Gene AqueK433 (A.queenslandica)

AqueK433

Species: A.queenslandica
Alias: AqueK433
External Links:
Annotation:

Classification

Group: TK
Family: Src
Subfamily: Src-Aque1

Sequence

Name Sequence Type Origin Length Description Download
AqueK433.AA Protein None 3228 None Fasta, JSON
AqueK433.kin_dom Protein Kinase Domain None 249 None Fasta, JSON

Protein domain

Protein domains of AqueK433.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DNA_pol_B_exo AqueK433.AA DNA_pol_B_exo 66-198 17 9.9e-09 29.61 Pfam 1-159 (441) Show / Hide 
Range on Protein: 66-198
Range on HMM: 1-159/441
Sequence Identity: 17% (29 aa)

STPAGQKTCLHVHGAFPYLFVPSLE----------EKPSERYLKLFAESINHALQVSLGAASKKESHVFKISVVRG-------------KPFYGYHASEC
 |  |   | ||.|  ||....  |            . ........|.            .|... .||| .|               . ||||.  ..
FTDDGHSCCVHVFGFKPYFYCACPEGFENCDVEKYINQMKDMKDCEHEF----------IWKKYGPCIFKIEIVMKYDYDEDNHLPGKYYSFYGYDGPPK

V-YLKIYLYNPRHIKRLADLLIVG--AIMR---IPLQPH--------ESHIPFILQFMIDHNLYGMNYLH
  |.|.|. ||... .. . .  .  .. .      .          |. ..... ||||... ......
DPYWKVYFPNPNMMCKIRKNFMPHWHNN-WFHANFYHVYDLDIVDIREYNVDYHTRFMIDNDIMPFCWYN
POLBc AqueK433.AA POLBc 1326-1902 19 8.8e-96 325.43 SMART 1-531 (531) Show / Hide 
Range on Protein: 1326-1902
Range on HMM: 1-531/531
Sequence Identity: 19% (128 aa)

SEVRTYSIYHTHEHLELHIRTR-------ENLNPDPE-WDPVLAIFYYIHNDWPR-------SPDSPAPSGCGLENATKGIIAIDLSQPSSQVTTPTKRG
 . .  ..        ..  ..       ....||||  ||. .| ... ..|         .  . . . |  ..  . ..  .   . ..        
PPYKCMCFD-------IECYSDHGKHGKNKHHFPDPEICDPIIMISCMCYDNWKWYWWDKHNN--Y-HWHNCCCCPEHRHCFTYGPCDEIDG--------

GARGRGGKGKGSPKTFSSLRKKFSSPSKILLGNQSKISAQEALDTTDTDRRPYLDNTGLSSNNIHITYVSNERNLFDKLVKLVRQVDPDVLLGYEIQKNS
                                                               .|. .. ||| .. .........|||.. |. |..  
---------------------------------------------------------------VHVYEFNNEREMLYAFFEFIKRYDPDIIYGHNIDNFD

WGYLKMRGSH-LGINLIG----------QISRVPTA-----TTPERGGSDKSGGSPSKKGAAWFEERHNSDIHVVGRVLLNVWRTMKQELS--LTSYSFE
| |.  |  . ..|.              |.|.        .  .  .. |..| . .        | ....| .||. ..... .. ...  |..|...
WPYIINRAEKWIYIDPWDMNDQRRYWHMFIGRLKNNCFIRWPRHKPWFHYKMYGDM-D------PTRKTIKYHIPGRMHIDMYQWCHRWYKNKLPNYKLD

S--------VTYHTLYQRLPKFSYQTLTEWYDYRNR-LYRSRVVDYYMTHCYGNCLLLEKFN-------LIGRTSELARLYGIEFHNVLARGSQYRVESM
.        |  | |     ...|  ... .|. |    | |.  | .. |. .  |..|.|        . ...|.||..|| .  .. .|.|.|||..
TDKCCPYKAVAEHYL---KDDIPYKKYWDMPDMYNNWEERQRLIRYCIQDCVLCYQLMNKYNNSYEYQDFHPEMIEMARIAGIPWRRTIYYGQQIRVEWC

MLRLAKQYNYIAASPSIQQRARMAAPECLPLIMEPESKLYTDPVLVLDFQSLYPSMVIAHNYCYSTCLGRVKHLTTNNDGYKFGTCSLSIPDDILLQLQD
.|..... |||. ....    .... .. ....||....| .||||.||.|||||  .|||.||||..|.                              
LLHECYKRNYIYPNKMM----KKFKYQGGMYVLEPKKGFYDNPVLVFDFNSLYPSIMMAHNLCYSTLVGY------------------------------

SVTISPNGVVFVKSDVRRGVMPQMLEEILNTRIMIKQSMKLYK-------------------DNKVL--QRILDARQLGLKLIANVTYGYTAANYSGRMP
          |||..||.|. |..|...|..| .||. || .|                    . ..  . ..| .|. .|...| .||.| ...| |..
----------FVKKHVRKGILPKLLMNWLDMRKEIKKWMKKCKMESCIRIGNKITKSHDHMMHDPCEWMYMLYDKQQCAIKVTCNSMYGCTGFTNS-RWY

CVEIA--DSIVRKGRETLERAIQLVEST------------------PKWQAKVIYGDTDSMFVLLKG
|...|  .|. ..|||.||... ..|.                    || .|||||||||.|| ..|
CKPCAFLASVTACGREMLEWTKDYIENMWYPFCILIFVFAWWNFMEEKWNFKVIYGDTDSIFVNCPG
DNA_pol_B AqueK433.AA DNA_pol_B 1668-2023 28 2.5e-92 303.15 Pfam 1-400 (514) Show / Hide 
Range on Protein: 1668-2023
Range on HMM: 1-400/514
Sequence Identity: 28% (118 aa)

GSQYRVESMMLRLAKQYNYIAASPSIQQRARMAAPECLPLIMEPESKLYTDPVLVLDFQSLYPSMVIAHNYCYSTCLGRVKHLTTNNDGYKFGTCSLSIP
| | ||.. .|..... |.|  ..  . . |  .  .  . .||....| .|||||||.|||||  .||| ||.| . ..     ...... ....  ..
GQQIRVFWCLLHECHERNFIMPDKQERRAGRKKEGYQGATVIEPKKGFYDNPVLVLDFASLYPSIMMAHNLCYTTLVRDD----CEHPMLRPEMMYP-PW

DDILLQLQDSVTISPNGVVFVK-SDVRRGVMPQMLEEILN-TRIMIKQSMKLYKDNKV-LQRILDARQLGLKLIANVTYGYTAANYSGRMPCVEIADSIV
 |.|    . |  ......||| . ||.|. | .|.. |   | .||. ||  ||..  .. |.| .|| .|. .|  ||.. .... |..|..|| |. 
YDYLH--CEFVCGGGVCHCFVKFPHVRKGILPELLRDWLAKMRKYIKKMMKQCKDPEKRRRMIYDKQQLAYKVTCNSVYGFMGFANG-RWYCLPIAESVT

RKGRETLERAIQLVES-TPK------WQ-------AKVIYGDTDSMFVLLKGVSK--AESFRIGREISKAVTADN-PKPVKLKFKKVYSSCILQT-KKRY
..||.........||.   .      .        .|||||||||.|. ..|.     | ..||.|. | ||..  .||.|| | ||| . .|.. ||||
AWGRYMIMKTKDYVEEKWCCNFLNGYMNNNCPPDYFKVIYGDTDSVFIWCGGKDYKMEEVMKIGDEMAKHVTKKLFYKPIKLEFEKVYKCLLLICYKKRY

AGFMYETLDQS--E-PVFEAKGIETVRRDNCPAVSKILEKSLKLLFSTKDVSLV-KSYVQ-SQCTKILNG---------------------R----V-PT
.| .|.  ..   . .  . ||...||||.|| . ..  | | ..|. |||. .  ....  .. ... .                     .    | | 
IGIKYDDDPDINNHKDKMDMKGVDLVRRDWCPFHKEVYRKVLDMIFKDKDVDDAHAQELKCRMIIDYWKNRGVPDGFHKFIRILCEAHYDKCRNNKVKPM

SDFVFAKE
..||. ||
EQFVITKE
DNA_pol_B_exo AqueK433.AA DNA_pol_B_exo 1466-1594 17 2e-07 25.24 Pfam 300-441 (441) Show / Hide 
Range on Protein: 1466-1594
Range on HMM: 300-441/441
Sequence Identity: 17% (25 aa)

NTGLSSNNIHITYV--SNERNLFDKLVKLVRQVDPDVLLGYEIQKNSWGYLKMRGSHLGINLIGQISRVPTATT--PERGGSDKSGGSPS--------KK
.  |  |. .....   .|. .  . .. .||.|||...|| |.   | |.  |  .|||...  . . .. .    ..|.. | .....         .
EK-LNMNGVYVYIFNECSEKEMLHRWFEFIRQYDPDFITGYNIDNFDWPYILNRAKILGIKMFPEYGFRWSKYGRIKRGGWFRKQYRTSNNMFQFQVPHW

GAAWFEERHNSDIHVVGRVLLNVWRTMKQEL--SLTSYSFESV
... .  . .. . . |.. . . . .|...  .|.||. ..|
DHGKGHFQSYEKYKINGCIHMDMYQWCKRDYYLKLPSYKLNAV
DNA_pol_B AqueK433.AA DNA_pol_B 2029-2091 26 3.1e-07 23.8 Pfam 429-492 (514) Show / Hide 
Range on Protein: 2029-2091
Range on HMM: 429-492/514
Sequence Identity: 26% (17 aa)

DRQAEPLVGERVPYVIVYG--PPGLPLIQLVRSLEDFTTASSSLRLNSNYYITKQILPALSRSFS
..  .| ||.|.||||. .    |.. .....  | .  . . |.....||. .|..|...| |.
GNEEAPQVGDRIPYVICKPDHKKGAWHYEMAEDPE-YVREHNHLPIDTDYYFDHQLVPPVERIFE
SH3 AqueK433.AA SH3 2794-2852 28 1.4e-12 49.07 SMART 1-58 (58) Show / Hide 
Range on Protein: 2794-2852
Range on HMM: 1-58/58
Sequence Identity: 28% (17 aa)

KLFKASYNFEGLSVYDLTLKKGEVLEVVKYHEDDEWWYMHSLHTDSKGYVPINYILPIE
. ..| |.... .  .|..|||....|.. . ||.||.    .|  .|..| ||. .|.
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 AqueK433.AA SH3_1 2797-2845 26 6.7e-08 29.77 Pfam 1-49 (49) Show / Hide 
Range on Protein: 2797-2845
Range on HMM: 1-49/49
Sequence Identity: 26% (13 aa)

KASYNFEGLSVYDLTLKKGEVLEVVKYHEDDEWWYMHSLHTDSKGYVPI
.| | ... .  .|..|||....|..  .|..||   .. |  .|..| 
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 AqueK433.AA SH3_2 2795-2851 16 1.9e-07 28.95 Pfam 1-68 (68) Show / Hide 
Range on Protein: 2795-2851
Range on HMM: 1-68/68
Sequence Identity: 16% (11 aa)

LFKASYNFEG-LSVYD-----LTLKKGEVLEVV--KYHEDDEWWYMHSL-HTDSK--GYVPINYILPI
....  ....  . ..     |..|||.|..|   . ...|.||. .    .  .  |..|.... ..
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 AqueK433.AA SH2 2864-2937 46 5.2e-29 86.99 Pfam 1-81 (81) Show / Hide 
Range on Protein: 2864-2937
Range on HMM: 1-81/81
Sequence Identity: 46% (38 aa)

YYH-TVSRDEAEERLSQADTQAGTFLIRESIS--GTNTLSVKDGA---TIRHYHISIENNK-YYIYPRVKFDSLNDLVHHY
.||  .|| |||..| .   . ||||.||| |  |  ||||.|.     ..||.|  ..|. |||. |.||.||..||.||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 AqueK433.AA SH2 2862-2943 39 1.3e-23 85.74 SMART 1-87 (87) Show / Hide 
Range on Protein: 2862-2943
Range on HMM: 1-87/87
Sequence Identity: 39% (35 aa)

YVYYH-TVSRDEAEERLSQADTQAGTFLIRESIS--GTNTLSVKDGATIRHYHISIEN-NKYYIYP--RVKFDSLNDLVHHYMTEAHG
. .||  .||.|||. | .   . |.||.|.| |  |  .|||...  ..||.|  .. .||||    |.||.|| .||.||.. . |
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase AqueK433.AA Src 2973-3220 42 4.6e-94 318.8 In-house 1-255 (255) Show / Hide 
Range on Protein: 2973-3220
Range on HMM: 1-255/255
Sequence Identity: 42% (108 aa)

IKFLKCMHAGHFGETWKGNCQGEGSVIIKTNIATNITQETLLVEAGILKKLHHKNIISLYGVCTESYPFYIVTEPMTRN-LKDYLI----TNNPTPAELV
||... . .|.||| |.|  .|.  | .||  . .  .| .| || |.||| |.....|| ||..  |.||||| |... | |||     . .    .|.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DIAIQVTDGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFYLAQHLN--GNKYWTVEKGTKLAIRWTAPEAYTLKQISIKSDVWSFGILLWELATKGNG
|.| || .|| ||... ||| ||.| |.| |..| .|.| | ||. .    . | . ..| |. |.|||||| .  . .||||||||||||.|. |.|  
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEY-CARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRV

PYPGMTDEKVKEAVPKGYHMPIPRDCPEPFKQ-LMINCWKYKDNERPSFDYIIDIL
|||||| . | ..| .||.|| |. ||. . . .|  ||. .  .|| |.|. . |
PYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK433.AA SFK-Src 2973-3214 42 5.9e-91 269.75 In-house 1-249 (259) Show / Hide 
Range on Protein: 2973-3214
Range on HMM: 1-249/259
Sequence Identity: 42% (105 aa)

IKFLKCMHAGHFGETWKGNCQGEGSVIIKTNIATNITQETLLVEAGILKKLHHKNIISLYGVCTESYPFYIVTEPMTR-NLKDYLIT---NNPTPAELVD
|.  | . .| ||. |||   .   | .||     . .|  | ||...||| | | | || |||   | ||.|| |    | |||        .   |||
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

IAIQVTDGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFYLAQHLNGNKY-WTVEKGTKLAIRWTAPEAYTLKQISIKSDVWSFGILLWELATKGNGPY
 | ||  || || .| ..| || | |.| || |..|.. | ..  |  .   .| ..| |  |.|||||| .  . ||||||||||||. |. | |  ||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGMTDEKVKEAVPK--GYHMPIPRDCPEPFKQLMINCWKYKDNERPSFD
||||   |   | .  || || |  ||. . ..|..||. .  .|| |.
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFE
Kinase AqueK433.AA Pkinase_Tyr 2973-3220 39 1.8e-84 286.69 Pfam 1-270 (270) Show / Hide 
Range on Protein: 2973-3220
Range on HMM: 1-270/270
Sequence Identity: 39% (107 aa)

IKFLKCMHAGHFGETWKGNCQ-----GEGSVIIKTN--IATNIT--QETLLVEAGILKKL-HHKNIISLYGVCT-ESYP--FYIVTEPMTR-NLKDYLIT
|.|.|   .|.||| .|| .      ..  | .|.    |.     .| .. || |.|.| ||.||..|||||| .. |   |||.| |   .|.||| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N-----NPTPAELVDIAIQVTDGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFYLAQHL-NGNKYWTVEKGTKLAIRWTAPEAYTLKQISIKSDVWSF
.     ..|. .|.....|. .|| || .. .|| ||.| |.|... |.|||. | ||  . |   | .. .|.|| |.|.|||.   .  ..|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILLWELATKGNGP-YPGMTDEKVKEAV-PKGYHMPIPRDCPEPFKQLMINCWKYKDNERPSFDYIIDIL
|.|.||. | |  | ||||..| |.|..  .|| ||.|..||..  .||  ||.|. ..||.| .|. .|
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK433.AA SrcA 2973-3220 46 4.8e-83 262.18 In-house 1-250 (250) Show / Hide 
Range on Protein: 2973-3220
Range on HMM: 1-250/250
Sequence Identity: 46% (118 aa)

IKFLKCMHAGHFGETWKGNCQGEGSVIIKTNIATNITQETLLVEAGILKKLHHKNIISLYGVCTESYPFYIVTEPMTR-NLKDYLITNNPTP---AELVD
|.  . .  | ||| | |   |.  | |||     .  |. | || |.|||.|  .. || |  |  | ||||| |..  | |.|  ..       .|||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEE-PIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVD

IAIQVTDGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFYLAQHLNGNKYWTVEKGTKLAIRWTAPEAYTLKQISIKSDVWSFGILLWELATKGNGPYP
.| || .|| |.    ||| |||| ||| |..   ||| | ||  .. | | | ..|.|  |.||||||       |||||||||||| || |||  |||
MAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEY-TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYP

GMTDEKVKEAVPKGYHMPIPRDCPEPFKQLMINCWKYKDNERPSFDYIIDIL
|| .  | | | .||||| |.||||   .||. ||.   .||| |.|.   |
GMNNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase AqueK433.AA Frk 2973-3224 41 1.3e-79 270.83 In-house 1-260 (260) Show / Hide 
Range on Protein: 2973-3224
Range on HMM: 1-260/260
Sequence Identity: 41% (108 aa)

IKFLKCMHAGHFGETWKGNCQGEGSVIIKTNIATNITQETLLVEAGILKKLHHKNIISLYGVCTESYPFYIVTEPMTRN-LKDYLI-----TNNPTPAEL
|.... . .| ||| | |    .  | .||  .  .  . .| || |.||| |  .|.|| |||   | ||.|| | .. |..||       ..    .|
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

VDIAIQVTDGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFYLAQHLNGNKY--WTVEKGTKLAIRWTAPEAYTLKQISIKSDVWSFGILLWELATKGN
||.| ||  || || .| ||| || | |.|.|.|| .||| | ||  |  ..   .    | .. |.||||||   .. .|||||||||||| |. | | 
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

GPYPGMTDEKVKEAVPKGYHMPIPRDCPEPFKQLMINCWKYKDNERPSFDYIIDILLEYK
 ||||||. .| . | .|| || | .||. . ..|..||. . ..|| |. .   | .| 
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase AqueK433.AA TK 2973-3220 19 6.5e-77 257.2 In-house 1-486 (486) Show / Hide 
Range on Protein: 2973-3220
Range on HMM: 1-486/486
Sequence Identity: 19% (97 aa)

IKFLKCMHAGHFG---ETWKGNCQGEG--------------------------SVIIKTNIATNITQET------------------LLVEAGILK--KL
|...|   .|.||   | .||  .|..                           | .|.  ... ....                  .. |. ...  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHKNIISLYGVCTES------------YPFYIVTEPMT-RN----LKDYLITN-----------------------------------------------
||.||..||||||..             |..||.| |   .    |.||| ..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------NPTPAELVDIAIQVTDGMIYLGEQ------DYIHCDLRAINILLGDHNT-----------VKIANFY---
                              ..|...|. .. |. .|| || ..       ..| || | |.|.|..|.           .||| |    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAQHL-NGNKYWTVE-----------------------KGTKLAIRWTAPEAYT---------LKQISIKSDVWSFGILLWELATKGNGPYPG-M
     ||  . ..  |....                       .|.|| |||.|||. .          .  ..||||||||.|.||. | | .||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TD---------EKVKEAVPKG--------------YHMPIPRDCP--------------EPFKQLMINCWKYKDNERPSFDYIIDIL
..         . | | . .|              . || | .||              | . .||  ||.|. ..||.|. . . |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK433.AA SrcB 2973-3221 42 6.8e-75 252.77 In-house 1-251 (251) Show / Hide 
Range on Protein: 2973-3221
Range on HMM: 1-251/251
Sequence Identity: 42% (108 aa)

IKFLKCMHAGHFGETWKGNCQGEGSVIIKTNIATNITQETLLVEAGILKKLHHKNIISLYGVCTESYPFYIVTEPMTR-NLKDYLITNNPTPAE---LVD
.|. | . || ||| | |  ...  | .||     .  |  | || ..|.| |. .. || | |   | ||.|| | .  | |.| |.. .  .   |.|
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

IAIQVTDGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFYLAQHLNGNKYWTVEKGTKLAIRWTAPEAYTLKQISIKSDVWSFGILLWELATKGNGPYP
.. |...|| |. .. ||| |||| |||  .    ||| | ||  .. | | |   | |  |.||||||       |||||||||||| |. | |  |||
MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEY-TAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYP

GMTDEKVKEAVPKGYHMPIPRDCPEPFKQLMINCWKYKDNERPSFDYIIDILL
|||   | ... .|| || |  |||   ..|. ||| .  ||| |||.  .| 
GMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase AqueK433.AA Src-Echino1 2973-3220 39 1.1e-73 251.11 In-house 1-252 (252) Show / Hide 
Range on Protein: 2973-3220
Range on HMM: 1-252/252
Sequence Identity: 39% (100 aa)

IKFLKCMHAGHFGETWKGNCQGEGSVIIKTNIATNITQETLLVEAGILKKLHHKNIISLYGVCTESYPFYIVTEPMTR-NLKDYLITNNPT---PAELVD
 .. | .  ||.|| |||  .|.  | .||     ...  .| || ..||. |..|. .| || .. | ||||| | . ||.|||  ..      ..|.|
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

IAIQVTDGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFYLAQHLNGNKYWTVEKGTKLAIRWTAPEAYTLKQISIKSDVWSFGILLWELATKGNGPYP
.  ..  || |||.....| || | |.|.|. | .|||.| ||. .. . | . . | || |.||||||    .  |||||||||||. |. | |  |||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQ-GAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYP

GMTDEKVKEAVPKGYHMPIPRDCPEPFKQL-MINCWKYKDNERPSFDYIIDIL
||..  | . | .|| || . .||.   .. |. ||      || |... | .
GMMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase AqueK433.AA Abl 2973-3220 39 2e-72 240.8 In-house 1-252 (252) Show / Hide 
Range on Protein: 2973-3220
Range on HMM: 1-252/252
Sequence Identity: 39% (99 aa)

IKFLKCMHAGHFGETWKGNCQGEGSVI-IKTNIATNITQETLLVEAGILKKLHHKNIISLYGVCTESYPFYIVTEPMTR-NLKDYLITNNPT---PAELV
|   . .  | .|| ..|  .  . .. .||    ..  .  | || |.|...|.|.. | ||||   ||||.|| |.  || |||  .. .   .  |.
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

DIAIQVTDGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFYLAQHLNGNKYWTVEKGTKLAIRWTAPEAYTLKQISIKSDVWSFGILLWELATKGNGPY
 .| |.. || || ....|| || | | |.|.|. ||.| | ||  .... | | . | |  |.|||||.   .. |.||||| ||.||||.|| |  ||
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTY-TAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPY

PGMTDEKVKEAVPKGYHMPIPRDCPEPFKQLMINCWKYKDNERPSFDYIIDIL
||.  ..| . . ||| |  |. ||.   .|| .||...  .||||  |   .
PGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase AqueK433.AA TyrKc 2973-3220 35 4.6e-71 243.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 2973-3220
Range on HMM: 1-280/280
Sequence Identity: 35% (102 aa)

IKFLKCMHAGHFGETWKGNCQGEGSVIIKTNIATNITQETLLVEAGILKKL--HHKNIISLYGVCTES-------YPFYIVTEPMTR-NLKDYLITNN--
|...|    |.||| .||       | .|.  .    .| .. || |..||  ||.||. ||||||..        | .||.| |   .|||||  .   
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

PTPAELVDIAIQVTDGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFYLAQHLNGN-------KYWTV--EKGTK--LAIRWTAPEAYTLKQISIKSDV
 ....|.....|. .|| || .. .|| || | |.|.|. .||||. | |.  .          .| ..  .||.|  | |||.|||.   .  ..||||
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSFGILLWELATKGNGPYPG-----MTDEKVKEAVPKGYHMPIPRD--------CPEPFKQLMINCWKYKDNERPSFDYIIDIL
||||...||. | |  ||||     |... | | | .|| ||.| .        ||.   |.|  ||... ..||.|  |....
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK433.AA Src-Unclassified 2973-3220 35 3e-65 222.68 In-house 1-284 (284) Show / Hide 
Range on Protein: 2973-3220
Range on HMM: 1-284/284
Sequence Identity: 35% (101 aa)

IKFLKCMHAGHFGETWKGNCQGEGSVIIKTNIAT---NITQETLL--------VEAGILKKLHHKNIISLYGVCTESYPFYIVTEPMTR-NLKDYLITNN
.. |. .  | ||| |.|   |   | .||  .        |  |         || |.||. | |.. ||.||..  |.||.|| |.   | ..| .  
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

---PTPAEL------------VDIAIQVTDGMIYLGEQDYIHCDLRAINILLGDHN-----TVKIANFYLA-QHLNGNKYWTVEKGTKLAIRWTAPEAYT
   .   ..            |||| ||  || || .  |.| || | |.| |. |      ||.. | ||   | .       .| .. . |.|||. .
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

LKQISIKSDVWSFGILLWELATKGNGPYPGMTDEKVKEAVPKGYHMPIP--RDCPEPFKQ-LMINCWKYKDNERPSFDYIIDIL
    ||||||||.||||||..|||  |||||  . | | |  || || |  . ||.   . .|  ||      || ||     .
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase AqueK433.AA UTK 2973-3220 32 1.1e-64 220.15 In-house 1-296 (296) Show / Hide 
Range on Protein: 2973-3220
Range on HMM: 1-296/296
Sequence Identity: 32% (95 aa)

IKFLKCMHAGHFGETWKGNCQ------GEGSVIIKTNI---ATNITQE---TLLVEAG---ILKKLH-HKNIISLYGVCTESYPFYIVTEPMT-RNLKDY
......  .|.|||  |.  .      .|  | .|..    ... ..|   ... ||    ..|..| | |.. |.|||| . |..|||| |   .| .|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LITNNPTPA---------ELVDIAIQVTDGMIYLGEQDYIHCDLRAINILLGDH-------NTVKIANFY---LAQHLN---------GNKYWTVEKGTK
| .. |||          .... | .. .|| || .. ..|.|| | |.|...|       ...|||.|    ..  .|         .  | .    ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

LAIRWTAPEAYTLK-QISIKSDVWSFGILLWELATKGNGPYPGMTDEKVKEAVPKG--YHMPIPRDCPEPFKQLMINCWKYKDNERPSFDYIIDIL
..|||.||||.|   . ..||||||||...||. | |. |||||....| ..| .|  |.|| |.|||.|  .||  ||.|   |||.|. . . .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase AqueK433.AA S_TKc 2973-3224 22 1.3e-26 95.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 2973-3224
Range on HMM: 1-231/231
Sequence Identity: 22% (61 aa)

IKFLKCMHAGHFGETWKGNCQG-EGSVIIKTNIATNITQETLLVEAGILKKLHHKNIISLYGVCTESYPFYIVTEPMTR---NLKDYLITNNP-------
 ..|.    | ||. .|.   .    | ||         |... |  |||| ||.||. ||.|. .   .|.|.| .     .|.||.  ...       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

TPAELVDIAIQVTDGMIYLGEQDYIHCDLRAINILLGDHNTVKIANFYLAQHLNGNKYWTVEKGTKLAIRWTAPEAYTLKQISI-KSDVWSFGILLWELA
.. .   .. |. ... |. ..  ||.||   |||| .  ..||. | || .|         .       . |||     . .  |.|.||.|..|.|..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TKGNGPYPGMTDEKVKEAVPKGYHMPIPRDCPEPFKQLMINCWKYKDNERPSFDYIID-----ILLEYK
. |  |.|   ..  |  .            ....|... .|...  ..||.   .        . .. 
C-GYPPFP-QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK433.AA Pkinase 2973-3220 22 1.1e-22 81.28 Pfam 1-293 (293) Show / Hide 
Range on Protein: 2973-3220
Range on HMM: 1-293/293
Sequence Identity: 22% (66 aa)

IKFLKCMHAGHFGETWKGNCQGEGS-VIIKTNIATNITQET---LLV--EAGILKKLHHKNIISLYGVCTESYPFYIVTEPMTR-----NLKDYLI---T
......  .| ||. .|.  .|.|  | .|.    ..  .    ..   |. |.|.|.|.||. ||......   |.|.| .        |.||.     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NNP--TPAELVDIAIQVTDGMIYLGEQDYIHCDLRAINILLGDHNTV----KIANFYLAQH--LNGNKYWTVEKGTKLAIRWTAPEAYT-LKQISIKSDV
..   .. |. ... |.  |. |. ..  ||.||   |||. .....    ||. | || .  .  |   |.  ||   ... |||     . .. |.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGT---PWYMAPEVIRGGQYYGPKVDM

WSFGILLWELATKGNGPYPGM----TDEKVKEAVPKGYHMPIPRDCP-----------------------EPFKQLMINCWKYKDNERPSFDYIIDI--L
||.|..|.|... |. |.||     .    .. . .  . |...|.|                       |..|... .|.... ..||... |     .
WSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF