Gene AqueK471 (A.queenslandica)

AqueK471

Species: A.queenslandica
Alias: AqueK471
External Links:
Annotation:

Classification

Group: TK
Family: TMR

Sequence

Name Sequence Type Origin Length Description Download
AqueK471.AA Protein None 1031 None Fasta, JSON
AqueK471.kin_dom Protein Kinase Domain None 294 None Fasta, JSON

Protein domain

Protein domains of AqueK471.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase_Tyr AqueK471.AA Pkinase_Tyr 168-461 31 6.8e-86 291.52 Pfam 1-270 (270) Show / Hide 
Range on Protein: 168-461
Range on HMM: 1-270/270
Sequence Identity: 31% (96 aa)

VCMLAELGESSFGKTYRGECAKLLTTDITTPVLIKTLREGAEAYL--CESFEKEMKLTSGW-NHPNILTLLAVST-IEFP--RYMIYEWLEFGNLKDFLL
. .. .||| .||. |.|..   .  . ..|| .|.|.|||       |.| .|.|. .   .||||. |..| |  . |   |.. |  . |.|.|.| 
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

STASVWLSMDIESVYNASQADLDSTIGSGGSTQHSMGTEEMIAIVVQVAEGMEYLEEQGFLHKDLTARNCQIGEGLIVKISNFGFSHDIQCMQYCEWTTS
.                             . ...  ..... . .|.|.||||||.... | || |||| ..|...|||. || . ||.   |   ...
KHR---------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKR

NGQKSFGPLRWTAPETLKDSTYSVQSDVWAYGIFLWEAFSFGQDP-YPELATDEEVKEYI-LSLNVMLQPDNCPKSVYKIMRSCWNPIPSKRPSFSWLKQ
 | |   | .|.||| .... ....||||..|. .|| |..|. | ||.. ..|||.|||  . . | .|.|||. .|..|..||.. |..||.|| . .
GGGK--LPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHE

AL
 |
QL
TyrKc AqueK471.AA TyrKc 168-461 29 1.1e-85 291.86 SMART 1-280 (280) Show / Hide 
Range on Protein: 168-461
Range on HMM: 1-280/280
Sequence Identity: 29% (96 aa)

VCMLAELGESSFGKTYRGECAKLLTTDITTPVLIKTLREGAEAYLCESFEKEMKLTSGW--NHPNILTLLAVSTIE-------FPRYMIYEWLEFGNLKD
. .. .|||  ||. |.|.          ..| .|.|.|.|     | | .|... .    .||||. |..| | .        | ... |  . |.|||
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLLSTASVWLSMDIESVYNASQADLDSTIGSGGSTQHSMGTEEMIAIVVQVAEGMEYLEEQGFLHKDLTARNCQIGEGLIVKISNFGFSHDIQCM-----
.| ..                                   ..... . .|.|.|||||..... | || |||| .||...|||| || | ||        
YLRKHRPK------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGE

--QYCEWTTSNGQKSFGPLRWTAPETLKDSTYSVQSDVWAYGIFLWEAFSFGQDPYPEL----ATDEEVKEYILSLNVMLQPDN--------CPKSVYKI
  .|   ... | |.  |.||.|||........ .||||..|. .|| |..|| |||.      ...|| ||. . . | ||.|        ||. .|.|
SKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQI

MRSCWNPIPSKRPSFSWLKQAL
|..||.  |..||.|| ... .
MKQCWHEDPEDRPTFSEIHECF
Kinase AqueK471.AA TK 168-461 21 9.8e-82 273.65 In-house 1-486 (486) Show / Hide 
Range on Protein: 168-461
Range on HMM: 1-486/486
Sequence Identity: 21% (103 aa)

VCMLAELGESSFG---KTYRGECAKLL--------------------TTDITTPVLIKTLREGAEAYLCESFE----------------KEMKLTSG--W
. .. .|||  ||   . |.||   .                     ... .||| .|.|.||...   | |.                 |||. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NHPNILTLLAVSTIE------------FPRYMIYEWLEFGN----LKDFLLSTAS-----------------------------VWLSMDIESVYNASQA
.||||. |..|.| .             | ... |. . |.    |.|.| .                                .  | . .|.  ... 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY-SHESNSPC-PEEQ

DLDS--------TIGSGGSTQ----------HSMGTEEMIAIVVQVAEGMEYLEEQ------GFLHKDLTARNCQIGEGLI-----------VKISNFG-
| |.        ...     |          | . ..... . .|.|.|||||...      .| | || |||| .||...           .||. || 
DYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL

-------FSHDIQCMQYCEWTTSNGQ--------------------KSFGPLRWTAPETLK---------DSTYSVQSDVWAYGIFLWEAFSFGQDPYPE
        . ||.  ..   ..| |                     .   |.||.|||.|.         . ... .||||..|...|| |..|| ||..
SRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYG

LATD---------EEVKEYILSL--------------NVMLQPDNCP--------------KSVYKIMRSCWNPIPSKRPSFSWLKQAL
  ..         .|| ||. .               . | ||..||              . .| .|..||.. |..||.|| |...|
GMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK471.AA Musk 168-461 31 2.1e-66 218.39 In-house 1-282 (282) Show / Hide 
Range on Protein: 168-461
Range on HMM: 1-282/282
Sequence Identity: 31% (93 aa)

VCMLAELGESSFGKTYRGECAKLLTTDITTPVLIKTLREGAEAYLCESFEKEMKLTSGWNHPNILTLLAVSTIEFPRYMIYEWLEFGNLKDFLLSTASVW
.    ..||  ||  .     .|.  .  | | .| |.. |.. . . |. |  .     ||||  || |  .  |  . .|..  | | .||       
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFL-------

LSMDIESVYNASQADLD--STIGSGGSTQHSMGTEEMIAIVVQVAEGMEYLEEQGFLHKDLTARNCQIGEGLIVKISNFGFSHDIQCMQYCEWTTSNGQK
 |.    .  ... |.   . . | |  |  . . .   .  |.| || || |  | | ||  ||| |.|   |||. || |. |    |        . 
HSCSPHRTCSRTHQDRGMRAQVSSPGPPQ--LKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYK----GHEN

SFGPLRWTAPETLKDSTYSVQSDVWAYGIFLWEAFSFGQDPYPELATDEEVKEYILSLNVMLQPDNCPKSVYKIMRSCWNPIPSKRPSFSWLKQAL
 . | ||..|| . .  ... |||||||. ||| ||..  ||  ..  |||  ||   |..  |.||| .||..|| ||.  |. ||.|  ... .
DHIPIRWMPPESIWYNQFTYESDVWAYGVCLWEIFSYALQPYYGMT-HEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase AqueK471.AA TK-Unique 168-461 26 4.5e-65 222.5 In-house 1-294 (294) Show / Hide 
Range on Protein: 168-461
Range on HMM: 1-294/294
Sequence Identity: 26% (87 aa)

VCMLAELGESSFGKTYRGECAKLL-TTDITTPVLIKTLREGAEAYLCESFEKEMKLTSGWN-HPNILTLLAVSTIEF-PRYMIYEWLEFGNLKDFLLSTA
. .. ..|| .||  .|||  ..  . | .. |..|.|...|       | || .. .    ||||...| ..|  . | ..|.|... ||| ..| ...
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

---------------------SVWLS-MDIESVYNASQADLDSTIGSGGSTQHSMGTEEMIAIVVQVAEGMEYLEE--QGFLHKDLTARNCQIGEGLIVK
                     .. ..  . ...|.                           . .|.| |||||..  ... |.|| |||. ..|....|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYH---------------------------FAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCK

ISNFGFSHDIQCMQYCEWTTSNGQKSFGPLRWTAPETLK--DSTY-SVQSDVWAYGIFLWEAFSFGQDPYPELATDEEVKEYILSLNVMLQPDNC-PKSV
|..||.. |..     . . ......  |.|| ||| ||  . .| . .||||..|...|| |..|. |||..  .. . | |     |.||..| .. .
ICDFGMARDVYT---NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMPQPEHCCSHEM

YKIMRSCWNPIPSKRPSFSWLKQAL
|..|.|||.  |..||||. .|. |
YNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK471.AA UTK 228-461 26 3.4e-60 204.62 In-house 69-296 (296) Show / Hide 
Range on Protein: 228-461
Range on HMM: 69-296/296
Sequence Identity: 26% (68 aa)

HPNILTLLAVSTIEFPRYMIYEWLEFGNLKDFLL----STASVWLSMDIESVYNASQADLDSTIGSGGSTQHSMGTEEMIAIVVQVAEGMEYLEEQGFLH
|||.| |..| | | | ....|  | |.| ..|     ..                              .|.   ....  ....|.||.||...|| |
HPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPP---------------------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVH

KDLTARNCQIGEG-------LIVKISNFG---FSHDIQ------CMQYCEWTTSNGQKSFGPLRWTAPETLKDS-TYSVQSDVWAYGIFLWEAFSFGQDP
 || |||| ...        ...||..||   .|....       ... .  ....|..  |.||.||| | .  ... .||||..|...|| ...|. |
RDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRW-PIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLP

YPELATDEEVKEYILSL-NVMLQPDNCPKSVYKIMRSCWNPIPSKRPSFSWLKQAL
||...... ...        | .|. || .||..|..||.. |..||.| .| |..
YPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase AqueK471.AA Trk 168-461 29 5.4e-60 202.04 In-house 1-275 (275) Show / Hide 
Range on Protein: 168-461
Range on HMM: 1-275/275
Sequence Identity: 29% (88 aa)

VCMLAELGESSFGKTYRGECAKLLTTDITTPVLIKTLREGAEAYLCESFEKEMKLTSGWNHPNILTLLAVSTIEFPRYMIYEWLEFGNLKDFLLSTASVW
. .  ||||  ||| . .|| .|. ..  . | .|||.. .|    . |..| .|     |..|  .  | | ..|  |..|... | |. .| . . . 
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKDASE-NARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPD-

LSMDIESVYNASQADLDSTIGSGGSTQHSMGTEEMIAIVVQVAEGMEYLEEQGFLHKDLTARNCQIGEGLIVKISNFGFSHDIQC-MQYCEWTTSNGQKS
   ..   |.. || ..            .. ..| .|. |.| || |. .| | | |. .||| .|..|||||. || | |.     |       | . 
--AMCYAQYQPRQAPGP------------LTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRV----GHHT

FGPLRWTAPETLKDSTYSVQSDVWAYGIFLWEAFSFGQDPYPELATDEEVKEYILSLNV-MLQPDNCPKSVYKIMRSCWNPIPSKRPSFSWLKQAL
  | ||  ||     .... |||| .|. .|| |..|. |.  |    || |.|.   . ...|  ||. ||.||. ||   | .| .   . ...
MLPIRWMPPESIMYRKFTYESDVWSFGVVMWECFTYGKQPWYQLS-NHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase AqueK471.AA Src 196-461 31 1.7e-54 183.56 In-house 23-255 (255) Show / Hide 
Range on Protein: 196-461
Range on HMM: 23-255/255
Sequence Identity: 31% (85 aa)

TTPVLIKTLREGAEAYLCESFEKEMKLTSGWNHPNILTLLAVSTIEFPRYMIYEWLEFGNLKDFLLSTASVWLSMDIESVYNASQADLDSTIGSGGSTQH
.|.| .|||..|      | | .| ..     |.... |.|| . | | | . |  . |.| |.|                               .. .
NTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----------------------------DGEGR

SMGTEEMIAIVVQVAEGMEYLEEQGFLHKDLTARNCQIGEGLIVKISNFGFSHDIQ--CMQYCEWTTSNGQKSFGPLRWTAPETLKDSTYSVQSDVWAYG
..  .. | .  ||||||.|||.. . | || |||  .||....|.  ||    |.     ||  .   | | | | .||||| .   .... |||| .|
HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH---GAK-F-PIKWTAPEAINYGRFTIKSDVWSFG

IFLWEAFSFGQDPYPELATDEEVKEYILSLNVMLQPDNCPKSVYK-IMRSCWNPIPSKRPSFSWLKQAL
| |.| ...|. |||   | .|| . .     | .|.|||...|. ||. ||.  | .|| |  | . |
ILLTEIVTYGRVPYPGM-TNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK471.AA Ror 168-455 34 4e-53 182.8 In-house 1-269 (308) Show / Hide 
Range on Protein: 168-455
Range on HMM: 1-269/308
Sequence Identity: 34% (99 aa)

VCMLAELGESSFGKTYRGECAKLLTTDITTPVLIKTLREGAEAYLCESFEKEMKLTSGWNHPNILTLLAVSTIEFPRYMIYEWLEFGNLKDFLLSTASVW
|  . ||||  ||| |.|.   ..  . .. | |||... |.  . . |..| .| .  .|||| .|| | | . |  |. |..  | |  ||       
VRFMEELGECQFGKVYKGHLMGPNFMYHCMAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEYMNHGDLHEFL-------

LSMDIESVYNASQADLDSTIGSGGSTQHSMGTEEMIAIVVQVAEGMEYLEEQGFLHKDLTARNCQIGEGLIVKISNFGFSHDIQCMQYCEWTTSNGQKSF
       . .   .| .   .  . .. |    . . |..|.|.|||||    | |.|| |||| .||.. |||| || . ||    |         || 
-------IMRSPHSDHGCSSDDDRMVKSSLDHPDFLHIAIQIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQ----HKSW

GPLRWTAPETLKDSTYSVQSDVWAYGIFLWEAFSFGQDPYPELATDEEVKEYILSLNVMLQPDNCPKSVYKIMRSCWNPIPSKRPSFS
 | || .||       |. ||.| .|. ||| .|.|  || . .   || | | .  .   |.|||  .|  |  ||. |||.|| |.
MPIRWMSPEAIMYGKFSEDSDIWSFGVVLWEIWSYGMQPY-YGYSNQEVIEMIRNRHLLPCPHNCPTWIYSLMIECWHEIPSRRPRFK
Kinase AqueK471.AA FGFR 308-461 42 1.7e-47 159.91 In-house 144-293 (293) Show / Hide 
Range on Protein: 308-461
Range on HMM: 144-293/293
Sequence Identity: 42% (65 aa)

QVAEGMEYLEEQGFLHKDLTARNCQIGEGLIVKISNFGFSHDIQCMQYCEWTTSNGQKSFGPLRWTAPETLKDSTYSVQSDVWAYGIFLWEAFSFGQDPY
||| |||||. .   | || |||  .... . ||. || . ||.|. |   || ||     |  | ||| | |  | .||||| ||. ||| . .|. ||
QVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTT-NGRL---PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPY

PELATDEEVKEYILSLNVMLQPDNCPKSVYKIMRSCWNPIPSKRPSFSWLKQAL
|  .  ||  .|  .   |  | ||.. .| .|..||   |. ||.|  |  .|
PHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase AqueK471.AA CTKA 308-461 38 5.1e-47 155.95 In-house 139-290 (290) Show / Hide 
Range on Protein: 308-461
Range on HMM: 139-290/290
Sequence Identity: 38% (61 aa)

QVAEGMEYLEEQGFLHKDLTARNCQIGEGLIVKISNFGFSHDIQCM-QYCEWTTSNGQKSFGPLRWTAPETLKDSTYSVQSDVWAYGIFLWEAFSFGQDP
|.| ||.|| | || | || .||| .| .  .||..|| .   .   ||  .. |   ..  | || |||.|.  ..| .|||||.|. ||| .|.|  |
QIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQY--YYVS--SQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKP

YPELATDEEVKEYILSL--NVMLQPDNCPKSVYKIMRSCWNPIPSKRPSFSWLKQAL
.  . .| ||.. ..|        | |||  .|  |  || . | .||.|  |.  |
WRHM-SDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase AqueK471.AA Abl 302-461 40 1.9e-45 149.26 In-house 99-252 (252) Show / Hide 
Range on Protein: 302-461
Range on HMM: 99-252/252
Sequence Identity: 40% (64 aa)

MIAIVVQVAEGMEYLEEQGFLHKDLTARNCQIGEGLIVKISNFGFSHDIQCMQYCEWTTSNGQKSFGPLRWTAPETLKDSTYSVQSDVWAYGIFLWEAFS
.. .  |.| ||.|||.. |.|.|| |||| .||  |||.  || .     |.   .|   | | | |..||||| |   ..|..|||||.|. |||   
LLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLA---RMMKDDTYTAHAGAK-F-PIKWTAPESLAYNKFSSKSDVWAFGVLLWEIAT

FGQDPYPELATDEEVKEYILSLNVMLQPDNCPKSVYKIMRSCWNPIPSKRPSFSWLKQAL
.|  ||| .   ..| . .     | .|. ||..||..|| ||.  .. ||||  . .|.
YGMSPYPGIDL-SHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase AqueK471.AA S_TKc 168-466 19 7.8e-14 25.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 168-466
Range on HMM: 1-231/231
Sequence Identity: 19% (60 aa)

VCMLAELGESSFGKTYRGECAKLLTTDITTPVLIKTLREGAEAYLCESFEKEMKLTSGWNHPNILTLLAVSTIEFPRYMIYEWLEF--GNLKDFLLSTAS
  .| ..|. .||| |..   |         | || ..        |....|... .  .|||| .|. |       ||. | ..   |.|.|.. .  .
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

VWLSMDIESVYNASQADLDSTIGSGGSTQHSMGTEEMIAIVVQVAEGMEYLEEQGFLHKDLTARNCQIGEGLIVKISNFGFSHDIQCMQYCEWTTSNGQK
  |                         .. .   .   .. |.....||. ..|..| ||   |  . |   .||. ||..  .               
HGL-------------------------RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TT

SFGPLRWTAPETLKDSTYSV-QSDVWAYGIFLWEAFSFGQDPYPELATDEEVKEYILSLNVMLQPDNCPKSVYKIMRSCWNPIPSKRPSFSWLKQ----A
  | . . ||| |    |.   .|.|. |. |.| .. |. |.|   ..... . |.           ....  ..| |..  |.|||.   . |    .
FCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

LKASVK
 .    
KCHPWF
Kinase AqueK471.AA Pkinase 227-461 18 2e-12 45.04 Pfam 58-293 (293) Show / Hide 
Range on Protein: 227-461
Range on HMM: 58-293/293
Sequence Identity: 18% (50 aa)

NHPNILTLLAVSTIEFPRYMIYEWLEFG----NLKDFLLSTASVWLSMDIESVYNASQADLDSTIGSGGSTQHSM--GTEEMIAIVVQVAEGMEYLEEQG
|||||..|. . . .   ||. |..| |     |.|..                               . . ..    .| . .. |...|.||. ..|
NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-----------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMG

FLHKDLTARNCQIGEGLIV----KISNFGFSHDIQCMQYCEWTTSNGQKSFGPLRWTAPETLK-DSTYSVQSDVWAYGIFLWEAFSFGQDPYPEL-----
..| ||   |. | .   .    ||. ||..  ..     .   |  .   | ... ||| .. .. |.  .|.|..|. |.| .. |. |.|.      
IIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN

ATDEEVKEYILSLNVMLQPD--------------------NCPKSVYKIMRSCWNPIPSKRPSFSWLKQA--L
... .. . |..  .. . .                    | ...  .....|... |.|||..  ..|   .
HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK471.AA Abl 168-280 31 6.7e-11 32.09 In-house 1-105 (252) Show / Hide 
Range on Protein: 168-280
Range on HMM: 1-105/252
Sequence Identity: 31% (36 aa)

VCMLAELGESSFGKTYRGECAKLLTTDITTPVLIKTLREGAEAYLCESFEKEMKLTSGWNHPNILTLLAVSTIEFPRYMIYEWLEFGNLKDFLLSTASVW
. |   ||   .|  | |   .   |     | .|||.|  ..   . | ||  .     |||.  || | | | | |.| |.. .||| |.| ..    
IMMKHKLGGGQYGEVYEGVWKRHDCT-----VAVKTLKE--DTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREE

LSMDIESVYNASQ
|.  .  .| |.|
LPA-VVLLYMATQ
Kinase AqueK471.AA CTKA 168-257 27 6.9e-07 19.03 In-house 1-97 (290) Show / Hide 
Range on Protein: 168-257
Range on HMM: 1-97/290
Sequence Identity: 27% (28 aa)

VCMLAELGESSFGKTYRGECAKLLTTDIT---------TPVLIKTLREGAEAYLCESFEKEMKLTS--GWNHPNILTLLAVSTIEFPRYMIYEWLEFGNL
 |   ..||  .|  .|     .|  |           . | .| |.. |     . |  |  . |     |||.| || | | . | .|| | . .| |
HCIMFKIGEGHYGQVFRA----WLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDL

K
.
H
Kinase AqueK471.AA FGFR 228-260 51 0.000255 10.57 In-house 64-96 (293) Show / Hide 
Range on Protein: 228-260
Range on HMM: 64-96/293
Sequence Identity: 51% (17 aa)

HPNILTLLAVSTIEFPRYMIYEWLEFGNLKDFL
|.||. || . | | | | | |  . |||.|||
HKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFL
Ammonium_transp AqueK471.AA Ammonium_transp 531-911 23 3e-58 193.7 Pfam 37-409 (434) Show / Hide 
Range on Protein: 531-911
Range on HMM: 37-409/434
Sequence Identity: 23% (97 aa)

YPFFQDVH----VMIFIGFGFLMTFLRRYGYGSVGFN------MLLAAFVIQWSTVTLGL--FSFIDTEHYRITIGLENLVLSDFAAAAVLITFGSMLGR
.. |.|.|    .|....||..|.|...|. ... .|      ....|. .||.| . .|  . |  .   ..||.. .  . ..... ..|.|. ..| 
MKNFMDFHIGICCMAWWFFGYSMMFGDDYWWNGFIGNGDWFGWLGFFAAGWQWGTIPDYLVFWMFQMMFAAKTTITIISGAVAERMKFSAYIIFSALWGT

ASPFQLFGIAIF--EVIFYSANNAINDHVFRAADVGGSMIIHSFGAYFGLACSVILQRKK----AIDHPRNSSAYHSDMFAMIGTLFLWLFWPSFN--GA
 .....   . .  .  |..    .|   . | | .||| .|.||.|.|||. ..| ...      ||  ... .|.. |||.||..|| .|..||   |
FVYPPVAHWVWGETGGWFAKMGFWCNN--LHAHDFAGSMVVHIFGGYAGLAAAWVLGPRIGRFPD-DHKPYAIRPHNMPFAMLGTFILWFGWFGFNAGSA

LASGNAQYR----AIINTYFSMTGSVIATFIFSMALDGKRKLDMVHVQNATLAGGVAIGSVADMLIGPWAGLFIGFLSGIISVVGYKYLTPTMDKWFYVQ
|. ....      | .||. ....  ... ..|  ..||  ..|.|..|..|||.||||. | . . ||. . ||. .|.... |||..||   ... . 
LTANHRCWYHTMRAMVNTNMAAAAGMLTWMFISWLKHGK--WNMLHTCNGILAGLVAIGTPACGVVHPWHAMIIGVIAGVVCYWGYKWITPWLKEKLGID

DTCGVHNLHGLPGLLSAVASAIAAGVASNTAGTNLVNYGSSLYLVFPARAPSSNLTVEEILLGIETGEGRSAGEQAGYQLALLASTLFIAGIGGIITGLI
|.|.|...||..|.. ..|..| |    |                          ....|  |. .|..   ..| ..|..  . ... | | ..| ..|
DPCDVWPVHGMCGIWGMIATGIFAAPYVNN------------------------NQPSHIYGGWFYGNW---WQQLWWQIICICVIIAWAFIVMFIIFWI

VGCIP
.....
LDKTM