Gene AqueK475 (A.queenslandica)

AqueK475

Species: A.queenslandica
Alias: AqueK475
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK

Sequence

Name Sequence Type Origin Length Description Download
AqueK475.AA Protein None 626 None Fasta, JSON
AqueK475.kin_dom Protein Kinase Domain None 211 None Fasta, JSON

Protein domain

Protein domains of AqueK475.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK475.AA TKL 371-583 22 3.5e-46 159.75 In-house 1-289 (364) Show / Hide 
Range on Protein: 371-583
Range on HMM: 1-289/364
Sequence Identity: 22% (68 aa)

LGRGGYGCVYLANDLRSV-------GTTAAIKILSKEGSQALTK-----------------GNDEAYQIQNELQALMK---YRHPNILEVMGYCFSPQL-
.|.||.|.|| ..            |.. |.|..... ..  ||                  ..     . | . .|     |||||.  ||||..|.  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------KALVYRYMVNGSLYSWIHLVETNAGYMQQWKLTWDRRISILKDVFRGVAYLHAGD------KPIIHQDIKSSNVLLDKDFN-------
             ..|. |. .|||.. .|               |..|... .|. ||..|||. .      .|||| |.||.|.|.|....       
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMY

-------AVIGDFGFALAIPRSESGRTLFTA-------------PLIAR-TEGYYPPELLS-----------------GKISPLCDVYSCGVLVLEVYTA
       . |.|||..  . .|..     |.                 . | .. .||.|                  .. |. ||||| |..  |..| 
NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR

LKPY
 .||
CRPY
Pkinase AqueK475.AA Pkinase 365-578 22 2.9e-28 101.03 Pfam 1-207 (293) Show / Hide 
Range on Protein: 365-578
Range on HMM: 1-207/293
Sequence Identity: 22% (50 aa)

LDKQNELGRGGYGCVYLANDLRSVGTTAAIKILSKEGSQALTKGNDEAYQIQNELQALMKYRHPNILEVMGYCFSPQLKALVYRYMVNG----SLYSWIH
. .   .|.|..||||.. . .. | . |.||..|..     . ..      .|.| . . .||||..  ... ...   .|  |. .|    .|...|.
YHIGRKIGSGSFGCVYKCHH-KGTGKIVAVKIIKKRHEKSWKDQTHRRL---SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

LVETNAGYMQQWKL--TWDRRISILKDVFRGVAYLHAGDKPIIHQDIKSSNVLLDKDFNA----VIGDFGFALAIPRSESGRTLFTAPLIARTEGYYPPE
        ... ..  ...  ..... ..||..|.|.  . ||| |.|..|.|.|.. .      |.|||.|  .   .   . .| .    | .| .||
T-------WRHGCFYFSEWECKFYMYQILRGLEYCHS--MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCG--TPWYMAPE

LLS--GKISPLCDVYSCGVLVLEVYT
..    ...| .|..|||... |...
VIRGGQYYGPKVDMWSCGCILYEMLC
Kinase AqueK475.AA IRAK 474-578 36 2.8e-26 90.22 In-house 106-219 (317) Show / Hide 
Range on Protein: 474-578
Range on HMM: 106-219/317
Sequence Identity: 36% (42 aa)

LTWDRRISILKDVFRGVAYLHAGD-K-PIIHQDIKSSNVLLDKDFNAVIGDFGFALAI-PRSESGRTLF---TAPLIARTEGYYPPELLS---GKISPLC
|.| .|.||.    .|. .||  . . ||||.||||.|.|||..|.. |.||| .    | |.. ..      . ..  |  | ||| .    |....  
LSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKT

DVYSCGVLVLEVYT
||||.|. .||| |
DVYSFGIVLLEVLT
Kinase AqueK475.AA RIPK 371-583 29 4.3e-25 82.44 In-house 1-228 (290) Show / Hide 
Range on Protein: 371-583
Range on HMM: 1-228/290
Sequence Identity: 29% (70 aa)

LGRGGYGCVYLANDLRSVGTTAAIKI-LSKEGSQALTKGNDEAYQIQNELQALMKYRHPNILEVMGYCFSP------QLKALVYRYMVNGSLYSWIHLVE
.|.|| | |..|   |. |. .|.|.  .|.  ... .  .. ||.. | ... | |. .|. . | |  .      .| ..| .|| ||||    |.  
VGGGGFGEVFKARH-RHWGDWVAKKCKPCKHCHTHM-DDQERMYQKE-EAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSL---WHFLH

TNAGYMQQWKLTWDRRISILKDVFRGVAYLHAGDKPIIHQDIKSSNVLLDKDFNAVIGDFGFALAIPRSESGR-------TLFTAPLIA-RTEGYYPPEL
|   | |.  . |. |  ... . .|. |||  . |||| | | .|.|.| .|.. | ||| |     |.|.         . .. .    |  | |||.
TKWPY-QHHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEH

LS---GKI----SPLCDVYSCGVLVLEVYTALKPY
.     |     .|  |||| .... || |  .||
FRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPY
Kinase AqueK475.AA TKL-Unique 417-578 30 3.3e-24 82.37 In-house 44-223 (290) Show / Hide 
Range on Protein: 417-578
Range on HMM: 44-223/290
Sequence Identity: 30% (57 aa)

NELQALMKYR-HPNILEVMGYCF----SPQLKALVYRYMVNGSLYSWIH-LVETNAGYMQQWKLTWDRRISILKDVFRGVAYLHAGDKPIIHQDIKSSNV
||.  . | . ||||.  ||||.    .|    .|  |.  ||||. .|     |   ..  ||.. .|... .|. .|  |||  ..|||| |.||||.
NEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNF

LLDKD-----FNAVIGDFGFALAIPRSESGRTLFTAPLI--------ARTEGYYPPELLSG---KISPLCDVYSCGVLVLEVYT
|.| .     .|. | |||..    .. | ..  |.  .          .  . .||.|..   ..|  .|||| |. . | .|
LVDNNSNIAEWNIKICDFGLS----KFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIAT
Kinase AqueK475.AA RAF 365-526 34 1.8e-23 72.68 In-house 1-150 (282) Show / Hide 
Range on Protein: 365-526
Range on HMM: 1-150/282
Sequence Identity: 34% (57 aa)

LDKQNELGRGGYGCVYLANDLRSVGTTAAIKILSKEGSQALTKGNDEA-YQIQNELQALMKYRHPNILEVMGYCFSPQ--LKALVYRYMVNGSLYSWIHL
.. ..  | | .| || ..   .|    |.|.|     ...|  .  |    .||.... | || |||  |||   ||    | |  .    |||  || 
VMVMTRIGSGSFGTVYRGHWHGDV----AVKMLN---VNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHV

VETNAGYMQQWKLTWDRRISILKDVFRGVAYLHAGDKPIIHQDIKSSNVLLDKDFNAVIGDFGFA
 ||   . ..|       | |.. |  |  ||||  | ||| |.|| |..|. |   .||||| .
QETREKFDMHW------LIDISRQVCQGMDYLHA--KNIIHRDLKSNNIFLHEDMTVKIGDFGLM
Kinase AqueK475.AA CAMK 370-572 18 3.2e-23 71.07 In-house 1-323 (425) Show / Hide 
Range on Protein: 370-572
Range on HMM: 1-323/425
Sequence Identity: 18% (62 aa)

ELGRGGYGCVYLANDLRSVG-----------TTAAIKILSKEGSQALTKGND----------------------EAYQIQNELQALMK-------YRHPN
.||||..| |.|. . .. |           .  ||||..|.  .  .. .|                         ....|.. ..|        .|||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQN-QDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

ILEVMGYCFS-------------------PQLKALVY---RYMVNG----SLYSWIHLVETNAGYMQQWKLTWD-------RRI------SILKDVFRGV
|.    .  .                   ..   .|     |. .|     |...|   . .   .       |       .|.       . . .  .|
IIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEF-------DQFDIVERGRFTEREARRYFRQICSAV

AYLHAGDKPIIHQDIKSSNVLLDKD-----------------FNAVIGDFGFALAIPRSES---------------------GRTLFTAPLIARTEGYYP
.|.|  .  |.| |.|  |.|||..                 .|  | |||||  ....|.                     |  . |      | .| .
HYCHSHN--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKT---FCGTPEYMA

-PELLSGK---------------ISPLCDVYSCGVL
 ||.|.||               ..| ||. ||||.
APEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVI
Kinase AqueK475.AA Ciliate-E2 365-626 17 6.5e-21 68.52 In-house 1-308 (365) Show / Hide 
Range on Protein: 365-626
Range on HMM: 1-308/365
Sequence Identity: 17% (61 aa)

LDKQNELGRGGYGCVYLANDLRSVGTTA----------------------AIKILSKEGSQALTKGNDEAYQIQ------NELQALMKYRHPNILEVMGY
 .... .|.|..|.||.... .     |                      |.||..| . ... . ...  .|.      ||.. | .  ||||..   .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CF--SPQLKALVYRYMVNGSLYSWIHLVETNAGYM---QQWKLTWDRRISILKDVFR---------------GVAYLHAGDKPIIHQDIKSSNVLLDKDF
    . .   ||  |   |.|...|    .. .     .  ..|.  .. | | ...               .. |||   . ||| ||| .|.|.    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF----

NAVIGDFGFA-LAIPRSE-----SGRTLFTAPL---------------------IARTEGYYPPELLSGK----------ISPLCDVYSCGVLVLEVYTA
   | |||..  . . ..     ... ...                        |. | || .|| |.||           .  ||..|.||.  |  . 
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

LKPYCKSRADHELVNHTEDYRQDLKQFKSIADASAIDEISDEECDFF
  |.                               ...| . ..||.
KPPF-------------------------------QQQIKQCKIDFP
Kinase AqueK475.AA Dicty4 365-526 29 6.7e-21 66.6 In-house 1-161 (277) Show / Hide 
Range on Protein: 365-526
Range on HMM: 1-161/277
Sequence Identity: 29% (52 aa)

LDKQNELGRGGYGCVYLANDLRSVGTTAAIKIL--SKEG--SQALTKGNDEAYQIQNELQALMKYRHPNILEVMGYCF----SPQLKALVYRYMVNGSLY
.......|.|..| ||..   .  |.  |.|.|   ...  .  |.          .|   . | |||||.  ||.|      |     |  ||  |.||
INIEQRIGKGSFGEVYKG---TWRGKEVAVKKLNNHNQNFDENMLN-------EFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLY

SWIHL--VETNAGYMQQWKLTWDRRIS---ILKDVFRGVAYLHAGDKPIIHQDIKSSNVLLDKDFNAVIGDFGFA
| .|    |      |  || | ....   . .|. ||...||. .  ||| |.||.| | ||.... ..|||..
SLLHDKPSE----QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLS
Kinase AqueK475.AA MLK 365-524 24 1.4e-19 64.64 In-house 1-178 (291) Show / Hide 
Range on Protein: 365-524
Range on HMM: 1-178/291
Sequence Identity: 24% (45 aa)

LDKQNELGRGGYGCVYLANDLRSVGTT-----AAIKILSKEGSQALTKGNDEAYQIQNELQALMKYRHPN----ILEVMGYCFSP-QLKALVYRYMVNGS
.. .  .| |..| |...   |  ...      |.|.   .   .  .   |. ... |   | . .|||    | ...| | .| .  ..|  |. .||
IQFHEWIGSGSFGKVWKG---RWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGS

LYSWIHLVET------NAGYMQQWKLTWDRRISILKDVFRGVAYLHAGD-KPIIHQDIKSSNVLLD------KDFNAVIGDFG
||. .|  ..      . .       . |  ... ... ||..|||. . ||||| |.||.|.|.|      .. ...| |||
LYNVLHGARSKWMDANHNQK-NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFG
Kinase AqueK475.AA IRAK 366-455 39 1.5e-19 66.04 In-house 2-90 (317) Show / Hide 
Range on Protein: 366-455
Range on HMM: 2-90/317
Sequence Identity: 39% (36 aa)

DKQNELGRGGYGCVYLANDLRSVGTT--AAIKILSKEGSQALTKGNDEAYQIQNELQALMKYRHPNILEVMGYCFSPQLKALVYRYMVNGSL
.| | .| ||.|||| .   . ..||   |.| | .. .   ..   .  |  |||... ..|||||... |||. .|   ||| || ||||
HKDNRIGEGGFGCVYRG---QWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSL
Kinase AqueK475.AA S_TKc 365-626 21 7e-19 69.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 365-626
Range on HMM: 1-231/231
Sequence Identity: 21% (58 aa)

LDKQNELGRGGYGCVYLANDLRSVGTTAAIKILSKEGSQALTKGNDEAYQIQNELQALMKYRHPNILEVMGYCFSPQLKALVYRYMVN--GSLYSWIHLV
 .. ...|.|..|.||.. . .  |   ||||..               .|..|.| |.| .||||    ... . .   .|  |. .  |.|.. |.  
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

ETNAGYMQQWKLTWDRRISILKDVFRGVAYLHAGDKPIIHQDIKSSNVLLDKDFNAVIGDFGFALAIPRSESGRTLFTAPLIARTEGYYPPELLSGKISP
 .. .. .   ..  .  .... ......|.|  .. ||| |.| .|.|||.  .  |.|||.|  .              .  |  | .||.|  . ..
GRHGLRFP---FPE-HARFYMYQICCALEYCH--SHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL--GYGK

-LCDVYSCGVLVLEVYTALKPYCKSRADHELVNHTEDYRQDLKQFKS---IADAS---AIDEISDEE-----CDFF
  ||..|||... | ..   |..    .... ..     ...|.| .     | .    . |.  .|       .|
CKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK475.AA STE 365-438 24 5.4e-14 45.9 In-house 1-100 (359) Show / Hide 
Range on Protein: 365-438
Range on HMM: 1-100/359
Sequence Identity: 24% (24 aa)

LDKQNELGRGGYGCVYLANDLRSV--------------GTTAAIKILSKEGSQA---------LTKGNDEAY-QIQNELQALMKYR--HPNILEVMGYCF
.... ..|.|..| ||.| .                  |.  |||....| ...         | . |.|   ||..|.. ..|..  |||| .  |..|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
Kinase AqueK475.AA TyrKc 365-625 18 1.9e-13 -5.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 365-625
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

LDKQNELGRGGYGCVYLANDLRSVGTTAAIKILSKEGSQALTKGNDEAYQIQNELQALMKY--RHPNILEVMGYCFSP-------QLKALVYRYMVNGSL
. .  .||.| .| ||..  ..   .. |.| | ..              . .|.. ..|.  .||||.   |.| ..       .   .|  || .|.|
ITLGKKLGEGAFGEVYKG-TWK---IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

YSWIHLVETNAGYMQQWKLTWDRRISILKDVFRGVAYLHAGDKPIIHQDIKSSNVLLDKDFNAVIGDFGFALAIPRS-------ESGRTLF--TAP--LI
 . ..  . .        |...  .|.  .. .| .|||    ..|| |.   |.|..... . |.||| . .|          .  |.     .   | 
KDYLRKHRPK--------LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

ARTEGYYPPELL-SGKISPLCDVYSCGVLVLEVYT-ALKPYCKS----RADHELVNHTEDYRQDLKQFK---------SIADASAIDEISDE--------
 |    ..|| .  || ..  ||.| ||.  |..|   .||         . |.... .. .   .            . .  . . .  .|        
IR---WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

---ECDF
     .|
SEIHECF
Kinase AqueK475.AA Pkinase_Tyr 365-524 22 2.6e-11 38.92 Pfam 1-156 (270) Show / Hide 
Range on Protein: 365-524
Range on HMM: 1-156/270
Sequence Identity: 22% (39 aa)

LDKQNELGRGGYGCVYLANDLR----SVGTTAAIKILSKEGSQALTKGNDEAY----QIQNELQALMKY-RHPNILEVMGYCFSPQLK---ALVYRYMVN
. .  .||.| .| ||..  ..    . ... |.|.| ||       | ..         .|.. .... .||||.  .| | . .      .|  || .
ITFGKKLGEGAFGEVYKG-TWKGDPDNTKIPVAVKML-KE-------GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPH

GSLYSWIHLVETNAGYMQQWKLTWDRRISILKDVFRGVAYLHAGDKPIIHQDIKSSNVLLDKDFNAVIGDFG
|.|..  .        ... .||  . ...  .. .| .||.  .|..|| |.   |.|..... . |.|||
GDLLDYLRKHR-----EDKQPLTMKDLLQMCWQIAKGMEYLE--SKNCIHRDLAARNCLVTENNVVKICDFG
Kinase AqueK475.AA STE 482-526 36 1.1e-08 26.91 In-house 156-194 (359) Show / Hide 
Range on Protein: 482-526
Range on HMM: 156-194/359
Sequence Identity: 36% (17 aa)

ILKDVFRG-VAYLHAGDKPIIHQDIKSSNVLLDKDFNAVIGDFGFA
|.... .|  .|||     ||| |||..|.||     . . |||..
ICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFGVC