Gene AqueK498 (A.queenslandica)

AqueK498

Species: A.queenslandica
Alias: AqueK498
External Links:
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
AqueK498.AA Protein None 2872 None Fasta, JSON
AqueK498.kin_dom Protein Kinase Domain None 355 None Fasta, JSON

Protein domain

Protein domains of AqueK498.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank AqueK498.AA Ank 46-78 39 9.2e-09 35.87 Pfam 1-33 (33) Show / Hide 
Range on Protein: 46-78
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

RGYTLLHYAAERDRPESLKILLINGADPNIRTS
 |.| ||.|......| .| || .|||.|... 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK498.AA Ank 82-114 36 7.9e-08 32.49 Pfam 1-33 (33) Show / Hide 
Range on Protein: 82-114
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

FEITPLHIAAANGHLDCLKRLVESGGDPLLRDS
   ||||.|. .||....| |.. | |. ..| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK498.AA Ank 243-275 24 0.015353 13.42 Pfam 1-33 (33) Show / Hide 
Range on Protein: 243-275
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

HYVTILHAAVQYNHISLVSFLVSNYPSLLTQPS
.  | || |....|.. |..|...  ..  |  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK498.AA Ank 277-309 27 0.001602 16.96 Pfam 1-33 (33) Show / Hide 
Range on Protein: 277-309
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

EGYTALHVAVSHKCFEIVQILTEAYMNIYRQRS
.|.|.||.|... . |.|. | ..  ..  |  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK498.AA Ank 339-362 33 2.379762 5.52 Pfam 1-24 (33) Show / Hide 
Range on Protein: 339-362
Range on HMM: 1-24/33
Sequence Identity: 33% (8 aa)

TGHTPLHMSVALCEREITLLFLSH
 | ||||. .     |.  ..|.|
DGFTPLHLACRCGHTEVVKMLLQH
Ank AqueK498.AA Ank 375-407 39 3.9e-09 37.2 Pfam 1-33 (33) Show / Hide 
Range on Protein: 375-407
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

CGYTALHLAVHFNQPEMAALLLSNGANPNATLA
.|.|.||||.. ...|.. .||..||..||.  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK498.AA Ank 417-445 24 0.165049 9.7 Pfam 5-33 (33) Show / Hide 
Range on Protein: 417-445
Range on HMM: 5-33/33
Sequence Identity: 24% (7 aa)

PLAEAAINNNPLMIRTLVSYGAEDRRHDA
||  |...... ... |...||.   .| 
PLHLACRCGHTEVVKMLLQHGADVNAQDD
LRR_1 AqueK498.AA LRR_1 561-581 33 0.002471 15.99 Pfam 1-26 (26) Show / Hide 
Range on Protein: 561-581
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLTTLNLSH-N--CL-GELPD--VVPM
||..|.||. |  .| |..|.     .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP AqueK498.AA LRR_TYP 559-582 41 0.002781 18.15 SMART 1-24 (24) Show / Hide 
Range on Protein: 559-582
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

LQNLTTLNLSHNCLGELPDVVPMA
| ||..|.||.| | .||. .   
LPNLRELDLSNNQLTHLPPGAFQG
LRR_BAC AqueK498.AA LRR_BAC 559-578 45 0.020147 14.17 SMART 1-20 (20) Show / Hide 
Range on Protein: 559-578
Range on HMM: 1-20/20
Sequence Identity: 45% (9 aa)

LQNLTTLNLSHNCLGELPDV
 ..|..|| |.| | |||. 
PPHLKWLNVSNNQLTELPEL
LRR_1 AqueK498.AA LRR_1 538-559 29 1.143058 6.54 Pfam 1-26 (26) Show / Hide 
Range on Protein: 538-559
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

FINRLNISK-N--KLT-FVPIE-FFRL
 . .|..|  |  .||  .| . |  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_BAC AqueK498.AA LRR_BAC 615-634 55 6.1e-05 23.65 SMART 1-20 (20) Show / Hide 
Range on Protein: 615-634
Range on HMM: 1-20/20
Sequence Identity: 55% (11 aa)

LPQLSILDASHNQLTALPVL
 |.| .|..|.|||| || |
PPHLKWLNVSNNQLTELPEL
LRR_1 AqueK498.AA LRR_1 594-615 29 0.017565 12.97 Pfam 1-26 (26) Show / Hide 
Range on Protein: 594-615
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLNKLDISH-N--QL-KELPIY-LFEL
.| .||.|. |  .| ...|   .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP AqueK498.AA LRR_TYP 592-615 41 0.018667 14.02 SMART 1-24 (24) Show / Hide 
Range on Protein: 592-615
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

CGSLNKLDISHNQLKELPIYLFEL
 ..| .|| |.|||..||  .|. 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP AqueK498.AA LRR_TYP 616-638 47 0.120972 7.37 SMART 2-24 (24) Show / Hide 
Range on Protein: 616-638
Range on HMM: 2-24/24
Sequence Identity: 47% (11 aa)

PQLSILDASHNQLTALPVLMWSA
|.|  || |.||||.||  ... 
PNLRELDLSNNQLTHLPPGAFQG
LRR_BAC AqueK498.AA LRR_BAC 592-611 45 0.121983 8.2 SMART 1-20 (20) Show / Hide 
Range on Protein: 592-611
Range on HMM: 1-20/20
Sequence Identity: 45% (9 aa)

CGSLNKLDISHNQLKELPIY
  .| .|..|.|||.|||  
PPHLKWLNVSNNQLTELPEL
LRR_1 AqueK498.AA LRR_1 640-661 22 0.156706 9.6 Pfam 1-26 (26) Show / Hide 
Range on Protein: 640-661
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

KLSSLNCSH-N--TIQ-EIPTN-LSYV
.| .|. |. |   .. .|| . .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_BAC AqueK498.AA LRR_BAC 638-657 40 0.457117 3.82 SMART 1-20 (20) Show / Hide 
Range on Protein: 638-657
Range on HMM: 1-20/20
Sequence Identity: 40% (8 aa)

APKLSSLNCSHNTIQEIPTN
 |.| .|| |.| . | | .
PPHLKWLNVSNNQLTELPEL
LRR_1 AqueK498.AA LRR_1 617-639 29 1.071191 6.64 Pfam 1-26 (26) Show / Hide 
Range on Protein: 617-639
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

QLSILDASH-N--QLT-ALPVLMWSAP
.| .|| |. |  .||  .|     . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK498.AA LRR_1 795-822 24 0.004022 15.24 Pfam 1-26 (26) Show / Hide 
Range on Protein: 795-822
Range on HMM: 1-26/26
Sequence Identity: 24% (8 aa)

KLTRLDLSH-N--GIS-DLALPRAVPSN-LKQL
.|..||||. |   .. .      .|.. . .|
NLQHLDLSGCNCCNLTGH------IPPSCF-NL
LRR_1 AqueK498.AA LRR_1 771-792 29 0.037067 11.82 Pfam 1-26 (26) Show / Hide 
Range on Protein: 771-792
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

GLNNLNLSH-N--EI-KVIPSN-LPCL
 |  |.||. |   . . ||.. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP AqueK498.AA LRR_TYP 769-792 25 0.063563 9.66 SMART 1-24 (24) Show / Hide 
Range on Protein: 769-792
Range on HMM: 1-24/24
Sequence Identity: 25% (6 aa)

FDGLNNLNLSHNEIKVIPSNLPCL
   |  |.||.| .. .|...   
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP AqueK498.AA LRR_TYP 793-818 30 0.359899 3.49 SMART 1-24 (24) Show / Hide 
Range on Protein: 793-818
Range on HMM: 1-24/24
Sequence Identity: 30% (8 aa)

CPKLTRLDLSHNGISDLALPRAVPSN
 |.|..||||.| .. |   . . ..
LPNLRELDLSNNQLTHLP--PGAFQG
LRR_BAC AqueK498.AA LRR_BAC 816-835 45 0.415065 4.14 SMART 1-20 (20) Show / Hide 
Range on Protein: 816-835
Range on HMM: 1-20/20
Sequence Identity: 45% (9 aa)

PSNLKQLNVSHNDILRLDSY
|..|| ||||.| . .|   
PPHLKWLNVSNNQLTELPEL
LRR_BAC AqueK498.AA LRR_BAC 769-788 30 0.956897 1.37 SMART 1-20 (20) Show / Hide 
Range on Protein: 769-788
Range on HMM: 1-20/20
Sequence Identity: 30% (6 aa)

FDGLNNLNLSHNEIKVIPSN
 . |  || |.|...  | .
PPHLKWLNVSNNQLTELPEL
LRR_TYP AqueK498.AA LRR_TYP 874-897 29 0.409554 3.03 SMART 1-24 (24) Show / Hide 
Range on Protein: 874-897
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)

LISLAVLDASHNQIADVKLYSPVH
| .| .|| |.||.  .      .
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK498.AA LRR_1 876-917 19 9.429819 3.29 Pfam 1-26 (26) Show / Hide 
Range on Protein: 876-917
Range on HMM: 1-26/26
Sequence Identity: 19% (9 aa)

SLAVLDASH-N--QIADVKLYSPVHLVSDRGGKIKVTDIPL--FAAL
.| .|| |. |  .. .                     ||   | .|
NLQHLDLSGCNCCNLTGH--------------------IPPSCF-NL
LRR_TYP AqueK498.AA LRR_TYP 959-982 29 0.022917 13.29 SMART 1-24 (24) Show / Hide 
Range on Protein: 959-982
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)

MTSLNSVDLSWNNIIELRPSLGKL
...| . |||.|.. .| | .   
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK498.AA LRR_1 961-982 33 0.051286 11.32 Pfam 1-26 (26) Show / Hide 
Range on Protein: 961-982
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLNSVDLSW-N--NII-ELRPS-LGKL
.| . |||  |  |.  .. || . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP AqueK498.AA LRR_TYP 936-958 33 0.387174 3.23 SMART 1-24 (24) Show / Hide 
Range on Protein: 936-958
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

CPLLTRLVLHHNQIAEVPPSV-CD
 | |..| |..||. ..|| .  .
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK498.AA LRR_1 938-959 25 2.304814 5.46 Pfam 1-26 (26) Show / Hide 
Range on Protein: 938-959
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

LLTRLVLHH-N--QIA-EVPPS-VCDM
 |..| | . |  ..  ..|||    .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
ROC AqueK498.AA ROC 1025-1227 26 3.6e-56 186.35 In-house 1-215 (215) Show / Hide 
Range on Protein: 1025-1227
Range on HMM: 1-215/215
Sequence Identity: 26% (68 aa)

YHRMKLMLVGKAGRGKTTLLRKISEKGQSGIQENLFLTRMSSDAKKF---------QKDLSTVGIV-VSDWTYTTKHHSDQTQTGLRNITFMTWDFGGQE
...|||||.|..| |||.|.. .                     |.          ... .|.||  . .|... | .        ..|.|  |||||||
CNEMKLMLCGQGGVGKTSLCKQLMH------------------DKFSDCSCYSCDKGNHPTTHGIEPIQQWVLDCKDMMF--RKKEDEIKFNVWDFGGQE

EYYATHQCFLSR-RSLYLVVWNVTH----GREG----VLE--LKPWLLNIQARAPN--------SPVIIVGTHYDKVKRSQ------------RHLVTEN
.|.|||| ||.  ||.||.||.       | .       .  |..|| .|..|.|.        |||||||||.||| | .            ....   
IYHATHQFFLTNHRSVYLLVWDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQDNKVYQHKQCCRMWQKL---

VELINRLYGSGSRLMHRQHGFPTI----------MYNVVVSCTSG-SNINDLRDK
                 .  || |           .  .|.|..| ..|..||..
-----------------RNKFPNICHSWMQIEHYQGFFHVDCETGCKGIDKLRHH
COR AqueK498.AA COR 1228-1795 13 7.8e-45 143.15 In-house 1-376 (434) Show / Hide 
Range on Protein: 1228-1795
Range on HMM: 1-376/434
Sequence Identity: 13% (85 aa)

IFDVACQVKE--NTVTGRGIGCGRIPEYRLLMDQLVPASYLQLEDSVRSIALTLRLLGKPPVLTYKEFKEYVFGDARTLVSRD-----------VGDREL
| ..| ..|.    ..              .|.| || |.. ....... . ....  . |....|||.. .        ..            . . ||
IRKTAKKIKHKQMFED--------------YMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQIC-------QEHGPPKRLRHQNIIIDEDEL

EQAVRFLHDNGTLLHYD----DPLLKELYFVDPQWLSDMLAHIVTVREINPF---VKDGI-MKIKDFTLLFNDK----------DFPIHWQKQYLRLLTT
......||| |...|..    || ||.....||||...|..||....|...|    . || .. .| . ..|..           .| | . ....|.  
HTVAMYLHDLGHIIHFKIWDHDPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEK

FEVAVEFKE----------GKLLIPSHLPELKPALS-HCYPPE---NTVYLPPLRHTYLL------AFVPSGFWPRLMSRVLSDPSIMRLAQVGCGLTDE
||..... .          . .|||. ||. .|. .  . .|.   |. .. .||  | .       | |.|||||.. | ...   |        .  .
FELCYPIDPDWTHFWHQETTTYLIPQLLPDDRPQHWEWWQWPQWETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKC-----FYER

ECRLLKWTKWRTGMILRFGNV----TLLSMEELSGKLFTGNGTKMAIMKDGGR--WEEHPLDTTVYGVNVEVPDVFPLLRYAELNPNRIRIVQRSGSTGQ
.|  . |  ||.|| | ...      |.....        ...|  |   |..  |                                            
SC--CEWMYWRNGMVLKWEGHNKNEALVKCDN--------HDNKIYITVRGCQDCWID------------------------------------------

QEEEGEEQEEERVRRPRQHLGDITEDPRERSFSDSMRTPPTQPPAASGSRNKRWTISEKVGSIARKVRSYTNIADINDSLTLPPTSSVSQSPRVASGFVV
                                                                                                    
----------------------------------------------------------------------------------------------------

LPDHHSNSSSSDSEDEKKDKEEEEGESTGGIGRVRGVLRKEEIQTQFEELKKKRAHGHHPGAIWNNDFNTMSSNGPPKLTEENNDRMRAGLLSKVVDHIT
                                                                                      |.  |.. . .|| 
--------------------------------------------------------------------------------------MCCQLWQIIRQHIQ

LLVEDWF--TGVR-------PRFLVVPCPHC-------SHG
 ....|.   |..       .|   .|||||       ...
HIHNSWWPWPGLQYQCQHWVCR-EWIPCPHCIQDHWDTCCD
Miro AqueK498.AA Miro 1108-1170 26 5.7e-10 37.79 Pfam 73-140 (140) Show / Hide 
Range on Protein: 1108-1170
Range on HMM: 73-140/140
Sequence Identity: 26% (18 aa)

WDFGGQEEYYATHQCF--LSRRSLYLVVWNVTHGR--EGVLELKPWLLNIQARAPN-SPVIIVGTHYD
||.||.|. ...|. |  . ... ...|  .| ..  . | ....|| ...... . .|||.||.. |
WDCGGREYWKFEHMHFACMKWADAICFVYDCTDYESFNRVSNYMAWLPHFRKWGKKAIPVIVVGNKCD
Miro AqueK498.AA Miro 1029-1047 26 0.013489 11.48 Pfam 1-19 (140) Show / Hide 
Range on Protein: 1029-1047
Range on HMM: 1-19/140
Sequence Identity: 26% (5 aa)

KLMLVGKAGRGKTTLLRKI
|....|. | ||.......
KVVVCGDKGCGKSSFIHQY
Kinase AqueK498.AA LRRK 1930-2254 27 5.1e-84 285.44 In-house 1-351 (351) Show / Hide 
Range on Protein: 1930-2254
Range on HMM: 1-351/351
Sequence Identity: 27% (106 aa)

VLKKERLGRGAFA-TVYHAQIKR-----------KLPN--------GQIHFEDVAIKALGNKGEDLDDDDDEDISLDEEEERPGGDDEYDG---------
. . | .|||.|. .|| |  ..           .| .        .   ...|||| .   .. . |  | .                ..         
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPM-TID-NDCN--------------NSNNNNNLNNNNS

ENAREPPPIQRSAIISGFNNLKKELSILSPLRHPYIIQLFGVSARPLGLVLELAPKGSLKSLLKEYSEAQ-----THIQSSAMQAVTLQISDALKYLHDL
|..   . .  .  .  |. . .|..|.| |.||.|..|.|.. .|| .|.|.|| |.| ..|..... .     .||  .  . . |||.....|||. 
EQVED-MDQNHEDCCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH

R--IIYRDLKSDNVLVWQFPSPY--DVLVPALPVHTDVVKVKLSDYGISQ--FASTQG-AKGLVGTPGFMAPEILMYYGKEAYNEKVDIFSFAMLIYEMI
.  ||.|||||.|.|.| .| ..  .          . |..|..|.|||.  .. . | |||.||.||.|||||. | |.| |.||||..||.|...| .
NPPIIHRDLKSPNILLWSSPQNHSPN-------YPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELL

TFR-LPFEHLT-------PSQANQANENGARPTLKRIDLPCPV-----LIRELMVWCWQQSEELRPTASQITKVSQMDQ
| . .||....        .|  ..  .| |||..     ||         .|...|||.  . ||..|||  |... |
TRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQH-Y-CPPCQPWHMYQDLIQHCWQHDPKKRPHFSQI--VKRLSQ
Kinase AqueK498.AA TKL 1936-2250 20 9.5e-62 211.46 In-house 1-364 (364) Show / Hide 
Range on Protein: 1936-2250
Range on HMM: 1-364/364
Sequence Identity: 20% (86 aa)

LGRGAFATVYHAQIKR-----KLPNGQIHFEDVAIKALGNKGEDLDDDDDEDISLDEEEERPGGDDEYDGENAREPPPIQRSAIISGFNN----------
.|.|.|..||... .      .   .    .|||.| .  . .|.... ....                                   ||          
IGSGGFGEVYKGKWRGWGGKCP---S-DTGKDVAVKKFKSHNDDEFTKNSQEN--------------------------------ND-NNNYSDMQLNDP

--------LKKELSILSPLRHPYIIQLFG---------VSARP------LGLVLELAPKGS-LKSLLKEYSEAQTHIQSSAMQAVT--LQISDALKYLHD
        ...|. ..| |||| |.|. |         |. .|      |..| |..|.|| |  |.               | .   |.|. .. ||| 
EASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------WHQRCRWALDIARGMNYLHS

LR--------IIYRDLKSDNVLVWQFPSPYDVLVPALPVHTDVVKVKLSDYGISQFASTQG---------------------AKGLVGTPGFMAPEILM-
 .        ||.|||||.|.||..   ...  ..    . . ...|..|.|.|.| |. |                         .|||..||||.|. 
MNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYM-Y-NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRG

--YYGK----------EAYNEKVDIFSFAMLIYEMITFRLPFE-HLTPSQA---------NQANENGARPTLK---------RIDLPCPVLIRELMVWCW
  .| .          . |.||.|..||.....|..| ..|.. .  ...           .. ..| ||...             .||  ...|| .||
QMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCW

QQSEELRPTASQITKVS
..  | ||....|.|  
DHDPEKRPSFQEILKRL
Kinase AqueK498.AA S_TKc 1930-2256 19 1e-44 155.81 SMART 1-231 (231) Show / Hide 
Range on Protein: 1930-2256
Range on HMM: 1-231/231
Sequence Identity: 19% (67 aa)

VLKKERLGRGAFATVYHAQIKRKLPNGQIHFEDVAIKALGNKGEDLDDDDDEDISLDEEEERPGGDDEYDGENAREPPPIQRSAIISGFNNLKKELSILS
  . . .|.|||..|| .. |.         . |||| .                                                  .....|..||.
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK-------------------------------------------------EHIRREIQILK

PLRHPYIIQLFGVSA-RPLGLVLELAPK--GSLKSLLKEYSEAQTH--IQSSAMQAVTLQISDALKYLHDLRIIYRDLKSDNVLVWQFPSPYDVLVPALP
  .||.|..|..|     | .|.|...   |.|....|..    ..  .     . .. || .||.|.|...||.|||| .|.|. .             
K-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------

VHTDVVKVKLSDYGISQFASTQGAKGLVGTPGFMAPEILMYYGKEAYNE-KVDIFSFAMLIYEMITFRLPFEHLTPSQANQANENGARPTLKRIDLPCPV
       .|..| |.. .      . ..||| .||||.|       |.  |.|. |.  ..|||.. . ||.     | ..  ..             . 
------HIKICDFGLARQL-----TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-----------SP

LIRELMVWCWQQSEELRPTASQITK---VSQMDQFL
  ....  |.|   | |||| .. .   .  .....
EAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK498.AA Pkinase 1930-2252 19 7.2e-43 152.66 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1930-2252
Range on HMM: 1-293/293
Sequence Identity: 19% (70 aa)

VLKKERLGRGAFATVYHAQIKRKLPNGQIHFEDVAIKALGNKGEDLDDDDDEDISLDEEEERPGGDDEYDGENAREPPPIQRSAIISGFNNLKKELSILS
  .....|.|.|..||..   ..  .|.     ||.| .  . .. .. | ... |                                      |..|. 
YHIGRKIGSGSFGCVYKC---HHKGTGK----IVAVKIIKKR-HEKSWKDQTHRRL-------------------------------------SEIQIMK

PLRHPYIIQLFGVSA---RPLGLVLELAPKG----SLKSLLKEYSEAQTHI--QSSAMQAVTLQISDALKYLHDLRIIYRDLKSDNVLVW---QFPSPYD
 |.||.|..|...     ..  .|.|....|    .|.....   .... .  .    . . .||  .|.|.|. .||.||||..|.|.    . ..   
RLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA---

VLVPALPVHTDVVKVKLSDYGISQ---FASTQGAKGLVGTPGFMAPEILMYYGKEAYNEKVDIFSFAMLIYEMITFRLPFEHL----TPSQANQANENGA
             .||..| |..      . . .....|||..||||...  | . |  |||..|.  ..|||.. |.|| .     .    .|  ..  
-------------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIM

RPTLKRI-DLPCPVL-------------------IRELMVWCWQQSEELRPTASQITKVSQM
.| |..  . .|..                     .... ||...  . |||| || .   .
GPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK498.AA STE 1931-2245 19 4.4e-41 142.8 In-house 1-350 (359) Show / Hide 
Range on Protein: 1931-2245
Range on HMM: 1-350/359
Sequence Identity: 19% (81 aa)

LKK-ERLGRGAFATVYHAQIKRKL---PNGQI-----HFEDVAIKALGNKGEDLDDDDDEDISLDEEEERPGGDDEYDGENAREPPPIQRSAIISG----
... |..|.||| ||| |  . .    ..|..       | .||| .  . ..  | .                      |       |  .        
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-E----------------------N-------Q-EN-Q-ELENK

----FNNLKKELSILSPLR--HPYIIQLFGVSARP---------LGLVLELAPKGSLKSLLKEYSEAQ----------THIQSSAMQAVTLQISDA-LKY
    .....||..|.. ..  ||.|.. .|   .          | ...|. . ||| ...|.. . .          .... |   ... ||  . |.|
NHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYY

LHDLRIIYRDLKSDNVLVWQFPSPYDVLVPALPVHTDVVKVKLSDYGISQFASTQGAKG------------------LVGTPGFMAPEILMYYG---KEA
||...|| ||.|..|.|.                      |||.| |..   .  .|..                  .|||| .||||...  |   .  
LHSHHIIHRDIKPANILL----------------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKG

YNEKVDIFSFAMLIYEMITFRLPFEHLTPSQANQANENG---------------ARPTLKRIDL----------------PCPVLIRELMVWCWQQSEEL
|..|.|| |.  .| ||.| . |.  ..| .|  .  ..                 |.|.                     .    .. .  | |   . 
YDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNK

RPTASQ
||||||
RPTASQ
Kinase AqueK498.AA Ciliate-E2 1930-2209 16 2e-36 122.54 In-house 1-303 (365) Show / Hide 
Range on Protein: 1930-2209
Range on HMM: 1-303/365
Sequence Identity: 16% (62 aa)

VLKKERLGRGAFATVYHAQIKRK-----------------LPNGQIHFEDVAIKALGNKGEDLDDDDDEDISLDEEEERPGGDDEYDGENAREPPPIQRS
  . . .|.|.|..|| .. ...                     |                                               |   |.  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQM---Q-----------------------------------------------EKVKIKIY

AIISG-FNNLKKELSILSPLR-------------------HPYIIQLFGVS----ARPLGLVLELAPKGSLKSLLKEYSEAQTHIQS-------SAMQAV
|. .   |...  ..... .|                   ||.||... .        . ||.|..  |.|....|. .  ..|...         .. .
AMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYI

TLQISD---------------ALKYLHDLR-IIYRDLKSDNVLVWQFPSPYDVLVPALPVHTDVVKVKLSDYGISQFASTQ-------------------
. || .               ||.|||    ||.||.| .|.|.                      .|..| |.|......                   
MKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDT

--------------GAKGLVGTPGFMAPEILM---YYG---KEAYNEKVDIFSFAMLIYEMITFRLPFEHLTPSQANQANENG
               .. ..||||.||||||.   |..   .. |..|.||.|. ...|||.. ..||         | ....
SRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQC
Kinase AqueK498.AA MLK 2023-2250 28 1.3e-33 114.02 In-house 57-291 (291) Show / Hide 
Range on Protein: 2023-2250
Range on HMM: 57-291/291
Sequence Identity: 28% (72 aa)

KELSILSPLR-HPYIIQLFGVSARP---LGLVLELAPKGSLKSLLKE-YSEAQ-------THIQSSAMQAVT--LQISDALKYLHDLR---IIYRDLKSD
..|.||| .  ||.|||. ||...|   ...|.| ...||| ..|..  |.           .  .  .|..  ||.. .. ||| .    || ||||| 
RHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSH

NVLVWQ-FPSPYDVLVPALPVHTDVVKVKLSDYGISQFASTQGAK---GLVGTPGFMAPEILMYYGKEAYNEKVDIFSFAMLIYEMITFRLPFE-HLTPS
|.|. .             . | ...|.  .| |.| . .. . .   .  ||. .||||..     | |.||.|..|......||.| ..|.. |. |.
NILIDEIC---------H-DMHHGTLKI--CDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPM

QANQAN-ENGARPTLKRIDLPCPVLIRELMVWCWQQSEELRPTASQITKVS
..   . .|| ||..      ||  . .||  ||.|  . ||. .|| .  
AIAWWVAYNGLRPPIPST---CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK498.AA TK 1930-2250 13 3.4e-33 108.07 In-house 1-486 (486) Show / Hide 
Range on Protein: 1930-2250
Range on HMM: 1-486/486
Sequence Identity: 13% (73 aa)

VLKKERLGRGAFA---TVYHAQIKRKLPNGQIHF------------------EDVAIKALGNKGEDLDDDDDE------DISLDEEEERPGGDDEYDGEN
.   . ||.|.|    .|| .. ... |..   |                  ..||.| |  . .. ...  .      |                    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRD--------------------

AREPPPIQRSAIISGFNNLK----KELSILSPLR-----HPYIIQLFGVSARP--------------LGLVLELAPKGS----LKSLLKEYSEAQTH---
              |         .|..... ..     || |..|.||. ..              . .|.|..|.|.    |.. |.. ..  .|   
--------------G----GEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQD

-------------------------------------------------IQSSAMQA-------------------VTLQISDALKYLHDL------RII
                                                 .. . .                       .||.... |||..      ...
CPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFV

YRDLKSDNVLV---WQ----FPSPYDVLVPALPVHTDVVKVKLSDYGIS--------QFASTQGAKGLVGTPGF--------------------------
 |||   |.||    .    |               ..  .|..|.| |              .    ....|                           
HRDLAARNCLVGENNVCKWHF-------------DGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPI

--MAPEILMYYG------KEAYNEKVDIFSFAMLIYEMIT--FRLPFEHLTP---------SQANQANENGARPTLK--------RIDLP----CP----
  |||| |..        .  . .| |..||  |..|. |     . . ..           .  .  ..| |. ..        |  .|    ||    
RWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRL-CRSGLNEVGYRMRMPQPPHCPDWMR

----------VLIRELMVWCWQQSEELRPTASQITKVS
           .. .||  ||.   | ||| ||. .  
YRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK498.AA TKL-Unique 2020-2246 23 1.7e-30 104.79 In-house 41-286 (290) Show / Hide 
Range on Protein: 2020-2246
Range on HMM: 41-286/290
Sequence Identity: 23% (61 aa)

NLKKELSILSPLR-HPYIIQLFGVSA----RPL--GLVLELAPKGSLKSLLK---EYS---EAQTHIQSSAMQAVTLQISDALKYLHDLR--IIYRDLKS
....|..... |. || | ...|...     |    .|.|  | ||| ..|      .   .  . .  . .    ..|.... ||| .   || |||||
EFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKS

DNVLVWQF-PSPYDVLVPALPVHTDVVKVKLSDYGISQFAS--TQGAKG---------LVGTPGFMAPEILMYYGKEAYNEKVDIFSFAMLIYEMITFRL
 |.|| .. ..               ...|..| |.| |.|  ... ..          .|..  ||||.|.    . |.||.|..||..  .|..|  .
SNFLVDNNSNI-------------AEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF-CQYSEKSDVYSFGIVLWEIATRKI

------PFEHLTPSQANQANEN---GARPTL-KRIDLPCPVLIRELMVWCWQQSEELRPTASQI
      |...... |  ..      . ||..  .    ||  .|.|.  || .  . ||. ..|
TKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNH----CPKEYRDLIQQCWHHDPSQRPSFDEI
Kinase AqueK498.AA TyrKc 1930-2252 21 1.3e-26 95.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 1930-2252
Range on HMM: 1-280/280
Sequence Identity: 21% (77 aa)

VLKKERLGRGAFATVYHAQIKRKLPNGQIHFEDVAIKALGNKGEDLDDDDDEDISLDEEEERPGGDDEYDGENAREPPPIQRSAIISGFNNLKKELSILS
. ... ||.||| .||... |          ..||.| | .                                                  . .|..|..
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA---------------------------------------------REDFMREARIMC

PL--RHPYIIQLFGVSA---------RPLGLVLELAPKGSLKSLLKEYSEAQTHIQSSAMQAVTLQISDALKYLHDLRIIYRDLKSDNVLVWQFPSPYDV
 |  .|| |..|.||            || .|.|..|.|.||. |... .    .. . .    .||..   |||. ..| |||   |.||         
KLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----

LVPALPVHTDVVKVKLSDYGISQFASTQ---GAKGLVGTP-----GF-------MAPEILMYYGKEAYNEKVDIFSFAMLIYEMITF-RLPFEH-----L
             || || | | .       |. . . ..     |        |||| ..|.    ...| |..||  ...|. |.   | .      .
------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG---KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMM

TPSQANQANENGARPTLKRIDLP-----CPVLIRELMVWCWQQSEELRPTASQITKVSQM
..... .  ..| |.     |.|     ||  . ..| .||.   | ||| |.|  ....
SNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase AqueK498.AA Dicty4 2131-2254 30 1.2e-20 65.79 In-house 152-277 (277) Show / Hide 
Range on Protein: 2131-2254
Range on HMM: 152-277/277
Sequence Identity: 30% (40 aa)

KVKLSDYGISQ----FASTQG-AKGLVGTPGFMAPEILMYYGKEAYNEKVDIFSFAMLIYEMITFRLPFE--HLTPSQANQANEN-GARPTLKRIDLPCP
.|| .| |.||      . .  ... .|||. ||||..|   ...||||.| .||... .|. |   |.   |  . |.  |  | . ||    |   ||
RVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMM---HQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRP---PIPDWCP

VLIRELMVWCWQQSEELRPTASQITKVSQMDQ
  ...|..|||  . . ||. ..|..   .. 
PSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK498.AA Dicty4-Unclassified 2132-2250 30 7e-15 47.37 In-house 148-263 (263) Show / Hide 
Range on Protein: 2132-2250
Range on HMM: 148-263/263
Sequence Identity: 30% (37 aa)

VKLSDYGISQFASTQGAKGLVG-TPGFMAPEILMYYGKEAYNEKVDIFSFAMLIYEMITFRLPFEHLT-PSQANQA-NENGARPTLKRIDLPCPVLIREL
.|  | |||   .       .. ||   .||.||    |.|| | |..|.||. ||..|   |.     .  |     . . ||   .|   |.  .. |
IKIADFGISRVIDFNFNMTTIAGTPKWESPECLM---HESYNQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRP---KIPDNCDNFWKKL

MVWCWQQSEELRPTASQITKVS
 .|||  .   |||  ||..  
IKWCWHNDPNKRPTMNQIIQYL
Kinase AqueK498.AA STE20 1932-2109 21 2.3e-14 49.14 In-house 3-150 (288) Show / Hide 
Range on Protein: 1932-2109
Range on HMM: 3-150/288
Sequence Identity: 21% (41 aa)

KKERLGRGAFATVYHAQIKRKLPNGQIHFEDVAIKALGNKGEDLDDDDDEDISLDEEEERPGGDDEYDGENAREPPPIQRSAIISGFNNLKKELSILSPL
. |..|.|.. .|| |   .. |.|..  ..|||| .  . .|                                   |       .....|| ||.. .
LLEKIGQGSYGKVYKA---YHKPTGEYCNQRVAIKKMNLEKCDNE---------------------------------Q-----DEWEDIQKEISIMKQC

RHPYIIQLFGVSARP------LGLVLELAPKGSLKSLLKEYSEAQT-----HIQSSAMQAVTLQISDALKYLHDLRIIYRDLKSDNVLV
.||.|.. .|   .       | .| |.   |||  ..|.. . .       .. .   ... ..  .|.|||  .|| ||.|.||.|.
KHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILL
Kinase AqueK498.AA Dicty4 2019-2109 33 1.6e-12 38.29 In-house 43-147 (277) Show / Hide 
Range on Protein: 2019-2109
Range on HMM: 43-147/277
Sequence Identity: 33% (35 aa)

NNLKKELSILSPLRHPYIIQLFGVSA----RP--LGLVLELAPKGSLKSLLKE-YSEAQTHIQSS--AMQA---VTLQISDALKYLHD--LRIIYRDLKS
| ..|| .|.. .||| |... | .      |  .  | |. |||.| |||    || |  |...   . .     . .   . .||    .|| |||||
NEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKS

DNVLV
.| ||
HNLLV
Kinase AqueK498.AA Dicty4-Unclassified 2022-2109 28 8.9e-12 36.57 In-house 46-142 (263) Show / Hide 
Range on Protein: 2022-2109
Range on HMM: 46-142/263
Sequence Identity: 28% (28 aa)

KKELSILSPLRHPYIIQLFGVSARP------LGLVLELAPKGSLKSLLK-EYSEAQTHIQSSA--MQAVTLQISDALKYLHDLRIIYRDLKSDNVLV
|||  ||  . ||  ... | .  |      .  | |. .|| |  .     || |  |.       .. . |   . .||   .| ||.|| |.|.
KKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILM
Kinase AqueK498.AA Pkinase_Tyr 2021-2109 29 1.2e-11 40.11 Pfam 50-144 (270) Show / Hide 
Range on Protein: 2021-2109
Range on HMM: 50-144/270
Sequence Identity: 29% (28 aa)

LKKELSILSPL-RHPYIIQLFGVSA---RP--LGLVLELAPKGSLKSLLKEYSEAQTHIQSSAMQAVTLQISDALKYLHDLRIIYRDLKSDNVLV
. .|..|.. | .|| |..| ||     .|  . .|.|..|.|.|.. |.. .| . ..  . .    .||.... ||.. ..| |||   |.||
FMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLV
Kinase AqueK498.AA STE20 2131-2202 28 2.8e-11 37.78 In-house 155-235 (288) Show / Hide 
Range on Protein: 2131-2202
Range on HMM: 155-235/288
Sequence Identity: 28% (23 aa)

KVKLSDYGISQFAST-------QGAKGLVGTPGFMAPEILMYYG--KEAYNEKVDIFSFAMLIYEMITFRLPFEHLTPSQA
.|||.| | ..  ..       .  . .|||| .||||...  .  .  |..|.|| |.   . ||.. . |.  . | .|
EVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRA
Kinase AqueK498.AA Pkinase_Tyr 2158-2252 30 2e-09 32.52 Pfam 181-270 (270) Show / Hide 
Range on Protein: 2158-2252
Range on HMM: 181-270/270
Sequence Identity: 30% (30 aa)

MAPEILMYYGKEAYNEKVDIFSFAMLIYEMITF-RLP-FEHLTPSQ-ANQANENGARPTLKRIDLPCPVLIRELMVWCWQQSEELRPTASQITKVSQM
|||| ..|.    ...| |. ||  |..|..|. . | .. .....  ..  |.| |  ...    ||  | .||  ||..  | ||| |.|  ..|.
MAPECINYGK---FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR--MPC-PENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL
Kinase AqueK498.AA Pkinase_Tyr 1930-1968 30 5.7e-05 17.46 Pfam 1-36 (270) Show / Hide 
Range on Protein: 1930-1968
Range on HMM: 1-36/270
Sequence Identity: 30% (12 aa)

VLKKERLGRGAFATVYHAQIKRKLPNGQIHFEDVAIKAL
. . . ||.||| .||..  |     .. .  .||.| |
ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKML
Kinase AqueK498.AA Dicty4 1930-1945 37 0.005481 6.0 In-house 1-16 (277) Show / Hide 
Range on Protein: 1930-1945
Range on HMM: 1-16/277
Sequence Identity: 37% (6 aa)

VLKKERLGRGAFATVY
  . .|.|.|.|..||
INIEQRIGKGSFGEVY