Gene AqueK446 (A.queenslandica)

AqueK446

Species: A.queenslandica
Alias: AqueK446
External Links:
Annotation:

Classification

Group: TK
Family: Tec

Sequence

Name Sequence Type Origin Length Description Download
AqueK446.AA Protein None 208 None Fasta, JSON
AqueK446.kin_dom Protein Kinase Domain None 197 None Fasta, JSON

Protein domain

Protein domains of AqueK446.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK446.AA Tec 1-206 51 6.4e-113 381.45 In-house 30-236 (254) Show / Hide 
Range on Protein: 1-206
Range on HMM: 30-236/254
Sequence Identity: 51% (107 aa)

MIKEDAMNEDDFIEEAILMIKFQHDNLVKLYGVCIRQGPVYIITELMANGSLLQYLRNNQHLVDNTD-IILDMAIQICAAMKFFEQSGFIHRNLAARNCL
|||| .| |.||||||  | | .| .||.|||||. | |.||.|| |..|.|| ||| ..|       | |.| ...| .| . |...|||| |||||||
MIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCL

VGDRNIVKVAGFGSARYVPDNEYTASEGTEFAVKWIAPEVITHARYSSKSDVWSYGILLWELWTGGKTPYPAFTNPQVLDEVLRGYRLEKPKLCPSKIYD
||| ..|||. || .||| | .|| | || | ||| .|||    |||||||||..|.| || ...|| ||....| .| ..| .|.||..|.||. .||.
VGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYENMSNSEVVEHVSQGHRLYRPHLCSMHIYQ

LMKRSWQ
 |.. |.
IMYHCWH
Kinase AqueK446.AA Pkinase_Tyr 1-206 42 9.4e-100 338.46 Pfam 35-254 (270) Show / Hide 
Range on Protein: 1-206
Range on HMM: 35-254/270
Sequence Identity: 42% (94 aa)

MIKEDAMNE----DDFIEEAILMIKF-QHDNLVKLYGVCI-RQGP--VYIITELMANGSLLQYLRNN---QHLVDNTDIILDMAIQICAAMKFFEQSGFI
|.||.|| |    .||..|| .| .. .|.|.|.|||||. ...|  .||..|.|..|.|| |||..   .. ..  | .|.|..||...| . |. ..|
MLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCI

HRNLAARNCLVGDRNIVKVAGFGSARYV-PDNEY-TASEGTEFAVKWIAPEVITHARYSSKSDVWSYGILLWELWTGGKTP-YPAFTNPQVLDEV-LRGY
|| ||||||||.. |.||.. || ||.. .| .| ....|. . .|| |||.| . ....||||||.|.|.||. | |..| ||  .| .|.. .  .||
HRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGY

RLEKPKLCPSKIYDLMKRSWQ
|...|..|| .||||||. |.
RMPCPENCPDEIYDLMKQCWH
Kinase AqueK446.AA Src 2-206 45 2.6e-92 312.96 In-house 31-239 (255) Show / Hide 
Range on Protein: 2-206
Range on HMM: 31-239/255
Sequence Identity: 45% (95 aa)

IKEDAMNEDDFIEEAILMIKFQHDNLVKLYGVCIRQGPVYIITELMANGSLLQYLR-NNQHLVDNTDIILDMAIQICAAMKFFEQSGFIHRNLAARNCLV
.|.. |  ..| .|| .| |..|..||.|| || .  |.||.||.|..||||.||. . .    .  . .||| |. . |.. |.  .||| ||||| ||
LKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLV

GDRNIVKVAGFGSARYVP--DNEYTASEGTEFAVKWIAPEVITHARYSSKSDVWSYGILLWELWTGGKTPYPAFTNPQVLDEVLRGYRLEKPKLCPSKIY
|. |..||| || || .   |.||.|..|  | .|| ||| |.. |.. ||||||.||||.|. | |..|||  ||..||..| ||||. .|. || ..|
GENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELY

D-LMKRSWQ
. .|.. |.
EQIMLQCWH
Kinase AqueK446.AA SFK-Src 3-207 47 4.6e-92 273.08 In-house 32-240 (259) Show / Hide 
Range on Protein: 3-207
Range on HMM: 32-240/259
Sequence Identity: 47% (99 aa)

KEDAMNEDDFIEEAILMIKFQHDNLVKLYGVCIRQGPVYIITELMANGSLLQYLRNNQHLVDNTDIILDMAIQICAAMKFFEQSGFIHRNLAARNCLVGD
|  || .. | .|| .| | .|.||..|| ||    |.|||||||..|||| ||.. .    .     ||| |. . | . |   |.|| ||||| ||||
KPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGD

RNIVKVAGFGSARYV-PDNE-YTASEGTEFAVKWIAPEVITHARYSSKSDVWSYGILLWELWTGGKTPYPAFTNPQVLDEVLR--GYRLEKPKLCPSKIY
 |..||. || .| .  |.| ||| ||  | .|| |||  .  |.| ||||||.|||. |. | |  |||  ||  ||  | |  |||...|. || . |
NNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYY

DLMKRSWQT
 .|   ||.
KIMFDCWQH
Kinase AqueK446.AA Abl 2-206 49 3.9e-85 283.92 In-house 32-236 (252) Show / Hide 
Range on Protein: 2-206
Range on HMM: 32-236/252
Sequence Identity: 49% (101 aa)

IKEDAMNEDDFIEEAILMIKFQHDNLVKLYGVCIRQGPVYIITELMANGSLLQYLRNNQHLVDNTDIILDMAIQICAAMKFFEQSGFIHRNLAARNCLVG
.|||.|. ..|..|| .| . .| |||.| ||| |  | ||||| |..| ||.|||....   .  ..| || ||  .|.. |.  |||| |||||||||
LKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVG

DRNIVKVAGFGSARYVPDNEYTASEGTEFAVKWIAPEVITHARYSSKSDVWSYGILLWELWTGGKTPYPAFTNPQVLDEVLRGYRLEKPKLCPSKIYDLM
. .||||| || || . |. |||  |  | .|| ||| . . ..||||||| .|.||||. | | .|||.    .| . . .|||.|.|. || |.|.||
EHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELM

KRSWQ
.. ||
RQCWQ
Kinase AqueK446.AA TK 1-206 20 2.1e-81 272.54 In-house 59-470 (486) Show / Hide 
Range on Protein: 1-206
Range on HMM: 59-470/486
Sequence Identity: 20% (85 aa)

MIKED-AMNEDDFIE--------------EAILMIKFQ-----HDNLVKLYGVCIRQ------------GPVYIITELMANGS----LLQYLRNNQHLVD
|.||. ||....|..              ||  | ...     |.|.|.||||| ..            .|..|..|.|..|.    |..|||.. .   
MLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQ

N------------------------------------------------------TDIILD-------------------MAIQICAAMKFFEQS-----
.                                                      |   |.                   |. ||...| . ..      
HEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFI

-GFIHRNLAARNCLVGDRNI-----------VKVAGFG--------SARYV-PDNEYTASE------------------------GTEFAVKWIAPEVIT
 .|.||.|||||||||..|.           .|.| ||         ||.. .| .|....                        |. . ..| |||...
QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLN

---------HARYSSKSDVWSYGILLWELWTGGKTPYPA-FTN---------PQVLDEVLRG--------------YRLEKPKLCP--------------
         . ....||||||.|.|.||..| |..||.   .|          .|.. . ||              .|...|..||              
DRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPP

SKIYDLMKRSWQ
  .||||.. |.
EEYYDLMQQCWH
Kinase AqueK446.AA Src-Unclassified 3-205 41 2.6e-77 263.17 In-house 32-267 (284) Show / Hide 
Range on Protein: 3-205
Range on HMM: 32-267/284
Sequence Identity: 41% (97 aa)

KED---AMNEDDFI--------EEAILMIKFQHDNLVKLYGVCIRQGPVYIITELMANGSLLQYLRNNQ-HLVDNTDI-----------ILDMAIQICAA
...    |    |         .|| .| |..| |||.||.|| .  | |||||.| ||||||.||     .    |              |.| |.   
RPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGGGQYLHIQDMSEETGRKNVLIGVDIAAQVASG

MKFFEQSGFIHRNLAARNCLVGDRN-----IVKVAGFGSA--RYVPDNEYTASEGTEFAVKWIAPEVITHARYSSKSDVWSYGILLWELWTGGKTPYPAF
|   |  . .|| ||||| |.|. |     .|||. || |  . . | .| .  |  | .|| ||| ..    | |||||||||||||. | |.||||  
MMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFIYGNFSIKSDVWSYGILLWEIMTKGQTPYPGM

TNPQVLDEVLRGYRLEKP--KLCPSKIYD-LMKRSW
 |  || .| ||||. ||  ..||  ||. .||. |
HNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCW
Kinase AqueK446.AA UTK 8-203 36 1.1e-75 257.72 In-house 46-277 (296) Show / Hide 
Range on Protein: 8-203
Range on HMM: 46-277/296
Sequence Identity: 36% (85 aa)

NED---DFIEEAI---LMIKFQ-HDNLVKLYGVCIRQGPVYIITELMANGSLLQYLRNNQHLVD------NTDIILDMAIQICAAMKFFEQSGFIHRNLA
...   ||.|||    .| .|. | |...|.||| ...| .|.||.|.||.|..|||.. . ..      . .  |.|| .| ..| . .. ||.||.||
EPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLA

ARNCLVGDR-------NIVKVAGFG---SARYVP----------DNEYTASEGTEFAVKWIAPEVITHA-RYSSKSDVWSYGILLWELWTGGKTPYPAFT
||||||..        ...|.|.||    .|.|.          ...|.|.. .. ...| |||..||. |...||||||.|...||.||.|..|||  .
ARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMS

NPQVLDEVLRG--YRLEKPKLCPSKIYDLMKR
|.||. .|..|  ||...|. ||  .|.||.|
NMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHR
Kinase AqueK446.AA SFK-Abl 2-205 45 4e-74 241.26 In-house 30-234 (251) Show / Hide 
Range on Protein: 2-205
Range on HMM: 30-234/251
Sequence Identity: 45% (94 aa)

IKEDAMNEDDFIEEAILMIKFQHDNLVKLYGVCIRQGPVYIITELMANGSLLQYLRNNQHLVDNTDI-ILDMAIQICAAMKFFEQSGFIHRNLAARNCLV
||...|   ||  ||  | . || |||.| ||| | || ||..| | .| || ||.  |  ..   .  .  | ||   | | |   |||| ||||||||
IKDESMETKDFMKEAHIMKRMQHPNLVRLIGVCTREGPMYIVQEFMNYGNLLDYLQSPQSRIQIDHVSMMHCAQQIADGMSFLEEQHFIHRDLAARNCLV

GDRNIVKVAGFGSARYVPDNEYTASEGTEFAVKWIAPEVITHARYSSKSDVWSYGILLWELWTGGKTPYPAFTNPQVLDEVLRGYRLEKPKLCPSKIYDL
||   .||| || || |    |.|  || . .|| |||    . .. ||||||.|| |||  | |  |||     .|..    |||. .|. ||  ||. 
GDNLQIKVADFGMARFVDSDFYEARIGTKMPIKWTAPESLCYDIFTIKSDVWSFGITLWEIATYGDVPYPGIHHRDVINQLMMGYRMQRPQDCPMEIYNI

MKRSW
|   |
MTQCW
Kinase AqueK446.AA TyrKc 2-208 30 2.5e-73 250.85 SMART 1-280 (280) Show / Hide 
Range on Protein: 2-208
Range on HMM: 1-280/280
Sequence Identity: 30% (86 aa)

I----------------------------KEDAMNEDDFIEEAILMIKF--QHDNLVKLYGVCIRQ-------GPVYIITELMANGSLLQYLRNNQHLVD
|                            ||||  . ||..|| .| |.  .|.|.|.|||||. |       .|..|..|.|..|.|..|||....   
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-L

NTDIILDMAIQICAAMKFFEQSGFIHRNLAARNCLVGDRNIVKVAGFGSARYVPDN--------EYTASE--GTE--FAVKWIAPEVITHARYSSKSDVW
...  |....||.. | . .. ..||| |||||||||....||.. || .|.. |          |...|  |.   . ..| |||.| . ....|||||
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVW

SYGILLWELWTGGKTPYPA-----FTNPQVLDEVLRGYRLEKPKL--------CPSKIYDLMKRSWQT--------------V
|.|...||. | |..|||       .| .|.  | .|||...|.         ||...|..||. |.                
SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK446.AA Frk 2-206 45 3.7e-73 249.34 In-house 31-240 (260) Show / Hide 
Range on Protein: 2-206
Range on HMM: 31-240/260
Sequence Identity: 45% (95 aa)

IKEDAMNEDDFIEEAILMIKFQHDNLVKLYGVCIRQGPVYIITELMANGSLLQYLR--NNQHLVDNTDIILDMAIQICAAMKFFEQSGFIHRNLAARNCL
.|  .|. .||. || .| | .|  |..|| || .. |.||||||| .|||..||.  |..    .  ...||| |. | | . |.  .||| ||||| |
LKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVL

VGDRNIVKVAGFGSAR-YVPDNE--YTASEGTEFAVKWIAPEVITHARYSSKSDVWSYGILLWELWTGGKTPYPAFTNPQVLDEVLRGYRLEKPKLCPSK
||. ||.|.| || ||  . |||  | .  |  | .|| ||| .   ... ||||||.|||| |. | |. |||  || .||. | .|||. .|  || .
VGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQ

IYDLMKRSWQ
.|..|   |.
LYEIMLECWH
Kinase AqueK446.AA SrcB 2-206 44 7e-72 242.43 In-house 31-234 (251) Show / Hide 
Range on Protein: 2-206
Range on HMM: 31-234/251
Sequence Identity: 44% (91 aa)

IKEDAMNEDDFIEEAILMIKFQHDNLVKLYGVCIRQGPVYIITELMANGSLLQYLRNNQHLVDNTDIILDMAIQICAAMKFFEQSGFIHRNLAARNCLVG
.|. .|  . |..|| .| . ||| ||.|| |  .  |.||||| ||.|.|| .|. ..    . . ..||. ||   | . |.  .||| | | | || 
MKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVS

DRNIVKVAGFGSARYVPDNEYTASEGTEFAVKWIAPEVITHARYSSKSDVWSYGILLWELWTGGKTPYPAFTNPQVLDEVLRGYRLEKPKLCPSKIYDLM
.  . |.| || || . |||||| ||  | .|| ||| | .  .  ||||||.|||| |. | |. |||  |||.|.  . ||||. .|  ||  .|..|
ETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIM

KRSWQ
.. |.
MMCWK
Kinase AqueK446.AA Pkinase 21-203 21 1.5e-22 80.84 Pfam 56-272 (293) Show / Hide 
Range on Protein: 21-203
Range on HMM: 56-272/293
Sequence Identity: 21% (48 aa)

KFQHDNLVKLYGVCIRQGPVYIITELMANG----SLLQYLR--NNQHLVDNTDIILDMAIQICAAMKFFEQSGFIHRNLAARNCLVGDRNIV----KVAG
...|.| |.||... . . .|...|.. .|    .|  |..  ..  .    . . ... ||. ....  . |.||| |   |.|. ... .    |.. 
RLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICD

FGSAR---YVPDNEYTASEGTEFAVKWIAPEVIT-HARYSSKSDVWSYGILLWELWTGGKTPYPAF------TNPQVLDEVLR-GYRLEKPKLCP-----
||.|.   | ..  .|   || .   ..|||||  .  |..|.|.||.|..|.|. . |..|.|        .  |.......  .. . |..|.     
FGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF

--------------SKIYDLMKR
              .   |..|.
FRHWHFHWTFHNWSEECKDFIKW
Kinase AqueK446.AA S_TKc 1-208 19 1e-14 39.0 SMART 18-231 (231) Show / Hide 
Range on Protein: 1-208
Range on HMM: 18-231/231
Sequence Identity: 19% (49 aa)

MIKED--------AMNEDDFIEEAILMIKFQHDNLVKLYGVCIRQGPVYIITELMAN--GSLLQYLRNNQH----LVDNTDIILDMAIQICAAMKFFEQS
 .. .         .. .... |  .. | .|.|.||||.|.   . .|...|.. .  |.|..|......     . .   .  .. ||| |...  . 
CRHKKTGRIVAIKIIK-EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH

GFIHRNLAARNCLVGDRNIVKVAGFGSARYVPDNEYTASEGTEFAV--KWIAPEVITHARYSS-KSDVWSYGILLWELWTGGKTPYPAFTNPQVLDEVLR
|.||| |   | |. .   .|.. ||.|| .          | | .   ..||||.    |.  |.|.|| |..|.|. . |..|.|  .  .... .. 
GIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-

GYRLEKPKLCPSKIYDLMKRSWQ------------T----------V
          ..   |.... .|            .          .
----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF