Gene AqueK435 (A.queenslandica)

AqueK435

Species: A.queenslandica
Alias: AqueK435
External Links:
Annotation:

Classification

Group: TK
Family: Src
Subfamily: Src-Aque1

Sequence

Name Sequence Type Origin Length Description Download
AqueK435.AA Protein None 1055 None Fasta, JSON
AqueK435.kin_dom Protein Kinase Domain None 251 None Fasta, JSON

Protein domain

Protein domains of AqueK435.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Death AqueK435.AA Death 32-108 21 0.000777 15.14 Pfam 13-87 (87) Show / Hide 
Range on Protein: 32-108
Range on HMM: 13-87/87
Sequence Identity: 21% (17 aa)

PEAKWFEFGLNLGLLYPTLEAIDA-NHRGNTSRCLMECLSKWLSKADENVYPPTWQTLASALRKLEAKAVAENIEKTM
| ..| ...  ||. .  .. |   .......   .. | ||  .   .    | ..|..||||..   .||.|.  .
PGKDWRRLARKLGMSDNEIDQIEHDQNPHDLRSQTYQMLWKWEQR---HGKNATVDHLIEALRKMGRRDCAEKIQSWL
SH3 AqueK435.AA SH3 617-675 32 1.4e-16 62.29 SMART 1-58 (58) Show / Hide 
Range on Protein: 617-675
Range on HMM: 1-58/58
Sequence Identity: 32% (19 aa)

KLFVANYNFEGLSPHDLTLKEGEVLEVVKYDDDDGWWYMHSLDTDSKGYVPINYIAPIK
. ..| |.... .| .|..|.|....|.. | |||||.    .|  .|..| ||...|.
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 AqueK435.AA SH3_1 620-668 30 2.6e-11 41.19 Pfam 1-49 (49) Show / Hide 
Range on Protein: 620-668
Range on HMM: 1-49/49
Sequence Identity: 30% (15 aa)

VANYNFEGLSPHDLTLKEGEVLEVVKYDDDDGWWYMHSLDTDSKGYVPI
|| | ... .| .|..|.|....|.. .||..||   ...|  .|..| 
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 AqueK435.AA SH3_2 618-674 16 1.7e-08 32.65 Pfam 1-68 (68) Show / Hide 
Range on Protein: 618-674
Range on HMM: 1-68/68
Sequence Identity: 16% (11 aa)

LFVANYNFEG-LSPHD-----LTLKEGEVLEVV--KYDDDDGWWYMHSL-DTDSK--GYVPINYIAPI
....  ....  .. .     |..|.|.|..|   .  |.|.||. .   ..  .  |..|.......
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 AqueK435.AA SH2 687-760 46 9.7e-28 83.27 Pfam 1-81 (81) Show / Hide 
Range on Protein: 687-760
Range on HMM: 1-81/81
Sequence Identity: 46% (38 aa)

YYH-TVSRDEAEERLSQADTQAGTFLIRESISGPN--TLSVKDGV---TIRHYHISIENN-QYYINPRVKFDSLNDLVQHY
.||  .|| |||..| .   . ||||.||| | |.  ||||.|.     ..||.|  ..| .|||  |.||.||..||.||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 AqueK435.AA SH2 685-766 37 1.3e-23 85.7 SMART 1-87 (87) Show / Hide 
Range on Protein: 685-766
Range on HMM: 1-87/87
Sequence Identity: 37% (33 aa)

YIYYH-TVSRDEAEERLSQADTQAGTFLIRESIS--GPNTLSVKDGVTIRHYHISIEN-NQYYINP--RVKFDSLNDLVQHYMTEADS
. .||  .||.|||. | .   . |.||.|.| |  |  .|||...  ..||.|  .. ..|||    |.||.|| .||.||.. ...
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase AqueK435.AA Src 796-1047 40 4.2e-86 292.36 In-house 1-255 (255) Show / Hide 
Range on Protein: 796-1047
Range on HMM: 1-255/255
Sequence Identity: 40% (104 aa)

IKFEQCINAGQFGETWKGDWKDKGPVIIKTNIATDITQETLLVEAGILQKLHHKNIISLYGVCTESYPFYIVTEPMNEN-LKYYLNK----TLITPAELV
||... . .||||| |.| |... .| .||  . .  .| .| || |. || |.....|| ||..  |.||||| |... |  || |      .   .|.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DIAIQVTEGMIYLGEQDYIHCDLRAENILVYINIGDHNTVKIANFHLIQHLN-GKKYWTVKEDTKVVLRWTAPEFFTLNRLSIKSDVWSFGILLWELATK
|.| || ||| ||... ||| ||.| |.||    |..| .|.| | | . .  ..   . ... |.  .||||| .. .| .||||||||||||.|. |.
DMAAQVAEGMAYLESMNYIHRDLAARNVLV----GENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTY

GKEPYPDMATEEVKEAVSKGYHMPIPRDCPEPFKQ-LMPNCWKNHEYKRPNFNNIIDIL
|. ||| |  .|| ..|..||.|| |. ||. . . .|  ||..   .|| |  . . |
GRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK435.AA SFK-Src 796-1042 41 9.8e-86 253.98 In-house 1-250 (259) Show / Hide 
Range on Protein: 796-1042
Range on HMM: 1-250/259
Sequence Identity: 41% (105 aa)

IKFEQCINAGQFGETWKGDWKDKGPVIIKTNIATDITQETLLVEAGILQKLHHKNIISLYGVCTESYPFYIVTEPM-NENLKYYLNK---TLITPAELVD
|. |.   .||||. ||| | ..  | .||     . .|  | ||... || | | | || |||   | ||.|| | .  |  ||        .   |||
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

IAIQVTEGMIYLGEQDYIHCDLRAENILVYINIGDHNTVKIANFHLIQHLNGKKY-WTVKEDTKVVLRWTAPEFFTLNRLSIKSDVWSFGILLWELATKG
 | ||  || || .| ..| || | |.||    || |..|.. | .   |  .   .| .|  |   .|||||  . || ||||||||||||. |. | |
MAAQVAHGMAYLEAQNFVHRDLAARNVLV----GDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYG

KEPYPDMATEEVKEAVSK--GYHMPIPRDCPEPFKQLMPNCWKNHEYKRPNFNN
  ||| |   ||   | .  || || |  ||. . ..| .||.     || | .
RIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFES
Kinase AqueK435.AA Pkinase_Tyr 796-1047 37 5.4e-77 261.39 Pfam 1-270 (270) Show / Hide 
Range on Protein: 796-1047
Range on HMM: 1-270/270
Sequence Identity: 37% (104 aa)

IKFEQCINAGQFGETWKGDWK-----DKGPVIIKTN--IATDIT--QETLLVEAGILQKL-HHKNIISLYGVCT-ESYP--FYIVTEPMNE-NLKYYLNK
|.| . . .|.||| .|| ||     .| || .|.    |..    .| .. || |. .| ||.||..|||||| .. |   |||.| |   .|. || |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

T-----LITPAELVDIAIQVTEGMIYLGEQDYIHCDLRAENILVYINIGDHNTVKIANFHLIQHLNGKKYW-TVKEDTKVVLRWTAPEFFTLNRLSIKSD
       .|. .|.....|. .|| || .. .|| ||.| |.||       |.|||. | |   .  . |  ......|.  .|.||| .  .. ..|||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSD

VWSFGILLWELATKGKEP-YPDMATEEVKEAV-SKGYHMPIPRDCPEPFKQLMPNCWKNHEYKRPNFNNIIDIL
|||||.|.||. | |..| ||.|  |||.|..  .|| ||.|..||..  .||  ||.    .|| |  |. .|
VWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK435.AA Frk 796-1051 40 4.4e-75 255.76 In-house 1-260 (260) Show / Hide 
Range on Protein: 796-1051
Range on HMM: 1-260/260
Sequence Identity: 40% (108 aa)

IKFEQCINAGQFGETWKGDWKDKGPVIIKTNIATDITQETLLVEAGILQKLHHKNIISLYGVCTESYPFYIVTEPMNEN-LKYYLN-----KTLITPAEL
|.. . . .||||| | | |  . || .||  .  .  . .| || |..|| |  .|.|| |||   | ||.|| | .. |. ||         .   .|
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

VDIAIQVTEGMIYLGEQDYIHCDLRAENILVYINIGDHNTVKIANFHLIQHLNGKKY--WTVKEDTKVVLRWTAPEFFTLNRLSIKSDVWSFGILLWELA
||.| ||  || || .| ||| || | |.||    |.|| .||| | |   |   .   .  . . .. ..|||||    |. .|||||||||||| |. 
VDMAAQVAAGMAYLESQNYIHRDLAARNVLV----GEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEII

TKGKEPYPDMATEEVKEAVSKGYHMPIPRDCPEPFKQLMPNCWKNHEYKRPNFNNIIDILLKYK
| |. ||| |   || . |..|| || | .||. . ..| .||. .  ||| |  .   | .| 
TYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase AqueK435.AA SrcA 796-1047 45 4.4e-73 230.14 In-house 1-250 (250) Show / Hide 
Range on Protein: 796-1047
Range on HMM: 1-250/250
Sequence Identity: 45% (116 aa)

IKFEQCINAGQFGETWKGDWKDKGPVIIKTNIATDITQETLLVEAGILQKLHHKNIISLYGVCTESYPFYIVTEPMNEN-----LKYYLNKTLITPAELV
|. |. .  |.||| | | |  .  | |||     .  |. | || |..||.|  .. || |  |  | ||||| |..      ||    | |  | .||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEE-PIYIVTEYMCKGSLLDFLKDEEGKYLKLP-QLV

DIAIQVTEGMIYLGEQDYIHCDLRAENILVYINIGDHNTVKIANFHLIQHLNGKKYWTVKEDTKVVLRWTAPEFFTLNRLSIKSDVWSFGILLWELATKG
|.| || ||| |.    ||| |||| ||||    |..   ||| | |   ..   | | .  .|  ..|||||     |  |||||||||||| || |||
DMAAQVAEGMAYMERMNYIHRDLRAANILV----GENLICKIADFGLARLIEDNEY-TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKG

KEPYPDMATEEVKEAVSKGYHMPIPRDCPEPFKQLMPNCWKNHEYKRPNFNNIIDIL
. ||| |   || | | .||||| |.||||   .||  ||.     || |  .   |
RVPYPGMNNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase AqueK435.AA TyrKc 796-1047 35 9.9e-69 235.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 796-1047
Range on HMM: 1-280/280
Sequence Identity: 35% (102 aa)

IKFEQCINAGQFGETWKGDWKDKGPVIIKTNIATDITQETLLVEAGILQKL--HHKNIISLYGVCTES-------YPFYIVTEPM-NENLKYYLNKTL--
|.... .  |.||| .|| ||   .| .|.  .    .| .. || |. ||  ||.||. ||||||..        | .||.| | . .|| || |.   
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

ITPAELVDIAIQVTEGMIYLGEQDYIHCDLRAENILVYINIGDHNTVKIANFHLIQHLNGK-------KYWTVKE--DTK--VVLRWTAPEFFTLNRLSI
.....|.....|. .|| || .. .|| || | |.||    |. .||||. | |   .  .       .| ..||  ..|  . .||.||| .  .. ..
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLV----GENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KSDVWSFGILLWELATKGKEPYPD-----MATEEVKEAVSKGYHMPIPRD--------CPEPFKQLMPNCWKNHEYKRPNFNNIIDIL
||||||||...||. | |..|||.     |  .|| | | .|| ||.| .        ||.   |.|  ||.    .||.|..|....
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK435.AA TK 796-1047 19 1.1e-68 229.18 In-house 1-486 (486) Show / Hide 
Range on Protein: 796-1047
Range on HMM: 1-486/486
Sequence Identity: 19% (95 aa)

IKFEQCINAGQFG---ETWKGDWKDKG--------------------------PVIIKTNIATDITQET------------------LLVEAGILQ--KL
|.... . .||||   | .|| |....                          || .|.  ..| ....                  .. |. ...  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHKNIISLYGVCTES------------YPFYIVTEPMN-EN----LKYYLNKTL----------------------------------------------
||.||..||||||..             |..||.| |.  .    |. || |                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------ITPAELVDIAIQVTEGMIYLGEQ------DYIHCDLRAENILVYINIGDH-------NTVKIANFH---
                               .|...|. .. |. .|| || ..       ..| || | |.||  |  ..        ..||| |    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LIQHL-NGKKYWTVKE-----------------------DTKVVLRWTAPEFFT---------LNRLSIKSDVWSFGILLWELATKGKEPYPD-M
     |   . ... |.....                       ..|. .||.||| ..          .. ..||||||||.|.||. | |.|||.  |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

AT---------EEVKEAVSKG--------------YHMPIPRDCP--------------EPFKQLMPNCWKNHEYKRPNFNNIIDIL
           .|| | . .|              . || | .||              | . .||  ||.    .||.|  . . |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK435.AA Abl 796-1047 37 2.3e-68 227.02 In-house 1-252 (252) Show / Hide 
Range on Protein: 796-1047
Range on HMM: 1-252/252
Sequence Identity: 37% (97 aa)

IKFEQCINAGQFGETWKGDWKDKGPVI-IKTNIATDITQETLLVEAGILQKLHHKNIISLYGVCTESYPFYIVTEPM-NENLKYYL---NKTLITPAELV
|  .. .  ||.|| ..| ||  . .. .||     .  .  | || |.....|.|.. | ||||   ||||.|| | . ||  ||   .......  |.
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

DIAIQVTEGMIYLGEQDYIHCDLRAENILVYINIGDHNTVKIANFHLIQHLNGKKYWTVKEDTKVVLRWTAPEFFTLNRLSIKSDVWSFGILLWELATKG
 .| |.. || || ....|| || | | ||    |.|. ||.| | |   ...  | | .   |  ..|||||    |. |.||||| ||.||||.|| |
YMATQIASGMSYLEKRHFIHRDLAARNCLV----GEHHIVKVADFGLARMMKDDTY-TAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYG

KEPYPDMATEEVKEAVSKGYHMPIPRDCPEPFKQLMPNCWKNHEYKRPNFNNIIDIL
  ||| .  ..| . . ||| |  |. ||.   .|| .||. ..  || |..|   .
MSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase AqueK435.AA Src-Echino1 796-1047 37 2.4e-66 226.75 In-house 1-252 (252) Show / Hide 
Range on Protein: 796-1047
Range on HMM: 1-252/252
Sequence Identity: 37% (96 aa)

IKFEQCINAGQFGETWKGDWKDKGPVIIKTNIATDITQETLLVEAGILQKLHHKNIISLYGVCTESYPFYIVTEPM-NENLKYYLNKTLIT---PAELVD
 .... |  |..|| ||| |.   || .||     ...  .| || ...|. |..|. .| || .. | ||||| | | ||. || .        ..|.|
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

IAIQVTEGMIYLGEQDYIHCDLRAENILVYINIGDHNTVKIANFHLIQHLNGKKYWTVKEDTKVVLRWTAPEFFTLNRLSIKSDVWSFGILLWELATKGK
.  ..  || |||.....| || | |.||    |. | .|||.| | . ..   | . .   |. ..|||||     |  |||||||||||. |. | |.
MGAHIASGMDYLGSKNVVHRDLAARNVLV----GKGNVCKIADFGLARMMQKDVYCGKQ-GAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGR

EPYPDMATEEVKEAVSKGYHMPIPRDCPEPFKQL-MPNCWKNHEYKRPNFNNIIDIL
 |||.| . || . | .|| || . .||.   .. |  ||     .|| |. . | .
YPYPGMMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase AqueK435.AA SrcB 796-1048 38 5.1e-64 215.42 In-house 1-251 (251) Show / Hide 
Range on Protein: 796-1048
Range on HMM: 1-251/251
Sequence Identity: 38% (99 aa)

IKFEQCINAGQFGETWKGDWKDKGPVIIKTNIATDITQETLLVEAGILQKLHHKNIISLYGVCTESYPFYIVTEPMNENLKYYLNKT----LITPAELVD
.|... . |||||| | | ....  | .||     .  |  | || ....| |. .. || | |   | ||.|| |..       ||     ..   |.|
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

IAIQVTEGMIYLGEQDYIHCDLRAENILVYINIGDHNTVKIANFHLIQHLNGKKYWTVKEDTKVVLRWTAPEFFTLNRLSIKSDVWSFGILLWELATKGK
.. |..||| |. .. ||| |||| ||||   .      ||| | |   ..   | | .|  |  ..|||||        |||||||||||| |. | |.
MSAQIAEGMAYIERMNYIHRDLRAANILVSETL----CCKIADFGLARIIEDNEY-TAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGR

EPYPDMATEEVKEAVSKGYHMPIPRDCPEPFKQLMPNCWKNHEYKRPNFNNIIDILL
 ||| |.  || .....|| || |  |||   ..|  |||..   || |. .  .| 
IPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase AqueK435.AA SRM 798-1048 41 5.4e-60 199.31 In-house 1-253 (253) Show / Hide 
Range on Protein: 798-1048
Range on HMM: 1-253/253
Sequence Identity: 41% (107 aa)

FEQC--INAGQFGETWKGDWKDKGPVIIKTNIATD-ITQETLLVEAGILQKLHHKNIISLYGVCTESYPFYIVTEPMNE-NLKYYL----NKTLITPAEL
|  |    .| ||| | | ||.. .| ||     . . |..|  |   . || || ||.|. ||.   | ||.|| |   ||  ||     | |  | .|
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIP-HL

VDIAIQVTEGMIYLGEQDYIHCDLRAENILVYINIGDHNTVKIANFHLIQHLNGKKYWTVKEDTKVVLRWTAPEFFTLNRLSIKSDVWSFGILLWELATK
.|.| || ||| || || ||| || | |.||    || |. |.. | |   .    |     | ..  .|||||       |.|||||||||||.|. |.
LDFACQVAEGMCYLEEQNYIHRDLAARNVLV----GDNNLCKVGDFGLARLIKDDIY-SPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTY

GKEPYPDMATEEVKEAVSKGYHMPIPRDCPEPFKQLMPNCWKNHEYKRPNFNNIIDILL
|  ||| |   |    ...|| || |  ||     ||  ||.    .|| |      | 
GQCPYPGMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase AqueK435.AA TK-Unique 796-1047 29 2.3e-58 199.83 In-house 1-294 (294) Show / Hide 
Range on Protein: 796-1047
Range on HMM: 1-294/294
Sequence Identity: 29% (87 aa)

IKFEQCINAGQFGETWKGDWK------DKG-PVIIKTNI--ATDITQETLLVEAGILQKLH-HKNIISLYGVCTESY-PFYIVTEPMNEN-LKYYLNKTL
..... |  |.||. |.|. .      ||   |..|..   ||| ..  .| |. ....|  |.||....|.||.|  |..|. |..    |  || .. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

---------------------------ITPAELVDIAIQVTEGMIYLGEQDY--IHCDLRAENILVYINIGDHNTVKIANFHLIQHLN-GKKYWTVKEDT
                           |.|  |. .|.|.  || || .| .  .| || | |.|    .......||..| .  ... ...| . ..  
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVL----LTEDKVCKICDFGMARDVYTNGVYSMMCSQG

KVVLRWTAPEFFT--LNRL-SIKSDVWSFGILLWELATKGKEPYPDMATEEVKEAVSKGYHMPIPRDC-PEPFKQLMPNCWKNHEYKRPNFNNIIDIL
.. .|| ||| .    .   ..||||||||.|.||..| |. |||.|  ... |.. .|| || |  | .. . .|| .||.  . .||.|  |...|
RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK435.AA S_TKc 796-1051 22 1.2e-25 92.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 796-1051
Range on HMM: 1-231/231
Sequence Identity: 22% (61 aa)

IKFEQCINAGQFGETWKGDWKD-KGPVIIKTNIATDITQETLLVEAGILQKLHHKNIISLYGVCTESYPFYIVTEPMNE---NLKYYLNKTL-------I
 .. . |  | ||. .|. .|. .  | ||         |... |  ||.| ||.||. ||.|. .   .|.|.| ..    .|. |. |         .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

TPAELVDIAIQVTEGMIYLGEQDYIHCDLRAENILVYINIGDHNTVKIANFHLIQHLNGKKYWTVKEDTKVVLRWTAPEFFTLNRLSI-KSDVWSFGILL
.. .   .. |. ... |. ..  ||.||  ||||.        ..||. | |  .|             . . . ||| .     .  |.|.||.|..|
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

WELATKGKEPYPDMATEEVKEAVSKGYHMPIPRDCPEPFKQLMPNCWKNHEYKRPNFNNIID-----ILLKYK
.|... |. |.|    .  |  .            ....|... .|..    |||    .        .  . 
YEMLC-GYPPFP-QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK435.AA Pkinase 796-920 24 3.6e-15 54.74 Pfam 1-141 (293) Show / Hide 
Range on Protein: 796-920
Range on HMM: 1-141/293
Sequence Identity: 24% (34 aa)

IKFEQCINAGQFGETWKGDWKDKG-PVIIKTNIATDITQET---LLV--EAGILQKLHHKNIISLYGVCTESYPFYIVTEPMNE-----NLKYYLN---K
......| .| ||. .|. .|. |  | .|.    ..  .    ..   |. |...|.|.||. ||......   |.|.| ..       |. |.    .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TLI--TPAELVDIAIQVTEGMIYLGEQDYIHCDLRAENILV
. .  .. |. ... |. .|. |. ..  ||.||  ||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI
Kinase AqueK435.AA Pkinase 973-1047 19 2.5e-08 30.55 Pfam 192-293 (293) Show / Hide 
Range on Protein: 973-1047
Range on HMM: 192-293/293
Sequence Identity: 19% (20 aa)

KSDVWSFGILLWELATKGKEPYPDM----ATEEVKEAVSKGYHMPIPRDCP-----------------------EPFKQLMPNCWKNHEYKRPNFNNIID
|.|.||.|..|.|... |. |.|.        . .. . .  . |...|.|                       |..|... .|..   .|||..  |  
KVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

I--L
   .
HPWF