Gene AqueK497 (A.queenslandica)

AqueK497

Species: A.queenslandica
Alias: AqueK497
External Links:
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
AqueK497.AA Protein None 1186 None Fasta, JSON
AqueK497.kin_dom Protein Kinase Domain None 309 None Fasta, JSON

Protein domain

Protein domains of AqueK497.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK497.AA LRRK 152-465 26 4.1e-91 309.02 In-house 1-351 (351) Show / Hide 
Range on Protein: 152-465
Range on HMM: 1-351/351
Sequence Identity: 26% (103 aa)

FEFNPKDLSTRLGRGGAG-AVYKGKYRN----------------------------VPVAVKEFLTQ------SQADAFQDEDELPPGGIHTYHDDDSIS
......     .|||| |  ||..|.|.                             .||.| ...       .  .                      |
LKIEEQ-----IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDND-CN---------------------NS

SG--------------------EALFLYRDMRQEVTVLAQLSHPNIVSILGVSLRPMCIALELAPMGSLFGILDKKLEA----IKTAQADLPTANIKMPG
..                    ...  .|  |.||...  | ||||||..|....|.|...|.|| |.|   | .| .     .|               
NNNNNLNNNNSEQVEDMDQNHEDCCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMK---------------

GVLGHQISARIALQVALATRYLHKIG--IVYRDLKSDNVLIWSLD-------VNESVNAKLADYGISR--FANPGG-IKGEEGTPGYMAPEAIKRRGEDQ
 ......  .||||.| . .|||.    |..|||||.|.|.||..       .|. |.||.||.||||  .. . | .|| .|.||.|||| ..  ||  
AHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGE-E

AFDEKVDIFSFGMLLFELITGQ-RPFESMS-T-----GQEVNRAVIQRERPQVSEGNMEPS---FPGMIELMEDCWRHLAADRPTADEVVQRISA
 ..||||..||||.|.||.|.| .||. ..         ..  ..|   || ...   .|    .. . .|...|| |   .||.. ..|.|.| 
EYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQH-YCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK497.AA TKL 163-463 22 2.5e-73 249.9 In-house 1-364 (364) Show / Hide 
Range on Protein: 163-463
Range on HMM: 1-364/364
Sequence Identity: 22% (91 aa)

LGRGGAGAVYKGKYRN----------VPVAVKEFLT---QSQADAFQDEDELPPGGIHTYHDDDSI-------SSGEALFLYRDMRQEVTVLAQLSHPNI
.|.|| | |||||.|.           .|||| | .   ..  .  |..             | ..        . || ..    ..|. .. .|.||||
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQEN------------ND-NNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNI

VSILG---------VSLRP------MCIALELAPMGSLFGILDKKLEAIKTAQADLPTANIKMPGGVLGHQISARIALQVALATRYLHKIG--------I
|...|         |...|      .||  |..| |||. .|                           ..   |.||..|..  |||  .        |
VQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPI

VYRDLKSDNVLIWSL---------DVNESVNAKLADYGISRFANPGG--------------------IKGEEG-TPGYMAPEAIKRRGEDQ---------
..|||||.|.|...          ..|. ...|..|.|.||| .. |                     .. .. ||..||||...  ....         
IHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFC

---AFDEKVDIFSFGMLLFELITGQRPFESMSTGQEV---------NRAVIQRERPQVSEGNM--------EPSFPGMIELMEDCWRHLAADRPTADEVV
    ..||.|..|||..|.|..|..||.. .   ...           ..  ..|| . .  .        ..  |.|..||.||| | . .||...|..
KGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEIL

QRI
.|.
KRL
Kinase AqueK497.AA Pkinase 157-463 18 9e-46 162.93 Pfam 1-293 (293) Show / Hide 
Range on Protein: 157-463
Range on HMM: 1-293/293
Sequence Identity: 18% (65 aa)

KDLSTRLGRGGAGAVYKGKYRNVP--VAVKEFLTQSQADAFQDEDELPPGGIHTYHDDDSISSGEALFLYRDMRQEVTVLAQLSHPNIVSILGVSLRP--
  .  ..|.|. | |||.. .. .  ||||..  ... . .. .. .                           .|. ... |.||||| ....  ..  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--------------------------SEIQIMKRLNHPNIVRLYDWFEDKDH

MCIALELAPMG----SLF----GILDKKLEAIKTAQADLPTANIKMPGGVL--GHQISARIALQVALATRYLHKIGIVYRDLKSDNVLIWSLDVNESVNA
... .|....|    .||    .                      . .|..    .   ....|.. .  |.|. ||..||||..|.||     ..  . 
IYMVMEYCEGGLYVMDLFDYIST----------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI-----DNNGHI

----KLADYGISR---FANPGGIKGEEGTPGYMAPEAIKRRGEDQAFDEKVDIFSFGMLLFELITGQRPFESMS----TGQEVNRAVIQRERPQVSEGNM
    |..| |...     | .  ..  |||.||||| |.   ..|  . |||..|.| .|.|...|. ||   .    .  . .  . .. .|....   
DACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWP

EPSF-------------------PGMIELMEDCWRHLAADRPTADEVVQR--I
...                    . .......|..   ..||||....|   .
WWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK497.AA S_TKc 157-469 20 3.1e-39 137.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 157-469
Range on HMM: 1-231/231
Sequence Identity: 20% (66 aa)

KDLSTRLGRGGAGAVYKGKYRN--VPVAVKEFLTQSQADAFQDEDELPPGGIHTYHDDDSISSGEALFLYRDMRQEVTVLAQLSHPNIVSILGVSL-RPM
 ..   .|.|. | |||.. ..    ||.|.                                       ...|.|. .| .  ||||| ...|     .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------EHIRREIQILKK-HHPNIVKLYDVFQDDHL

CIALELAPM--GSLFGILDKKLEAIKTAQADLPTANIKMPGGV------LGHQISARIALQVALATRYLHKIGIVYRDLKSDNVLIWSLDVNESVNAKLA
.. .|...   |.|| ...|.                    |       .     .... |...|  |.|. ||..|||| .|.|. .       . |..
YMVMEYCDGDLGDLFDYIKKR--------------------GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKIC

DYGISRFANPGGIKGEEGTPGYMAPEAIKRRGEDQAFDE-KVDIFSFGMLLFELITGQRPFESMSTGQEVNRAVIQRERPQVSEGNMEPSFPGMIELMED
| |..|.      .   ||| ||||| .        ..  |.|. |.| .|.|...|. ||.          ..... .            | ...... 
DFGLARQL-----TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG-----------SPEAKDFIRK

CWRHLAADRPTADEVVQ---RISAPGFL
|..   ..|||| |. |    | .  ..
CLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK497.AA MLK 225-463 28 1.6e-37 127.74 In-house 50-291 (291) Show / Hide 
Range on Protein: 225-463
Range on HMM: 50-291/291
Sequence Identity: 28% (75 aa)

RDMRQEVTVLAQLSHPN----IVSILGVSLRP---MCIALELAPMGSLFGIL---DKKLEAIKTAQADLPTANIKMPGGVLGHQISARIALQVALATRYL
.|...|.  |. |||||    |. ..||.|.|    || .| .. |||. .|   ..| ..           | |   .|  |.  ...|||.| .  ||
WDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDAN--------HNQK-NDRVYDHDHAMNWALQCARGMHYL

HKIG---IVYRDLKSDNVLIW---SLDVNESVNAKLADYGISRFANPGGIK---GEEGTPGYMAPEAIKR-RGEDQAFDEKVDIFSFGMLLFELITGQRP
|.     |. ||||| |.||    . | .. . .| .| |.||. .  . .   .  ||. .||||.|.. |.|   ..||.|..|.|..| |..|.. |
HSMAPKPIIHRDLKSHNILIDEICH-DMHHGT-LKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCE--KYSEKCDVWSWGVVLWEMLTREVP

FE-SMSTGQEVNRAVIQRERPQVSEGNMEPSFPGMIELMEDCWRHLAADRPTADEVVQRI
..  ..  .    ..  ..|| .  .      ... .||..||   ...||. ...||  
YKQHYDPMAIAWWVAYNGLRPPIPST----CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK497.AA TK 225-463 17 1.6e-36 119.42 In-house 74-486 (486) Show / Hide 
Range on Protein: 225-463
Range on HMM: 74-486/486
Sequence Identity: 17% (74 aa)

RDMR---------QEVTVLAQLS-----HPNIVSILGVSLRP--------------MCIALELAPMGS----LFGILDKKLEAIKTAQADLPTAN-----
..|.         .|. ......     |||||...||....              ..| .|..| |.    |   | |. .  .. |   .. .     
EEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPP

-------------------------------IKMPGGVLGHQISAR-------------------IALQVALATRYLHKI------GIVYRDLKSDNVLI
                               ||. .  |...   .                   ...|.| . .|||.       ..| |||   |.|.
SKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLV

WSLDV------NESVNAKLADYGIS--------RFANPG---GIKGEEGTPG-------------------------YMAPEAIKRRGEDQA-----FDE
 . .|      .    .|.||.| |        |  ...     |...||..                         .||||... | . .|     | .
GENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTT

KVDIFSFGMLLFELIT-GQRPFESMSTG---------QEVNRAVIQRERP------QVSEGNMEP---SFP--------------GMI-ELMEDCWRHLA
| |..||| |..|. | || |.  . .          ||| . . .  |.      .| ...  |     |               .. .|| .||.. .
KSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDP

ADRPTADEVVQRI
.|||| .......
EDRPTFSQLHEQL
Kinase AqueK497.AA STE 157-409 18 3.3e-33 114.64 In-house 1-272 (359) Show / Hide 
Range on Protein: 157-409
Range on HMM: 1-272/359
Sequence Identity: 18% (60 aa)

KDLSTRLGRGGAGAVYKGKYR-----------------NVPVAVKEFLTQSQ-ADAFQDEDELPPGGIHTYHDDDSISSGEAL-----------FLYRDM
 ..  ..|.|. | |||....                 .. .|.|.   ... .   .                        .               . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-E------------------------NQENQELENKNHEEMQQI

RQEVTVLAQLS--HPNIVSILGVSLRP---------MCIALELAPMGSLFGILDKKLEAIKT----AQADLPTANIKMPGGVLGHQISARIALQVALA-T
 .|. .. ...  |||||  .|  ..           .|..|. . |||  |...| .  |.     |           ....  .. |.|. |.  .  
LKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQ---------H-QHRFPESQIAYICRQILKGLL

RYLHKIGIVYRDLKSDNVLIWSLDVNESVNAKLADYGISRFANPGGI-------------KGEE-----GTPGYMAPEAIKRRGED--QAFDEKVDIFSF
 |||. .|. ||.|..|.|.          .||.| |..   .. .               ...     ||| .|||| |...|..  .  |.|.|| |.
YYLHSHHIIHRDIKPANILL----------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSL

GMLLFELITGQRPFESMS
| .. |..||. |.  |.
GCTIIEMATGKPPWHDMH
Kinase AqueK497.AA TKL-Unique 302-463 26 4.7e-31 106.81 In-house 114-290 (290) Show / Hide 
Range on Protein: 302-463
Range on HMM: 114-290/290
Sequence Identity: 26% (48 aa)

RIALQVALATRYLHKIG--IVYRDLKSDNVLIWSLDVNESVNAKLADYGISRFAN--PGGIKGEE---------GTPGYMAPEAIKRRGEDQAFDEKVDI
..|...|..  |||  .  |  ||||| |.|. .      .|.|..| |.|.|..    ....|          |.. .|||| ...      ..||.|.
KMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF--CQYSEKSDV

FSFGMLLFELITGQR------PFESMSTGQEVNRAVIQ---RERPQVSEGNMEPSFPGMIELMEDCWRHLAADRPTADEVVQRI
.|||. | |..|...      |...|.  ...  .| .   . || ... ......    .|...||.|   .||. ||.. |.
YSFGIVLWEIATRKITKTYKKPYQGMD-QEQWCEMVHYMEENYRPPIPN-HCPKEY---RDLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK497.AA TyrKc 157-463 23 7.5e-31 109.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 157-463
Range on HMM: 1-280/280
Sequence Identity: 23% (81 aa)

KDLSTRLGRGGAGAVYKGKYRNVPVAVKEFLTQSQADAFQDEDELPPGGIHTYHDDDSISSGEALFLYRDMRQEVTVLAQL--SHPNIVSILGVSL----
  |   ||.|  | ||||... ..||||     .                                  .|...|  .. .|  .||||| ..|| .    
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---------------------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGR

-----RPMCIALELAPMGSLFGILDKKLEAIKTAQADLPTANIKMPGGVLGHQISARIALQVALATRYLHKIGIVYRDLKSDNVLIWSLDVNESVNAKLA
      |..| .|..| |.|   | |. .                    | ..    ...|.|   .|||. ... |||   |.|. .        .| .
NFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKIS

DYGISRFANPG-------GIKGEE---GTPG-----YMAPEAIKRRGEDQAFDEKVDIFSFGMLLFELIT-GQRPFESM----STGQEVNRAVIQRERPQ
| | ||.   .         .      |. .      ||||.|     .  | .| |..||| ...|. | || | . |     . ||| . | |..|. 
DFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMP

VSEGNMEP-----SFPGMIELMEDCWRHLAADRPTADEVVQRI
  . .  |       . | ..|..||.. ..||||  |.....
QPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK497.AA Ciliate-E2 312-405 25 5.6e-30 100.09 In-house 174-296 (365) Show / Hide 
Range on Protein: 312-405
Range on HMM: 174-296/365
Sequence Identity: 25% (34 aa)

RYLHKIG-IVYRDLKSDNVLIWSLDVNESVNAKLADYGISRFANPGGIKGEE---------------------------------GTPGYMAPEAIKRRG
.|||. . |..||.| .|.|.           |..| |.|.....  ... .                                 ||||||||| ... .
EYLHSKNNIIHRDIKPENILF----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKK

ED-----QAFDEKVDIFSFGMLLFELITGQRPF
.|     .  |.|.||.|.|..|.|...|..||
YDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF
Kinase AqueK497.AA TK-Unique 225-463 25 1.6e-28 95.53 In-house 48-294 (294) Show / Hide 
Range on Protein: 225-463
Range on HMM: 48-294/294
Sequence Identity: 25% (66 aa)

RDMRQEVTVLAQLS-HPNIVSILGVSL---RPMCIALELAPMGSLFGILDKKLEAIKTAQ------ADLPTANIKMPGGVLGHQISARIALQVALATRYL
.|. .|  .. .|  |||||..||..     |..|..| .|.|.| . | ..  | .. |       |..... |..   .  .  ...| |.| .  ||
QDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYL

HK--IGIVYRDLKSDNVLIWSLDVNESVNAKLADYGISR-FANPGGIKGEE--GTPG--YMAPEAIKRRGEDQAF-DEKVDIFSFGMLLFELIT-GQRPF
..   .||.||| . |||. .       ..|..|.|..|   ..| .  ..  |.    .||||..|.   .. .  .| |. ||| |..|. | |..|.
ASQRKKIVHRDLCARNVLLTE-----DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCY--HGMYHTTKSDVWSFGVLMWEIFTLGACPY

ESMSTGQEVNRAVIQRERPQVSEGNMEPS-FPGMIELMEDCWRHLAADRPTADEVVQRI
 .|.  . . ... .  |... |.    .  . | .||. ||.. . .||. .....|.
PGMPWKD-IMECIRDGYRMPQPEH----CCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK497.AA RIPK 302-463 25 9.4e-27 88.18 In-house 111-290 (290) Show / Hide 
Range on Protein: 302-463
Range on HMM: 111-290/290
Sequence Identity: 25% (47 aa)

RIALQVALATRYLHKIG--IVYRDLKSDNVLIWSLDVNESVNAKLADYGISRFANPGGIKG--------------EE-GTPGYMAPEAIKRRGEDQA---
|.  .....  ||| ..  |  ||||  |.|   .| |   ..|.|| | . .      ..              .. ||  ||.||.. | ..  .   
RMIHEISCGMCYLHSMNPPIIHRDLKPENIL---VDNN--FHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHF-RTDNKKPIKV

FDEKVDIFSFGMLLFELITGQRPFESMSTGQEVNRAVIQRERPQVSEGNMEPSFPG------MIELMEDCWRHLAADRPTADEVVQRI
...| |. ||.....|. |.  |.|   . .     . |  ||....    ...|       |||||..||.  . |||.  |.  ..
VTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQP--VPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase AqueK497.AA Pkinase_Tyr 225-463 24 4.6e-26 88.91 Pfam 48-270 (270) Show / Hide 
Range on Protein: 225-463
Range on HMM: 48-270/270
Sequence Identity: 24% (63 aa)

RDMRQEVTVLAQL-SHPNIVSILGVSL---RP--MCIALELAPMGSLFGILDKKLEAIKTAQADLPTANIKMPGGVLGHQISARIALQVALATRYLHKIG
.|. .|. .. || .|||||. .|| .   .|  ..| .|..| |.|   | |.                 .... | ..    ...|.| .  ||. ..
EDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR----------------EDKQPLTMKDLLQMCWQIAKGMEYLESKN

IVYRDLKSDNVLIWSLDVNESVNAKLADYGISRFANPGGIKGEEG-TPG--------YMAPEAIKRRGEDQAFDEKVDIFSFGMLLFELIT-GQRP-FES
.. |||   |.|. .     .  .| .| | .|       . ..  . .         ||||.|. .     | .| |. ||| |..|..| |. | .. 
CIHRDLAARNCLVTE-----NNVVKICDFGLARDI----YNDDYYYRKRGGGKLPIKWMAPECINYGK----FTTKSDVWSFGVLMWEIFTYGEQPTYPG

MSTGQEVNRAV-IQRERPQVSEGNMEPSF---PGMIELMEDCWRHLAADRPTADEVVQRI
| . .|| ...  ...|       |..     . . .|| .||.. ..||||  |.....
M-SNEEVYEYIYEDGYR-------MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK497.AA Dicty4 302-465 30 5.8e-25 80.33 In-house 116-277 (277) Show / Hide 
Range on Protein: 302-465
Range on HMM: 116-277/277
Sequence Identity: 30% (53 aa)

RIALQVALATRYLHK-I-GIVYRDLKSDNVLIWSLDVNESVNAKLADYGISR----FANPGG-IKGEEGTPGYMAPEAIKRRGEDQAFDEKVDIFSFGML
|.|. .|.   .||  .  |. |||||.| |     | .. ..| .| |.|.      . .   ..  |||..||||        |...||.| .|||..
RMAFDAARGMNWLHCCNPVIIHRDLKSHNLL-----VDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMH----QPYNEKADVYSFGIV

LFELITGQRPFE-SMSTGQEVNRAVIQ-RERPQVSEGNMEPSFPGMIELMEDCWRHLAADRPTADEVVQR--ISA
|.|. |.| |.    .   .. ||| .  .|| ..  .  ||.   ..|...|| |    ||.  |..||    .
LWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPD-WCPPSW---KHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK497.AA Dicty4 226-269 34 5e-10 29.82 In-house 44-93 (277) Show / Hide 
Range on Protein: 226-269
Range on HMM: 44-93/277
Sequence Identity: 34% (17 aa)

DMRQEVTVLAQLSHPNIVSILGVSL----RP--MCIALELAPMGSLFGIL
. |.||. .....||||.  .| ..     |  |||  |. | |.|. .|
EFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLL
Kinase AqueK497.AA MLK 157-198 27 1.4e-08 25.97 In-house 1-55 (291) Show / Hide 
Range on Protein: 157-198
Range on HMM: 1-55/291
Sequence Identity: 27% (15 aa)

KDLSTRLGRGGAGAVYKGKYRNVP-----VAVKEFL--------TQSQADAFQDE
 .... .| |. |.|.||..||       ||||..         | .....|. |
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEME
Kinase AqueK497.AA TKL-Unique 159-186 53 5.1e-07 20.98 In-house 1-28 (290) Show / Hide 
Range on Protein: 159-186
Range on HMM: 1-28/290
Sequence Identity: 53% (15 aa)

LSTRLGRGGAGAVYKGKYRNVPVAVKEF
 .  .|.||.|.|||||.|  |||.| |
FWNKIGEGGYGQVYKGKWRGYPVAIKQF
Kinase AqueK497.AA TKL-Unique 228-265 37 3.4e-05 14.47 In-house 43-87 (290) Show / Hide 
Range on Protein: 228-265
Range on HMM: 43-87/290
Sequence Identity: 37% (17 aa)

RQEVTVLAQLS-HPNIVSILGVSL----RPM--CIALELAPMGSL
. ||...  |  ||||| . |..      |   || .|  |.|||
ENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSL
Kinase AqueK497.AA Dicty4 158-184 48 0.000203 10.84 In-house 2-28 (277) Show / Hide 
Range on Protein: 158-184
Range on HMM: 2-28/277
Sequence Identity: 48% (13 aa)

DLSTRLGRGGAGAVYKGKYRNVPVAVK
.   |.|.|. | ||||. |   ||||
NIEQRIGKGSFGEVYKGTWRGKEVAVK
Kinase AqueK497.AA RIPK 163-173 54 0.093669 1.72 In-house 1-11 (290) Show / Hide 
Range on Protein: 163-173
Range on HMM: 1-11/290
Sequence Identity: 54% (6 aa)

LGRGGAGAVYK
.|.|| | |.|
VGGGGFGEVFK
Kinase AqueK497.AA Ciliate-E2 157-243 17 0.109829 1.54 In-house 1-95 (365) Show / Hide 
Range on Protein: 157-243
Range on HMM: 1-95/365
Sequence Identity: 17% (20 aa)

KDLSTRLGRGGAGAVYKGKYRNVP-------------------------VAVKEFLTQSQADAFQDEDEL----PPGGIHTYHDDDSISSGEALFLYRDM
 ..   .|.|. | |||.| ..|.                         .|.| .  .     .| ....    . .                   |.  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-F-------------------YKKI

RQEVTVLAQLSHPNIV
 .|  .| ||.||||.
-NEKNILEQLNHPNII
Kinase AqueK497.AA Pkinase_Tyr 169-198 29 0.235618 5.21 Pfam 13-53 (270) Show / Hide 
Range on Protein: 169-198
Range on HMM: 13-53/270
Sequence Identity: 29% (12 aa)

GAVYKGKYR------NVPVAVKEF--LTQSQA---DAFQDE
| ||||...      ..|||||     . ...   ..|  |
GEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMRE
Kinase AqueK497.AA TKL 550-627 24 1.2e-20 71.12 In-house 270-364 (364) Show / Hide 
Range on Protein: 550-627
Range on HMM: 270-364/364
Sequence Identity: 24% (23 aa)

VDIFSFGMLLFELITGQRPFESMSTGQEV---------NRAVIQRERPQVSEGNM--------EPSFPGMIELMEDCWRHLAADRPTADEVVQRI
.|..|||..|.|..|..||.. .   ...           ..  ..|| . .  .        ..  |.|..||.||| | . .||...|...|.
CDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK497.AA LRRK 549-629 28 3.8e-20 67.94 In-house 262-351 (351) Show / Hide 
Range on Protein: 549-629
Range on HMM: 262-351/351
Sequence Identity: 28% (26 aa)

EVDIFSFGMLLFELITGQ-RPFESMS-T-----GQEVNRAVIQRERPQVSEGNMEPS---FPGMIELMEDCWRHLAADRPTADEVVQRISA
.||..||||.|.||.|.| .||. ..         ..  ..|   || ...   .|    .. . .|...|| |   .||.. ..|.|.| 
KVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQH-YCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK497.AA TK 551-627 22 1.7e-13 40.84 In-house 376-486 (486) Show / Hide 
Range on Protein: 551-627
Range on HMM: 376-486/486
Sequence Identity: 22% (25 aa)

DIFSFGMLLFELIT-GQRPFESMSTG---------QEVNRAVIQRERP------QVSEGNMEP---SFP--------------GMI-ELMEDCWRHLAAD
|..||| |..|. | || |.  . .          ||| . . .  |.      .| ...  |     |               .. .|| .||.. ..|
DVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPED

RPTADEVVQRI
||| .......
RPTFSQLHEQL
Kinase AqueK497.AA RIPK 551-627 26 4.4e-13 40.91 In-house 210-290 (290) Show / Hide 
Range on Protein: 551-627
Range on HMM: 210-290/290
Sequence Identity: 26% (22 aa)

DIFSFGMLLFELITGQRPFESMSTGQEVNRAVIQRERPQVSEGNMEPSFPG------MIELMEDCWRHLAADRPTADEVVQRI
|. ||.....|. |.  |.|   . .     . |  ||....    ...|       |||||..||.  . |||.  |.  ..
DVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQP--VPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase AqueK497.AA TKL-Unique 550-627 24 3.8e-12 39.31 In-house 209-290 (290) Show / Hide 
Range on Protein: 550-627
Range on HMM: 209-290/290
Sequence Identity: 24% (21 aa)

VDIFSFGMLLFELITGQR------PFESMSTGQEVNRAVIQ---RERPQVSEGNMEPSFPGMIELMEDCWRHLAADRPTADEVVQRI
.|..|||. | |..|...      |...|.  ...  .| .   . || ... ......    .|...||.|   .||. ||.. |.
SDVYSFGIVLWEIATRKITKTYKKPYQGMD-QEQWCEMVHYMEENYRPPIPN-HCPKEY---RDLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK497.AA MLK 550-627 21 6.4e-12 37.75 In-house 217-291 (291) Show / Hide 
Range on Protein: 550-627
Range on HMM: 217-291/291
Sequence Identity: 21% (17 aa)

VDIFSFGMLLFELITGQRPFE-SMSTGQEVNRAVIQRERPQVSEGNMEPSFPGMIELMEDCWRHLAADRPTADEVVQRI
.|..|.|..| |..|.. |..  ..  .    ..  ..|| .  .      ... .||..||   ...||. ...||  
CDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST----CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK497.AA Pkinase_Tyr 551-627 27 4.7e-11 38.05 Pfam 196-270 (270) Show / Hide 
Range on Protein: 551-627
Range on HMM: 196-270/270
Sequence Identity: 27% (23 aa)

DIFSFGMLLFELIT-GQRP-FESMSTGQEVNRAV-IQRERPQVSEGNMEPSF---PGMIELMEDCWRHLAADRPTADEVVQRI
|. ||| |..|..| |. | .. | . .|| ...  ...|       |..     . . .|| .||.. ..||||  |.....
DVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYR-------MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK497.AA Dicty4 547-629 28 1.2e-09 28.5 In-house 195-277 (277) Show / Hide 
Range on Protein: 547-629
Range on HMM: 195-277/277
Sequence Identity: 28% (25 aa)

TGEVDIFSFGMLLFELITGQRPFE-SMSTGQEVNRAVIQ-RERPQVSEGNMEPSFPGMIELMEDCWRHLAADRPTADEVVQR--ISA
.. .| .|||..|.|. |.| |.    .   .. ||| .  .|| ..  .  ||.   ..|...|| |    ||.  |..||    .
NEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPD-WCPPSW---KHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK497.AA TK-Unique 551-627 25 1.8e-09 28.91 In-house 221-294 (294) Show / Hide 
Range on Protein: 551-627
Range on HMM: 221-294/294
Sequence Identity: 25% (20 aa)

DIFSFGMLLFELIT-GQRPFESMSTGQEVNRAVIQRERPQVSEGNMEPS-FPGMIELMEDCWRHLAADRPTADEVVQRI
|. ||| |..|. | |..|. .|.  . . ... .  |... |.    .  . | .||. ||.. . .||. .....|.
DVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMPQPEH----CCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Pkinase AqueK497.AA Pkinase 547-627 15 3.2e-08 30.16 Pfam 190-293 (293) Show / Hide 
Range on Protein: 547-627
Range on HMM: 190-293/293
Sequence Identity: 15% (16 aa)

TGEVDIFSFGMLLFELITGQRPFESMS----TGQEVNRAVIQRERPQVSEGNMEPSF-------------------PGMIELMEDCWRHLAADRPTADEV
. .||..|.| .|.|...|. ||   .    .  . .  . .. .|....   ...                    . .......|..   ..||||...
GPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

VQR--I
.|   .
LQHPWF
Kinase AqueK497.AA Ciliate-E2 549-569 42 1e-06 19.01 In-house 276-296 (365) Show / Hide 
Range on Protein: 549-569
Range on HMM: 276-296/365
Sequence Identity: 42% (9 aa)

EVDIFSFGMLLFELITGQRPF
..||.|.|..|.|...|..||
KCDIWSLGVILYEMLFGKPPF
Kinase AqueK497.AA STE 550-573 37 0.003124 7.41 In-house 249-272 (359) Show / Hide 
Range on Protein: 550-573
Range on HMM: 249-272/359
Sequence Identity: 37% (9 aa)

VDIFSFGMLLFELITGQRPFESMS
.|| |.| .. |..||. |.  |.
CDIWSLGCTIIEMATGKPPWHDMH