AqueK493

Species: A.queenslandica
Alias: AqueK493
External Links:
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
AqueK493.AA Protein None 1120 None Fasta, JSON
AqueK493.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of AqueK493.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
COR AqueK493.AA COR 1-200 22 6.9e-37 116.94 In-house 18-262 (434) Show / Hide
Range on Protein: 1-200
Range on HMM: 18-262/434
Sequence Identity: 22% (57 aa)

MGQEIPASYIKLNEELEKIREEVRKGVRDPVMNVAQFRNLVHKLN----------LTDLCSDEELRTATLFLNDVGTILHYD--DRSHGINELYFIDPQW
|.| .| |. |... ||. |.  .   . |.|   .|.... . .          ..|   ..||.|.. .|.| |.|.|..  |   . ......||||
MCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIID---EDELHTVAMYLHDLGHIIHFKIWDHDPMLKDFVVLDPQW

LCNMMSEIVTVREKNPF---VKNGI-FYSRNVPFLFRDP----------RFQWEYFGCYLTLLDRFEIALPLNN----------RQILIPSMLPDERPEN
.| ||. |....| ..|    ..|| |  . .  ....|          |.. .. . .. |. .||...|...          .. |||..|||.||..
FCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHFWHQETTTYLIPQLLPDDRPQH

AD---IPY----DKSAPLYIRFINF-----QSSSPPGFWSRLISRIMH
..   .|.    ...     |  ..         |.|||.|.. |. |
WEWWQWPQWETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLHH

Kinase AqueK493.AA LRRK 438-698 25 6e-51 175.58 In-house 1-351 (351) Show / Hide
Range on Protein: 438-698
Range on HMM: 1-351/351
Sequence Identity: 25% (90 aa)

EDKDSLLGEGGFG-KVYRGKFRS----------------------------KSVAIKKYLMR----------------------------------QEEA
  . ...|.|||| .|||.|.|.                            ..|||||...                                     .|
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FNELCHEAKLLQKSHHPFIVCLVGVNVHPLTALILEEAPMGSLERHLI--KESTL------IPRLTMFRIAAQAAAALRFLHQHG--IIFRSLKAANVLL
|.|. ||. .. . .|| || |.|.  ||| ....| || |.| ..|   |.. .      |.. .  .|| | | ....|| |   ||.| ||  |.||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPL-CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

WSLDET-------SLCHSKLTDFGIAT--HLAPLG-VMGIQGDKSVIAPEVLYIGQK--RTIYNHKADIFSFGMLLYQMIARR-HPFHNVQ-------PV
||...           . |. |||| .     . | ..|  | .   |||..   ..  .  |. |.|..||||.|.  . |. ||| . .         
WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIM---RYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWME

RIDTKVVQGDRPSTVDMPIAET-GYF-----FLTRLMEKCWKDKADDRPETSELISDVSK
.|  |.  | ||.     | ..  .       .  |...||. . ..||  |. ..  | 
QIEDKIIEGLRPT-----IPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ

Kinase AqueK493.AA TKL 444-696 19 2.6e-46 160.2 In-house 1-364 (364) Show / Hide
Range on Protein: 444-696
Range on HMM: 1-364/364
Sequence Identity: 19% (74 aa)

LGEGGFGKVYRGKFRS----------KSVAIKKYLMRQEEAFNE-------------------------LCHEAKLLQKSH--HPFIVCLVG--------
.|.||||.||.||.|           | ||.||. ....  |..                          . |  ....|   || || ..|        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VNVHP-----LTALILEEAPMGSLERHLIKESTLIPRLTMFRIAAQAAAALRFLHQHG--------IIFRSLKAANVLLWSLDET---------SLCHS
 | .||       ... | .| |||. .|.          ..|.| ..| .. .||...        || | || .|.|...  ..         . .. 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KLTDFGIATHLAPLG---------------------VMGIQGDKSVIAPEVLYIGQKRT------------IYNHKADIFSFGMLLYQMIARRHPFHNVQ
|..|||... . . |                      | . | .   |||||   .. |             |. |.|..|||..|. ...|..|...  
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

PVRID---------TKVVQGDRPSTVDM--------PIAETGYFFLTRLMEKCWKDKADDRPETSELISDV
.  ..          .|..  .. ...         .  ..    . .||..||. ....||  .|...  
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase AqueK493.AA MLK 434-696 25 2.5e-36 123.55 In-house 1-291 (291) Show / Hide
Range on Protein: 434-696
Range on HMM: 1-291/291
Sequence Identity: 25% (77 aa)

IKFQEDKDSLLGEGGFGKVYRGKFRSKS-----VAIKKYLMRQ---------EEAFNELCHEAKLLQKSH-HPFIVCLVGV-NVHPL-TALILEEAPMGS
|.|.|     .|.|.||||..|..| |      ||.|..  |           ..|.. | ... |..   || |. ..|| . .|   ....| .. ||
IQFHE----WIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGS

LERHLIKEST-------------LIPRLTMFRIAAQAAAALRFLHQHG---IIFRSLKAANVLLWS----LDETSLCHSKLTDFGIATHLAPL-G-VMGI
| . |  ...              ..   ....| | | .. .||..    || | ||  |.|.      .... |   | .|||... .       |. 
LYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTL---KICDFGTSRDWHQMCTNMMSN

QGDKSVIAPEVLYIGQ-KRTIYNHKADIFSFGMLLYQMIARRHPFH-NVQPVRIDTKVVQGD-R---PSTVDMPIAETGYFFLTRLMEKCWKDKADDRPE
.|     ||||  | | . . |. |.|..|.|..|..|..|..|..  . | .|  .|..   |   ||| . ....        ||..||.... .|| 
AGTYAWMAPEV--IQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKK--------LMKQCWNQDPHKRPS

TSELISDV
 .. ..  
FRQIVQHL

Kinase AqueK493.AA TK 438-696 14 1.3e-29 95.89 In-house 1-486 (486) Show / Hide
Range on Protein: 438-696
Range on HMM: 1-486/486
Sequence Identity: 14% (73 aa)

EDKDSLLGEGGFG---KVYRGKFRSKS-----------------------------VAIKK--YLMRQEEAFN-------------ELCHEAKLLQ--KS
      |||| ||   .||.|. |...                             |...|    | ||| |              |...|.|...  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHPFIVCLVGVNVH-------------PLTALILEEAPMGS----LERHLIKESTL--------------------------------------------
||| || |.|| ..             .   ...| .| |.    |  .| | .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IPRLTMFRIAAQAAAALRFLHQH------GIIFRSLKAANVLLWSLDE------TSLCHSKLTDFGIAT
                               ..  ..  ...|.|.....||..      ... | | | |.|. . .        . .. |..||| . 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

H----LAPLG----VMGIQGDKSV----------------------------IAPEVLYIGQ-----KRTIYNHKADIFSFGMLLYQMIA--RRHPFHNV
.    ||           ......                             |||.|  ..     |  .. .| |..||| |.. .    .  .  ..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

QP---------VRIDTKVVQGDRPST----------VDMPIAETGY--------------FFLTRLMEKCWKDKADDRPETSELISDV
             .  ....| |. .            ||  .                  .. .|| .||. ...|||  |.| .  
SNQDVWKDGDNQEVMEYLRRGGRL-CRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase AqueK493.AA Ciliate-E2 438-638 18 9.5e-28 92.31 In-house 1-296 (365) Show / Hide
Range on Protein: 438-638
Range on HMM: 1-296/365
Sequence Identity: 18% (58 aa)

EDKDSLLGEGGFGKVYRG-------------------------KFRSKSVAIKKYLMRQEEAFNE---LC----------HEAKLLQKSHHPFIVCLVGV
 ..  ..|.|.||.||..                         |. .| .|.| .  .| |...    ..           | ..|..  ||.|. .. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

NV---HPLTALILEEAPMGSLERHL----IKESTLIP---RLTMFRIA---AQAAA---------------ALRFLHQHG-IIFRSLKAANVLLWSLDET
          |..| .  |.|. ..    .|.   |.   ..|.. |.   .| .                ||..||. . || | .|  |.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

SLCHSKLTDFGIATHLAPL-------GVMG--------------------------IQGDKSVIAPEVLYIGQ-----KRTIYNHKADIFSFGMLLYQMI
     |..|||... . .          ..                          | |     |||.|  ..     |.. |..|.||.|.|..||.|.
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

ARRHPF
  ..||
FGKPPF

Kinase AqueK493.AA Pkinase 438-640 23 1.8e-27 98.22 Pfam 1-214 (293) Show / Hide
Range on Protein: 438-640
Range on HMM: 1-214/293
Sequence Identity: 23% (53 aa)

EDKDSLLGEGGFGKVYRGKFRSKS--VAIKKYLMRQEEAFNE--LCH--EAKLLQKSHHPFIVCLVGVNV-HPLTALILEEAPMG----SLERHLI-KES
  . . .|.|.||.||... .. .  ||.|.   | |.   .  . .  |...... .||.|| | ..   ..   ...| ...|    .| ...  ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TLI--PRLTMFRIAAQAAAALRFLHQHGIIFRSLKAANVLLWSLDETSLC--HSKLTDFGIAT---HLAPLGVMGIQGDKSVIAPEVLYIGQKRTIYNHK
. .  .  .  ... | . .| ..|..||| | || .|.|   .|..  .  . |..|||.|    .      ... |    .||||.    ... | .|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENIL---IDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPK

ADIFSFGMLLYQMIARRHPFHN
.|..|.| .||.|. .| || .
VDMWSCGCILYEMLCGRPPFPG

Kinase AqueK493.AA MLK 439-696 26 4.1e-27 86.48 In-house 2-280 (280) Show / Hide
Range on Protein: 439-696
Range on HMM: 2-280/280
Sequence Identity: 26% (76 aa)

DKDSLLGEGGFGKVYRGKFRSKSVAIKKYLMRQEEAFNEL-------CHEAKLLQKSHHPFIVCLVGVNVH-PLTALILEEAPMGSLERHLIKESTLIPR
.   ..| ||||||||. .. . ||.|      |.   .        . ||.|..  .|| |. | ||  . |   |..| .  |||.| .      || 
KIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGK--RIPP

LTMFRIAAQAAAALRFLHQHG---IIFRSLKAANVLLWSLDE------------------TSLCHS--KLTDFGIATHLAPLGVMGIQGDKSVIAPEVLY
  .   | | |  . .||. .   || | ||. |.|.    .                    .|.   | ||||.|  .     |   |    .||||. 
HVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKICLCMDEEMFQYAYCLKCGHHDMCNKQLKITDFGLAREWHKTTRMSAAGTYAWMAPEVI-

IGQKRTIYNHKADIFSFGMLLYQMIARRHPFHNVQPVRIDTKVVQGDRPSTVDMPIAETGYFFLTRLMEKCWKDKADDRPETSELISDV
   |  ..    |. |.| ||  .. .  |.  . |. .   |       .  .|| .|      .||. ||.     ||. ||..   
---KESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAM----NKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL

Kinase AqueK493.AA RIPK 444-696 22 9.2e-27 88.21 In-house 1-290 (290) Show / Hide
Range on Protein: 444-696
Range on HMM: 1-290/290
Sequence Identity: 22% (67 aa)

LGEGGFGKVYRGKFRS-KSVAIKKY---LMRQEE----AFNELCHEAKLLQKSHHPFIVCLVGVNVHP-------LTALILEEAPMGSLERHLIKES---
.| ||||.|..   |. . ...||    . ....      ...  ||| ..|  . .|| . |.   .       | ..  |  . |||.  |. ..   
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---TLIPRLTMFRIAAQAAAALRFLHQHG--IIFRSLKAANVLLWSLDETSLCHSKLTDFGIATHLAPLGVMG--------------IQ-GDKSVIAPEV
   .. | |. .|.  . . .  .||  .  || | || .|.|   .|     | |. ||| || .    ...               . |  | ..|| 
HHPDPWP-LR-CRMIHEISCGMCYLHSMNPPIIHRDLKPENIL---VDNN--FHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEH

LYIGQKRT--IYNHKADIFSFGMLLYQMIARRHPFHN-VQPVRIDTKVVQGDRPSTVDMPIAET---GYFFLTRLMEKCWKDKADDRPETSELISDV
.  ..|    . . | |. ||......  ...||. .   .  | ....|| ||.. . | .     .   . .||..||.  ..|||   |  . .
FRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT

Kinase AqueK493.AA S_TKc 438-698 23 1.6e-26 95.39 SMART 1-231 (231) Show / Hide
Range on Protein: 438-698
Range on HMM: 1-231/231
Sequence Identity: 23% (68 aa)

EDKDSLLGEGGFGKVYRGKFRS--KSVAIKKYLMRQEEAFNELCHEAKLLQKSHHPFIVCLVGVNVHPLTALILEEAPM--GSLERHLIKESTL-----I
 ..  ..|.|.|||||... ..  . ||||.         . .. | ..|.| |||.|| | .| ..    ...| ..   |.| ... |  .      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PRLTMFRIAAQAAAALRFLHQHGIIFRSLKAANVLLWSLDETSLCHSKLTDFGIATHLAPLGVMGIQGDKSVI------APEVLYIGQKRTIYNH-KADI
|  .  ....| . || ..|.|||| | || .|.|| .       | |..|||.|..|           ....      |||||        |.. |.|.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-----------TTFCGTPWYMAPEVL-------GYGKCKCDW

FSFGMLLYQMIARRHPFHNVQPVRIDTKVVQGDRPSTVDMPIAETGYFFLTRLMEKCWKDKADDRPETSELIS-------DVSK
 |.| .|| |.... ||.    .    |..                   .  ...||..   ..||   |.         .   
WSCGCILYEMLCGYPPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase AqueK493.AA TKL-Unique 442-696 25 2.9e-25 86.13 In-house 3-290 (290) Show / Hide
Range on Protein: 442-696
Range on HMM: 3-290/290
Sequence Identity: 25% (74 aa)

SLLGEGGFGKVYRGKFRSKSVAIKKYLMRQEEAFNE----LCHEAKLLQKSH-HPFIVCLVGVNV----HPL-TALILEEAPMGSLERHLI---------
...||||.|.||.||.|...||||.    .|.  ||    .  | ... | | ||.|| ..|. .    .|    ...|  |.|||  .|          
NKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

KESTLIPRLTMFRIAAQAAAALRFLHQHG--IIFRSLKAANVLLWSLDETSLCHSKLTDFGIATHLAPLGVMGIQ-----GDKSVI------APEVLYIG
.... .. . . ..| ..| .. .||  .  || | ||  |.|. .         |. |||... ..    | .      .. ...      |||||   
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMN

QKRTIYNHKADIFSFGMLLYQMIARRH------PFHNVQPVRIDTKVVQ---GDRPSTVDMPIAETGYFFLTRLMEKCWKDKADDRPETSELISDV
   . |. |.|..|||. |. .. |        |.... .  .  .| .   . ||     || .     .. |...||..  ..||  .| |.  
F--CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRP-----PIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL

Kinase AqueK493.AA TyrKc 438-696 22 5.2e-20 73.72 SMART 1-280 (280) Show / Hide
Range on Protein: 438-696
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

EDKDSLLGEGGFGKVYRGKFRSKSVAIKKYLMRQEEAFNELCHEAKLLQKS--HHPFIVCLVGVNVH--------PLTALILEEAPMGSLERHLIKESTL
  ..  |||| ||.||.|. .   ||.|.          ....||... |   ||| ||.|.|| ..        .   ...| .| |.|  .| |    
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

IPRLTMFRIAAQAAAALRFLHQHGIIFRSLKAANVLLWSLDETSLCHSKLTDFGIATHLAPL-------GVMGIQ---GDKSVI-----APEVLYIGQKR
..  ..  .. |.|.  ..||....| | | | |.|. .       . | .||| .  .           .   .   | |...     |||..    . 
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NY

TIYNHKADIFSFGMLLYQMIAR-RHPFHN-----VQPVRIDTKVVQGDRPSTVDM------PIAETGYFFLTRLMEKCWKDKADDRPETSELISDV
 ....| |..||| ... .  .   |  .     . . ..  .| ||.|.   .       ... .    . ..|..||. ...|||  ||.... 
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPD---EMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase AqueK493.AA STE 535-645 29 4.4e-17 56.95 In-house 155-275 (359) Show / Hide
Range on Protein: 535-645
Range on HMM: 155-275/359
Sequence Identity: 29% (39 aa)

RIAAQAAAA-LRFLHQHGIIFRSLKAANVLLWSLDETSLCHSKLTDFGIATHLAPLGV-------------MGIQGDKSV----IAPEVLYI-GQK-RTI
.|. |   . | .||.|.|| | .|.||.||           ||.|||... |.. .              |. . .  |     ||||.   ||. .  
YICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTPWMAPEVIQQNGQGRDKG

YNHKADIFSFGMLLYQMIARRHPFHNVQPVR
|. |.|| |.| ..  |.  ..|.|. .| |
YDTKCDIWSLGCTIIEMATGKPPWHDMHPMR

Kinase AqueK493.AA Pkinase_Tyr 434-553 26 1.5e-16 56.68 Pfam 1-133 (270) Show / Hide
Range on Protein: 434-553
Range on HMM: 1-133/270
Sequence Identity: 26% (36 aa)

IKFQEDKDSLLGEGGFGKVYRGKFR------SKSVAIKKY--LMRQEE-AFNELCHEAKLLQKS-HHPFIVCLVGVNV--HPL--TALILEEAPMGSLER
|.| .     |||| ||.||.|. .         ||.|.      .|.    .. .|||.. .  ||| ||.|.|| .         ...| .| |.|  
ITFGKK----LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

HLIKE---STLIPRLTMFRIAAQAAAALRFLHQHGII
.| |       ..  ..  ...| |... .|.....|
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCI

Kinase AqueK493.AA STE 438-494 18 5.1e-10 31.68 In-house 1-93 (359) Show / Hide
Range on Protein: 438-494
Range on HMM: 1-93/359
Sequence Identity: 18% (17 aa)

EDKDSLLGEGGFGKVYRGKFRSKS-----------------VAIKKYLMRQE-----------------EAFNELCHEAKLLQKSH--HPFIV
 .. . .|.|.||.||... . ..                 .|||.  ....                 | .... .| |...|..  ||.||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIV

Kinase AqueK493.AA Gdt 439-498 28 7.8e-09 26.41 In-house 2-68 (289) Show / Hide
Range on Protein: 439-498
Range on HMM: 2-68/289
Sequence Identity: 28% (20 aa)

DKDSLLGEGGFGKVYRGKFRSKSVAIKKYLMRQEEA---------FNELCHEAKLLQKSHHPFIVCLVG
| . ....| || ||.|..|| .||.|  ... . .         . |   |  .| |  |. || ..|
DFKEYCSQGTFGMVYKGIWRSSQVAVK--MFKHHYVNYTKTYSQSCDEIYREMDILSKIKHQNIVSFIG

Kinase AqueK493.AA Gdt 535-581 46 2.6e-07 21.09 In-house 134-180 (289) Show / Hide
Range on Protein: 535-581
Range on HMM: 134-180/289
Sequence Identity: 46% (22 aa)

RIAAQAAAALRFLHQHGIIFRSLKAANVLLWSLDETSLCHSKLTDFG
||.  .| .  |||| ||| | ||. |.|. |..| |.   |  |||
RIMIDIAKGCQFLHQNGIIHRDLKPDNILIFSTNENSEVCAKICDFG

Kinase AqueK493.AA Gdt 615-657 39 4e-06 16.84 In-house 211-253 (289) Show / Hide
Range on Protein: 615-657
Range on HMM: 211-253/289
Sequence Identity: 39% (17 aa)

YNHKADIFSFGMLLYQMIARRHPFHNVQPVRIDTKVVQGDRPS
|   .|. |||.|.| |   | ||| .   .|  .| .| ||.
YQKSTDVYSFGILFYEMMIERIPFHEICHWEIPNFVQDGWRPT

Kinase AqueK493.AA Pkinase_Tyr 671-696 34 0.011054 9.71 Pfam 245-270 (270) Show / Hide
Range on Protein: 671-696
Range on HMM: 245-270/270
Sequence Identity: 34% (9 aa)

LTRLMEKCWKDKADDRPETSELISDV
. .|| .||. ...|||  ||.... 
IYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase AqueK493.AA Pkinase_Tyr 614-629 37 2.117809 1.98 Pfam 190-205 (270) Show / Hide
Range on Protein: 614-629
Range on HMM: 190-205/270
Sequence Identity: 37% (6 aa)

IYNHKADIFSFGMLLY
....| |. ||| |..
KFTTKSDVWSFGVLMW