Gene AqueK496 (A.queenslandica)

AqueK496

Species: A.queenslandica
Alias: AqueK496
External Links:
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
AqueK496.AA Protein None 2637 None Fasta, JSON
AqueK496.kin_dom Protein Kinase Domain None 300 None Fasta, JSON

Protein domain

Protein domains of AqueK496.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank AqueK496.AA Ank 52-84 33 0.006362 14.8 Pfam 1-33 (33) Show / Hide 
Range on Protein: 52-84
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

NGRTLVHIAADKGLSEYLEKLLLEGGDPNKPSS
.|.|  |.|. .|  | .. ||  | |.|    
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK496.AA Ank 88-120 36 3.3e-07 30.27 Pfam 1-33 (33) Show / Hide 
Range on Protein: 88-120
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

LCQTPLHLAAFQGYAKCLQVLVKHGAQIRVQNA
  .||||||.. |...... |..||| . .|. 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK496.AA Ank 198-221 33 0.28947 8.82 Pfam 1-24 (33) Show / Hide 
Range on Protein: 198-221
Range on HMM: 1-24/33
Sequence Identity: 33% (8 aa)

FQQTLLYRAADKDHVQIVTFLLQQ
  .| |  |. ..|...|..|||.
DGFTPLHLACRCGHTEVVKMLLQH
Ank AqueK496.AA Ank 232-255 41 2.8e-05 23.32 Pfam 1-24 (33) Show / Hide 
Range on Protein: 232-255
Range on HMM: 1-24/33
Sequence Identity: 41% (10 aa)

HGDTPLMIACRHSNLKLVDLLINH
.|.|||..|||. ... | .|..|
DGFTPLHLACRCGHTEVVKMLLQH
Kinase AqueK496.AA CAMK 281-304 29 0.079263 0.86 In-house 182-205 (425) Show / Hide 
Range on Protein: 281-304
Range on HMM: 182-205/425
Sequence Identity: 29% (7 aa)

KGIVQSMLDAVQGLYEKGITHRDL
. ... ...||. . ...| ||||
RRYFRQICSAVHYCHSHNIVHRDL
Ank AqueK496.AA Ank 267-290 25 11.962846 2.99 Pfam 1-24 (33) Show / Hide 
Range on Protein: 267-290
Range on HMM: 1-24/33
Sequence Identity: 25% (6 aa)

NSLSPLHVSTSRGDKGIVQSMLDA
.  .|||.  ..|.. .|.  |..
DGFTPLHLACRCGHTEVVKMLLQH
Ank AqueK496.AA Ank 310-335 38 0.113973 10.28 Pfam 1-26 (33) Show / Hide 
Range on Protein: 310-335
Range on HMM: 1-26/33
Sequence Identity: 38% (10 aa)

IGRTPFYNACYHGQLPIVKAFLEFKA
 |.||   ||..|.. .|| .|.  |
DGFTPLHLACRCGHTEVVKMLLQHGA
Ank AqueK496.AA Ank 349-373 28 20.973053 2.11 Pfam 1-23 (33) Show / Hide 
Range on Protein: 349-373
Range on HMM: 1-23/33
Sequence Identity: 28% (7 aa)

SRRSPLHAAVSAPKFSKEIVELLVK
  ..||| |..    ..|.|..|..
DGFTPLHLACRCG--HTEVVKMLLQ
Ank AqueK496.AA Ank 518-543 38 0.029257 12.41 Pfam 1-26 (33) Show / Hide 
Range on Protein: 518-543
Range on HMM: 1-26/33
Sequence Identity: 38% (10 aa)

LLLTPLAEACVFNSQDIVEILINHGA
   |||  ||  .. ..|. |..|||
DGFTPLHLACRCGHTEVVKMLLQHGA
LRR_TYP AqueK496.AA LRR_TYP 654-677 37 0.222592 5.2 SMART 1-24 (24) Show / Hide 
Range on Protein: 654-677
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

LPNVAEINVAENSLTSLPDIDSDS
|||  | .   | ||.||.   ..
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK496.AA LRR_1 633-654 18 3.38074 4.87 Pfam 1-26 (26) Show / Hide 
Range on Protein: 633-654
Range on HMM: 1-26/26
Sequence Identity: 18% (5 aa)

SIHIVHLQK-N--CLQ-TLPIE-LFQL
.. . .|.  |  .|. ..| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK496.AA LRR_1 656-678 18 20.950081 2.06 Pfam 1-26 (26) Show / Hide 
Range on Protein: 656-678
Range on HMM: 1-26/26
Sequence Identity: 18% (5 aa)

NVAEINVAE-N--SLT-SLPDIDSDSC
|  ....   |  .|| ..|.    ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK496.AA LRR_1 691-712 33 0.024782 12.44 Pfam 1-26 (26) Show / Hide 
Range on Protein: 691-712
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

QLTVLILSS-N--NLS-CLPTC-LWFL
.|..| ||. |  ||. ..|   .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP AqueK496.AA LRR_TYP 712-737 42 0.075874 9.03 SMART 1-24 (24) Show / Hide 
Range on Protein: 712-737
Range on HMM: 1-24/24
Sequence Identity: 42% (11 aa)

LPSLEILKASMNKLESLVPLPEAFNS
||.|. |  | |.|..|   |.||..
LPNLRELDLSNNQLTHLP--PGAFQG
LRR_TYP AqueK496.AA LRR_TYP 689-711 33 0.369116 3.4 SMART 1-24 (24) Show / Hide 
Range on Protein: 689-711
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

CSQLTVLILSSNNLSCLP-TCLWF
 ..|..| ||.|.|. ||   .. 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK496.AA LRR_1 714-738 26 0.853418 6.99 Pfam 1-26 (26) Show / Hide 
Range on Protein: 714-738
Range on HMM: 1-26/26
Sequence Identity: 26% (8 aa)

SLEILKASM-N--KLE-SLVPLPEA-FNSL
.|..|  |  |  .|. .   .|.  | .|
NLQHLDLSGCNCCNLTGH---IPPSCF-NL
LRR_TYP AqueK496.AA LRR_TYP 771-794 37 1.2e-05 25.95 SMART 1-24 (24) Show / Hide 
Range on Protein: 771-794
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

LSELSKLNLSQNELQSLPDSLWDC
|..| .|.|| | |..||. ....
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK496.AA LRR_1 773-794 29 0.011592 13.61 Pfam 1-26 (26) Show / Hide 
Range on Protein: 773-794
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

ELSKLNLSQ-N--ELQ-SLPDS-LWDC
 | .|.||  |   |. ..|.| .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK496.AA LRR_1 750-771 33 0.014363 13.28 Pfam 1-26 (26) Show / Hide 
Range on Protein: 750-771
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLREIDLSR-N--SL-KEIDNF-VFGL
||...|||. |  .| ..| .    .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP AqueK496.AA LRR_TYP 749-770 47 0.815132 0.58 SMART 2-24 (24) Show / Hide 
Range on Protein: 749-770
Range on HMM: 2-24/24
Sequence Identity: 47% (11 aa)

PNLREIDLSRNSLKEIDNFV-FG
||||| |||.| |... . .  |
PNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK496.AA LRR_1 796-816 29 0.012695 13.47 Pfam 1-26 (26) Show / Hide 
Range on Protein: 796-816
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

TLHQLDVSS-N--SLS-SLPR--CGGL
.|  ||.|. |  .|. ..|   . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP AqueK496.AA LRR_TYP 797-817 38 0.906949 0.2 SMART 4-24 (24) Show / Hide 
Range on Protein: 797-817
Range on HMM: 4-24/24
Sequence Identity: 38% (8 aa)

LHQLDVSSNSLSSLPRCGGLE
|  || |.| |..||.     
LRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK496.AA LRR_1 904-925 25 0.095664 10.36 Pfam 1-26 (26) Show / Hide 
Range on Protein: 904-925
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

VLTRLNLSK-N--RF-KSFPIG-LPCL
 |..|.||  |  .. ...| . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP AqueK496.AA LRR_TYP 902-925 29 0.757722 0.84 SMART 1-24 (24) Show / Hide 
Range on Protein: 902-925
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)

YSVLTRLNLSKNRFKSFPIGLPCL
 . |..|.|| |.... | |.   
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK496.AA LRR_1 928-954 28 0.191652 9.29 Pfam 1-26 (26) Show / Hide 
Range on Protein: 928-954
Range on HMM: 1-26/26
Sequence Identity: 28% (9 aa)

NLFELDISD-N--NIQ-VIDITFLPQI-LRKL
|| .||.|. |  |..       .|   . .|
NLQHLDLSGCNCCNLTGH-----IPPSCF-NL
LRR_1 AqueK496.AA LRR_1 1047-1069 29 0.679917 7.34 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1047-1069
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLEGLDLTS-N--CLVGTFNPN-IGRQ
.|. ||| . |  .|.|.. |. .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK496.AA LRR_1 1071-1093 29 0.146853 9.7 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1071-1093
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

QLKWLWLSQ-N-KELE-KLPLH-LADL
.|. | ||  |   |. ..|   .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
ROC AqueK496.AA ROC 1141-1317 25 1.9e-41 136.62 In-house 1-215 (215) Show / Hide 
Range on Protein: 1141-1317
Range on HMM: 1-215/215
Sequence Identity: 25% (57 aa)

YRTLKLFFIGCGQRGKTTLLRRLRERQAG----------ETERTEGID-IEEWSCRGAKRRLFRAPQEPIQFLAWDFAGQEVYQVTHQCFYSR-RAIYLA
.. .||...| |  |||.|...|. ..            . ..| ||. |..|.  .    . |.. . |.|  |||.|||.|  ||| |..  |..||.
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSCDKGNHPTTHGIEPIQQWVLDCKDMMF-RKKEDEIKFNVWDFGGQEIYHATHQFFLTNHRSVYLL

LFRMID----GEEG----INE--LEPWLRNVQLRAEG--------CIVIIVGTYLDKVSDSK-------VAE--IDKIIKQKFFTKSSNIYPKI------
 .   .    |..     ...  ||.|||... |. .          |||||| .|||.. .       . .   .|.          | .|.|      
VWDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQDNKVYQHKQCCRMWQKL---------RNKFPNICHSWMQ

----ISYISVSCVSKFGNNMDKLRQL
       ..|.| .  ....||||. 
IEHYQGFFHVDCETG-CKGIDKLRHH
COR AqueK496.AA COR 1318-1603 16 4.7e-27 84.53 In-house 1-303 (434) Show / Hide 
Range on Protein: 1318-1603
Range on HMM: 1-303/434
Sequence Identity: 16% (57 aa)

IYDVSVHLKV----SPRDGITLVHDPKLSLSSSYALLNQQIPRNFLELQERVSDLVKDLNESQKPPYLSHEEFSSRFLSIF----------EGDEEEMNE
|....  .|      .                   .. |..|. .... . . .. |..|.... |..| .||.   ..              ||.| . 
IRKTAKKIKHKQMFED-------------------YMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHT

AVNYLTLQGTLLHFD----DYGLRDLYFLDPQWLAKLMARLISPNSAKNMS--LVDGK-ILLSSLFEQDLFLSEH-------------RAIASKYLQLLQ
.. ||   |...||.    |..|.|...|||||... |.......  .  .     |. .  . | .   .....              . .  ...|..
VAMYLHDLGHIIHFKIWDHDPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEK---IWNPPCRHNPHMNWRRYPDHDHEYLVELME

KFEVALCIGD----------KEVIIPSLFPESQSYPK-PNDSLKDVTFTAGVELNYLPPIRRIWF-----SNYIPDGFWPRLICRLLNDQLI-KSILSNY
|||... |..          ....||.| |...     ...    . .|   ...||   |.  .     ....|.|||||...||.....   ..    
KFELCYPIDPDWTHFWHQETTTYLIPQLLPDDRPQHWEWWQWPQ-W-ETNEHDCRYL--RRHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKC----

YDSVENSDESVVKSDWTCWKSGLVYVSRGR---TLLLVRH
        |  .   | .|..|.|.. .|    . |.. .
------FYERSC-CEWMYWRNGMVLKWEGHNKNEALVKCD
Kinase AqueK496.AA TKL 1793-2086 22 1.3e-58 201.08 In-house 1-364 (364) Show / Hide 
Range on Protein: 1793-2086
Range on HMM: 1-364/364
Sequence Identity: 22% (90 aa)

LGKGGYGFVCTGELKGPTGSPP-----ELVAVKVFLT---NLEGKID---------SLSSAELLEEAAKDSQLRSAYKEIRQEVNFLSTLKHQNITKLIG
.|.||.| |. |...| .|        . ||||.| .   ... |..         |           .|  .. . .....|.. .| |.|.|| ...|
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYS-----D-M-QLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMG

---------VRTKPV-----YCLLLELAPMKS-LRSMLKDYQLCKLTMEPITLKQCAKQISDGLNYLHTHQ--------IVHLDMKSPNVLVWEF-----
         |  .||     .|.  |..|  | |  ..           .  . . |..|. |.||||...        |.| | ||.|.||.|      
YCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS

--PIAGMPRKERLKYAGNVW-LKIADYGISQVAT-----SMMMK-------------VTTNQPGTPGYMAPELFETG--------------QEIYSTKVD
  ..          .  . | .||.|.|.|.. .     ...|.              | .| |||..||||...                .. ||.|.|
NYMY----------NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCD

VFAYGMTLYEIISLQAPFQKQEAMKRN---------AEVR-AGKRPPTG---------NKEKHTPLLLQDLMRLCWSKDPSARPKMKECLQWT
|...|. |.||.. . |....  | .          . |   |.|||            .....|  . .||  ||. ||..|| ..|.|.. 
VYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK496.AA LRRK 1787-2088 25 3.8e-57 196.17 In-house 1-351 (351) Show / Hide 
Range on Protein: 1787-2088
Range on HMM: 1-351/351
Sequence Identity: 25% (95 aa)

ILEKEVLGKGGYG-FVCTGELKG----------------------PTGSPPELVAVKVFLT--------------------NLEGKIDSLSSAELLEEAA
. . | .|.||.| ||  ....|                      ..    . ||.|....                    |.             .| .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNN-------------SEQV

KDSQ------LRSAYKEIRQEVNFLSTLKHQNITKLIGVRTKPVYCLLLELAPMKSLRSMLKDYQLCKL-----TMEPITLKQCAKQISDGLNYLHTHQ-
 |        .  |. | |.||  .|.|.| || .|.|.  .| .|. .|.||  .| . |....  ..      . . .. . | ||..|..||| |  
ED-MDQNHEDCCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHP-LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP

-IVHLDMKSPNVLVWEFP---IAGMPRKERLKYAGNVWLKIADYGISQ-VATSMMMKVTTNQPGTPGYMAPELFE-TGQEIYSTKVDVFAYGMTLYEIIS
 |.| | ||||.|.|..|     .         . .|  ||||.|||.   ..  |.|.    |.||.||||    .| | |..|||....|| |.|...
PIIHRDLKSPNILLWSSPQNHSPN-------YPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLT

LQ-APFQKQE---AMKRNAEVRA----GKRPPTG---NKEKHTPLLLQDLMRLCWSKDPSARPKMKECLQWTST
.|  ||.  .    |. . ...     | ||.     .... ..  .|||. .||. ||  ||.. . ..  |.
RQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK496.AA S_TKc 1787-2086 22 8.1e-43 149.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 1787-2086
Range on HMM: 1-231/231
Sequence Identity: 22% (71 aa)

ILEKEVLGKGGYGFVCTGELKGPTGSPPELVAVKVFLTNLEGKIDSLSSAELLEEAAKDSQLRSAYKEIRQEVNFLSTLKHQNITKLIGVRTKPVYCLLL
    ...|||..| |. .  |.      ..||.|.                               . ||.|.. |.  .| || ||..|     ... .
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK-----------------------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVM

ELAPM--KSLRSMLKDYQL--CKLTMEPITLKQCAKQISDGLNYLHTHQIVHLDMKSPNVLVWEFPIAGMPRKERLKYAGNVWLKIADYGISQVATSMMM
|...    .|....|...    .  . . . .  ..|| ..|.|.| |.|.| | |  |.|. |                   .||.| |.. .      
EYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------------HIKICDFGLARQL-----

KVTTNQPGTPGYMAPELFETGQEIYST-KVDVFAYGMTLYEIISLQAPFQKQEAMKRNAEVRAGKRPPTGNKEKHTPLLLQDLMRLCWSKDPSARPKMKE
   | . ||| |||||..      |.. |.|. . | .||| .. . ||. |..|  .  .               .  . |..| |. |||. ||   |
---TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-E

CLQ---------WT
.||         | 
ALQDEWDIKCHPWF
Kinase AqueK496.AA TKL-Unique 1853-2077 28 2.3e-41 143.66 In-house 40-281 (290) Show / Hide 
Range on Protein: 1853-2077
Range on HMM: 40-281/290
Sequence Identity: 28% (73 aa)

KEIRQEVNFLSTLK-HQNITKLIGVRT----KPV-YCLLLELAPMKSLRSMLKD--------YQLCKLTMEPITLKQCAKQISDGLNYLHTHQ--IVHLD
.| . ||| ...|. | ||....|. .    .|  .|. .|  |. ||.. | .         . |||.|. .   . |..|..|..|||. .  | |.|
QEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQR--VKMAIDIAQGMYYLHHCEPPIIHRD

MKSPNVLVWEF-PIAGMPRKERLKYAGNVWLKIADYGISQVATSMMMKVTTNQ--------PGTPGYMAPELFETGQEIYSTKVDVFAYGMTLYEIISLQ
.||.|.|| .. .||             .  ||.| |.| ...... . ...          |.. .||||...   . ||.|.||...|. |.||.. .
LKSSNFLVDNNSNIA------------EWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRK

A------PFQKQEAMKRNAEVRA---GKRPPTGNKEKHTPLLLQDLMRLCWSKDPSARP
       |.|. .  .  . |.    ..||| .|   | |  ..||.. ||  ||| ||
ITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPN---HCPKEYRDLIQQCWHHDPSQRP
Kinase AqueK496.AA MLK 1853-2086 26 1e-35 121.44 In-house 50-291 (291) Show / Hide 
Range on Protein: 1853-2086
Range on HMM: 50-291/291
Sequence Identity: 26% (67 aa)

KEIRQEVNFLSTLKHQN----ITKLIGVRTKP-V-YCLLLELAPMKSLRSMLKD-YQLCK---------LTMEPITLKQCAKQISDGLNYLHTHQ---IV
.....|.. |. |.|.|    | .. || ..|   .|...| ..  || . |..                .. .  . . |.|.. |..||| ..   |.
WDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPII

HLDMKSPNVLVWEFPIAGMPRKERLKYAGNVWLKIADYGISQVATSMMMKVTTNQPGTPGYMAPELFET-GQEIYSTKVDVFAYGMTLYEIISLQAPFQ-
| | ||.|.|. |  |         .  ..  |||.| |.|   ..|  .  ....||. .|||| ..    | || |.||. .|. |.|... . |.. 
HRDLKSHNILIDE--IC--------HDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQ

KQEAMKRNAEVRAGK-RPPTGNKEKHTPLLLQDLMRLCWSKDPSARPKMKECLQWT
 ...| . ..| . . ||| ..     |  .  ||  ||. ||. ||......|  
HYDPMAIAWWVAYNGLRPPIPST---CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK496.AA STE 1788-2086 18 2.2e-35 122.44 In-house 1-359 (359) Show / Hide 
Range on Protein: 1788-2086
Range on HMM: 1-359/359
Sequence Identity: 18% (73 aa)

LEK-EVLGKGGYGFVCTGELKG-----PTGSP------PELVAVKVFL----TNLEGKIDSLSSAELLEEAAKDSQLR------SAYKEIRQEVNFLSTL
.|. |..|||..| |...  .      .||         |..|.|.      .| . .         .     . |        .  ..| .|..... .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-E---------N--Q-EN-Q-ELENKNHEEMQQILKEIKIMKKC

K--HQNITKLIGVRTKP--------VYCLLLELAPMKSLRSMLKDYQLCKLTM-----------EPITLKQCAKQISDG-LNYLHTHQIVHLDMKSPNVL
.  |.|| | .|   |           .. .|. .  ||....| .  |. ..           |.. ..  ..||  | |.||| |.|.| | |. |.|
NHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQ-IAYICRQILKGLLYYLHSHHIIHRDIKPANIL

VWEFPIAGMPRKERLKYAGNVWLKIADYGISQ-VATSMM--------------MKVTTNQPGTPGYMAPELFETGQEI----YSTKVDVFAYGMTLYEII
.                      |..| |..  .. ||                . ..   ||| .||||  . ...     |.||.|.   | |. | .
L---------------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA

SLQAPFQKQEAMKRNAEVRAGK-------------RPPTGNKE------------------KHTPLLLQDLMRLCWSKDPSARPKMKECLQ----WT
  . |. .   |.   .   ..              ||   ..                  ..    ..| ...|  |||. ||. .. |.    . 
TGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase AqueK496.AA Ciliate-E2 1787-2085 17 5.1e-33 110.68 In-house 1-362 (365) Show / Hide 
Range on Protein: 1787-2085
Range on HMM: 1-362/365
Sequence Identity: 17% (71 aa)

ILEKEVLGKGGYGFVCTGELKGPTGSPPELVAVKVFLTNL------EGKIDSLSSAELLEEAAKDSQLRSAYKEIR---------QEVNFLSTLKHQNIT
.   ...|.|..| |. .. .    . ....| |..  ..      . | ..   |    .  .  |. .  ...|         .| | |..|.| || 
YKFIKKIGQGNFGSVYKCKVW----KVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNII

KLIGVR---TKPVYCLLLELAPMKSLRSMLKDYQLCKLTM----EPITLKQCA---KQISD---------------GLNYLHTHQ-IVHLDMKSPNVLVW
|.. .    ..  . | .|..  ..|.. .|. .....      ...|.|...   ||| .               .|.|||    |.| | |  |.|. 
KMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-

EFPIAGMPRKERLKYAGNVWLKIADYGISQVATSM-----------MMKVTTNQP--------------------GTPGYMAPELFE-------TGQEIY
                    .||.| |.|. ..             ...   |.                     ||||||||| ..       ..|. |
--------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGY

STKVDVFAYGMTLYEIISLQAPFQKQEAMKRNAEVRAGKRPPTGN--------------KEKHTPLLLQDLMRL----CWSKDPSARPK-MKECLQW
..|.|... |..||| .. . ||          .   .|     .              . |. ..  .||..     .  |||. |.  ....|..
DYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNH
Kinase AqueK496.AA Pkinase 1787-2084 21 1.2e-32 116.51 Pfam 1-289 (293) Show / Hide 
Range on Protein: 1787-2084
Range on HMM: 1-289/293
Sequence Identity: 21% (71 aa)

ILEKEVLGKGGYGFVCTGELKGPTGSPPELVAVKVFLTNLEGKIDS-----LSSAELLEEAAKDSQLRSAYKEIRQEVNFLSTLKHQNITKLIGVR-TKP
.  ....|.|..| |. .  || ||    .||||..    | .        |                       .|.  .  |.| || .|...  .|.
YHIGRKIGSGSFGCVYKCHHKG-TGK---IVAVKIIKKRHEKSWKDQTHRRL-----------------------SEIQIMKRLNHPNIVRLYDWFEDKD

VYCLLLELAPMK----SLRSMLK-DYQLCKLTMEPITLKQCAKQISDGLNYLHTHQIVHLDMKSPNVLVWEFPIAGMPRKERLKYAGNVWLKIADYGISQ
 ... .|....     .| .... ... | . ... ..| ...||  ||.|.| . |.| |.|. |.|. . .  .              .||.| |.. 
HIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA------------CVKICDFGLAK

VATSMMMKVTTNQPGTPGYMAPELFETGQEIYSTKVDVFAYGMTLYEIISLQAPFQKQ------EAMKRNAEVRAGKRPPTGNKEKHTP-----------
..     ...|   |||.|||||.   |.. |..|||....| .||| .. . ||. .      . |.. .... .. .    ..   .           
QFD-Y-NNSMTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHW

------LLLQDLMRLCWSKDPSARPKMKECLQ
        ..|... |. |||. ||  ...||
TFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ
Kinase AqueK496.AA CAMK 1792-2086 16 5.4e-26 80.14 In-house 1-425 (425) Show / Hide 
Range on Protein: 1792-2086
Range on HMM: 1-425/425
Sequence Identity: 16% (73 aa)

VLGKGGYGFVCTGELKGPTGSP--------PELVAVKVFLTNLEGK------IDSLSSAELLEEAAKDSQLR---SAYKEIRQEVNFLST-------LKH
.||.|..| |  .. |  ||          .. ||.|.  ..   .      . .. .  .  . .|... .   .  |..|.|.. ...       |.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYS-NC-Y-KIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDH

QNITKLIGVRTKPV--------------------YCLLL---ELAPMK----SLRSMLKDY-----------QLCKL-TMEPITLKQCAKQISDGLNYLH
 || ||. |   |                     ... .   |...       | .....             . .   ..    ... .|| ....|.|
PNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCH

THQIVHLDMKSPNVLVWE-------------FPIAGMPRKERLKYAGNVW-LKIADYGISQVATS-------------------------MMMKVTTNQP
 | |||.| |  |.|. .             |.             .|.. .||.| | ... ..                          .||      
SHNIVHRDLKPENILLDDNNDDSDPVEHDEIFD-------------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFC---

GTPGYMA-PELFET-G-----------QEIYSTKVDVFAYGMTLYEIISLQAPFQKQ-------------EAMKRNAEVRAGKRPPTGNKEKHTP-----
|||.||| ||...  |           .. |. |.|. . |  ||   .   ||.               .  .    ...||      . ....     
GTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGP

---------------LLLQDLMRLCWSKDPSARPKMKECLQ--WT
                  .|| | .  .||. |.. ..||.  | 
EWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase AqueK496.AA TyrKc 1787-2086 20 6.1e-25 90.09 SMART 1-280 (280) Show / Hide 
Range on Protein: 1787-2086
Range on HMM: 1-280/280
Sequence Identity: 20% (70 aa)

ILEKEVLGKGGYGFVCTGELKGPTGSPPELVAVKVFLTNLEGKIDSLSSAELLEEAAKDSQLRSAYKEIRQEVNFLSTL--KHQNITKLIGVRTK-----
|  ...|| | .| |. |..|       . ||||.   .                           .....| . .. |  .|.|| .|.|| |.     
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-------------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNF

---PVYCLLLELAPMKSLRSMLKDYQLCKLTMEPITLKQCAKQISDGLNYLHTHQIVHLDMKSPNVLVWEFPIAGMPRKERLKYAGNVWLKIADYGISQV
   . .....|..|  .|.. |....       . .| . . ||..| .||| ....| |    |.|| |                    ||.| | |  
MYIEPLMIVMEYMPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----------------TVKISDFGLSRD

ATSM--------MMKV----TTNQPGTPGYMAPELFETGQEIYSTKVDVFAYGMTLYEIISLQAPFQKQEAM--KRNAEVRA----GKRPPTGNKEKH--
 ..         . ..     .. .     |||| . .|  ...|| ||...| ...|| .. ..    ..   . |.||..    |.|.|   . ..  
IYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG--KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMP---QPPNDY

------TPLLLQDLMRLCWSKDPSARPKMKECLQWT
       |  . ..|. ||  ||. || ..|. .  
PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK496.AA RIPK 1967-2086 25 7.8e-21 67.71 In-house 149-290 (290) Show / Hide 
Range on Protein: 1967-2086
Range on HMM: 149-290/290
Sequence Identity: 25% (36 aa)

KIADYGISQV-ATSMMMK---------VTTNQP--GTPGYMAPELFETGQEIY----STKVDVFAYGMTLYEIISLQAPFQK-QEAMKRNAEVRAGKRPP
|||| | .    .|  ..          .. ..  ||  ||.||.|.|..       ..| ||  ......|. .   |.      | . . . .|.||.
KIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPC

TGNKEKHTP-----LLLQDLMRLCWSKDPSARPKMKECLQWT
.    . .|       . .||..||. || .||   ||  ||
LQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase AqueK496.AA TAK1 1966-2085 26 1.3e-20 66.21 In-house 145-284 (284) Show / Hide 
Range on Protein: 1966-2085
Range on HMM: 145-284/284
Sequence Identity: 26% (38 aa)

LKIADYGISQVATSMMMKVTTNQPGTPGYMAPEL----------------------FETGQEIYSTKVDVFAYGMTLYEIISLQAPFQKQEA----MKRN
||| | |    ...|    | |. ||. .||||                       |.   | |. | |.. .| .. |.|| . |... .      .  
LKICDFGT---FCDMHQMMTCNR-GTCRWMAPEVRELFDFKSNRIIINQPTGFQKVFRC--EKYNMKCDIYSWGIIMWEVISRKHPYDHIMNPNSAYRIM

AEVRAGKRPPTGNKEKHTPLLLQDLMRLCWSKDPSARPKMKECLQW
  .  |.|||        |  . ..|  ||...|. || |.||  .
WAIHNGNRPPMETNRSDCPKRIEQFMKCCWDDNPEKRPSMQECVKY
Kinase AqueK496.AA TK 1967-2086 19 1.3e-17 54.85 In-house 291-486 (486) Show / Hide 
Range on Protein: 1967-2086
Range on HMM: 291-486/486
Sequence Identity: 19% (38 aa)

KIADYGISQ-----VATSMMMK---VTTNQPGTPG-------------------------YMAPELFETGQE-------IYSTKVDVFAYGMTLYEIISL
||||.| |       |  .  .   ......||..                         .|||| ......       ...|| ||...| ...|| ..
KIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTY

Q-APFQK-------------QEAMKRNA-----------EVRAGKRPP--TGNKE---------KHTPLLLQDLMRLCWSKDPSARPKMKECLQWT
  .|.               || |..             ||  . |.|   .  .          . | ...|||. ||..||. || ......  
GQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK496.AA TK 1787-1944 15 3.8e-16 49.9 In-house 1-273 (486) Show / Hide 
Range on Protein: 1787-1944
Range on HMM: 1-273/486
Sequence Identity: 15% (44 aa)

ILEKEVLGKGGYG---FVCTGELKGP---------------------TGSPPELVAVKVFLTNLEGKIDSLSSAELLEEAAKDSQLRSAYKEIR----QE
|   ..||.| .|    |. ||..|.                     ..  .. ||||.     .   .    .|. .    |        .      .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHD--R-D--------G-GEDFLEE

VNFLSTLK-----HQNITKLIG----VRTK---------PVYCLLLELAPMKS----LRSMLKDY-----------------------------------
.. .. ..     |.|| .|.|    ...|         . .....|..|  .    ||. |..                                    
AEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSH

----------------------------------QLCKLT----MEPITLKQCAKQISDGLNYLHTH------QIVHLDMKSPNVLV
                                  |.| ||    . . .|  .. ||..|. ||| .      ..|| |    |.||
ESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWC-LTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLV
Kinase AqueK496.AA Pkinase_Tyr 1787-1934 25 2e-14 49.48 Pfam 1-134 (270) Show / Hide 
Range on Protein: 1787-1934
Range on HMM: 1-134/270
Sequence Identity: 25% (39 aa)

ILEKEVLGKGGYGFVCTGELKGPTGSPPELVAVKVFLTNLEGKIDSLSSAELLEEAAKDSQLRSAYKEIRQEVNFLSTL-KHQNITKLIGVRT---KP-V
|   ..||.| .| |. |..||  ...   ||||.                   | | ..|.    ..  .|.. ...| .|.|| .|.|| |   .|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----------------EGAMHEQN--CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQ

YCLLLELAPMKSLRSMLKDYQLCKLTMEPITLKQCAKQISDGLNYLHTHQIVH
... .|..|  .|.. |..    |    . .| | . ||..|..||. ....|
IYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH
Kinase AqueK496.AA Pkinase_Tyr 1995-2084 29 8.2e-13 44.01 Pfam 181-268 (270) Show / Hide 
Range on Protein: 1995-2084
Range on HMM: 181-268/270
Sequence Identity: 29% (27 aa)

MAPELFETGQEIYSTKVDVFAYGMTLYEIISL-QAP-FQKQEAMKRNAEV-RAGKRPPTGNKEKHTPLLLQDLMRLCWSKDPSARPKMKECLQ
|||| . .|   ..|| || ..| ...||... . | ..        . . . | | |     ...|  . |||..|| .||. || ..|...
MAPECINYGK--FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC---PENCPDEIYDLMKQCWHYDPEDRPTFSEIHE
Kinase AqueK496.AA TAK1 1853-1943 28 5e-08 23.09 In-house 43-137 (284) Show / Hide 
Range on Protein: 1853-1943
Range on HMM: 43-137/284
Sequence Identity: 28% (28 aa)

KEIRQEVNFLSTLKHQNITKLIG--VRTKPVYCLLLELAPMKSLRSMLKD-YQLCKLTMEPITLKQCAKQISDGLNYLHTHQ---IVHLDMKSPNVL
|.|. |.  .|  .| || ||.|   ...   ||. | .   || . | .  .    |..       . |.. |..|||  |   ..| | | .| |
KNIEREIMQWSRVDHPNIIKLYGMYACHRQCQCLVMEYMDCGSLHNFLHGAKPKWEYTHAHAM--SWMHQCAQGVAYLHSMQPKPQIHRDIKPQNML
Kinase AqueK496.AA RIPK 1918-1944 44 9e-06 15.67 In-house 114-142 (290) Show / Hide 
Range on Protein: 1918-1944
Range on HMM: 114-142/290
Sequence Identity: 44% (13 aa)

KQISDGLNYLHTHQ--IVHLDMKSPNVLV
..|| | .|||  .  | |.| |  |.||
HEISCGMCYLHSMNPPIIHRDLKPENILV
Kinase AqueK496.AA TAK1 1787-1802 50 0.000504 9.37 In-house 1-16 (284) Show / Hide 
Range on Protein: 1787-1802
Range on HMM: 1-16/284
Sequence Identity: 50% (8 aa)

ILEKEVLGKGGYGFVC
|. ....||| || ||
IQNEHFVGKGTYGVVC
Kinase AqueK496.AA MLK 1787-1820 32 0.002091 7.83 In-house 1-33 (291) Show / Hide 
Range on Protein: 1787-1820
Range on HMM: 1-33/291
Sequence Identity: 32% (11 aa)

ILEKEVLGKGGYGFVCTGELKGPTGSPPELVAVK
|...|..|.|..| |. |. .. ...    ||||
IQFHEWIGSGSFGKVWKGRWRNKDIV-AKIVAVK