Gene AqueK492 (A.queenslandica)

AqueK492

Species: A.queenslandica
Alias: AqueK492
External Links:
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
AqueK492.AA Protein None 1390 None Fasta, JSON
AqueK492.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of AqueK492.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank AqueK492.AA Ank 80-112 54 1e-10 42.9 Pfam 1-33 (33) Show / Hide 
Range on Protein: 80-112
Range on HMM: 1-33/33
Sequence Identity: 54% (18 aa)

SGYTPLHLAAIVGHIECVRVLLDCSADVSLTDD
 |.||||||.. ||.|.|. ||.. ||| ..||
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK492.AA Ank 47-79 39 2e-09 38.27 Pfam 1-33 (33) Show / Hide 
Range on Protein: 47-79
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

FGYTPLHEAVSGNRLKVIPYLIEQGANVNAKAN
 |.|||| |.. ....|. .|...||.|||. .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK492.AA Ank 113-133 28 0.89038 7.06 Pfam 1-21 (33) Show / Hide 
Range on Protein: 113-133
Range on HMM: 1-21/33
Sequence Identity: 28% (6 aa)

YGKTPRQTASLGKNSNIVRLL
.| ||   |..  . ..|..|
DGFTPLHLACRCGHTEVVKML
LRR_1 AqueK492.AA LRR_1 313-335 22 29.546276 1.53 Pfam 1-26 (26) Show / Hide 
Range on Protein: 313-335
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

WVKRLRLAR-N--GFQ-AIPNEIGDYL
  ..| | . |   ..  ||...   |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK492.AA LRR_1 337-358 22 3.607533 4.77 Pfam 1-26 (26) Show / Hide 
Range on Protein: 337-358
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

QVVKLDFQR-N--ELV-TVPCC-LFEL
.  .||... |   |. ..|.  .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK492.AA LRR_1 360-380 29 0.096287 10.35 Pfam 1-26 (26) Show / Hide 
Range on Protein: 360-380
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLNELNLSN-N--KLI-EIPY--VHEW
.| .|.||. |  .|  .||       
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK492.AA LRR_1 383-404 29 0.032978 12.0 Pfam 1-26 (26) Show / Hide 
Range on Protein: 383-404
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

GLTVLDLSS-N--ELS-SLPAD-IVAP
 |..||||. |   |. ..| . . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK492.AA LRR_1 405-426 18 0.520988 7.75 Pfam 1-26 (26) Show / Hide 
Range on Protein: 405-426
Range on HMM: 1-26/26
Sequence Identity: 18% (5 aa)

SIRTLNISY-N--CF-RTVPLS-VCSF
....|..|. |  .. ...| |   ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK492.AA LRR_1 428-450 33 0.000958 17.45 Pfam 1-26 (26) Show / Hide 
Range on Protein: 428-450
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLQHLNISF-N-KNIC-SLPVE-MGRL
.||||..|  |  |.. ..| .    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
ROC AqueK492.AA ROC 492-664 27 4.4e-42 138.72 In-house 1-215 (215) Show / Hide 
Range on Protein: 492-664
Range on HMM: 1-215/215
Sequence Identity: 27% (59 aa)

FYQMKLMLLGKQNCGKTTLVARLQGLDVG----------INQSTVGVD-VSKWHYAGGLG---RKKIEYQFSIWDFGGQEEYCAIYQCFLSE-RSMYLLA
 ..|||||.|... |||.|. .| .               ...|.|.. .  | . .  .    |. | .|..|||||||.| | .| ||.. || ||| 
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSCDKGNHPTTHGIEPIQQWVLDCKDMMFRKKEDEIKFNVWDFGGQEIYHATHQFFLTNHRSVYLLV

WNVQD----GEEG----IQE--LKPWLDNIALRAPR--------SCVLIVGTHLDSVEEGD-------RPE--VDKLLEKVAELVQTYQNKLLVPEVLAV
|. ..    |..     ...  |..|| .|. |.|.        |.|.|||||.| |.. |        ..  ..|| .|.   .. .  ..  .... |
WDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQDNKVYQHKQCCRMWQKLRNKFPNICHSWMQIEHYQGFFHV

GLMNRLENIELLREA
    . ..|. ||..
DCETGCKGIDKLRHH
COR AqueK492.AA COR 661-875 20 2.1e-30 95.57 In-house 1-257 (434) Show / Hide 
Range on Protein: 661-875
Range on HMM: 1-257/434
Sequence Identity: 20% (54 aa)

LREAIYNQATKYRGKRSLPIMGQEIPASYIKLNEELEKVQEEVRKGLRDPVMTVAQFRNLVHKLN----------LTDLCSDEELRTATLFLNDIGTILH
.|. ....  |  .      |.| .| |. |... ||.  .  .   . |.|.  .|.... . .          ..|   ..||.|.. .|.| |.|.|
IRKTAKKIKHKQMFED---YMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIID---EDELHTVAMYLHDLGHIIH

YD--DRSHGINELYFIDLQWFYKVMCEIVTVREKNSF---IKNGI-FYSRNVPFLFRDP----------KFQWEYFERYLTLLDRFEIALPLNN------
..  |   . ......| ||| ..|  |....| ..|    ..|| |  . .  ....|          ... .. | .. |. .||...|...      
FKIWDHDPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHFW

----RQILIPSMLPDERPEKAD---IPY----DKSAPLYIRFINF-----QSSSPPGFWSRLI
    .. |||..|||.||. ..   .|.    ...     |  ..         |.|||.|..
HQETTTYLIPQLLPDDRPQHWEWWQWPQWETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQ
Miro AqueK492.AA Miro 496-613 17 7.1e-10 37.47 Pfam 1-140 (140) Show / Hide 
Range on Protein: 496-613
Range on HMM: 1-140/140
Sequence Identity: 17% (26 aa)

KLMLLGKQNCGKTTLVARLQGLDVG---------------INQSTVGVDVSKWHYAGGLGRKKIEYQ-------FSIWDFGGQEEYCAIYQCF--LSERS
|....|.. |||....... |..                 .. .|..||     .    . ...|         |.|||.||.|.  .  . |  . ...
KVVVCGDKGCGKSSFIHQYCGEEFPPNIPRVLPDKTMPREMHGHTYYVD-----TMQVDWDTQSENVDRVKMCYFHIWDCGGREYWKFEHMHFACMKWAD

MYLLAWNVQDGE--EGIQELKPWLDNIALRAPR-SCVLIVGTHLD
 ...   . |.|  .   ....||...  ..   . | .||...|
AICFVYDCTDYESFNRVSNYMAWLPHFRKWGKKAIPVIVVGNKCD
RAB AqueK492.AA RAB 495-668 20 0.000409 -91.29 SMART 1-172 (172) Show / Hide 
Range on Protein: 495-668
Range on HMM: 1-172/172
Sequence Identity: 20% (40 aa)

MKLMLLGKQNCGKTTLVARLQGLDVGINQ-STVGVDV-SKWHYAGGLGRKKIEYQFSIWDFGGQEEYCAIYQCF------------LSERSMYLLAWNVQ
.|..|.|  . ||. |. |        .. .|.|||  .|  .    . |..  |  |||  ||| ...| . .            .. |. .       
FKIILIGDSGVGKSCLLHRFTDDKFSEQYKHTIGVDFKTKTIEV---DGKRVKLQ--IWDTAGQERFRSITSSYYRGAHGCILVYDITNRESF-------

DGEEGIQELKPWLDNIALRAPR----SCVLIVGTHLDSVEEGDRPEVDKLLEKVAELVQ--TYQNKLLVP-EVLAVGLMNRLENIELLREAIYNQ
      . .| ||. |   |.      ....||   | ..  .| .|..  |   ....    .....   |. |   .|  |  . | . ||..
------ENVKNWLKEIRMHANPPPENVVIMLVGNKCDLEH--QR-QVST--EEAQKFCCDCAEKHGMPFMFETSAKTNTNVEEAFQCLARKIYQR
Kinase AqueK492.AA LRRK 1120-1380 25 5.7e-55 188.93 In-house 1-351 (351) Show / Hide 
Range on Protein: 1120-1380
Range on HMM: 1-351/351
Sequence Identity: 25% (90 aa)

EDKDSLLGEGGFG-KVYRGKFHG----------------------------KSVAIKKYLTR----------------------------------QEEA
  . ...|.|||| .|||.|. |                            ..|||||...                                     .|
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FNELRHEAKLLQKSYHPSIVCLVGVNVHPLTALILEEAPMGSLDRHLIKES-TP-------IPRLTMFRIAAQVAAALRFLHQHG--IIFRSLKAANVLL
|.|.|||. .. .  ||.|| |.|.  ||| ....| || |.|...| ... ..       |.. .  .|| |.| ....|| |   ||.| ||  |.||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPL-CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

WSLDET-------SLCHSKLTDFGIAT--HLAPLG-VMGIQGDKCVIAPEVLYIGQK--RTIYNHKADIFSFGMLLYQMIARR-HPFHNVQ-------PV
||...           . |. |||| .     . | ..|  | .   |||..   ..  .  |. |.|..||||.|.  . |. ||| . .         
WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIM---RYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWME

RIDTKVVQGDRPSTVDMPIAET-GYF-----FLTRLMEKCWKDKADDRPETSELISDVSK
.|  |.  | ||.     | ..  .       .  |...||. . ..||  |. ..  | 
QIEDKIIEGLRPT-----IPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK492.AA TKL 1126-1378 19 2.3e-47 163.7 In-house 1-364 (364) Show / Hide 
Range on Protein: 1126-1378
Range on HMM: 1-364/364
Sequence Identity: 19% (72 aa)

LGEGGFGKVYRGKFHG----------KSVAIKKYLT---------------------------RQEEAFNELRHEAKLLQKSYHPSIVCLVG--------
.|.||||.||.||..|          | ||.||. .                            .. .. ... |.... .  || || ..|        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VNVHP-----LTALILEEAPMGSLDRHLIKESTPIPRLTMFRIAAQVAAALRFLHQHG--------IIFRSLKAANVLLWSLDET---------SLCHS
 | .||       ... | .| |||  .|.          ..|.| ..| .. .||...        || | || .|.|...  ..         . .. 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KLTDFGIATHLAPLG---------------------VMGIQGDKCVIAPEVLYIGQKRT------------IYNHKADIFSFGMLLYQMIARRHPFHNVQ
|..|||... . . |                      | . | ..  |||||   .. |             |. |.|..|||..|. ...|..|...  
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

PVRID---------TKVVQGDRPSTVDM--------PIAETGYFFLTRLMEKCWKDKADDRPETSELISDV
.  ..          .|..  .. ...         .  ..    . .||..||. ....||  .|...  
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK492.AA MLK 1116-1378 24 1.1e-37 128.31 In-house 1-291 (291) Show / Hide 
Range on Protein: 1116-1378
Range on HMM: 1-291/291
Sequence Identity: 24% (75 aa)

IKFQEDKDSLLGEGGFGKVYRGKFHGKS-----VAIKKYLTRQEEAFNE-------LRHEAKLLQKSYHPS----IVCLVGV-NVHPL-TALILEEAPMG
|.|.|     .|.|.||||..|....|      ||.|.. .| . .  .       .. |...| .  ||     |. ..|| . .|   ....| .. |
IQFHE----WIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGG

SLDRHLIKEST-------------PIPRLTMFRIAAQVAAALRFLHQHG---IIFRSLKAANVLLWS----LDETSLCHSKLTDFGIATHLAPL-G-VMG
|| . |  ...              ..   ....| |.| .. .||..    || | ||  |.|.      .... |   | .|||... .       |.
SLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTL---KICDFGTSRDWHQMCTNMMS

IQGDKCVIAPEVLYIGQ-KRTIYNHKADIFSFGMLLYQMIARRHPFH-NVQPVRIDTKVVQGD-R---PSTVDMPIAETGYFFLTRLMEKCWKDKADDRP
 .|     ||||  | | . . |. |.|..|.|..|..|..|..|..  . | .|  .|..   |   ||| . ....        ||..||.... .||
NAGTYAWMAPEV--IQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKK--------LMKQCWNQDPHKRP

ETSELISDV
  .. ..  
SFRQIVQHL
Kinase AqueK492.AA Pkinase 1120-1322 24 2.6e-30 108.28 Pfam 1-214 (293) Show / Hide 
Range on Protein: 1120-1322
Range on HMM: 1-214/293
Sequence Identity: 24% (55 aa)

EDKDSLLGEGGFGKVYRGKFHGKS--VAIKKYLTRQEEAFNE--LRH--EAKLLQKSYHPSIVCLVGVNV-HPLTALILEEAPMG----SLDRHLI-KES
  . . .|.|.||.||... .| .  ||.|.   | |.   .  .|.  |......  || || | ..   ..   ...| ...|    .| ...  ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TPI--PRLTMFRIAAQVAAALRFLHQHGIIFRSLKAANVLLWSLDETSLC--HSKLTDFGIAT---HLAPLGVMGIQGDKCVIAPEVLYIGQKRTIYNHK
...  .  .  ... |.. .| ..|..||| | || .|.|   .|..  .  . |..|||.|    .      ... |    .||||.    ... | .|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENIL---IDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPK

ADIFSFGMLLYQMIARRHPFHN
.|..|.| .||.|. .| || .
VDMWSCGCILYEMLCGRPPFPG
Kinase AqueK492.AA TK 1120-1378 14 1.5e-29 95.6 In-house 1-486 (486) Show / Hide 
Range on Protein: 1120-1378
Range on HMM: 1-486/486
Sequence Identity: 14% (71 aa)

EDKDSLLGEGGFG---KVYRGKFHGKS-----------------------------VAIKK--YLTRQEEAFN-------------ELRHEAKLLQ--KS
      |||| ||   .||.|. .|..                             |...|    . ||| |              |. .|.|...  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

YHPSIVCLVGVNVH-------------PLTALILEEAPMGS----LDRHLIKESTP--------------------------------------------
 || || |.|| ..             .   ...| .| |.    |. .| | . .                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IPRLTMFRIAAQVAAALRFLHQH------GIIFRSLKAANVLLWSLDE------TSLCHSKLTDFGIAT
                               ..  ..  ...|.|.....||..      ... | | | |.|. . .        . .. |..||| . 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

H----LAPLGVMGIQGDKCV--------------------------------IAPEVLYIGQ-----KRTIYNHKADIFSFGMLLYQMIA--RRHPFHNV
.    ||     .    .                                   |||.|  ..     |  .. .| |..||| |.. .    .  .  ..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

QP---------VRIDTKVVQGDRPST----------VDMPIAETGY--------------FFLTRLMEKCWKDKADDRPETSELISDV
             .  ....| |. .            ||  .                  .. .|| .||. ...|||  |.| .  
SNQDVWKDGDNQEVMEYLRRGGRL-CRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK492.AA MLK 1121-1378 26 4.9e-29 92.92 In-house 2-280 (280) Show / Hide 
Range on Protein: 1121-1378
Range on HMM: 2-280/280
Sequence Identity: 26% (78 aa)

DKDSLLGEGGFGKVYRGKFHGKSVAIKKYLTRQEEAFNEL-------RHEAKLLQKSYHPSIVCLVGVNVH-PLTALILEEAPMGSLDRHLIKESTPIPR
.   ..| ||||||||. ..|. ||.|      |.   .        | ||.|..   || |. | ||  . |   |..| .  ||| | .      || 
KIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGK--RIPP

LTMFRIAAQVAAALRFLHQHG---IIFRSLKAANVLLWSLDE------------------TSLCHS--KLTDFGIATHLAPLGVMGIQGDKCVIAPEVLY
  .   | |.|  . .||. .   || | ||. |.|.    .                    .|.   | ||||.|  .     |   |    .||||. 
HVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKICLCMDEEMFQYAYCLKCGHHDMCNKQLKITDFGLAREWHKTTRMSAAGTYAWMAPEVI-

IGQKRTIYNHKADIFSFGMLLYQMIARRHPFHNVQPVRIDTKVVQGDRPSTVDMPIAETGYFFLTRLMEKCWKDKADDRPETSELISDV
   |  ..    |. |.| ||  .. .  |.  . |. .   |       .  .|| .|      .||. ||.     ||. ||..   
---KESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAM----NKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL
Kinase AqueK492.AA RIPK 1126-1378 22 3.9e-27 89.51 In-house 1-290 (290) Show / Hide 
Range on Protein: 1126-1378
Range on HMM: 1-290/290
Sequence Identity: 22% (67 aa)

LGEGGFGKVYRG--KFHGKSVAIKKY--LTRQEE----AFNELRHEAKLLQKSYHPSIVCLVGVNVHP-------LTALILEEAPMGSLDRHLIKES---
.| ||||.|..   . .|  ||.| .  . ....      ...  ||| ..|  .  || . |.   .       | ..  |  . |||   |. ..   
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

-TPIPRLTMFRIAAQVAAALRFLHQHG--IIFRSLKAANVLLWSLDETSLCHSKLTDFGIATHLAPLGVMG--------------IQ-GDKCVIAPEVLY
  |.|    .|.  ... .  .||  .  || | || .|.|   .|     | |. ||| || .    ...               . |    ..|| . 
HHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENIL---VDNN--FHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFR

IGQKRT--IYNHKADIFSFGMLLYQMIARRHPFHN-VQPVRIDTKVVQGDRPSTVDMPIAET---GYFFLTRLMEKCWKDKADDRPETSELISDV
 ..|    . . | |. ||......  ...||. .   .  | ....|| ||.. . | .     .   . .||..||.  ..|||   |  . .
TDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase AqueK492.AA S_TKc 1120-1380 24 1.4e-26 95.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 1120-1380
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)

EDKDSLLGEGGFGKVYRGKFHG--KSVAIKKYLTRQEEAFNELRHEAKLLQKSYHPSIVCLVGVNVHPLTALILEEAPM--GSLDRHLIKESTP-----I
 ..  ..|.|.|||||... ..  . ||||.         . .| | ..|.|  || || | .| ..    ...| ..   |.| ... |  ..     .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PRLTMFRIAAQVAAALRFLHQHGIIFRSLKAANVLLWSLDETSLCHSKLTDFGIATHLAPLGVMGIQGDKCV----IAPEVLYIGQKRTIYNH-KADIFS
|  .  ....|.. || ..|.|||| | || .|.|| .       | |..|||.|..|            |.    .|||||        |.. |.|. |
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL---------TTFCGTPWYMAPEVL-------GYGKCKCDWWS

FGMLLYQMIARRHPFHNVQPVRIDTKVVQGDRPSTVDMPIAETGYFFLTRLMEKCWKDKADDRPETSELIS-------DVSK
.| .|| |.... ||.    .    |..                   .  ...||..   ..||   |.         .   
CGCILYEMLCGYPPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK492.AA Ciliate-E2 1120-1320 18 1.8e-26 87.87 In-house 1-296 (365) Show / Hide 
Range on Protein: 1120-1320
Range on HMM: 1-296/365
Sequence Identity: 18% (57 aa)

EDKDSLLGEGGFGKVYRG-------------------------KFHGKSVAIKKYLTRQEEAFNELRHEAK-------------LLQKSYHPSIVCLVGV
 ..  ..|.|.||.||..                         |. .| .|.| .  .| |...   |. .             .|..  || |. .. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

NV---HPLTALILEEAPMGSLDRHLI---KESTPI----PRLTMFRIA---AQVAA---------------ALRFLHQHG-IIFRSLKAANVLLWSLDET
          |..| .  |.|  ...   | .. .     ..|.. |.   .|..                ||..||. . || | .|  |.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

SLCHSKLTDFGIATHLAPL-------GVMG--------------------------IQGDKCVIAPEVLYIGQ-----KRTIYNHKADIFSFGMLLYQMI
     |..|||... . .          ..                          | |     |||.|  ..     |.. |..|.||.|.|..||.|.
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

ARRHPF
  ..||
FGKPPF
Kinase AqueK492.AA STE 1120-1327 23 8.5e-26 88.14 In-house 1-275 (359) Show / Hide 
Range on Protein: 1120-1327
Range on HMM: 1-275/359
Sequence Identity: 23% (66 aa)

EDKDSLLGEGGFGKVYRGKFH-----------------GKSVAIKKYLTRQE-----------------EAFNELRHEAKLLQKSY--HPSIVCLVGVNV
 .. . .|.|.||.||... |                 |. .|||.   ...                 | .... .| |...|.   || ||   |  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HPL--------TALILEEAPMGSLD---RH--LIKES--------TPIPRLTMFRIAAQVAAA-LRFLHQHGIIFRSLKAANVLLWSLDETSLCHSKLTD
.            ...|  . ||||   .|   ....        ...|     .|. |.  . | .||.|.|| | .|.||.||           ||.|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCD

FGIATHLAPLGV-------------MGIQGDKCV----IAPEVLYI-GQK-RTIYNHKADIFSFGMLLYQMIARRHPFHNVQPVR
||... |.. .              |. . . .|     ||||.   ||. .  |. |.|| |.| ..  |.  ..|.|. .| |
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTPWMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMR
Kinase AqueK492.AA TKL-Unique 1124-1378 25 5.6e-25 85.13 In-house 3-290 (290) Show / Hide 
Range on Protein: 1124-1378
Range on HMM: 3-290/290
Sequence Identity: 25% (74 aa)

SLLGEGGFGKVYRGKFHGKSVAIKKYLTRQEEAFNE----LRHEAKLLQKSY-HPSIVCLVGVNV----HPL-TALILEEAPMGSLDRHLI---------
...||||.|.||.||..|..||||.    .|.  ||    .. | ... |   || || ..|. .    .|    ...|  |.|||. .|          
NKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

KESTPIPRLTMFRIAAQVAAALRFLHQHG--IIFRSLKAANVLLWSLDETSLCHSKLTDFGIATHLAPLGVMGIQG-------DKC----VIAPEVLYIG
....... . . ..| ..| .. .||  .  || | ||  |.|. .         |. |||... ..    | . .       ..|     .|||||   
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMN

QKRTIYNHKADIFSFGMLLYQMIARRH------PFHNVQPVRIDTKVVQ---GDRPSTVDMPIAETGYFFLTRLMEKCWKDKADDRPETSELISDV
   . |. |.|..|||. |. .. |        |.... .  .  .| .   . ||     || .     .. |...||..  ..||  .| |.  
F--CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRP-----PIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK492.AA TyrKc 1120-1378 22 2.8e-19 71.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 1120-1378
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

EDKDSLLGEGGFGKVYRGKFHGKSVAIKKYLTRQEEAFNELRHEAKLLQKS--YHPSIVCLVGVNVH--------PLTALILEEAPMGSLDRHLIKESTP
  ..  |||| ||.||.|.     ||.|.          ....||... |    || ||.|.|| ..        .   ...| .| |.|. .| |    
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

IPRLTMFRIAAQVAAALRFLHQHGIIFRSLKAANVLLWSLDETSLCHSKLTDFGIATHLAPL-------GVMGIQ---GDK--CVI---APEVLYIGQKR
..  ..  .. |.|.  ..||....| | | | |.|. .       . | .||| .  .           .   .   | |    |   |||..    . 
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NY

TIYNHKADIFSFGMLLYQMIAR-RHPFHN-----VQPVRIDTKVVQGDRPSTVDM------PIAETGYFFLTRLMEKCWKDKADDRPETSELISDV
 ....| |..||| ... .  .   |  .     . . ..  .| ||.|.   .       ... .    . ..|..||. ...|||  ||.... 
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPD---EMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK492.AA Pkinase_Tyr 1116-1235 26 1.6e-18 63.34 Pfam 1-133 (270) Show / Hide 
Range on Protein: 1116-1235
Range on HMM: 1-133/270
Sequence Identity: 26% (36 aa)

IKFQEDKDSLLGEGGFGKVYRGKFH------GKSVAIKKY--LTRQEE-AFNELRHEAKLLQKS-YHPSIVCLVGVNV--HPL--TALILEEAPMGSLDR
|.| .     |||| ||.||.|. .      .  ||.|.    . .|.    .. .|||.. .  .|| ||.|.|| .         ...| .| |.|. 
ITFGKK----LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

HLIKE---STPIPRLTMFRIAAQVAAALRFLHQHGII
.| |      |..  ..  ...|.|... .|.....|
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCI
Kinase AqueK492.AA TK-Unique 1123-1311 24 8.4e-18 58.06 In-house 4-230 (294) Show / Hide 
Range on Protein: 1123-1311
Range on HMM: 4-230/294
Sequence Identity: 24% (58 aa)

DSLLGEGGFGKVYRGKFHG--------KSVAIKKYL-----TRQEEAFNELRHEAKLLQKSYHPSIVCLVGVNVHPL--TALILEEAPMGSLDRHLI---
....||| || |.||.. |        |.||.|.       |.. . ..|...   . .. .|| || ..|. . .   . .|.| .|.|.|. .|    
GDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQM---MKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

----------------------KESTPIPRLTMFRIAAQVAAALRFLHQ--HGIIFRSLKAANVLLWSLDETSLCHSKLTDFGIATHLA---PLGVMGIQ
                      .. .||   .....| |.| .. .|..  ..|. | | | |||| .      .  |..|||.|...    ..  |. |
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE-----DKVCKICDFGMARDVYTNGVYSMMCSQ

GDKCV--IAPEVLYIGQKRTIYNHKADIFSFGMLLY
|   .   |||.|.   ...... | |. ||| |..
GRIPIRWMAPESLKCY-HGMYHTTKSDVWSFGVLMW
Kinase AqueK492.AA TK-Unique 1356-1378 26 0.000416 10.2 In-house 272-294 (294) Show / Hide 
Range on Protein: 1356-1378
Range on HMM: 272-294/294
Sequence Identity: 26% (6 aa)

LMEKCWKDKADDRPETSELISDV
||. ||......||  .....  
LMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK492.AA Pkinase_Tyr 1353-1378 34 0.011054 9.71 Pfam 245-270 (270) Show / Hide 
Range on Protein: 1353-1378
Range on HMM: 245-270/270
Sequence Identity: 34% (9 aa)

LTRLMEKCWKDKADDRPETSELISDV
. .|| .||. ...|||  ||.... 
IYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK492.AA Pkinase_Tyr 1296-1311 37 2.117809 1.98 Pfam 190-205 (270) Show / Hide 
Range on Protein: 1296-1311
Range on HMM: 190-205/270
Sequence Identity: 37% (6 aa)

IYNHKADIFSFGMLLY
....| |. ||| |..
KFTTKSDVWSFGVLMW