Gene AqueK478 (A.queenslandica)

AqueK478

Species: A.queenslandica
Alias: AqueK478
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK

Sequence

Name Sequence Type Origin Length Description Download
AqueK478.AA Protein None 464 None Fasta, JSON
AqueK478.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of AqueK478.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Death AqueK478.AA Death 24-104 20 3.2e-05 19.81 Pfam 1-87 (87) Show / Hide 
Range on Protein: 24-104
Range on HMM: 1-87/87
Sequence Identity: 20% (18 aa)

RKIAAFL--DSSHTLNWKDLLSMMPEYGPLQMQQLSQ-QEAR-GKSPTISLLSHMASR---GRTVGQLYDFCKTLGMNRICELIVQGL
.|. ..|  |.    .|. | . .  . . ...|. . |. .  .|.|...|     |   . ||..|..  . .|.... |.| . |
QKLCRLLDPDHHPGKDWRRLARKL-GMSDNEIDQIEHDQNPHDLRSQTYQMLWKWEQRHGKNATVDHLIEALRKMGRRDCAEKIQSWL
Kinase AqueK478.AA TKL 219-464 22 1.9e-58 200.52 In-house 1-364 (364) Show / Hide 
Range on Protein: 219-464
Range on HMM: 1-364/364
Sequence Identity: 22% (82 aa)

LGQGGFGVVYQGQINLGEG-------NREVAVKVFVDDH-------------------------------------LLIFHRLKHPNLLPLLGYTSNQST
.|.||||.||.|. . |.|       ...||||.|  ..                                     ... .||.|||.....||  . . 
IGSGGFGEVYKGKWR-GWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

-------------LCLVYPYMALGS-LDKHLSRLELGSERRLQILRDIASGLHYLHT----GCGEI--LVHRDVKSANILLDQNWR--------------
             ||.|. |.  || |. ..       ..|... .|||.|..|||.    .|.    ..||| ||.|||.|.||.              
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

GVLTDFGIARTLSLET------TTVV-----------TQRIVGTRVYMSPEYCT-----------------GLVSPSADVYSLGVVILELVFGCLALHSP
  ..|||..|..| ..      ||.            | ...||  .|.||                    .  |...|||| |.|. |.. .|.  . .
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

KGSDTDII-----SFLDECDETAEFYLS---------CWSRSDGESLEELAEKCTNPYRDQRPTIAKVLEKL
. .. ..       |   ||.     .          |.  .  .|. .|...| ..  ..||.  ..|..|
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK478.AA IRAK 256-400 36 6.3e-38 132.03 In-house 59-221 (317) Show / Hide 
Range on Protein: 256-400
Range on HMM: 59-221/317
Sequence Identity: 36% (60 aa)

RLKHPNLLPLLGYTSNQSTLCLVYPYMALGSLDKHLSRLE-LGS------ERRLQILRDIASGLHYLHTGC-GEILVHRDVKSANILLDQNWRGVLTDFG
|. |||..||.|| .  . .|||||||. |||   |. .   ..       .|. |.  .| |...||.   .  . |.|.|||||||||.    ..|||
RCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFG

IAR----TLSLETTTV---VTQRIVGTRVYMSPEYCT---GLVSPSADVYSLGVVILELVFGC
 .|    . ..| .|.    |....||  || ||. .   |  ..  |||| |.|.||.. ||
LHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGC
Pkinase AqueK478.AA Pkinase 213-464 20 3.5e-34 121.93 Pfam 1-293 (293) Show / Hide 
Range on Protein: 213-464
Range on HMM: 1-293/293
Sequence Identity: 20% (63 aa)

SEGGHKLGQGGFGVVYQGQINLGEGNREVAVKVFVDDHLLI--------------FHRLKHPNLLPLLGYTSNQSTLCLVYPYMALG----SLDKHLS--
 . | |.|.|.||.||.. .. |.|  .||||..  .|                  .||.||| . |...  . . ...| .|.  |    .|  ..|  
YHIGRKIGSGSFGCVYKC-HHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

-RLEL--GSERRLQILRDIASGLHYLHTGCGEILVHRDVKSANILLDQNWRG----VLTDFGIARTLSLETTTVVTQRIVGTRVYMSPEYCT--GLVSPS
 .  .    .    ... |..|| |.|  .    .|||.|..|||.|.|        ..|||.|. .. .   . .. ..||. ||.|| .      .|.
RHGCFYFSEWECKFYMYQILRGLEYCHS-M--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

ADVYSLGVVILELVFGCLALHSPKGS----DTDIISFLDECDETAEFYLSCWSRSDG------------------ESLEELAEKCTNPYRDQRPTIAKVL
.|..|.|... |...|       .|.    . .   .. . .  ...  ...  ...                  |.. .. ..| ..   .|||.. .|
VDMWSCGCILYEMLCGR---PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

EK--L
.   .
QHPWF
S_TKc AqueK478.AA S_TKc 213-462 22 1.3e-32 115.55 SMART 1-220 (231) Show / Hide 
Range on Protein: 213-462
Range on HMM: 1-220/231
Sequence Identity: 22% (59 aa)

SEGGHKLGQGGFGVVYQGQINLGEGNREVAVKVFVDDHLL----IFHRLKHPNLLPLLGYTSNQSTLCLVYPYMAL--GSLDKHLSRLE-------LGSE
 | . |.|.|.||.||... .    .|.||.|.   .|..    | .. .|||.  |...  . . |..|  |.    |.| ... .         .   
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

RRLQILRDIASGLHYLHTGCGEILVHRDVKSANILLDQNWRGVLTDFGIARTLSLETTTVVTQRIVGTRVYMSPEYCTGLVSP-SADVYSLGVVILELVF
.   ... |...| |.|       .|||.| .|||||.  .  ..|||.|| |           ..||. ||.|| .    .. ..|..|.|... |.. 
HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLC

GCLALHSPKGSDTDIISFLDECDETAEFYLSCWSRSDGESLEELAEKCTNPYRDQRPTIAKVLE
|.   .     .  ..  .                   ... .. .|| .   ..|||. ..|.
GYPPFP----QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase AqueK478.AA STE 213-400 22 3.6e-32 110.92 In-house 1-265 (359) Show / Hide 
Range on Protein: 213-400
Range on HMM: 1-265/359
Sequence Identity: 22% (62 aa)

SEGGHKLGQGGFGVVYQGQIN-----LGEGNRE---------VAVKVFV---------------------DDH------LLIFHRLK--HPNLLPLLGY-
 ||  |.|.|.||.||..  .       . ...         .|.|.                       ...      . | ....  |||    .|. 
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

------TSNQSTLCLVYPYMALGSLDKHLS-RLELGS-------------ERRL-QILRDIASG-LHYLHTGCGEILVHRDVKSANILLDQNWRGVLTDF
      ..| ..|...  ||. ||||. .  . . |              |  .  |.|.|  | |.|||       .|||.|.|||||       |.||
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDF

GIARTLSLE--------------TTTVVTQRIVGTRVYMSPEYCTGLVSP-------SADVYSLGVVILELVFGC
|..  |. .              |.   .. .|||  .|.||  ..  ..       ..|..||| .|.|.. |.
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase AqueK478.AA TK 213-464 13 1.1e-30 99.43 In-house 1-486 (486) Show / Hide 
Range on Protein: 213-464
Range on HMM: 1-486/486
Sequence Identity: 13% (68 aa)

SEGGHKLGQGGFG---VVYQGQINLG-----------------------EGNREVAVKVFV---DDHLLIFHR--------------------------L
 . |.|||.| ||   .||.|. . .                       .|. .||||.     ...   |.                           .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHPNLLPLLGYTSNQST------------LCLVYPYMALGS----LDKHLSRLE----------------------------------------------
.|||.. |.|. . . .            ...|  ||..|.    |...| .                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LGSERRLQILRDIASGLHYLHTG-CGEI---LVHRDVKSANILLDQNWR-----------GVLTDFGIA
                               |  ...| . ..||.|. |||   |      .||||.   |.|...| .             ..||| .
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

--------RTLSLETTTVVTQ-RIV--------------------GTRV---YMSPEYCT----------GLVSPSADVYSLGVVILELVFGCLALHSPK
        | .  ..  .... . .                    |...   .|.||  .          |  ..  ||.|.||.. |..  . .   . 
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

GSD---------TDIISFLDEC---------DETAEFYLSCWSRSDG-------------ESLEELAEKCTNPYRDQRPTIAKVLEKL
 |.         .... .| .          .    . . .                   | ...|  .| ..  ..||| . ..|.|
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK478.AA TKL-Unique 216-401 26 2.5e-30 104.22 In-house 2-226 (290) Show / Hide 
Range on Protein: 216-401
Range on HMM: 2-226/290
Sequence Identity: 26% (61 aa)

GHKLGQGGFGVVYQGQINLGEGNREVAVKVFVD-------------DHLLIFHRLK-HPNLLPLLGYTS----NQSTLCLVYPYMALGSLDKHLS-----
. |.|.||.|.||.|  .      .||.|.|               ... .  .|. |||.. . ||.      .. .|.|  |. .|||...|.     
WNKIGEGGYGQVYKGKWR----GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN

------RLELGSERRLQILRDIASGLHYLHTGCGEILVHRDVKSANILLDQN-----WRGVLTDFGIARTLSLETTTVVT-------QRIVGTRVYMSPE
       ..|  ..|... .|||.|..|||.  .    ||| || |.|.|.|     |.  . |||.....| .... ..       |  .|.  .|.||
NNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE

YCTG---LVSPSADVYSLGVVILELVFGCL
  ..   . | ..|||| |.|  |.. ...
VLRMNFCQYSEKSDVYSFGIVLWEIATRKI
Kinase AqueK478.AA MLK 213-397 23 1.4e-23 78.71 In-house 1-230 (291) Show / Hide 
Range on Protein: 213-397
Range on HMM: 1-230/291
Sequence Identity: 23% (55 aa)

SEGGHKLGQGGFGVVYQGQINLGE-GNREVAVKV-F---------------VDDHLLIFHRLKHPN----LLPLLGY-TSNQSTLCLVYPYMALGSLDKH
 .  ...| |.||.|. |.    .   ..||||  .               ..    .. .|.|||      ...|  ..... .|.|  |.. |||   
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LSRLE---------------LGSERRLQILRDIASGLHYLHTGCGEILVHRDVKSANILLDQ------NWRGVLTDFGIARTLSLETTTVVTQRIVGTRV
|   .                  .  ...  ..|.|.||||      ..||| || |||.|.      .   . .|||..| ..  . |  . .. ||  
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA-GTYA

YMSPEYC----TGLVSPSADVYSLGVVILELV
.|.||       . .| ..||.| |||. |..
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML
Kinase AqueK478.AA Ciliate-E2 213-401 17 9.1e-22 71.49 In-house 1-294 (365) Show / Hide 
Range on Protein: 213-401
Range on HMM: 1-294/365
Sequence Identity: 17% (53 aa)

SEGGHKLGQGGFGVVYQGQINLGEG---------------------NREVAVKVFVDDHLLIFH-----------------------RLKHPNLLPLLGY
 .   |.|||.||.||...  .                        . ..|.|..  . . ..                        .|.|||.. .  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

TS--NQSTLCLVYPYMALGSLDKHLS--RLELGSE----------RRLQILRDIAS---------------GLHYLHTGCGEILVHRDVKSANILLDQNW
    ..... ||  |   |.| ...   ..  ..|           ...| . |..               .|.|||       .||| |  |||.    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF----

RGVLTDFGIARTLSLE---------------------TTT--------VVTQRIVGTRVYMSPEYCTGL----------VSPSADVYSLGVVILELVFGC
   ..|||... .. .                     |..         ....|.||  ||.||   |            . ..|..||||.. |..|| 
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

L
.
P
Kinase AqueK478.AA UTK 213-350 25 9.2e-22 71.23 In-house 1-176 (296) Show / Hide 
Range on Protein: 213-350
Range on HMM: 1-176/296
Sequence Identity: 25% (45 aa)

SEGGHKLGQGGFGVVYQGQINLGE---GNREVAVKVFV------DDHL---------L---IFHRLK-HPNLLPLLGYTSNQSTLCLVYPYMALGSLDKH
 . | .|||| ||.|. .  .      .   ||||| .      ...              .  ... |||.| |.|. .... ...|. ||. |.|.. 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LS--RLELG-------SERRLQILRDIASGLHYLHTGCGEILVHRDVKSANILLDQN-------WRGVLTDFG---IAR
|   | ...       ...||.  .|||.|..|||.     .||||.   |.|....       .  .. |||    .|
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHS---CGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSR
Kinase AqueK478.AA ULK 217-399 21 9.2e-22 74.04 In-house 5-248 (324) Show / Hide 
Range on Protein: 217-399
Range on HMM: 5-248/324
Sequence Identity: 21% (53 aa)

HKLGQGGFG-VVYQGQ-INLGEGNREVAVKVFV--------DD---------------HLLIFHRLKHPN--LLPLLGYTSNQ--STLCLVYPYMALGSL
|.||.| || .||.|  .. .. |  ||.|.           .                . ....|||||     |. .. ..    ..... |   | |
HCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDL

DKHLSRLELGSERR-----------LQILRDIASGLHYLHTGCGEILVHRDVKSANILLDQNWRGV------------LTDFGIARTLSL-ETTTVVTQR
.. . .    .|             .|....|..|. .||    .  .||| | .|||.  .  .             ..||| |...   .    ..| 
EQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHK---HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

IV------GTRVYMSPEYCTGL-----VSPS-ADVYSLGVVILELVFG
.|      ||  ||.|.   |.      . . .|..|||... |...|
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYG
Pkinase_Tyr AqueK478.AA Pkinase_Tyr 212-352 28 4.1e-21 72.13 Pfam 1-161 (270) Show / Hide 
Range on Protein: 212-352
Range on HMM: 1-161/270
Sequence Identity: 28% (47 aa)

FSEGGHKLGQGGFGVVYQGQIN--LGEGNREVAVKVF--VDDHLL-----------IFHRL-KHPNLLPLLGYTS-NQST--LCLVYPYMALGSLDKHLS
 . | .|||.| ||.||.|  .   .... .||||.     .|             | . | .|||.. |.|  .  .    ...| .||..|.|...| 
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RL-----ELGSERRLQILRDIASGLHYLHTGCGEILVHRDVKSANILLDQNWRGVLTDFGIARTL
.       |  .. ||. ..||.|. ||.      ..|||.   |.|.. |     .||| ||..
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase AqueK478.AA ULK 217-399 22 1e-20 69.14 In-house 5-252 (329) Show / Hide 
Range on Protein: 217-399
Range on HMM: 5-252/329
Sequence Identity: 22% (56 aa)

HKLGQGGFGVVYQGQINLGEG---NREVAVKV-----FVDDHLL---------------IFHRLK--------HPNLLPLLGYTSNQ--STLCLVYPYMA
|.||.| ||.||.| .|   .   |  ||.|.     .  .  .               | ..||        |||   |. .. ..    . ... |  
HCLGKGSFGKVYKG-RNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCN

LGSLDKHLSRLELGSERR-----------LQILRDIASGLHYLHTGCGEILVHRDVKSANILLDQNWRGV------------LTDFGIARTLSLE-----
 | |.. ...    .|             .|....|..|. .||    .  .||| | .|||.. .  .             ..||| |.... .     
GGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHK---HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-TTTVV--TQRIVGTRVYMSPEYCTGL-----VSPS-ADVYSLGVVILELVFG
 ..| |  . |. ||  ||.|.   |.      . . .|..|||... |...|
MMMTCVNEK-RLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYG
Kinase AqueK478.AA TyrKc 216-464 23 2.9e-16 40.35 SMART 4-280 (280) Show / Hide 
Range on Protein: 216-464
Range on HMM: 4-280/280
Sequence Identity: 23% (67 aa)

GHKLGQGGFGVVYQGQINLGEGNREVAVKVFVDDH-------LLIFHRL--KHPNLLPLLGYTSNQ-------STLCLVYPYMALGSLDKHLSRLE--LG
|.||| | ||.||.|. .     ..||||.  .|.       . | ..|  .|||.. |.|. . |         |..|  ||..|.|...| . .  | 
GKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC

SERRLQILRDIASGLHYLHTGCGEILVHRDVKSANILLDQNWRGVLTDFGIARTLSLE------TTTVVTQRIVGTR--V---YMSPEYC-TGLVSPSAD
 .  |..  .||.|  |||      ..|||    |.|.. | .   .||| .| .  .      . . ...   |..  .    |.||   .|  ..  |
MKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VYSLGVVILELVFGCLALHSP----KGSDTDIISFLDECDETAEFYLSCWSR--------SDGESLEELAEKCTNPYRDQRPTIAKVLEKL
|.| ||.. |.   .   ..     . |....| ....      ... .              |  . . ..| .   ..||| . . |..
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG-----YRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK478.AA IRAK 213-244 38 1.3e-07 23.2 In-house 1-30 (317) Show / Hide 
Range on Protein: 213-244
Range on HMM: 1-30/317
Sequence Identity: 38% (13 aa)

SEGGHKLGQGGFGVVYQGQINLGEGNRE--VAVK
. .....|.||||.||.||..    | .  .|||
FHKDNRIGEGGFGCVYRGQWK----NTTGIYAVK
Kinase AqueK478.AA TKL-Unique 437-464 21 0.145953 1.5 In-house 263-290 (290) Show / Hide 
Range on Protein: 437-464
Range on HMM: 263-290/290
Sequence Identity: 21% (6 aa)

ESLEELAEKCTNPYRDQRPTIAKVLEKL
... .| ..| ..  .|||.   ....|
KEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK478.AA IRAK 454-464 36 0.355676 0.12 In-house 307-317 (317) Show / Hide 
Range on Protein: 454-464
Range on HMM: 307-317/317
Sequence Identity: 36% (4 aa)

RPTIAKVLEKL
|...|.|...|
RCDMAWVMQQL