPVKWMAIESLH--DGLF-SKKTDVWSYGILCWEVFSLGRAPYPGLDPVGVVEFLDTGGRLLAPRGEAC-SKEIYSLMTSCWSESPDDRPVFSD
. .  ..|..||| |||   .| . . |.||||.|.| ||.|.||  ||||...  ..| .  | |.. |  | | |.|.|.|| |||...|..|| |..
MCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQP--EHCCSHEMYNLMKSCWQWEPEERPSFRQ

LVSSI
... .
IKHRL
Kinase AqueK388.AA UTK 675-957 31 1.2e-82 280.83 In-house 1-296 (296) Show / Hide 
Range on Protein: 675-957
Range on HMM: 1-296/296
Sequence Identity: 31% (97 aa)

LTIQESVGQGEFGIVYRGLI-SVKNDIPQ-AIAAKTLKGFYSKSD----ID---SLLEECI---IMMSFD-NLNVLPLIGVCLDLGPAPYIIMPFMSRGS
. . .  |||.||.|...    ...  .. . | |...   ...|     .    ..||.    .|. |.   ||| |.|||.. .| ..|.. .|..|.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ---HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGD

LLSYLKKERPNLTVADTSEEDIVLNVRKQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNG-------IIKVADFG---LSEDIYAKNYFRQFKRN
|.||| . ||..      ...  |. . |.|. ....|.|| ||.|..|.||||||||| .....       ..|.||||   .| ....   |     .
LRSYLRRHRPTPP-----ACPHWLTLH-QRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFH-FSNRYWE

SNDSPSLTTVKLPVKWMAIESLHDG-LFSKKTDVWSYGILCWEVFSLGRAPYPGLDPVGVVEFLDTGGRLLAPRGEACSKEIYSLMTSCWSESPDDRPVF
|. . .    ..|..||| |.| ..  |. |.||||.|..|||... ||.||||.  . |....  |||.. |. ..|. ..| ||..||  .|..|| |
SYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDF

SDLVSSI
 |||. .
EDLVQQM
Kinase AqueK388.AA ALK 675-959 39 4.2e-72 245.87 In-house 1-273 (273) Show / Hide 
Range on Protein: 675-959
Range on HMM: 1-273/273
Sequence Identity: 39% (114 aa)

LTIQESVGQGEFGIVYRGLISV-KND-IPQAIAAKTLKGFYSKSDIDSLLEECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKERPN
.|     |.| || || |. |   .|  | ..| |||.   |. |    . |  ||  |.  ||  .||.|..  |  .|.  .|. | ..|.|.  ||.
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPY-MIVLEYMEGGDMKSFLRECRPH

LTVADTSEEDIVLNVRKQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNG---IIKVADFGLSEDI-YAKNYFRQFKRNSNDSPSLTTVKLPVKWM
      |   ..    | || .|. || |  || ...||||| |||||     |   . |.|||| . || |   |.|   |         .  .|||||
PESLQPSQ--LTM---KDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGR---------AM-MPVKWM

AIESLHDGLFSKKTDVWSYGILCWEVFSLGRAPYPGLDPVGVVEFLDTGGRLLAPRGEACSKEIYSLMTSCWSESPDDRPVFSDLVSSINA
  | . ||.|  ||||||.|.||||.||||. ||||     | ||. .|||.  ||.  |   .| .|| ||   | ||| | ... .| .
PPEAFMDGIFTSKTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRN--CPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase AqueK388.AA Axl 675-955 37 1.7e-71 243.8 In-house 1-267 (267) Show / Hide 
Range on Protein: 675-955
Range on HMM: 1-267/267
Sequence Identity: 37% (108 aa)

LTIQESVGQGEFGIVYRGLISVKNDIPQAIAAKTLK-GFYSKSDIDSLLEECIIMMSFDNLNVLPLIGVCLDLG-----PAPYIIMPFMSRGSLLSYLKK
...   .|.|||| |  | .       . .| |..|    ..|.|.  | | . |  ||  ||. |||||. .      |.| .|.|||  | | ..|  
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY

ERPNLTVADTSEEDIVLNVRKQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYAKNYFRQFKRNSNDSPSLTTVKLPVKWM
 |         .. . | . . |.   . .| || ||....||||||||||||. ..  . |||||||  ||.  |.|| .            |.||||.
SR-------LGDQPFYLPL-QMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQGC----------IAKMPVKWI

AIESLHDGLFSKKTDVWSYGILCWEVFSLGRAPYPGLDPVGVVEFLDTGGRLLAPRGEACSKEIYSLMTSCWSESPDDRPVFSDLVS
||||| | ..  | |||..|.  ||.   |. ||||..   . ..|  | ||  |  | |  |.| || .||.  | ||| || |  
AIESLADRVYTSKSDVWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQP--EDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase AqueK388.AA InsR 675-959 33 9.2e-69 230.06 In-house 1-278 (278) Show / Hide 
Range on Protein: 675-959
Range on HMM: 1-278/278
Sequence Identity: 33% (98 aa)

LTIQESVGQGEFGIVYRG----LISVKNDIPQAIAAKTLKGFYSKSDIDSLLEECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKER
...    ||| || || |    ...   ..  ..| ||..   |  .    | |  .|  |.  .|  | |||    |. |..| .| .| | |||   |
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPM-YVVMEMMTYGDLKSYLRSRR

PNLTVADTSEEDIVLN------VRKQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYAKNYFRQFKRNSNDSPSLTTVKLP
|          ....|       . |...   ... || |||.  |.|||||.||||... . .|..|||.  |||   | |  ..           .||
PEEEF-----NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKG----------MLP

VKWMAIESLHDGLFSKKTDVWSYGILCWEVFSLGRAPYPGLDPVGVVEFL-DTGGRLLAPRGEACSKEIYSLMTSCWSESPDDRPVFSDLVSSINA
| ||| ||| || |. . ||||.|.. ||. .||  || ||    | ..    |. |  |  | |..  . ||  ||  .| .|| | |.....  
VRWMAPESLKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPP--ENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase AqueK388.AA Src 675-957 35 9.5e-68 229.24 In-house 1-255 (255) Show / Hide 
Range on Protein: 675-957
Range on HMM: 1-255/255
Sequence Identity: 35% (102 aa)

LTIQESVGQGEFGIVYRGLISVKNDIPQAIAAKTLKGFYSKSDIDSLLEECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKERPNLT
..  .  ||| || |. |.   .. .. |.  ||||      . . .|.|  || ...  ... |  || .  |  ||.  .||.|||| ||||      
IKLCRKLGQGQFGEVWMGYW--NGNTKVAV--KTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPI-YIVTEYMSHGSLLDYLKK------

VADTSEEDIVLNVRKQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIY--AKNY-FRQFKRNSNDSPSLTTVKLPVKWMAIE
    ..|   |... ||...  |||.||.|| |...|||||||||  ...| . |||||||   |     .|  |.              |.|.||.| |
----DGEGRHLHLP-QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH------------GAKFPIKWTAPE

SLHDGLFSKKTDVWSYGILCWEVFSLGRAPYPGLDPVGVVEFLDTGGRLLAPRGEACSKEIYS-LMTSCWSESPDDRPVFSDLVSSI
 .. | |. |.||||.||| .|... || |||| .   |.. .. | |.  |. . | .|.|  .|. || ..|..|| |  | .  
AINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRM--PCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK388.AA FGFR 675-957 33 3.4e-66 224.6 In-house 1-293 (293) Show / Hide 
Range on Protein: 675-957
Range on HMM: 1-293/293
Sequence Identity: 33% (102 aa)

LTIQESVGQGEFGIVYRGLIS--VKN--DIPQAIAAKTLKGFYSKSDIDSLLEECIIM-MSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKE
||. .  | | || | ..     ...  .   ..| | ||   .  |. .|  |  .| |   . |.. |.|.|   || .|.|  . ..| |  .|.. 
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGP-LYVIVEYCHHGNLRDFLRAR

RPNLTVADTSEE-------DIVLNV----------RKQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYAKNYFRQFKRNS
||    .. . .        .   .           |.| |.  ||| || ||||.. |||||||||  . |. ..|..||||. ||    |.|  |.  
RPPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYR--KT--

NDSPSLTTVKLPVKWMAIESLHDGLFSKKTDVWSYGILCWEVFSLGRAPYPGLD-PVGVVEFLDTGGRLLAPRGEACSKEIYSLMTSCWSESPDDRPVFS
      |   ||.|||| |.| |  .  . ||||||.| ||.. .|  |||.        ..| .| |.  |  . ||.||| .| .|| ..|..|| | 
------TNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKP--HNCSQEIYHMMCQCWHFKPCQRPTFK

DLVSSI
 || ..
QLVEYL
Kinase AqueK388.AA Pkinase_Tyr 675-844 36 3.1e-64 218.18 Pfam 1-166 (270) Show / Hide 
Range on Protein: 675-844
Range on HMM: 1-166/270
Sequence Identity: 36% (65 aa)

LTIQESVGQGEFGIVYRGLIS-VKNDIPQAIAAKTLKGFYSKSD--IDSLLEECIIMMSF-DNLNVLPLIGVCLDLGPA--PYIIMPFMSRGSLLSYLKK
.|. .  |.|.|| ||.|     . .  .  | |.||  .....  ......|  ||... .. |.. |.|||.| |    .||.|..|  |.||.||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

ERPNLTVADTSEEDIVLNVRKQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYAKNY
 |         |..  |..   ||..|.|.|.|| ||.|...||||||||||....|...|..||||. ||| . |
HR---------EDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDY
Kinase AqueK388.AA Pkinase_Tyr 862-957 44 9.7e-47 158.92 Pfam 175-270 (270) Show / Hide 
Range on Protein: 862-957
Range on HMM: 175-270/270
Sequence Identity: 44% (44 aa)

KLPVKWMAIESLHDGLFSKKTDVWSYGILCWEVFSLGRAP-YPGLDPVGVVEFL-DTGGRLLAPRGEACSKEIYSLMTSCWSESPDDRPVFSDLVSSI
|||.|||| |....| |. |.||||.|.|.||.|..|. | |||...  |.|.. . |.|. .|..  |..|||.||..|| . |.||| ||.... .
KLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPEN--CPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK388.AA Tec 862-959 43 6.8e-35 119.37 In-house 159-254 (254) Show / Hide 
Range on Protein: 862-959
Range on HMM: 159-254/254
Sequence Identity: 43% (43 aa)

KLPVKWMAIESLHDGLFSKKTDVWSYGILCWEVFSLGRAPYPGLDPVGVVEFLDTGGRLLAPRGEACSKEIYSLMTSCWSESPDDRPVFSDLVSSINA
| |||| . | .|   .| | |||..|.| |||||.|..||. .. . |||   .| ||  |.   ||..||  | .||.|.|..|| |..| ..|  
KFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYENMSNSEVVEHVSQGHRLYRPH--LCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase AqueK388.AA S_TKc 675-961 20 3.1e-31 111.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 675-961
Range on HMM: 1-231/231
Sequence Identity: 20% (62 aa)

LTIQESVGQGEFGIVYRGLISVKNDIPQAIAAKTLKGFYSKSDIDSLLEECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSR--GSLLSYLKKERPN
 .| . .|.| || ||..         .  | | .|        .... |  |... .  |.  |..|. |     |..| ...   |.|..|.|| ...
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LTVADTSEEDIVLNVRKQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYAKNYFRQFKRNSNDSPSLTTVKLPVKW
     ..  ..              ... |..... |. |...|||||   | ..|.   ||..||||.  .                   ||.     .
GLRFPFPE-HAR-------------FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------TTFCGTPWY

MAIESLHDGLFSK-KTDVWSYGILCWEVFSLGRAPYPGLDPVGVVEFLDTGGRLLAPRGEACSKEIYSLMTSCWSESPDDRPVFSDLVSSI-----NALI
|| | |    ..| | |.|| |.. .| .. |. |.|      . . ..  |          |.|  ...  |.   |..||   ..  .         .
MAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK388.AA Tec 675-836 34 4.6e-31 105.82 In-house 1-144 (254) Show / Hide 
Range on Protein: 675-836
Range on HMM: 1-144/254
Sequence Identity: 34% (57 aa)

LTIQESVGQGEFGIVYRGLISVKNDIPQAIAAKTLK-GFYSKSDIDSLLEECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKERPNL
||. . .|.| ||.| .|    . |    .| |..| |  |  |    .||  .||     .   | |||.   |  ||.  .|..|.||.||....  .
LTFMKELGSGQFGVVHLGKWRHQYD----VAIKMIKEGSMSEED---FIEEAKVMMKLSHPKLVQLYGVCSQQRPI-YIVTEYMEHGCLLNYLREHKHHF

TVADTSEEDIVLNVRKQ--LLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLS
              ...  ||..|..|  || || .. ||||||||||| ..|....||.|||..
Q-------------KNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMT
Kinase AqueK388.AA Pkinase 675-957 20 4.2e-27 96.93 Pfam 1-293 (293) Show / Hide 
Range on Protein: 675-957
Range on HMM: 1-293/293
Sequence Identity: 20% (68 aa)

LTIQESVGQGEFGIVYRGLISVKNDIPQAIAAKTLKGFYSKSDIDSLLE---ECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRG----SLLSYLK
..| . .|.| || ||..   .. . ..  | |..|    ||. |  .    |. || ...  |.. |.... | .. .|..|...  |    .| .|..
YHIGRKIGSGSFGCVYKC---HHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIS

KERPNLTVADTSEEDIVL--NVRKQLLSICLQVANGMCYLASQRFIHRDLAARNCMIDDNGII----KVADFGLSEDIYAKNYFRQFKRNSNDSPSLTTV
            ... ..     ... ....|.. |. |. |...|||||   |..||.|| |    |..||||.. ..              .. .||.
T-----------WRHGCFYFS-EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----------Y-NNS-MTTF

KLPVKWMAIESLH-DGLFSKKTDVWSYGILCWEVFSLGRAPYPGL----DPVGVVEFLDTGGR--LLAPRGEACS-------------------KEIYSL
     .|| | .  .   ..| |.||.|....|... || |.||     . .   . ..  ..  |  .. . ||                   .|  ..
CGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDF

MTSCWSESPDDRPVFSDLVSS--I
...|.   | .|| . ... .  .
IKWCLCKDPKKRPTAEQILQHPWF
Pkinase_Tyr AqueK388.AA Pkinase_Tyr 1513-1790 38 2.3e-110 374.43 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1513-1790
Range on HMM: 1-270/270
Sequence Identity: 38% (111 aa)

LKIQESVGQGELGIVYRGLIS-VKNGMPQTVAAKTLKGLYSKSD--IDSLLDECIIMMSF-DNLNVLPLIGVCLDLGPA--PYIIMPFMSRGSLLSYLKK
... .  |.|. | ||.|     . .  ..|| |.||  .....  ..... |  ||... .. |.. |.|||.| |    .||.|..|  |.||.||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

ERPNLTVADTSEEDIILNVRKQLLSACLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYSQNYF-RQLKGNNSSPVKLPLKWMALES
 |         |..  |..   ||. |.|.|.|| ||.|...||||||||||....|...|..||||. |||.  |  |. .|      ||| ||||.|.
HR---------EDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGG-----KLPIKWMAPEC

LHDGLFSEKSDVWSYGILCWEVFSLGRVP-YPGLDPVGVVEFL-DTGGRLLAPRGEACSKEIYSLMTSCWSEFPNDRPVFSDLVSSI
...| |..||||||.|.|.||.|..|. | |||...  |.|.. . |.|. .|..  |..|||.||..|| . |.||| ||.... .
INYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPEN--CPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
TyrKc AqueK388.AA TyrKc 1513-1790 34 2.3e-108 367.24 SMART 1-280 (280) Show / Hide 
Range on Protein: 1513-1790
Range on HMM: 1-280/280
Sequence Identity: 34% (107 aa)

LKIQESVGQGELGIVYRGLISVKNGMPQTVAAKTLKGLYSKSDIDSLLDECIIMMSF--DNLNVLPLIGVCLDLG------PAPYIIMPFMSRGSLLSYL
..  .  | |. |.||.|  .      ..|| |.||       .  ...|  ||...  .. |.. |.|||.. |      . ..|.| .|. |.|..||
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKERPNLTVADTSEEDIILNVRKQLLSACLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYSQ-------NYFRQLKGNNSSPVK--
.| ||.            |.. |.||| |.|.|.|| ||.|...||||||||||....|...|..||||| |||.         | |. ..   .  |  
RKHRPK------------LCM-KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEH---KGGKTM

LPLKWMALESLHDGLFSEKSDVWSYGILCWEVFSLGRVPYPG-----LDPVGVVEFLDTGGRLLAPRGEA------CSKEIYSLMTSCWSEFPNDRPVFS
||..|||.|.. .| |..||||||.|...||.|..|  ||||     ...  |.|....|.|.  |          |..|.|..|..|| | |.||| ||
LPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFS

DLVSSI
.... .
EIHECF
Kinase AqueK388.AA TK 1513-1790 23 1.8e-96 323.96 In-house 1-486 (486) Show / Hide 
Range on Protein: 1513-1790
Range on HMM: 1-486/486
Sequence Identity: 23% (113 aa)

LKIQESVGQGELG---IVYRGLISV----------------------KNGMPQTVAAKTLKGLYSKSDIDSLL---------------DECIIMMS---F
... .  |.|. |    ||.|.                         |.| ...|| |.||   . |. . ..                | . ||.   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DNLNVLPLIGVCLDLG-----------PAPYIIMPFMSRGS----LLSYLKKERP-----------------------------NLTVADTSEEDIILNV
.  |.. |.|||.. .           . ..|.| .|. |.    |..||.| ||                             ..  .. .... . . 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY-SHESNSPC-PEEQ

---------------RKQLLS-------------------ACLQVANGMCYLASQ------RFIHRDLAARNCMIDDNGI-----------IKVADFG--
                |.||.                    |.|.|.|| ||.|.      .|.|||||||||....|..           .|.||||  
DYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LSEDIYS-QNYFRQLKGNNSSPV------------------KLPLKWMALESLHDGL---------FSEKSDVWSYGILCWEVFSLGRVPYPGL
      |. |||| ..| |.  .  . |.                  |||..||| |.| |.          |..||||||.|.|.||.|..|..||.| 
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

DPV----------GVVEFLDTGGR------------LLAPRGEACS--------------KEIYSLMTSCWSEFPNDRPVFSDLVSSI
 .            |.|.| .|||            .  |. . |.              .|.| ||..||.. |.||| ||.|.. .
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK388.AA Met 1514-1784 37 3e-86 282.77 In-house 1-271 (271) Show / Hide 
Range on Protein: 1514-1784
Range on HMM: 1-271/271
Sequence Identity: 37% (108 aa)

KIQESVGQGELGIVYRGLISVKNGMPQTVAAKTLK--GLYSKSDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGP-APYIIMPFMSRGSLLSYLKKERPN
   . .|||  | ||.|  . . |    .| |.|.         |   | | |.|  ||  ||| |||.|||     |... |.|  | |... . .  |
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNN

LTVADTSEEDIILNVRKQLLSACLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDI-YSQNYFRQLKGNNSSPVKLPLKWMALESLH--
..|             ..|.. |.||| || |.|||.|.|||||.||||.|   ..|||||||. |. |   |  |   .   | .||.||||.|.|   
PCV-------------RDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQM--HHTHPARLPVKWMAPECLQQG

------DGL-FSEKSDVWSYGILCWEVFSLGRVPYPGLDP-VGVVEFLDTG--GRLLAPRGEACSKEIY-SLMTSCWSEFPNDRPVFS
      .   |. |||||| |.. || .  | .|||  |. . .  .| .|   ||. |  | |   .|  .| .||.  | ||| ||
VCLGCPTYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQP--EYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase AqueK388.AA UTK 1513-1790 31 1.3e-83 284.07 In-house 1-296 (296) Show / Hide 
Range on Protein: 1513-1790
Range on HMM: 1-296/296
Sequence Identity: 31% (96 aa)

LKIQESVGQGELGIVYRGLI-SVKNGMPQ-TVAAKTLK-GLYSKSDID---SLLDECI---IMMSFD-NLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLS
... .  |||. |.|...    ... |..  || |... .  .  . .    .. |.    .|. |.   ||| |.|||.. .| ..|.. .|..|.|.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

YLKKERPNLTVADTSEEDIILNVRKQLLSACLQVANGMCYLASQRFIHRDLAARNCMIDDNG-------IIKVADFG---LSEDIY---------SQNYF
|| . ||..      ... .|. . |.|. ....|.|| ||.|..|.||||||||| .....       ..|.||||   .| ...         ...|.
YLRRHRPTPP-----ACPHWLTLH-QRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYY

RQLKGNNSSPVKLPLKWMALESLHDG-LFSEKSDVWSYGILCWEVFSLGRVPYPGLDPVGVVEFLDTGGRLLAPRGEACSKEIYSLMTSCWSEFPNDRPV
..     ..  ..|..||| |.| ..  |..||||||.|..|||... ||.||||.  . |....  |||.. |. ..|. ..| ||..||   | .|| 
MA-----QHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPD

FSDLVSSI
| |||. .
FEDLVQQM
Kinase AqueK388.AA TK-Unique 1513-1790 32 5.3e-83 282.05 In-house 1-294 (294) Show / Hide 
Range on Protein: 1513-1790
Range on HMM: 1-294/294
Sequence Identity: 32% (97 aa)

LKIQESVGQGELGIVYRGLISVKN---GMPQTVAAKTLKGLYSKSDIDSLLDECIIMMSFD-NLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKER
|......|.|. | |.|| .. ..   . .. || |.||   .. | . .|.|  .|.. .   |.. ..|.| . .  ..|||.....|.|..||.. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

P---------NLT-VADTSEEDIILN-VR-KQLLSACLQVANGMCYLAS--QRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYSQNYFRQLKGNNSSPV
|         ||   ... ...  .. .  |.|.. . |.|.|| ||||  ....||||.|||... .....|..|||...|.|     ..   .. |  
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT----NGVYSMMCSQG

KLPLKWMALESLH--DGLF-SEKSDVWSYGILCWEVFSLGRVPYPGLDPVGVVEFLDTGGRLLAPRGEAC-SKEIYSLMTSCWSEFPNDRPVFSDLVSSI
..|..|||.|||   .| . ..||||||.|.| ||.|.||  ||||...  ..| .  | |.. |  | | |.|.|.|| |||.. | .|| |..... .
RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQP--EHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK388.AA Axl 1513-1788 39 4.3e-72 245.81 In-house 1-267 (267) Show / Hide 
Range on Protein: 1513-1788
Range on HMM: 1-267/267
Sequence Identity: 39% (110 aa)

LKIQESVGQGELGIVYRGLISVKNGMPQTVAAKTLK-GLYSKSDIDSLLDECIIMMSFDNLNVLPLIGVCLDLG-----PAPYIIMPFMSRGSLLSYLKK
. .   .|.|| | |  | .    |  . || |..|    ..|.|.  | | . |  ||  ||. |||||. .      |.| .|.|||  | | ..|  
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY

ERPNLTVADTSEEDIILNVRKQLLSACLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYSQNYFRQLKGNNSSPVKLPLKWMALESL
 |         .. . | . . |.   . .| || ||....||||||||||||. ..  . |||||||  |||  |.||  |  .   |.| ||.|.|||
SR-------LGDQPFYLPL-QMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQ--GCIA---KMPVKWIAIESL

HDGLFSEKSDVWSYGILCWEVFSLGRVPYPGLDPVGVVEFLDTGGRLLAPRGEACSKEIYSLMTSCWSEFPNDRPVFSDLVS
 | ..  |||||..|.  ||.   |. ||||..   . ..|  | ||  |  | |  |.| || .||.  | ||| || |  
ADRVYTSKSDVWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQP--EDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase AqueK388.AA ALK 1513-1792 38 3.8e-69 236.03 In-house 1-273 (273) Show / Hide 
Range on Protein: 1513-1792
Range on HMM: 1-273/273
Sequence Identity: 38% (111 aa)

LKIQESVGQGELGIVYRGLISV--KNGMPQTVAAKTLKGLYSKSDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKERPN
..     |.|  | || |. |       |  || |||. . |. |    . |  ||  |.  ||  .||.|..  |  .|.  .|. | ..|.|.  ||.
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPY-MIVLEYMEGGDMKSFLRECRPH

LTVADTSEE--DIILNVRKQLLSACLQVANGMCYLASQRFIHRDLAARNCMIDDNG---IIKVADFGLSEDI-YSQNYFRQLKGNNSSPVKLPLKWMALE
       .|     . . | ||  |. || |  || ...||||| |||||     |   . |.|||| . || |   |.|  ||       .| |||  |
-------PESLQPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYR--KGGRA---MMPVKWMPPE

SLHDGLFSEKSDVWSYGILCWEVFSLGRVPYPGLDPVGVVEFLDTGGRLLAPRGEACSKEIYSLMTSCWSEFPNDRPVFSDLVSSINA
 . ||.|  |.||||.|.||||.||||..||||     | ||. .|||.  ||.  |   .| .|| ||   | ||| | ... .| .
AFMDGIFTSKTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRN--CPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase AqueK388.AA InsR 1513-1792 33 1.6e-67 225.85 In-house 1-278 (278) Show / Hide 
Range on Protein: 1513-1792
Range on HMM: 1-278/278
Sequence Identity: 33% (96 aa)

LKIQESVGQGELGIVYRG-LISVKNGMPQT---VAAKTLKGLYSKSDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKER
. .    |||  | || | . ..  ... .   .| ||..   |  .    | |  .|  |.  .|  | |||    |. |..| .| .| | |||   |
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPM-YVVMEMMTYGDLKSYLRSRR

PNLTVADTSEEDII----LNVRKQLLSACLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYSQNYFRQLKGNNSSPVKLPLKWMALE
|        . ...       . |...   ... || |||.  |.|||||.||||... . .|..|||.  |||   | |  ..      .||  ||| |
PEEEF---NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKG-----MLPVRWMAPE

SLHDGLFSEKSDVWSYGILCWEVFSLGRVPYPGLDPVGVVEFL-DTGGRLLAPRGEACSKEIYSLMTSCWSEFPNDRPVFSDLVSSINA
|| || |. .|||||.|.. ||. .||  || ||    | ..    |. |  |  | |..  . ||  ||   | .|| | |.....  
SLKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPP--ENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase AqueK388.AA Src 1513-1790 37 1.1e-66 225.52 In-house 1-255 (255) Show / Hide 
Range on Protein: 1513-1790
Range on HMM: 1-255/255
Sequence Identity: 37% (105 aa)

LKIQESVGQGELGIVYRGLISVKNGMPQTVAAKTLKGLYSKSDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKERPNLT
.|  .  |||  | |. |.   .. ..  || ||||      . . .| |  || ...  ... |  || .  |  ||.  .||.|||| ||||      
IKLCRKLGQGQFGEVWMGYW--NGNTK--VAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPI-YIVTEYMSHGSLLDYLKK------

VADTSEEDIILNVRKQLLSACLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIY--SQNY-FRQLKGNNSSPVKLPLKWMALESLHDG
    ..|   |... ||..   |||.||.|| |...|||||||||  ...| . |||||||   |     .|  |.         |.| ||.| | .. |
----DGEGRHLHLP-QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH-------GAKFPIKWTAPEAINYG

LFSEKSDVWSYGILCWEVFSLGRVPYPGLDPVGVVEFLDTGGRLLAPRGEACSKEIYS-LMTSCWSEFPNDRPVFSDLVSSI
 |. ||||||.||| .|... ||||||| .   |.. .. | |.  |. . | .|.|  .|. || . | .|| |  | .  
RFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRM--PCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK388.AA FGFR 1513-1790 34 1.2e-64 219.22 In-house 1-293 (293) Show / Hide 
Range on Protein: 1513-1790
Range on HMM: 1-293/293
Sequence Identity: 34% (103 aa)

LKIQESVGQGELGIVYRGLIS--VKN--GMPQTVAAKTLKGLYSKSDIDSLLDECIIM-MSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRGSLLSYLKKE
| . .  | |  | | ..     ...      ||| | ||   .  |. .|  |  .| |   . |.. |.|.|   || .|.|  . ..| |  .|.. 
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGP-LYVIVEYCHHGNLRDFLRAR

RPNLTVADTSEE-------DIILNV----------RKQLLSACLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYSQNYFRQLKGNN
||    .. . .        .   .           |.| |   ||| || ||||.. |||||||||  . |. ..|..||||. || .  |.|  |  |
RPPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYR--KTTN

SSPVKLPLKWMALESLHDGLFSEKSDVWSYGILCWEVFSLGRVPYPGLD-PVGVVEFLDTGGRLLAPRGEACSKEIYSLMTSCWSEFPNDRPVFSDLVSS
     || ||||.|.| |  .  .|||||||.| ||.. .|  |||.        ..| .| |.  |  . ||.||| .| .|| . | .|| |  || .
G---RLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKP--HNCSQEIYHMMCQCWHFKPCQRPTFKQLVEY

I
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L
Kinase AqueK388.AA Tec 1579-1792 38 4.3e-63 215.93 In-house 61-254 (254) Show / Hide 
Range on Protein: 1579-1792
Range on HMM: 61-254/254
Sequence Identity: 38% (83 aa)

GVCLDLGPAPYIIMPFMSRGSLLSYLKKERPNLTVADTSEEDIILNVRKQ--LLSACLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSED
|||.   |  ||.  .|..|.||.||....  .              ...  ||. |..|  || || .. ||||||||||| ..|....||.|||..  
GVCSQQRPI-YIVTEYMEHGCLLNYLREHKHHFQ-------------KNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRY

IYSQNYFRQLKGNNSSP-VKLPLKWMALESLHDGLFSEKSDVWSYGILCWEVFSLGRVPYPGLDPVGVVEFLDTGGRLLAPRGEACSKEIYSLMTSCWSE
.    |        ||   | | || . | .|   .| |||||..|.| |||||.|..||. .. . |||   .| ||  |.   ||..||  | .||.|
VLDDQYT-------SSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYENMSNSEVVEHVSQGHRLYRPH--LCSMHIYQIMYHCWHE

FPNDRPVFSDLVSSINA
 | .|| |..| ..|  
KPEERPTFQQLLRQITE
Kinase AqueK388.AA S_TKc 1513-1794 20 2.1e-26 94.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 1513-1794
Range on HMM: 1-231/231
Sequence Identity: 20% (59 aa)

LKIQESVGQGELGIVYRGLISVKNGMPQTVAAKTLKGLYSKSDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSR--GSLLSYLKKERPN
 .| . .|.|  | ||..         . || | .|        .... |  |... .  |.  |..|. |     |..| ...   |.|..|.|| ...
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LTVADTSEEDIILNVRKQLLSACLQVANGMCYLASQRFIHRDLAARNCMIDDNGIIKVADFGLSEDIYSQNYFRQLKGNNSSPVKLPLKWMALES
     ..  ..              . . |..... |. |...|||||   | ..|.   ||..||||.  .              . .   . .|| | 
GLRFPFPE-HAR-------------FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEV

LHDGLFSE-KSDVWSYGILCWEVFSLGRVPYPGLDPVGVVEFLDTGGRLLAPRGEACSKEIYSLMTSCWSEFPNDRPVFSDLVSSI-----NALI
|    ..  |.|.|| |.. .| .. |. |.|      . . ..  |          |.|  ...  |.   |..||   ..  .         .
L---GYGKCKCDWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK388.AA Pkinase 1513-1790 21 1.4e-22 80.97 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1513-1790
Range on HMM: 1-293/293
Sequence Identity: 21% (67 aa)

LKIQESVGQGELGIVYRGLISVKNGMPQTVAAKTLKGLYSKSDID--SLL-DECIIMMSFDNLNVLPLIGVCLDLGPAPYIIMPFMSRG----SLLSYLK
..| . .|.|  | ||..   .. | ...|| |..|    ||. |   ..  |. || ...  |.. |.... | .. .|..|...  |    .| .|..
YHIGRKIGSGSFGCVYKC---HHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIS

KERPNLTVADTSEEDIIL--NVRKQLLSACLQVANGMCYLASQRFIHRDLAARNCMIDDNGII----KVADFGLSEDIYSQNYFRQLKGNNSSPVKLPLK
            ...  .     ... . ..|.. |. |. |...|||||   |..||.|| |    |..||||.. ..        ..   . .   . 
T-----------WRHGCFYFS-EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPW

WMALESLH-DGLFSEKSDVWSYGILCWEVFSLGRVPYPGL----DPVGVVEFLDTGGR--LLAPRGEACS-------------------KEIYSLMTSCW
.|| | .  .   . |.|.||.|....|... || |.||     . .   . ..  ..  |  .. . ||                   .|  .....|.
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

SEFPNDRPVFSDLVSS--I
   |..|| . ... .  .
CKDPKKRPTAEQILQHPWF