Gene AqueK444 (A.queenslandica)

AqueK444

Species: A.queenslandica
Alias: AqueK444
External Links:
Annotation:

Classification

Group: TK
Family: Tec

Sequence

Name Sequence Type Origin Length Description Download
AqueK444.AA Protein None 449 None Fasta, JSON
AqueK444.kin_dom Protein Kinase Domain None 266 None Fasta, JSON

Protein domain

Protein domains of AqueK444.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 AqueK444.AA SH2 1-30 33 1.9e-12 38.36 Pfam 52-81 (81) Show / Hide 
Range on Protein: 1-30
Range on HMM: 52-81/81
Sequence Identity: 33% (10 aa)

HYHIKNDEEKKYFVSEKHRFPTITELIEYY
||.|.......|.....|.|... ||.|.|
HYRIQRTDNGGYYITGRHKFCSLQELVEHY
TyrKc AqueK444.AA TyrKc 70-336 30 2.8e-87 297.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 70-336
Range on HMM: 1-280/280
Sequence Identity: 30% (96 aa)

LSFGKELGSGEFKRVVAGQWRNKVDVAIKMIKEDVMNEDDFIEEAILMLKF--QHDNLVKLYGVCIRQ-------GPVYIITELMANGCLLQYIRNNQHL
...||.||.|.| .|. |.|.  ..||.||.|||   . ||..|| .| |.  .|.|.|.|||||. |       .|..|..|.|..|.|..|.|.... 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

VKKTGIILDMAIQISDGMKFFEQSGLIHRDLYMEQISNLKHKIKVTTKVAKKFQLVMINMAARNCLVGDRNIVKVGGFSLARFVPDD--------EYTAS
  ..   |....||..|| . .. ..|||||                             ||||||||....||.. | |.|.. ||         |...
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDL-----------------------------AARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKK

V--GAK--YAVKWSPPEVITHARFSSKSDIWSYGILLWELWSGGKTPYPA-----FTNPQALDEVSKGYRLEKPKL--------CPSKVYDLMKRSWQK-
   |.|    ..| .||.| . .|..|||.||.|...||. . |..|||       .| ...  | .|||...|.         ||...|..||. |.  
EHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHED

------------GL
             .
PEDRPTFSEIHECF
Kinase AqueK444.AA Tec 221-333 51 7.9e-62 211.73 In-house 124-236 (254) Show / Hide 
Range on Protein: 221-333
Range on HMM: 124-236/254
Sequence Identity: 51% (58 aa)

AARNCLVGDRNIVKVGGFSLARFVPDDEYTASVGAKYAVKWSPPEVITHARFSSKSDIWSYGILLWELWSGGKTPYPAFTNPQALDEVSKGYRLEKPKLC
||||||||| ..|||  | ..|.| ||.|| |||.|. |||.||||    |.|||||.|..|.| || .|.|| ||....| .  ..||.|.||..|.||
AARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYENMSNSEVVEHVSQGHRLYRPHLC

PSKVYDLMKRSWQ
. ..|. |.. |.
SMHIYQIMYHCWH
Kinase AqueK444.AA Tec 70-191 53 4.5e-57 195.94 In-house 1-123 (254) Show / Hide 
Range on Protein: 70-191
Range on HMM: 1-123/254
Sequence Identity: 53% (66 aa)

LSFGKELGSGEFKRVVAGQWRNKVDVAIKMIKEDVMNEDDFIEEAILMLKFQHDNLVKLYGVCIRQGPVYIITELMANGCLLQYIRNNQH-LVKKTGIIL
| | |||||| |  |  |.||.. |||||||||  | |.||||||  | | .| .||.|||||. | |.||.|| |..|||| | | ..| . |...| |
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

DMAIQISDGMKFFEQSGLIHRDL
.| .... || . |... |||||
EMCQDVCEGMAYLERHCFIHRDL
Kinase AqueK444.AA Pkinase_Tyr 221-333 43 2.7e-53 181.1 Pfam 138-254 (270) Show / Hide 
Range on Protein: 221-333
Range on HMM: 138-254/270
Sequence Identity: 43% (51 aa)

AARNCLVGDRNIVKVGGFSLARFV-PDDEY-TASVGAKYAVKWSPPEVITHARFSSKSDIWSYGILLWELWSGGKTP-YPAFTNPQALDEV-SKGYRLEK
|||||||.. |.||.. | ||| . .||.| ... |.|  .|| .||.| . .|..|||.||.|.|.||. . |..| ||  .| . .. .  .|||...
AARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC

PKLCPSKVYDLMKRSWQ
|..|| ..|||||. |.
PENCPDEIYDLMKQCWH
Kinase AqueK444.AA Src 221-334 48 2.9e-49 165.48 In-house 124-240 (255) Show / Hide 
Range on Protein: 221-334
Range on HMM: 124-240/255
Sequence Identity: 48% (57 aa)

AARNCLVGDRNIVKVGGFSLARFVP--DDEYTASVGAKYAVKWSPPEVITHARFSSKSDIWSYGILLWELWSGGKTPYPAFTNPQALDEVSKGYRLEKPK
|||| |||. |..||. | ||| .   ||||.|. |||  .||  || |.. ||. ||| ||.||||.|. . |..|||  ||...|..|..|||. .|.
AARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPH

LCPSKVYD-LMKRSWQK
 || ..|. .|.. |.|
NCPDELYEQIMLQCWHK
Kinase AqueK444.AA Pkinase_Tyr 70-191 39 3.1e-49 167.37 Pfam 1-137 (270) Show / Hide 
Range on Protein: 70-191
Range on HMM: 1-137/270
Sequence Identity: 39% (54 aa)

LSFGKELGSGEFKRVVAGQWR-----NKVDVAIKMIKEDVMNE----DDFIEEAILMLKF-QHDNLVKLYGVCI-RQGP--VYIITELMANGCLLQYIRN
..|||.||.|.| .|. | |.     .|..||.||.||. | |    .||..|| .| .. .|.|.|.|||||. ...|  .||..|.|..|.|| | |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---QHLVKKTGIILDMAIQISDGMKFFEQSGLIHRDL
.   .. ..    .|.|..||..|| . |. ..|||||
HREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDL
Kinase AqueK444.AA Src 70-191 37 1.4e-48 163.12 In-house 1-123 (255) Show / Hide 
Range on Protein: 70-191
Range on HMM: 1-123/255
Sequence Identity: 37% (46 aa)

LSFGKELGSGEFKRVVAGQWRNKVDVAIKMIKEDVMNEDDFIEEAILMLKFQHDNLVKLYGVCIRQGPVYIITELMANGCLLQYIR-NNQHLVKKTGIIL
. . ..||.| |  |  | |.....||.| .|.. |  ..| .|| .| |..|..||.|| || .  |.||.||.|..|.||.| . . .    .  . .
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMAIQISDGMKFFEQSGLIHRDL
||| |...||.. |.  .|||||
DMAAQVAEGMAYLESMNYIHRDL
Kinase AqueK444.AA SFK-Src 220-334 47 2.2e-48 141.16 In-house 122-240 (259) Show / Hide 
Range on Protein: 220-334
Range on HMM: 122-240/259
Sequence Identity: 47% (57 aa)

MAARNCLVGDRNIVKVGGFSLARFV-PDDE-YTASVGAKYAVKWSPPEVITHARFSSKSDIWSYGILLWELWSGGKTPYPAFTNPQALDEVSK--GYRLE
.|||| |||| |..||| | ..| .  ||| |||  |||. .||  ||  .  ||| |||.||.|||. |.   |  |||  ||   |  | .  |||..
LAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPYPGMTNMEVLQQVDRPEGYRMP

KPKLCPSKVYDLMKRSWQK
.|. || . | .|   ||.
CPPNCPDEYYKIMFDCWQH
Kinase AqueK444.AA Abl 220-333 51 3.6e-47 155.12 In-house 123-236 (252) Show / Hide 
Range on Protein: 220-333
Range on HMM: 123-236/252
Sequence Identity: 51% (59 aa)

MAARNCLVGDRNIVKVGGFSLARFVPDDEYTASVGAKYAVKWSPPEVITHARFSSKSDIWSYGILLWELWSGGKTPYPAFTNPQALDEVSKGYRLEKPKL
.||||||||. .||||  | |||.. || |||  |||. .||  || . . .||||||.| .|.||||.   | .|||.    .  . . ||||.|.|. 
LAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYPGIDLSHVYHKLEKGYRMERPEG

CPSKVYDLMKRSWQ
|| |||.||.. ||
CPPKVYELMRQCWQ
Kinase AqueK444.AA UTK 221-330 35 1.1e-43 147.33 In-house 145-277 (296) Show / Hide 
Range on Protein: 221-330
Range on HMM: 145-277/296
Sequence Identity: 35% (47 aa)

AARNCLVGDR-------NIVKVGGFS---LARFVP----------DDEYTASVGAKYAVKWSPPEVITHA-RFSSKSDIWSYGILLWELWSGGKTPYPAF
|||||||..        ...|...|    ..| |.          ...|.|..  . ...|  ||..||. ||..|||.||.|...||.|..|..|||  
AARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGM

TNPQALDEVSKG--YRLEKPKLCPSKVYDLMKR
.|.|.. .|..|  ||...|. ||  ||.||.|
SNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHR
Kinase AqueK444.AA Src-Unclassified 221-334 45 2.3e-43 146.53 In-house 146-269 (284) Show / Hide 
Range on Protein: 221-334
Range on HMM: 146-269/284
Sequence Identity: 45% (56 aa)

AARNCLVGDRN-----IVKVGGFSLA--RFVPDDEYTASVGAKYAVKWSPPEVITHARFSSKSDIWSYGILLWELWSGGKTPYPAFTNPQALDEVSKGYR
|||| |.|. |     .|||  | ||  . . ||.| .  ||.  .||  || ..   || |||.|||||||||.   |.||||   |  .| .|. |||
AARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFIYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYR

LEKP--KLCPSKVYD-LMKRSWQK
. ||  ..||  .|. .||. | |
MPKPTNHYCPDYIYEDIMKKCWHK
Kinase AqueK444.AA SFK-Src 70-191 40 4.6e-43 125.08 In-house 1-122 (259) Show / Hide 
Range on Protein: 70-191
Range on HMM: 1-122/259
Sequence Identity: 40% (50 aa)

LSFGKELGSGEFKRVVAGQWRNKVDVAIKMIKEDVMNEDDFIEEAILMLKFQHDNLVKLYGVCIRQGPVYIITELMANGCLLQYIRNNQHLVKKTGIILD
    | |||| |  |  | | |. .||.|  |   | .. | .|| .| | .|.||..|| ||    |.|||||||..| || | .. .    .     |
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MAIQISDGMKFFEQSGLIHRDL
|| |.  || . |    .||||
MAAQVAHGMAYLEAQNFVHRDL
Kinase AqueK444.AA TK 221-333 22 2.6e-42 139.17 In-house 267-470 (486) Show / Hide 
Range on Protein: 221-333
Range on HMM: 267-470/486
Sequence Identity: 22% (45 aa)

AARNCLVGDRNI-----------VKVGGFS--------LARFVPDD-EYTASV------------------------GAKYAVKWSPPEVIT--------
||||||||..|.           .|.. |         ||| ...| .|...                         |.|  ..| .||...        
AARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAE

-HARFSSKSDIWSYGILLWELWSGGKTPYPA-FTN---------PQALDEVSKG--------------YRLEKPKLCP--------------SKVYDLMK
 . .|..|||.||.|.|.||... |..||.   .|          . .. . .|              .|...|..||                .||||.
KYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQ

RSWQ
. |.
QCWH
Kinase AqueK444.AA Frk 220-334 43 4.3e-41 140.0 In-house 124-241 (260) Show / Hide 
Range on Protein: 220-334
Range on HMM: 124-241/260
Sequence Identity: 43% (51 aa)

MAARNCLVGDRNIVKVGGFSLAR-FVPDDE--YTASVGAKYAVKWSPPEVITHARFSSKSDIWSYGILLWELWSGGKTPYPAFTNPQALDEVSKGYRLEK
.|||| |||. ||.|.  | ||| .. |.|  | . .||.. .||  || .   .|. |||.||.|||| |.   |. |||  || . |. |..|||. .
LAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQ

PKLCPSKVYDLMKRSWQK
|  || ..|..|   |..
PPNCPQQLYEIMLECWHS
Kinase AqueK444.AA SRM 220-334 44 3.4e-39 128.64 In-house 123-237 (253) Show / Hide 
Range on Protein: 220-334
Range on HMM: 123-237/253
Sequence Identity: 44% (51 aa)

MAARNCLVGDRNIVKVGGFSLARFVPDDEYTASVGAKYAVKWSPPEVITHARFSSKSDIWSYGILLWELWSGGKTPYPAFTNPQALDEVSKGYRLEKPKL
.|||| |||| |. ||| | ||| . || |  | . .  .||  || .    .| |||.||.||||.|. . |  |||  ||  ..  ...|||.  |  
LAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYPGMTNHETFQQIDRGYRMPCPAE

CPSKVYDLMKRSWQK
||  |. ||   |..
CPPEVHKLMLECWCR
Kinase AqueK444.AA TK 70-191 18 5.3e-38 124.45 In-house 1-266 (486) Show / Hide 
Range on Protein: 70-191
Range on HMM: 1-266/486
Sequence Identity: 18% (48 aa)

LSFGKELGSGEFK---RVVAGQWRNK--------------------------VDVAIKMIKED-VMNEDDFIE--------------EAILMLKFQ----
. .||.||.|.|    .|  |.||..                          ..||.||.||.  |....|..              ||  | ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HDNLVKLYGVCIRQ------------GPVYIITELMANGC----LLQYIRNNQHLVKK-----------------------------------------
 |.|.|.||||| ..            .|..|..|.|..|.    |..| |.. .  ..                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------TGIILD-------------------MAIQISDGMKFFEQS------GLIHRDL
             |   |.                   |. ||..|| . ..       ...||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDL
Kinase AqueK444.AA Src-Unclassified 70-191 36 8.9e-38 127.08 In-house 1-145 (284) Show / Hide 
Range on Protein: 70-191
Range on HMM: 1-145/284
Sequence Identity: 36% (53 aa)

LSFGKELGSGEFKRVVAGQWRNKVDVAIKMIKED---VMNEDDFI--------EEAILMLKFQHDNLVKLYGVCIRQGPVYIITELMANGCLLQYIRNNQ
.   ..|| | |  |  | ||.|||||.|  ...    |    |         .|| .| |..| |||.||.|| .  | |||||.| || |||. |   
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

------HLV------KKTGIILDMAIQISDGMKFFEQSGLIHRDL
       .       |   |  |.| |.  ||   |  ...||||
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDL
Kinase AqueK444.AA Abl 70-191 42 2.9e-37 121.5 In-house 1-123 (252) Show / Hide 
Range on Protein: 70-191
Range on HMM: 1-123/252
Sequence Identity: 42% (52 aa)

LSFGKELGSGEFKRVVAGQW-RNKVDVAIKMIKEDVMNEDDFIEEAILMLKFQHDNLVKLYGVCIRQGPVYIITELMANGCLLQYIRNNQHLVKKTGIIL
..  . || | .  |  | | | .  ||.| .||| |. ..|..|| .| . .| |||.| ||| |  | ||||| |..| ||.|.|....   .  ..|
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

DMAIQISDGMKFFEQSGLIHRDL
 || ||. ||.. |.   |||||
YMATQIASGMSYLEKRHFIHRDL
Kinase AqueK444.AA SrcB 70-191 40 5.6e-37 122.56 In-house 1-121 (251) Show / Hide 
Range on Protein: 70-191
Range on HMM: 1-121/251
Sequence Identity: 40% (50 aa)

LSFGKELGSGEFKRVVAGQWRNKVDVAIKMIKEDVMNEDDFIEEAILMLKFQHDNLVKLYGVCIRQGPVYIITELMANGCLLQYIRNNQHLVKKTGIILD
| . | ||.| |  |  | ..|.. ||.| .|.  |  . |..|| .| . ||| ||.|| |  .  |.||||| ||.|||| ... ..    .   ..|
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

MAIQISDGMKFFEQSGLIHRDL
|. ||..|| . |.   |||||
MSAQIAEGMAYIERMNYIHRDL
Kinase AqueK444.AA SrcB 222-334 43 3.4e-36 119.86 In-house 123-235 (251) Show / Hide 
Range on Protein: 222-334
Range on HMM: 123-235/251
Sequence Identity: 43% (49 aa)

ARNCLVGDRNIVKVGGFSLARFVPDDEYTASVGAKYAVKWSPPEVITHARFSSKSDIWSYGILLWELWSGGKTPYPAFTNPQALDEVSKGYRLEKPKLCP
| | || .  . |.  | ||| . |.||||  |||. .||  || | .  |  |||.||.|||| |.   |. |||  |||. .  ...|||. .|  ||
AANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGMTNPEVIRNLERGYRMPRPDNCP

SKVYDLMKRSWQK
  .|..|.. |..
EELYNIMMMCWKE
Kinase AqueK444.AA Frk 70-191 40 2.7e-34 116.04 In-house 1-124 (260) Show / Hide 
Range on Protein: 70-191
Range on HMM: 1-124/260
Sequence Identity: 40% (50 aa)

LSFGKELGSGEFKRVVAGQWRNKVDVAIKMIKEDVMNEDDFIEEAILMLKFQHDNLVKLYGVCIRQGPVYIITELMANGCLLQYIR--NNQHLVKKTGII
. . ..|||| |  |  |.| |.. ||.| .|   |. .||. || .| | .|  |..|| || .. |.||||||| .| |..|..  |..    .  ..
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

LDMAIQISDGMKFFEQSGLIHRDL
.||| |.  || . |.   |||||
VDMAAQVAAGMAYLESQNYIHRDL
Kinase AqueK444.AA SRM 70-191 39 2.9e-31 101.68 In-house 1-123 (253) Show / Hide 
Range on Protein: 70-191
Range on HMM: 1-123/253
Sequence Identity: 39% (49 aa)

LSFGKELGSGEFKRVVAGQWRNKVDVAIKMIKEDV-MNEDDFIEEAILMLKFQHDNLVKLYGVCIRQGPVYIITELMANGCLLQYIRNNQHLVKKTGIIL
  ... ||.| |  |  | |. .| |||| || |  |   ..  |   | |  |  ...|. ||    |||||||||. | |.|| |     . .    |
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLL

DMAIQISDGMKFFEQSGLIHRDL
|.| |.  || . |    |||||
DFACQVAEGMCYLEEQNYIHRDL
Kinase AqueK444.AA UTK 70-191 30 2.8e-26 86.9 In-house 1-144 (296) Show / Hide 
Range on Protein: 70-191
Range on HMM: 1-144/296
Sequence Identity: 30% (44 aa)

LSFGKELGSGEFKRVVAGQWRN------KVDVAIKMIKEDVM---NED---DFIEEAI---LMLKFQ-HDNLVKLYGVCIRQGPVYIITELMANGCLLQY
. .|..||.|.|  |  . ...      ..|||.|  ... .   ...   ||.|||    .| .|. | |...|.||| ...| .|.||.|.|| |..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

IRNNQH------LVKKTGIILDMAIQISDGMKFFEQSGLIHRDL
 |.. .      .  .    |.|| .|..|| . .. |..||||
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDL
Kinase AqueK444.AA S_TKc 70-346 20 6.6e-19 70.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 70-346
Range on HMM: 1-231/231
Sequence Identity: 20% (60 aa)

LSFGKELGSGEFKRVVAGQWRN-KVDVAIKMIKEDVMNEDDFIEEAILMLKFQHDNLVKLYGVCIRQGPVYIITELMAN--GCLLQYIRNNQH----LVK
  .....|.| | .|  ..... .  ||||.||      .... |  .. | .|.|.||||.|.   . .|...|.. .  | |..||.....     . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

KTGIILDMAIQISDGMKFFEQSGLIHRDLYMEQISNLKHKIKVTTKVAKKFQLVMINMAARNCLVGDRNIVKVGGFSLARFVPDDEYTASVGAKYAVKWS
    .  .. || .....  . | |||||                                | |. .   .|.. | |||..     |  .|  .   . 
PE-HARFYMYQICCALEYCHSHGIIHRDL-----------------------------KPENILLDE--HIKICDFGLARQL-----TTFCGTPW---YM

PPEVITHARFSS-KSDIWSYGILLWELWSGGKTPYPAFTNPQALDEVSKGYRLEKPKLCPSKVYDLMKRSWQK------GLCYLHG------KHPPI
.|||.    ..  |.|.|| |..|.|. . |..|.|  .  . .. .            .. . |.... .||      .   .        .|| .
APEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK444.AA Pkinase 70-191 24 2.6e-16 58.78 Pfam 1-134 (293) Show / Hide 
Range on Protein: 70-191
Range on HMM: 1-134/293
Sequence Identity: 24% (33 aa)

LSFGKELGSGEFKRVVAGQWRNKVD-VAIKMIKEDVMNEDDFIE-----EAILMLKFQHDNLVKLYGVCIRQGPVYIITELMANG----CLLQYIR--NN
. .|. .||| | .|  .....  . ||.| || .  ...  ..     |. .|....|.| |.||... . . .|...|.. .|     |  ||.  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QHLVKKTGIILDMAIQISDGMKFFEQSGLIHRDL
  .      . ... ||  |...  . | |||||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDL
Kinase AqueK444.AA TK 334-407 19 5.1e-13 39.23 In-house 245-374 (486) Show / Hide 
Range on Protein: 334-407
Range on HMM: 245-374/486
Sequence Identity: 19% (25 aa)

KGLCYLHGKHP----PIVHRDLTANNVLLTSSYS-----------AKISDLG--------VSRLADMFKKHHLTTAPG---------------------N
.|. ||| |.      .||||| | |.|.....            .||.| |         .|  .  .  . .. .|                     .
CGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSG

AMV----MPPEALKDNP--------VYDHK
...    |.||.|.|.         .. .|
GKLPIRWMAPECLNDRVFSEAEKYGKFTTK
Kinase AqueK444.AA UTK 335-387 26 8.3e-12 36.68 In-house 130-202 (296) Show / Hide 
Range on Protein: 335-387
Range on HMM: 130-202/296
Sequence Identity: 26% (20 aa)

GLCYLHGKHPPIVHRDLTANNVLLTSS-------YSAKISDLG---VSRLAD------------MFKKHHLTTAP
|. |||...  .||||| | |.|....       ...||.|.|    ||..             .....| . .|
GMQYLHSCG--FVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWP
Kinase AqueK444.AA Pkinase_Tyr 334-374 43 8.4e-10 33.82 Pfam 122-160 (270) Show / Hide 
Range on Protein: 334-374
Range on HMM: 122-160/270
Sequence Identity: 43% (18 aa)

KGLCYLHGKHPPIVHRDLTANNVLLTSSYSAKISDLGVSRL
||. ||. |.  ..|||| | |.|.|..  .||.| | .|.
KGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARD
Kinase AqueK444.AA SRM 335-374 42 1e-06 18.23 In-house 109-146 (253) Show / Hide 
Range on Protein: 335-374
Range on HMM: 109-146/253
Sequence Identity: 42% (17 aa)

GLCYLHGKHPPIVHRDLTANNVLLTSSYSAKISDLGVSRL
|.|||  .   ..|||| | ||| .     |. | |  ||
GMCYLEEQN--YIHRDLAARNVLVGDNNLCKVGDFGLARL
Kinase AqueK444.AA Src 346-374 44 2e-06 17.88 In-house 118-146 (255) Show / Hide 
Range on Protein: 346-374
Range on HMM: 118-146/255
Sequence Identity: 44% (13 aa)

IVHRDLTANNVLLTSSYSAKISDLGVSRL
..|||| | |||   .  .|. | |  ||
YIHRDLAARNVLVGENNVCKVADFGLARL
Kinase AqueK444.AA DUSP 408-447 32 2e-06 23.76 Pfam 5-44 (96) Show / Hide 
Range on Protein: 408-447
Range on HMM: 5-44/96
Sequence Identity: 32% (14 aa)

YLVDQKWLKKWKKYTGFDSWDQATAEHAHPGPI-D--TAILFK
||.. ||...||.| ..|..|        |||| |     ...
YLISMKWWNQWKQYVYYDNNDNDNM---RPGPIEDDKNSDILC
Kinase AqueK444.AA Pkinase 261-297 36 4e-06 22.66 Pfam 177-213 (293) Show / Hide 
Range on Protein: 261-297
Range on HMM: 177-213/293
Sequence Identity: 36% (14 aa)

WSPPEVIT-HARFSSKSDIWSYGILLWELWSGGKTPYP
. .||||  .   ..|.|.||.|..|.|. . |..|.|
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFP
Kinase AqueK444.AA Pkinase 334-407 30 1.4e-05 20.81 Pfam 119-192 (293) Show / Hide 
Range on Protein: 334-407
Range on HMM: 119-192/293
Sequence Identity: 30% (24 aa)

KGLCYLHGKHPPIVHRDLTANNVLLTSSYSA----KISDLGVSRLADMFKKHHLTTAPGNAMVMPPEALKDNPVYDHK
.|| |.| .   |.||||   |.|. . .      ||.| |.....|  ... .||  |    |.|| ..... |..|
RGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK
Kinase AqueK444.AA SrcB 347-376 40 3e-05 13.62 In-house 117-146 (251) Show / Hide 
Range on Protein: 347-376
Range on HMM: 117-146/251
Sequence Identity: 40% (12 aa)

VHRDLTANNVLLTSSYSAKISDLGVSRLAD
.|||| | |.|   . . || | |. |. .
IHRDLRAANILVSETLCCKIADFGLARIIE
Kinase AqueK444.AA SFK-Src 347-373 51 3e-05 10.85 In-house 118-144 (259) Show / Hide 
Range on Protein: 347-373
Range on HMM: 118-144/259
Sequence Identity: 51% (14 aa)

VHRDLTANNVLLTSSYSAKISDLGVSR
||||| | |||   .   |. | | ||
VHRDLAARNVLVGDNNVCKVGDFGMSR
Kinase AqueK444.AA Frk 335-374 40 4.7e-05 13.06 In-house 110-147 (260) Show / Hide 
Range on Protein: 335-374
Range on HMM: 110-147/260
Sequence Identity: 40% (16 aa)

GLCYLHGKHPPIVHRDLTANNVLLTSSYSAKISDLGVSRL
|. ||  .    .|||| | |||.  . . || | |. |.
GMAYLESQN--YIHRDLAARNVLVGEHNICKIADFGLARV
Kinase AqueK444.AA Abl 335-374 37 0.000155 10.5 In-house 109-146 (252) Show / Hide 
Range on Protein: 335-374
Range on HMM: 109-146/252
Sequence Identity: 37% (15 aa)

GLCYLHGKHPPIVHRDLTANNVLLTSSYSAKISDLGVSRL
|. ||  .|   .|||| | | |.      |. | |..|.
GMSYLEKRH--FIHRDLAARNCLVGEHHIVKVADFGLARM
Kinase AqueK444.AA Tec 347-373 44 0.001865 8.03 In-house 119-145 (254) Show / Hide 
Range on Protein: 347-373
Range on HMM: 119-145/254
Sequence Identity: 44% (12 aa)

VHRDLTANNVLLTSSYSAKISDLGVSR
.|||| | | |  .    |.|| | .|
IHRDLAARNCLVGDQCVVKVSDFGMTR
Kinase AqueK444.AA Src-Unclassified 346-370 43 0.0144 4.55 In-house 140-169 (284) Show / Hide 
Range on Protein: 346-370
Range on HMM: 140-169/284
Sequence Identity: 43% (13 aa)

IVHRDLTANNVLLTSSYS-----AKISDLG
.||||| | |||     |     .|. | |
YVHRDLAARNVLIGHNNSNGVPVVKVCDFG