Gene AqueK393 (A.queenslandica)
AqueK393
Species: A.queenslandica
Alias: AqueK393
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| AqueK393.AA | Protein | None | 406 | None | Fasta, JSON |
| AqueK393.kin_dom | Protein Kinase Domain | None | 234 | None | Fasta, JSON |
Protein domains of AqueK393.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | AqueK393.AA | TK | 171-406 | 19 | 2.6e-51 | 169.84 | In-house | 1-391 (486) | Show / Hide |
Range on Protein: 171-406
Range on HMM: 1-391/486
Sequence Identity: 19% (78 aa)
VEKGALIGIGTFG---PVHKVSVPVGGKGK-----------------KGKETKEVAVISLKSSATKRDADDFY----------DYLELLKILSNFKD--S
.. | .| | || |.| . ..... |.... .||| ||. .. ... | |.||.. ... ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
SSLPVLQLVG-------------FNTTETPHYIMTELSTHGD----LLTYLIDIRQNMEGGS--------------------------------------
...|.| . . . | .|..|. ||| |..|| . | .. .
HHPNIVRLYGVCTQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD
----IHDDIPASTTTGVLPY--------RADRLNPSDVLSFAKQIASAMDALSDT------GIVHKDLACRNIYLDSGLN-----------LKVAFFGIV
. .|.| . || | . . ..|.. . | .. |||..| |.. ..|| |||.||. ...... |.| ||
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS
P-----ASRGLKRDSVYPL----------------------------DLPLRWMALESILD--------NNNFTTASDVWGFGVTIWEIVTLG
. .| . .|. | ||.|||| |...| .. |||.|||| |||..|||.|.|
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYG
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| Kinase | AqueK393.AA | Pkinase_Tyr | 171-406 | 29 | 8.6e-41 | 138.77 | Pfam | 1-211 (270) | Show / Hide |
Range on Protein: 171-406 Range on HMM: 1-211/270 Sequence Identity: 29% (74 aa) VEKGALIGIGTFGPVHKVSVPVGGKGKKGKETKEVAVISLKSSATKRD--ADDFYDYLELLKIL-SNFKDSSSLPVLQLVGFNT-TETP--HYIMTELST ...| .| | || |.| ...... .||| .|| .|.... .|| ....| | .. . ...|.| | . | .|| .|. ITFGKKLGEGAFGEVYKGTWKG----DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPN------IVRLYGVCTDQGEPNQIYIVMEYMP HGDLLTYLIDIRQNMEGGSIHDDIPASTTTGVLPYRADRLNPSDVLSFAKQIASAMDALSDTGIVHKDLACRNIYLDSGLNLKVAFFGIVPASRGLKRDS |||||.|| . | ..|...| |... |||..|. |.. ...| |||.||. ..... |.. || .| . |. HGDLLDYLRKHR----------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGL---ARDIYNDD VY-----PLDLPLRWMALESILDNNNFTTASDVWGFGVTIWEIVTLG | .|| .|||.|.| .. |||.|||| |||..|||.|.| YYYRKRGGGKLPIKWMAPECINYGK-FTTKSDVWSFGVLMWEIFTYG |
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| Kinase | AqueK393.AA | TK-Unique | 171-406 | 32 | 1.4e-39 | 134.15 | In-house | 1-236 (294) | Show / Hide |
Range on Protein: 171-406 Range on HMM: 1-236/294 Sequence Identity: 32% (81 aa) VEKGALIGIGTFGPVHKVSVPVGGKGKKGKETKEVAVISLKSSATKRDADDFYDYLELLKILS---NFKDSSSLPVLQLVGFNTTET-PHYIMTELSTHG .| | .|| | ||.|.. | . |. ..| ||| || .||. | .|| . ....| | | ..|..| |. . |..|. | | LEVGDVIGEGAFGQVWRGEVWGIW--KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPN--------IVQCLGCCTKSDEPWMIIMEYCPCG DLLTYLIDIRQNM----EGGSIHDDIPASTTTGVLPYRADR--LNPSDVLSFAKQIASAMDALSD--TGIVHKDLACRNIYLDSGLNLKVAFFGIVP--- .|..|| |..| .| . .... | . . ..| |...||.|||..| |. .|||.||. ||. | .....|.. ||. . NLQHYLRTCRPAMRQHQTYGNLK------FDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVY ASRGLKRDSVYPLDLPLRWMALESIL--DNNNFTTASDVWGFGVTIWEIVTLG . .| . .|.||||.||.. ... .|| |||| |||..|||.||| T-NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLG |
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| Kinase | AqueK393.AA | UTK | 171-406 | 29 | 3.6e-33 | 110.84 | In-house | 1-237 (296) | Show / Hide |
Range on Protein: 171-406 Range on HMM: 1-237/296 Sequence Identity: 29% (78 aa) VEKGALIGIGTFGPVHKVSVPVGGKGKKGK---ETKEVAVISLKSSATKRDADDFY-DYLELLK---ILSNFKDSSSLPVLQLVGFNTTETPHYIMTELS |. |...| | || ||| .. .. . .. ||| ....|..... . | | .|. . ....|. ||.||| | | | .| ||. VQLGRQLGQGAFGEVHK------ARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFH--WHPNVLRLVGVCTQEEPWMIVTEYM THGDLLTYLIDIRQNMEGGSIHDDIPASTTTGVLPYRADRLNPSDVLSFAKQIASAMDALSDTGIVHKDLACRNIYLDSG-------LNLKVAFFG-IVP |||..|| . |.. . . . |. . |..| .||..| |. |.|| |||.||..... . |.| || ENGDLRSYLRRHRPTPP------------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGG- ASRGLKR--------DS-VYPLD----LPLRWMALESILDNNNFTTASDVWGFGVTIWEIVTLG ||.... .| | . .|.|||| |.. .. |||.|||| |||. |||.| | MSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWG |
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| Kinase | AqueK393.AA | Tie | 180-406 | 34 | 1.6e-32 | 95.81 | In-house | 2-210 (267) | Show / Hide |
Range on Protein: 180-406 Range on HMM: 2-210/267 Sequence Identity: 34% (79 aa) GTFGPVHKVSVPVGGKGKKGKETKEVAVISLKSSATKRDADDFYDYLELLKILSNFKDSSSLPVLQLVGFNTTETPHYIMTELSTHGDLLTYLIDIRQNM | || | | . || |||. .| | . | || ||.. . .. ||| |. .| .| || .| | . GNFGQVMKAMI------KKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPN-----IINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRV-I EGGSIHDDIPASTTTGVLPYRADRLNPSDVLSFAKQIASAMDALSDTGIVHKDLACRNIYLDSGLNLKVAFFGIVPASRGLKRDSVYPLD----LPLRWM | . . . || . | | .| || .| |. ||. ...|.||| ||| . |.| ||. ||| | || || ||| ETDPA---FAREHTTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGL---SRG---DEVYVKKTMGRLPVRWM ALESILDNNNFTTASDVWGFGVTIWEIVTLG |.|| | .|| |||| .|| .||||.|| AIES-LNYSVYTTKSDVWSYGVLLWEIVSLG |
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| Kinase | AqueK393.AA | DDR | 310-405 | 40 | 4.5e-26 | 87.92 | In-house | 137-239 (306) | Show / Hide |
Range on Protein: 310-405 Range on HMM: 137-239/306 Sequence Identity: 40% (43 aa) LSFAKQIASAMDALSDTGIVHKDLACRNIYLDSGLNLKVAFFGIVPASRGLKRDSVYPLDL---------PLRWMALESILDNNNFTTASDVWGFGVTIW .. ..||||.| |. .|| ||| ||. . .. |.. || | || | | .. |.|||| |||| .. |||.||||.||||.| VYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTV-MSRNLYSQDYYRVEGFTGRQRHHMPIRWMAWESIL-LGKFTTKSDVWAFGVTMW EIVTL |. .. EMFMF |
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| Kinase | AqueK393.AA | CTKA | 311-406 | 42 | 4.3e-25 | 81.15 | In-house | 135-231 (290) | Show / Hide |
Range on Protein: 311-406 Range on HMM: 135-231/290 Sequence Identity: 42% (43 aa) SFAKQIASAMDALSDTGIVHKDLACRNIYLDSGLNLKVAFFGIVPASRGLKRD-SVYPLD----LPLRWMALESILDNNNFTTASDVWGFGVTIWEIVTL . | ||| |. |. |.|| ||||||. | .. |.| || .| |. | . .| |||| | | . |..||||| ||| .||| . YMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGH---GRTLRTESQYYYVSSQRVMPVRWMAPEA-LCFGKFSCASDVWAFGVLLWEIMSM G | G |
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| Kinase | AqueK393.AA | EGFR | 302-406 | 36 | 2.6e-24 | 77.45 | In-house | 96-200 (258) | Show / Hide |
Range on Protein: 302-406 Range on HMM: 96-200/258 Sequence Identity: 36% (40 aa) DRLNPSDVLSFAKQIASAMDALSDTGIVHKDLACRNIYLDSGLNLKVAFFGIVPASRGLKRDSV-YPLDL---PLRWMALESILDNNNFTTASDVWGFGV |.. . . | .. |||. | | . .|| ||| ||. . | |.. ||. .. |. |. | . | .|||||.|. . .| .|||| .|| DNIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGL---AKLLEHDEKEYHAQGGKMPIKWMALECIH-HRCYTHQSDVWSYGV TIWEIVTLG |.||..| | TCWELMTFG |
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| Kinase | AqueK393.AA | RTKB | 310-406 | 38 | 3.9e-24 | 78.27 | In-house | 112-207 (264) | Show / Hide |
Range on Protein: 310-406 Range on HMM: 112-207/264 Sequence Identity: 38% (38 aa) LSFAKQIASAMDALSDTGIVHKDLACRNIYLDSGLNLKVAFFGIVPASRGLKRDSVYPLD-LPLRWMALESILDNNNFTTAS-DVWGFGVTIWEIVTLG ..|. |||. | |. ...| ||. ||. .|..| |.. ||..... . .. ... || .||| || . .|| | ||| |||| ||| .|| VDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDH--ECYETTCTRLPIKWMAPES-WAHRIYTTKSGDVWSFGVTMWEIFSLG |
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| Kinase | AqueK393.AA | Met | 308-404 | 36 | 1.4e-23 | 73.88 | In-house | 105-214 (271) | Show / Hide |
Range on Protein: 308-404 Range on HMM: 105-214/271 Sequence Identity: 36% (41 aa) DVLSFAKQIASAMDALSDTGIVHKDLACRNIYLDSGLNLKVAFFGIVPASRGL--------KRDSVYPLDLPLRWMALESIL--------DNNNFTTASD | ..|. |.| | . || |||||| || . ||| || .|.. .. | ||..|||.|. .. |||.|| DLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGL---CRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFTTKSD VWGFGVTIWEIVT || ||| .|| | VWSFGVVMWELMT |
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| Kinase | AqueK393.AA | Ryk | 371-406 | 58 | 7.1e-18 | 52.88 | In-house | 201-235 (292) | Show / Hide |
Range on Protein: 371-406 Range on HMM: 201-235/292 Sequence Identity: 58% (21 aa) PLRWMALESILDNNNFTTASDVWGFGVTIWEIVTLG |..||.||| | .. . .||||| |||| || .||| PVKWMSLES-LQHKHYSHASDVWSFGVTMWELMTLG |
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| Kinase | AqueK393.AA | TyrKc | 171-405 | 22 | 3.2e-16 | 39.65 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 171-405
Range on HMM: 1-280/280
Sequence Identity: 22% (73 aa)
VEKGALIGIGTFGPVHKVSVPVGGKGKKGKETKEVAVISLKSSATKRDADDFYDYLELLKILSNF--KDSSSLPVLQLVGFNTTE-------TPHYIMTE
...| .| | || |.| .||| .||..| | .. ..|.... . ...|.| |.. |..| .|
ITLGKKLGEGAFGEVYKGTWK-----------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPN---IVRLYGVCTQQGRNFMYIEPLMIVME
LSTHGDLLTYLIDIRQNMEGGSIHDDIPASTTTGVLPYRADRLNPSDVLSFAKQIASAMDALSDTGIVHKDLACRNIYLDSGLNLKVAFFGIVPASRGLK
. ||||. || . | . |...| |||. |||. |. |.. ...| |||.||. ..... |.. || || ..
YMPHGDLKDYLRKHRPK-------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGL---SRDIY
RD-------SVYP------LD--LPLRWMALESILDNNNFTTASDVWGFGVTIWEIVT------------------------------------------
| ..| . ||.||||.|.| . . |||.|||| |||..||| |
DDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVC
-----------------------------L
.
CPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | AqueK393.AA | Ryk | 308-347 | 37 | 1.1e-09 | 26.5 | In-house | 134-176 (292) | Show / Hide |
Range on Protein: 308-347 Range on HMM: 134-176/292 Sequence Identity: 37% (16 aa) DVLSFAKQIASAMDALSDTGIVHKDLACRNIYLDSG---LNLK . ..| ||...|. | .|||||.| || ..| |..| QLVHMAIQITMGMMHLHKHRIVHKDIATRNCVIDEQNGRLQVK |
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| Kinase | AqueK393.AA | S_TKc | 171-406 | 15 | 3e-07 | -70.68 | SMART | 1-220 (231) | Show / Hide |
Range on Protein: 171-406 Range on HMM: 1-220/231 Sequence Identity: 15% (43 aa) VEKGALIGIGTFGPVHKVSVPVGGKGKKGKETKEVAVISLKSSATKRDADDFYDYLELLKILSNFKDSSSLPVLQLVGFNTTETPHYIMTELSTH--GDL |.. .|| |.|| |.|. ..||. .| . . ..||.. . .| .. . . |. .|. . ||| YEILRKIGKGAFGKVYKCRHKK--------TGRIVAIKIIK-----------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDL LTYLIDIRQNMEGGSIHDDIPASTTTGVLPYRADRLNPSDVLSFAKQIASAMDALSDTGIVHKDLACRNIYLDSGLNLKVAFFGIVPASRGLKRDSVYPL ..|. . . . . .... .. ....||..|.. . . ||.| || || ||. ..|.. ||. . . FDYIKKRGRHGLR--------------------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTF DLPLRWMALESILDNNNFTT-ASDVWGFGVTIWEIVT----------------------------------------LG . .|| | . ... ..|.| .|....| .. | CGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQ |
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| Kinase | AqueK393.AA | Pkinase | 372-404 | 24 | 0.000629 | 14.97 | Pfam | 175-207 (293) | Show / Hide |
Range on Protein: 372-404 Range on HMM: 175-207/293 Sequence Identity: 24% (8 aa) LRWMALESILDNNNFTTASDVWGFGVTIWEIVT ...|| | |.... ....|.|..|....| .. PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC |
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| Kinase | AqueK393.AA | EGFR | 171-187 | 41 | 0.105967 | 1.22 | In-house | 1-17 (258) | Show / Hide |
Range on Protein: 171-187 Range on HMM: 1-17/258 Sequence Identity: 41% (7 aa) VEKGALIGIGTFGPVHK . |. | | || |.| LKKVKVLGSGAFGTVYK |
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| Kinase | AqueK393.AA | RTKB | 171-230 | 25 | 0.183244 | 0.72 | In-house | 1-56 (264) | Show / Hide |
Range on Protein: 171-230 Range on HMM: 1-56/264 Sequence Identity: 25% (15 aa) VEKGALIGIGTFGPVHKVSVPVGGKGKKGKETKEVAVISLKSSATKRDADDFYDYLELLK | | | | || | . | . . ... .|. || .| .. .|| ... ..| VWLGEKLGNGAFGEVFQAWVRNRHMN----TEQSCAAKVLKPGASYEERQDFCSEMTVMK |
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| Kinase | AqueK393.AA | Pkinase | 243-333 | 15 | 0.943214 | 3.74 | Pfam | 62-134 (293) | Show / Hide |
Range on Protein: 243-333 Range on HMM: 62-134/293 Sequence Identity: 15% (15 aa) VLQLVGFNTTETPHYIMTELSTHG----DLLTYLIDIRQNMEGGSIHDDIPASTTTGVLPYRADRL--NPSDVLSFAKQIASAMDALSDTGIVHKDL ...| .. .... |. .|. .| || .|. | .. . .. ....||..... . . ||.| || IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDL |
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