AqueK501

Species: A.queenslandica
Alias: AqueK501
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a1

Sequence

Name Sequence Type Origin Length Description Download
AqueK501.AA Protein None 369 None Fasta, JSON
AqueK501.kin_dom Protein Kinase Domain None 195 None Fasta, JSON

Protein domain

Protein domains of AqueK501.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK501.AA TKL 24-277 21 9.8e-37 128.37 In-house 1-364 (364) Show / Hide
Range on Protein: 24-277
Range on HMM: 1-364/364
Sequence Identity: 21% (79 aa)

LGRGSYGVVIELRVNG----------NQCAGKKLH---DFLDTEDS---------------------LLSKLGEGIILHSQQHHPNIVKLLG-VHYPSG-
.|.|..|.|   . .|          .  | ||..   | ..|. |                     .  .. | | ..|. .|||||...| . .|.. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------SQLPMLVMEYLPY-SLLQLIERRVAMNKEAILLDVASGLDYLHSKR------PPVIHRNIKASNILLTVDHN--------------PKITD
         .  ...|||| |  ||| ..       .  . ||.|.|..||||..      ||.|||..| .|||.  . .              .||.|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICD

LSMSKFGDALKQHHYTT------------------APGNPYLMPPEALVQNP---------------VYNEKLDVFSFGCLILHMLTGNIIVPTDQYKPK
.  |.| .  ..   |                     |.|. |.||.| ...                |.|| ||.||| ..  .||. .  | ..|.. 
FGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR--PYYDYPYM

PEDPG----SFIKVSEWDRRADSIK------------PVLGNQLIPLVKYCLEDDPFRRINASDIIEII
|....     ....   ...   |.            |    ... | . | . ||  | ....|....
PMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

S_TKc AqueK501.AA S_TKc 18-282 23 3.9e-32 113.98 SMART 1-231 (231) Show / Hide
Range on Protein: 18-282
Range on HMM: 1-231/231
Sequence Identity: 23% (67 aa)

RVTRKELGRGSYGVVIELRVNG--NQCAGKKLHDFLDTEDSLLSKLGEGIILHSQQHHPNIVKLLGVHYPSGSQLPMLVMEYLPY---SLLQLIERRVA-
    ...|.|..|.|   | ..   ..| |...          . . |  ||..  ||||||||..| .    .   .||||..    .|...|..|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----MNKEA---ILLDVASGLDYLHSKRPPVIHRNIKASNILLTVDHNPKITDLSMSKFGDALKQHHYTTAPGNPYLMPPEALVQNPVYNE-KLDVFSF
     ..      ..  ....|.|.||.   .||| .| .||||.   . ||.|  ....         ||  | |. |.|| |     |.  | |. |.
GLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSC

GCLILHMLTGNIIVPTDQYKPKPEDPGSFIKVSEWDRRADSIKPVLGNQLIPLVKYCLEDDPFRRINASDIIE----IISRLQI
||..  ||.|    |         ..   .|.                ... ... ||. || .|. | .. .    | .   .
GCILYEMLCGYPPFP---------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase AqueK501.AA TK 22-206 14 3e-29 94.57 In-house 5-384 (486) Show / Hide
Range on Protein: 22-206
Range on HMM: 5-384/486
Sequence Identity: 14% (56 aa)

KELGRGSYG---VVIELRVNGN---------------------------QCAGKKLHDFLDTEDSLLSK---------------LGEGIILHS-QQHHPN
|.||.| .|   .| . ...|                            ..| | |..  ....                    . |  ....   ||||
KKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPN

IVKLLG------------VHYPSGSQLPMLVMEYLPY-----SLLQLIE--RRVAMNKEA----------------------------------------
||.|.|            | . .... .|.|||| |.     ||..     |. ... .                                         
IVRLYGVCTQGEPKPCFEV-V-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDD

------------------------------------ILLDVASGLDYLHSKRP----PVIHRNIKASNILLTVDHN-----------PKITDLSMSK---
                                    . ...|.|. |||||.      ..||.. | |.|.. ...            ||.|  .|.   
DLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGS

--FGDALKQHHYTTAPGNPYL----------------------------MPPEALVQNP--------VYNEKLDVFSFGCLI
     .. .... .. ....                             |.||.|  .         .. .| ||.|||.|.
GVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM

Kinase AqueK501.AA STE 19-213 22 2.4e-27 93.71 In-house 1-265 (359) Show / Hide
Range on Protein: 19-213
Range on HMM: 1-265/359
Sequence Identity: 22% (63 aa)

VTR-KELGRGSYG-VVIELRVN----------------GNQCAGKKLH----DFLDTE------------DSLLSKLGEGIILHSQQH-HPNIVKLLGVH
 .. ...|.|..| |.  ....                |. .| |...    .  | |            . . . | |  |..  .| |||||| .| .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

Y-----PSG-SQLPMLVMEYLP-YSLLQLIERRVAMNK-------------EAIL----LDVASG-LDYLHSKRPPVIHRNIKASNILLTVDHNPKITDL
.      .  ..|  ..|||..  || ..|...  ..|             | ..     ..  | |.||||..  .||| ||..||||      |..| 
FKEGHNHKNDDEL-WICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDF

SMSKFGDA--------------LKQH-HYTTAPGNPYLMPPEALVQ-----NPVYNEKLDVFSFGCLILHMLTGN
  ..  .               . .  . .|  | |  | || . |     .. |..| |. |.||.|..|.||.
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK

Pkinase AqueK501.AA Pkinase 18-277 22 9e-26 92.21 Pfam 1-293 (293) Show / Hide
Range on Protein: 18-277
Range on HMM: 1-293/293
Sequence Identity: 22% (68 aa)

RVTRKELGRGSYGVVIELRVNGNQ--CAGKKLHDFLDTEDSLLSKLG--EGIILHSQQHHPNIVKLLGVHYPSGSQLPMLVMEYLPY-----SLLQLIE-
 .. . .|.||.|.| . .  |..   | |..    . .. . ...   |  |...  .|||||.|... .   .. . .||||..      .|  .|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

-RRVAM--NKEA---ILLDVASGLDYLHSKRPPVIHRNIKASNILLTVDHNP----KITDLSMSKFGDALKQHHYTTAPGNPYLMPPEALVQNPVYNEKL
 |. ..    .    ... ...||.|.||.   .||| .| .|||.  . ..    ||.|   .|. |  ... .||  | |. |.|| .  .. |  | 
WRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVFSFGCLILHMLTGNIIVPTD-------QYKPKPEDPGSFIKVSEWDRRADS------------IKPVLGNQLIPLVKYCLEDDPFRRINASDIIEI--
|..|.||..  ||.|. . | .       |..   .. |  .. ...  .  |              . .   .. ..|.||. || .|..| .| .   
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

I
.
F

Kinase AqueK501.AA HH498 114-214 36 2e-23 70.78 In-house 123-224 (284) Show / Hide
Range on Protein: 114-214
Range on HMM: 123-224/284
Sequence Identity: 36% (37 aa)

KEAILLDVASGLDYLHS-KRPPVIHRNIKASNILLTVDHNPKITDLSMSKFGDALKQHHYTTAPGNPYLMPPEALVQNPVYNEKLDVFSFGCLILHMLTG
|  | .||| | .|||.   .|.|||     |||.  |   .. |   | |   .     |  |||.  | ||   |.  | .| ||||..  |  |.|.
KMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEMHTR

NI
 .
EV

Kinase AqueK501.AA Ciliate-E2 18-213 19 1.7e-22 73.99 In-house 1-293 (365) Show / Hide
Range on Protein: 18-213
Range on HMM: 1-293/365
Sequence Identity: 19% (58 aa)

RVTRKELGRGSYGVVIELRVNGNQC-------------------AGKKLHDFLDTEDSLLSKLGEGIILHSQQH----------------HPNIVKLLGV
    | .|.|..|.| . .|  .|.                   . .|.      . . .  .   | .  . .                ||||.|.  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

HYPSGSQLPMLVMEYLPY-SLLQLIERR-----------VAMNKEAIL---LDVAS---------------GLDYLHSKRPPVIHRNIKASNILLTVDHN
 .    .   |||||. . .|...|. .             .. . |.     ...               .| ||||| . .|||.|| .|||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-----

PKITDLSMSKFGD------------------------------ALKQHHYTTAPGNPYLMPPEALVQNPV--------YNEKLDVFSFGCLILHMLTGN
.||.|. .||. |                               ..|. . |  |.|. |.|| |   .         |..| |..|.|...  ||.|.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

Kinase AqueK501.AA Ciliate-E2-Unclassified 19-213 19 6.9e-22 72.72 In-house 2-267 (352) Show / Hide
Range on Protein: 19-213
Range on HMM: 2-267/352
Sequence Identity: 19% (53 aa)

VTRKELGRGSYGVVIELRVNGNQ--CAGKKLHDFLDTEDSLLSK----LGEGIILHSQQ----------------HHPNIVKLLGVHYPSGSQLPMLVME
   | .|.|..|.| ... . ..   | | .... .  . .  .    . | ... ...                .||.....  ...    | . .|||
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME

YLPY-SLLQLIE-------------------RRVAMNKEA------ILLDVASGLDYLHSKRPPVIHRNIKASNILLTVDH---NPKITDLSMSKFGDAL
|... .|.| |.                   ...  .. .      ..  . .||.|||.|   .|||.|| .|||.. ..   ..||.|.. ||. .  
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

--------------KQHHYTTAPGNPYLM----PPEALVQNPVYN---EKLDVFSFGCLILHMLTGN
              ||....|  |.|. |    .|| | ..  ..   .| |..|.|...  ||.|.
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY

Kinase AqueK501.AA CMGC 18-220 17 7.1e-22 67.84 In-house 1-362 (513) Show / Hide
Range on Protein: 18-220
Range on HMM: 1-362/513
Sequence Identity: 17% (65 aa)

RVTRKELGRGSYGVVIE----------------LRVNGNQCAGKKLH-DFLDTEDSL---------LSKLGEGIILHSQQ----------------HHPN
    | .|.|.|||| .                .. .....| ||.  .| ..|. .          . | |  ||   .                ||.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKLLGVHYPSGSQLP---------------MLVMEYLPYSLLQLIE---------RRVAMNKEA---------------IL------LDVASGLD--YL
||||. . |...|. .                ||.||....|.|.|.         |.. ..                  ..        .  ||.  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSKRPPVIHRNIKASNILLTVDHNP--------------------KITDLSMSK-FGDALKQHH-------------------YTTAPGNPYLMPPEALV
||..  .||| .| .|||.. .                       || |  ... ...  ..|.                   ||.     .  .|| |.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

QNPVYN---------EKLDVFSFGCLILHMLTG--------NIIVP---------------TDQ
  . |.         .. |. |.|| .  |.||         .. |                ||
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQ

Kinase AqueK501.AA MLK 73-214 27 2.4e-20 67.37 In-house 64-234 (291) Show / Hide
Range on Protein: 73-214
Range on HMM: 64-234/291
Sequence Identity: 27% (49 aa)

HPN----IVKLLGVHYPSGSQLPMLVMEYLPYSLLQLIE---------------------RRVAMNKEAILLDVASGLDYLHS-KRPPVIHRNIKASNIL
|||    |....||   .. .   .||||.... |  .                        .|||   . |..|.|..|||| ...|.||| .| .|||
HPNNHPCIIQFYGVCLQPP-CHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMN---WALQCARGMHYLHSMAPKPIIHRDLKSHNIL

LTV------DHNPKITDLSMSKFGDALKQHHY----TTAPGNPYLMPPEAL--VQNPVYNEKLDVFSFGCLILHMLTGNI
..       . . ||.|     || . . |.     . ..|..  | ||..   ..  |.|| ||.|.| ..  |||. .
IDEICHDMHHGTLKICD-----FGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREV

Kinase AqueK501.AA TK-Unique 117-206 31 9.9e-18 57.82 In-house 136-229 (294) Show / Hide
Range on Protein: 117-206
Range on HMM: 136-229/294
Sequence Identity: 31% (30 aa)

ILLDVASGLDYLHSKRPPVIHRNIKASNILLTVDHNPKITDLSMSKFGDALKQHHYTTAPGNPYL--MPPEALV--QNPVYNEKLDVFSFGCLI
.. ..|.|. ||.| |  ..||.. |.|.||| |.. ||.|. |.. ... ...  ..  |  ..  |.||.|   ... ...| || |||.|.
FAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLM

Kinase AqueK501.AA STE-Unique 93-212 21 1.3e-17 58.6 In-house 371-549 (616) Show / Hide
Range on Protein: 93-212
Range on HMM: 371-549/616
Sequence Identity: 21% (38 aa)

LVMEYLPY-SLLQLIERRVA---------MNKEAI---LLDVASGLDYLHSKRPPVIHRNIKASNILLTVDHNPKITDLSMSKFGDALKQHHY-------
..|||..  .| |.|.|  .         .  . .   .. .. ||.||||.. |.|||..|..||... |   ...    . || | .           
IFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNN

-----------------------------------TTAPGNPYLMPPEALVQN----PVYNEKLDVFSFGCLILHMLTG
                                   .. .|.|  | || .  .      |. | |..|.||...||..|
SKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCG

Kinase AqueK501.AA TyrKc 18-277 25 1.1e-14 14.76 SMART 1-280 (280) Show / Hide
Range on Protein: 18-277
Range on HMM: 1-280/280
Sequence Identity: 25% (74 aa)

RVTRKELGRGSYGVVIELRVNGNQCAGKKLHDFLDTEDSLLSKLGEGIILHSQ-QHHPNIVKLLGVHYPSGS-----QLPMLVMEYLPY-SLLQLI-ERR
 .  |.||.| .|.| . . .  |.| |.|..       .   . |  |...   ||||||.|.||   .|      . .|.|||| |. .|.. . ..|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

VAMNKE---AILLDVASGLDYLHSKRPPVIHRNIKASNILLTVDHNPKITDLSMSKFGDAL----KQHHYTTA----PGNPYL----MPPEALVQNPVYN
   . .    . ...|.| .|||||  ..||| . | |.|.. .|  ||.|  .|....        . | ..     |.  |    |.||.. .  ...
PKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

EKLDVFSFGCLILHMLTGNIIVPTDQYKPKPED-PGSFIKVSEWDRRADSIKPVLG----------NQLIPLVKYCLEDDPFRRINASDIIEII
.| ||.||| ..  ..|       .|  | ..  . | . | |. .. .  ..               .  . | | . ||  | . |.|.|..
TKSDVWSFGVCMWEIFTY-----GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase AqueK501.AA Pkinase_Tyr 72-162 32 6.7e-11 37.54 Pfam 62-159 (270) Show / Hide
Range on Protein: 72-162
Range on HMM: 62-159/270
Sequence Identity: 32% (32 aa)

HHPNIVKLLGVHY-PSGSQLPMLVMEYLPY-SLLQLIERR-------VAMNKEAILLDVASGLDYLHSKRPPVIHRNIKASNILLTVDHNPKITDLSMSK
||||||.|.|| .  .... ...|||| |. .||    ..           .  . ...|.|..||.||.   ||| . | |.|.| ..  ||.|  ...
HHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLAR





Kinase AqueK501.AA STE-Unique 19-81 27 2e-06 17.91 In-house 1-68 (616) Show / Hide
Range on Protein: 19-81
Range on HMM: 1-68/616
Sequence Identity: 27% (19 aa)

VTRKELGRGSYGVVIELR--VNGNQCAGKKLHDFLDT---EDSLLSKLGEGIILHSQQHHPNIVKLLG
.    .|||| |.|   .  .....|| |..|    .    . | ... . | ...  ||.||||..|
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYG

Kinase AqueK501.AA TK-Unique 73-104 46 4e-06 17.44 In-house 63-93 (294) Show / Hide
Range on Protein: 73-104
Range on HMM: 63-93/294
Sequence Identity: 46% (15 aa)

HPNIVKLLGVHYPSGSQLPMLVMEYLPYSLLQ
|||||..||.   |. . .|..|||.|.. ||
HPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQ