Gene AqueK487 (A.queenslandica)

AqueK487

Species: A.queenslandica
Alias: AqueK487
External Links:
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
AqueK487.AA Protein None 170 None Fasta, JSON
AqueK487.kin_dom Protein Kinase Domain None 128 None Fasta, JSON

Protein domain

Protein domains of AqueK487.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK487.AA TK 43-170 15 1e-19 62.04 In-house 1-249 (486) Show / Hide 
Range on Protein: 43-170
Range on HMM: 1-249/486
Sequence Identity: 15% (40 aa)

ISKLEVLGSGGFG---SVYKGLIEEGQ-------------------------VTVAIKEFSSIAGKMEEDTLI-------GHELNAWDIYING------S
|  ...||.| ||    ||||. ...                          ..||.|   . ..  .|. .        |           |       
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDG-----------GEDFLEEA

REARMMHQ--LQHKNILSLVGLAFQP--------------LRLILELAPLGD----LKNSLKPFRQEKIK------------------------------
.|. ||..  ..|.||..|.|  .|.              . ...|..|.||    |.. |.  | ....                              
EEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHE

----------------------LNCRTLKQ-------------------LIYQVADAMEY
                      |  . | |                     .|.|..|||
SNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEY
Kinase AqueK487.AA LRRK 102-170 32 4.3e-17 57.0 In-house 106-179 (351) Show / Hide 
Range on Protein: 102-170
Range on HMM: 106-179/351
Sequence Identity: 32% (24 aa)

REARMMHQLQHKNILSLVGLAFQPLRLILELAPLGDLKNSLKPFRQEK-----IKLNCRTLKQLIYQVADAMEY
.|. .|. |.| ||.||.|. ..||....|.||.|||   |. ..| .     ....  .. .. .|.|..|||
HEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEY
Kinase AqueK487.AA Pkinase_Tyr 102-170 37 1.7e-15 53.14 Pfam 52-126 (270) Show / Hide 
Range on Protein: 102-170
Range on HMM: 52-126/270
Sequence Identity: 37% (28 aa)

REARMMHQL-QHKNILSLVGLAF---QP--LRLILELAPLGDLKNSLKPFRQEKIKLNCRTLKQLIYQVADAMEY
|||..|.|| .|.||..|.|      .|  . ...|..|.|||.. |.  | .| .|.  .| |  .|.|..|||
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEY
Kinase AqueK487.AA TKL 49-170 22 1.6e-13 45.11 In-house 1-147 (364) Show / Hide 
Range on Protein: 49-170
Range on HMM: 1-147/364
Sequence Identity: 22% (35 aa)

LGSGGFGSVYKG-LIEEG-------QVTVAIKEFSSIAGKMEEDTLIG------------HELNAWDIYINGSREARMMHQLQHKNILSLVGLAFQP---
.|||||| |||| .  .|         .||.| |.|   . .....              ..  |. .     .|..||..|.| ||....| ...|   
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LRLILELAPLGDLKNSLKPFRQEKIKLNCRTLKQLIYQVADAMEY
            | .. |..| |.| . |              . ......| .|.|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNY
Kinase AqueK487.AA UTK 43-170 23 2.3e-13 42.1 In-house 1-133 (296) Show / Hide 
Range on Protein: 43-170
Range on HMM: 1-133/296
Sequence Identity: 23% (34 aa)

ISKLEVLGSGGFGSVYKGLIEE-----GQVTVAIKEFSSIAGKMEEDTLIGHELNAWDIYINGS---REAR---MMHQLQ-HKNILSLVGLAFQ--PLRL
.  .. ||.| || |.|.  ..     ... ||.|. .  .... ...  .        |       .|||   || |.. | |.| |||. .|  |. .
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ--HHADAQQEPEP--------Y---PDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMI

ILELAPLGDLKNSLK----PFRQEKIKLNCRTLKQLIYQVADAMEY
..|... ||| . |      ....   |. ... .  ...|..|.|
VTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQY
Kinase AqueK487.AA Ack 43-170 29 3e-13 41.05 In-house 1-120 (266) Show / Hide 
Range on Protein: 43-170
Range on HMM: 1-120/266
Sequence Identity: 29% (39 aa)

ISKLEVLGSGGFGSVYKGLIEE---GQVTVAIKEFSSIAGKMEEDTLIGHELNAWDIYINGSREARMMHQLQHKNILSLVGLAF-QPL-RLILELAPLGD
|. .| ||.| ||.| .|.        . ||.|  .|.  ||  .. ..  |          ||.  ||.|.| ... | |.   ||. ... ||||.| 
ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSD--KMQQPNCMDDFL----------REVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGS

LKNSLKPFRQEKIKLNCRTLKQLIYQVADAMEY
|   |.   .   ..   || .   |.|..| |
LLDCLRK-HCRTAFFLIHTLCDFCMQIAMGMRY
Kinase AqueK487.AA Pkinase 43-170 19 3.6e-12 44.11 Pfam 1-123 (293) Show / Hide 
Range on Protein: 43-170
Range on HMM: 1-123/293
Sequence Identity: 19% (28 aa)

ISKLEVLGSGGFGSVYKGLIEEGQVTVAIKEFSSIAGKMEE---DTLIGHELNAWDIYINGSREARMMHQLQHKNILSLVGLA--FQPLRLILELAPLG-
. .....|||.||.|||.     . .||.|...    |...   ....              .|...|. |.|.||. | .     . . ...|... | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--------------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGL

---DLK----NSLKPFRQEKIKL--NCRTLKQLIYQVADAMEY
   ||.           ... ..    ...|  .||.. ..||
YVMDLFDYIST------WRHGCFYFSEWECKFYMYQILRGLEY
Kinase AqueK487.AA EGFR 43-170 28 5.1e-11 32.63 In-house 1-116 (258) Show / Hide 
Range on Protein: 43-170
Range on HMM: 1-116/258
Sequence Identity: 28% (38 aa)

ISKLEVLGSGGFGSVYKGL-IEEG---QVTVAIKEFSSIAGKMEEDTLIGHELNAWDIYINGSREARMMHQLQHKNILSLVGLAFQP-LRLILELAPLGD
. |. ||||| || ||||. | ||   .. ||||..    |.   . ..              .|| .|  ..|.... |.|.  .. ..|.  . |.| 
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEML--------------DEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGC

LKNSLKPFRQEKIKLNCRTLKQLIYQVADAMEY
| . .   || | ..  . |    .|.|  |.|
LLDYV---RQHKDNIGSQHLLNWCVQIAKGMQY
Kinase AqueK487.AA Src 43-118 25 3.6e-08 23.82 In-house 1-59 (255) Show / Hide 
Range on Protein: 43-118
Range on HMM: 1-59/255
Sequence Identity: 25% (19 aa)

ISKLEVLGSGGFGSVYKGLIEEGQVTVAIKEFSSIAGKMEEDTLIGHELNAWDIYINGSREARMMHQLQHKNILSL
|  .. ||.| || |..|.   |.. ||.|  ..    |. . .               .||  | .|.|.....|
IKLCRKLGQGQFGEVWMGYW-NGNTKVAVKTLKPGT--MSPEAFL--------------QEAQIMKKLRHEKLVQL
Kinase AqueK487.AA TK-Unique 102-170 24 9.7e-08 22.9 In-house 52-146 (294) Show / Hide 
Range on Protein: 102-170
Range on HMM: 52-146/294
Sequence Identity: 24% (23 aa)

REARMMHQLQ-HKNILSLVGLAF---QPLRLILELAPLGDLKNSLKPFRQE--------KIK--------------LNCRTLKQLIYQVADAMEY
.|..|| .|  |.||....|      .|  .|.| .| |.| . |. .|..         .|              .. ..| . ..|.| .|||
KEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEY
Kinase AqueK487.AA Pkinase_Tyr 43-72 38 4.3e-07 24.63 Pfam 1-34 (270) Show / Hide 
Range on Protein: 43-72
Range on HMM: 1-34/270
Sequence Identity: 38% (13 aa)

ISKLEVLGSGGFGSVYKGLIE----EGQVTVAIK
|.....||.| ||.||||       .....||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK
Kinase AqueK487.AA Fer 102-143 31 2e-06 18.38 In-house 57-101 (283) Show / Hide 
Range on Protein: 102-143
Range on HMM: 57-101/283
Sequence Identity: 31% (14 aa)

REARMMHQ-LQHKNILSLVGLAF--QPLRLILELAPLGDLKNSLK
.|||.| . ..|.|.  . | .   ||. ...|... |.|.. ||
HEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYLK
Kinase AqueK487.AA Met 102-125 45 5e-06 15.48 In-house 50-73 (271) Show / Hide 
Range on Protein: 102-125
Range on HMM: 50-73/271
Sequence Identity: 45% (11 aa)

REARMMHQLQHKNILSLVGLAFQP
||..||  ..| |.|||.| . .|
REGIMMKHFDHPNVLSLIGICLDP
Kinase AqueK487.AA TyrKc 43-168 11 5.1e-05 -141.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 43-168
Range on HMM: 1-280/280
Sequence Identity: 11% (36 aa)

ISKLEVLGSGGFGSVYKGLIEEGQVTVAIKEFSSIAGKMEEDTLIGHELNAWDIYINGSREARMMHQL--QHKNILSLVGLAF---------QPLRLILE
|.....||.| || ||||      ..||.|   . |                       ||||.|..|  .|.||. |.| .          .|| ...|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME

LAPLGDLKNSLKPFR----------------------------------------QEK-------------------------IKL----NCR-------
..|.||||. |.  |                                         ..                         ..     ...       
YMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

--------------------------------------------------------TLKQLIY--------------------------------QVADA
                                                         ..|  .                                .. . 
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

M
.
F
Kinase AqueK487.AA LRRK 43-60 42 0.00051 10.09 In-house 1-19 (351) Show / Hide 
Range on Protein: 43-60
Range on HMM: 1-19/351
Sequence Identity: 42% (8 aa)

ISKLEVLGSGGFG-SVYKG
. . | .|.|||| .||..
LKIEEQIGRGGFGTFVYRA
Kinase AqueK487.AA TK-Unique 43-72 27 0.000814 9.18 In-house 1-36 (294) Show / Hide 
Range on Protein: 43-72
Range on HMM: 1-36/294
Sequence Identity: 27% (10 aa)

ISKLEVLGSGGFGSVYKGLIEEGQ------VTVAIK
.  ..|.|.| || |..| ....       . ||.|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVK
Kinase AqueK487.AA Met 44-60 47 0.001747 6.96 In-house 1-17 (271) Show / Hide 
Range on Protein: 44-60
Range on HMM: 1-17/271
Sequence Identity: 47% (8 aa)

SKLEVLGSGGFGSVYKG
 ...|.| | || ||.|
HFDDVIGQGHFGCVYHG
Kinase AqueK487.AA Fer 43-72 31 0.006152 5.97 In-house 1-38 (283) Show / Hide 
Range on Protein: 43-72
Range on HMM: 1-38/283
Sequence Identity: 31% (12 aa)

ISKLEVLGSGGFGSVYKG-----LIEEGQVTV---AIK
.   ..||.| || ||||     .. .....|   |.|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVK