Gene AqueK502 (A.queenslandica)

AqueK502

Species: A.queenslandica
Alias: AqueK502
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a1

Sequence

Name Sequence Type Origin Length Description Download
AqueK502.AA Protein None 320 None Fasta, JSON
AqueK502.kin_dom Protein Kinase Domain None 196 None Fasta, JSON

Protein domain

Protein domains of AqueK502.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK502.AA TKL 24-278 20 4.9e-35 122.73 In-house 1-364 (364) Show / Hide 
Range on Protein: 24-278
Range on HMM: 1-364/364
Sequence Identity: 20% (76 aa)

LGHGSYGVVNELRVNG----------NQCAGKKLNDLL-----------------------AMEDSLLSEFGNAII-LHRQQHHPNIVKLLG-VHYPS--
.| |..|.|   . .|          .  | ||..                          ..| | . .| .  | .... .|||||...| . .|.  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------GFAQLPMLVMEYLPY-SLLQLIEGRVAINKEAILLDVANGLDYLHSKR------PPIIHCNIKASNILLTVGHN--------------AKITD
       |    ...|||| |  ||| ..       .  . ||.| |..||||..      |||||...| .|||.    .              .||.|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICD

LSMSKFGDALKQHHYTT------------------APGNPYLMPPEALVHNP---------------VYNKKLDVFSFGCLILHMLTGNIIVPTDQYEPK
.  |.| .  ..   |                     |.|. |.||.|  ..                |..| ||.||| ..  .||. .  | ..| . 
FGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR--PYYDYPYM

PHDPG----SYVKISEWNRRAKYIK------------PALDHILIPVAMNCLEDDPLRRLNTSDIIEII
|....     . ..   ...   |.            |  .. ..  .. | . ||  |.. ..|....
PMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK502.AA TK 22-207 14 2.8e-26 84.44 In-house 5-384 (486) Show / Hide 
Range on Protein: 22-207
Range on HMM: 5-384/486
Sequence Identity: 14% (55 aa)

KELGHGSYG---VVNELRVNGN---------------------------QCAGKKLNDLLAMEDSLLSE--------------FGNAIILHRQ--QHHPN
|.||.| .|   .| . ...|                            ..| | | .  ||..    .              . ... . ..   ||||
KKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPN

IVKLLG----VHYPSGFA-----QLPMLVMEYLPY-----SLLQLIEGRVAINKEA--------------------------------------------
||.|.|    .   ..|      . .|.|||| |.     ||..    .    ..                                             
IVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDL

----------------------------------ILLDVANGLDYLHSKRP----PIIHCNIKASNILLTVGHN-----------AKITDLSMSK-----
                                  . ...|.|. |||||.      ..| .. | |.|.. ...           .||.|  .|.     
IKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGV

FGDALKQHHYTTAPGNPYL----------------------------MPPEALVHNP--------VYNKKLDVFSFGCLI
   .. .... .. ....                             |.||.| ..         ..  | ||.|||.|.
LARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM
S_TKc AqueK502.AA S_TKc 18-283 22 2.2e-25 91.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-283
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

RVTRKELGHGSYGVVNELRVNG--NQCAGKKLNDLLAMEDSLLSEFGNAIILHRQQHHPNIVKLLGVHYPSGFAQLPMLVMEYLPY---SLLQLIEGRVA
    ...|.|..|.|   | ..   ..| |...            . . | .... ||||||||..| .     .   .||||..    .|...|. |  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGR

------INKEA---ILLDVANGLDYLHSKRPPIIHCNIKASNILLTVGHNAKITDLSMSKFGDALKQHHYTTAPGNPYLMPPEALVHNPVYNK-KLDVFS
      ..      ..  ....|.|.||.   |||. .| .||||.   . ||.|  ....         ||  | |. |.|| |     |.| | |. |
HGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWS

FGCLILHMLTGNIIVPTDQYEPKPHDPGSYVKISEWNRRAKYIKPALDHILIPVAMNCLEDDPLRRLNTSDIIE----IISRLQL
.||..  ||.|    |         ..    |.              .. ..   ..||. || .|.   .. .    | .   .
CGCILYEMLCGYPPFP---------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK502.AA STE 19-214 22 4.2e-21 71.35 In-house 1-265 (359) Show / Hide 
Range on Protein: 19-214
Range on HMM: 1-265/359
Sequence Identity: 22% (61 aa)

VTR-KELGHGSYG-VVNELRVN----------------GNQCAGKKLN------------------DLLAMEDSLLSEFGNAIILHRQQH-HPNIVKLLG
 .. ...|.|..| |.  ....                |. .| |..|                  .    ....| |     |... .| |||||| .|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIK---IMKKCNHMHPNIVKYYG

VHY-----PSGFAQLPMLVMEYLP-YSLLQLIEGRVAINK-------------EAIL----LDVANG-LDYLHSKRPPIIHCNIKASNILLTVGHNAKIT
 ..      .   .|  ..|||..  || ..|. .  ..|             | ..     ..  | |.||||..  |||  ||..||||     .|..
CYFKEGHNHKNDDEL-WICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLC

DLSMSKFGDA--------------LKQH-HYTTAPGNPYLMPPEALVH-----NPVYNKKLDVFSFGCLILHMLTGN
|   ..  .               . .  . .|  | |  | || .       .. |. | |. |.||.|..|.||.
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase AqueK502.AA HH498 115-215 35 1.4e-20 61.58 In-house 123-224 (284) Show / Hide 
Range on Protein: 115-215
Range on HMM: 123-224/284
Sequence Identity: 35% (36 aa)

KEAILLDVANGLDYLHS-KRPPIIHCNIKASNILLTVGHNAKITDLSMSKFGDALKQHHYTTAPGNPYLMPPEALVHNPVYNKKLDVFSFGCLILHMLTG
|  | .|||.| .|||.   .||||      |||.     |.. |   | |   .     |  |||.  | ||    .  | .| ||||..  |  |.|.
KMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEMHTR

NI
 .
EV
Kinase AqueK502.AA TK-Unique 73-207 26 5.2e-20 65.77 In-house 63-229 (294) Show / Hide 
Range on Protein: 73-207
Range on HMM: 63-229/294
Sequence Identity: 26% (44 aa)

HPNIVKLLGVHYPSGFAQLPMLVMEYLPYS-LLQLIEGRVAINKEA-----------------------------ILLDVANGLDYLHSKRPPIIHCNIK
|||||..||.   |.  . .|..|||.|.. |. ..  .    ..                              .. ..|.|. ||.| |  |.| .. 
HPNIVQCLGCCTKSD--EPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLC

ASNILLTVGHNAKITDLSMSKFGDALKQHHYTTAPGNPYL--MPPEALV--HNPVYNKKLDVFSFGCLI
|.|.||| ....||.|. |.. ... ...  ..  |  ..  |.||.|   |.. .. | || |||.|.
ARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLM
Kinase AqueK502.AA Ciliate-E2 18-214 20 6.4e-20 65.05 In-house 1-293 (365) Show / Hide 
Range on Protein: 18-214
Range on HMM: 1-293/365
Sequence Identity: 20% (61 aa)

RVTRKELGHGSYGVVNELRVNGNQC-------------------AGKKLNDLLAMEDSLLSEFGNAIILHRQQH----------------HPNIVKLLGV
    | .| |..|.| . .|  .|.                   . .|.  .  |. . . .. . | . |. .                ||||.|.  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

HYPSGF----AQLPMLVMEYLPY-SLLQLIE------------GRVAINKEAIL---LDVAN---------------GLDYLHSKRPPIIHCNIKASNIL
     |     .   |||||. . .|...|.            .   .. . |.     ...               .| ||||| . ||| .|| .|||
-----FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENIL

LTVGHNAKITDLSMSKFGD------------------------------ALKQHHYTTAPGNPYLMPPEALVHNPV--------YNKKLDVFSFGCLILH
.      ||.|. .||. |                               ..|. . |  |.|. |.|| |   .         |..| |..|.|...  
F-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE

MLTGN
||.|.
MLFGK
Kinase AqueK502.AA TKL-Unique 118-204 35 4.5e-19 64.03 In-house 115-215 (290) Show / Hide 
Range on Protein: 118-204
Range on HMM: 115-215/290
Sequence Identity: 35% (36 aa)

ILLDVANGLDYLHSKRPPIIHCNIKASNILLTVG-----HNAKITDLSMSKFGDALKQHHYT--------TAPGNPYLMPPEALVHN-PVYNKKLDVFSF
. .|.| |..|||.. |||||...| ||.|.. .      |.|| | . ||| .   .  ..        |  |..  |.|| |  |   |..| ||.||
MAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSF

G
|
G
Pkinase AqueK502.AA Pkinase 18-214 26 1.2e-18 66.99 Pfam 1-209 (293) Show / Hide 
Range on Protein: 18-214
Range on HMM: 1-209/293
Sequence Identity: 26% (58 aa)

RVTRKELGHGSYGVVNELRVNGNQ--CAGKKLNDLLAMEDSLLSEFG--NAIILHRQQHHPNIVKLLGVHYPSGFAQLPMLVMEYLPY-----SLLQLIE
 .. . .| ||.|.| . .  |..   | |...   . .. . . .    . |..|  .|||||.|... .      .  .||||..      .|  .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIY-MVMEYCEGGLYVMDLFDYIS

----GRV--AINK-EAILLDVANGLDYLHSKRPPIIHCNIKASNILLT-VGHNA---KITDLSMSKFGDALKQHHYTTAPGNPYLMPPEALVHNPVYNKK
    |..    .    ... .. ||.|.||.   |||. .| .|||.   ||..   ||.|   .|. |  ... .||  | |. |.|| . ... | .|
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

LDVFSFGCLILHMLTGN
 |..|.||..  ||.|.
VDMWSCGCILYEMLCGR
Kinase AqueK502.AA MLK 73-215 27 1.9e-17 57.23 In-house 64-234 (291) Show / Hide 
Range on Protein: 73-215
Range on HMM: 64-234/291
Sequence Identity: 27% (50 aa)

HPN----IVKLLGV--HYPSGFAQLPMLVMEYLPY-SLLQLIEG-RVAIN----------------KEAILLDVANGLDYLHS-KRPPIIHCNIKASNIL
|||    |....||   .|..|.    .||||... ||  .. | |  ..                .  . |..|.|..|||| ...||||  .| .|||
HPNNHPCIIQFYGVCLQPPCHFC----IVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNIL

LTV------GHNAKITDLSMSKFGDALKQHHY----TTAPGNPYLMPPEAL--VHNPVYNKKLDVFSFGCLILHMLTGNI
..       . ..||.|     || . . |.     . ..|..  | ||..    .  |..| ||.|.| ..  |||. .
IDEICHDMHHGTLKICD-----FGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREV
Kinase AqueK502.AA Ciliate-E2-Unclassified 19-214 19 2.4e-17 56.74 In-house 2-267 (352) Show / Hide 
Range on Protein: 19-214
Range on HMM: 2-267/352
Sequence Identity: 19% (52 aa)

VTRKELGHGSYGVVNELRVNGNQ-------CAGKKLNDLLAMEDSLLSEFGNAIILHRQQ----------------HHPNIVKLLGVHYPSGF--AQLPM
   | .|.|..|.| ... . ..          .. .. . .. .   .  ..... ...                .||.....  ...   |   | . 
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYC---FQDKQNIY

LVMEYLPY-SLLQLIEGR-----------------VAINKEAIL--------LDVANGLDYLHSKRPPIIHCNIKASNILLTVGH---NAKITDLSMSKF
.||||... .|.| |. |                   .  ....          . .||.|||.|   ||| .|| .|||.. ..   . ||.|.. ||.
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKK

GDAL--------------KQHHYTTAPGNPYLM----PPEALVHNPVYN---KKLDVFSFGCLILHMLTGN
 .                ||....|  |.|. |    .|| |  .  ..   .| |..|.|...  ||.|.
YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY
Kinase AqueK502.AA STE-Unique 118-213 21 5e-17 56.52 In-house 408-549 (616) Show / Hide 
Range on Protein: 118-213
Range on HMM: 408-549/616
Sequence Identity: 21% (30 aa)

ILLDVANGLDYLHSKRPPIIHCNIKASNILLTVGH-----NAKITDLSMSKFGDALKQ-------------------------------------HHYTT
... .. ||.||||.. |||| ..|..||... .      ..|| |   .. . .                                           ..
YTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKY

APGNPYLMPPEALVHN----PVYNKKLDVFSFGCLILHMLTG
 .|.|  | || .  .      |. | |..|.||...||..|
CCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCG
Kinase AqueK502.AA TyrKc 18-278 24 2.4e-14 9.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 18-278
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

RVTRKELGHGSYGVVNELRVNGNQCAGKKLNDLLAMEDSLLSEFGNAIILHRQ-QHHPNIVKLLGVHYPSG----FAQLPMLVMEYLPY-SLLQLIEGRV
 .  |.||.| .|.| . . .  |.| |.|..    .  ...|   | |...   ||||||.|.||   .|     .. .|.|||| |. .|.. .  . 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--REDFMRE---ARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

----AINKEAILLDVANGLDYLHSKRPPIIHCNIKASNILLTVGHNAKITDLSMSKFGDAL----KQHHYTTA----PGNPYL----MPPEALVHNPVYN
       .  . ...|.| .|||||  ..||  . | |.|.. .| .||.|  .|....        . | ..     |.  |    |.||.. .. ...
PKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG-KFT

KKLDVFSFGCLILHMLTGNIIVPTDQYEPKPH-----DPGSYV--KISEWNRRAKYIKP-------ALDHILIPVAMNCLEDDPLRRLNTSDIIEII
 | ||.||| ..  ..|          .| |       . . |  .. . .|. .   .       . | .   .   | . ||  | . |.|.|..
TKSDVWSFGVCMWEIFTYG-------QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Pkinase_Tyr AqueK502.AA Pkinase_Tyr 12-163 25 1.3e-09 33.16 Pfam 1-159 (270) Show / Hide 
Range on Protein: 12-163
Range on HMM: 1-159/270
Sequence Identity: 25% (44 aa)

LILQRVRVTRKELGHGSYGVVNELRVN------GNQCAGKKLNDLLAMEDS-LLSEFGNAIILHRQQ-HHPNIVKLLGVHY-PSG-FAQLPMLVMEYLPY
... ..      ||.|..|.| . . .      . ..| |.|..  ||..  .. .| . . . .|  ||||||.|.|| .  ..     ...|||| |.
ITFGKK------LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPH

-SLLQLIEG----RVAINKEAIL---LDVANGLDYLHSKRPPIIHCNIKASNILLTVGHNAKITDLSMSK
 .||         . ... . .|   ...|.|..||.||.  .||  . | |.|.| .. .||.|  ...
GDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLAR
Kinase AqueK502.AA STE-Unique 19-81 27 0.000111 11.91 In-house 1-68 (616) Show / Hide 
Range on Protein: 19-81
Range on HMM: 1-68/616
Sequence Identity: 27% (19 aa)

VTRKELGHGSYGVVNELR--VNGNQCAGKKLNDLLAMEDS----LLSEFGNAIILHRQQHHPNIVKLLG
.    .| || |.|.  .  .....|| |..  |    |.    | . . . | ..   ||.||||..|
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIH-LKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYG