Gene AqueK503 (A.queenslandica)

AqueK503

Species: A.queenslandica
Alias: AqueK503
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a1

Sequence

Name Sequence Type Origin Length Description Download
AqueK503.AA Protein None 369 None Fasta, JSON
AqueK503.kin_dom Protein Kinase Domain None 196 None Fasta, JSON

Protein domain

Protein domains of AqueK503.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK503.AA TKL 22-276 20 4.3e-34 119.58 In-house 1-364 (364) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-364/364
Sequence Identity: 20% (74 aa)

LGRGSYGVVNELRVNG----------NQCAGKKLNDLL-----------------------AMEDSLLSEFGNAII-LHRQQHHPNIVKLLG-VHYPS--
.|.|..|.|   . .|          .  | ||..                          ..| | . .| .  | .... .|||||...| . .|.  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------GSAPLPMLVMEYLPY-SLLQLIEGRVAINKEAILLDVANGLDYLHLKR------PPIIHRNIKASNILLTVGHN--------------AKITD
       |. . ...|||| |  ||| ..       .  . ||.| |..||| ..      ||||||..| .|||.    .              .||.|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICD

LSMSKFGDALKQHHYTTAP-------------GNHFM-----MPPEALVHNP---------------VYNKKLDVFSFGCLILHMFTGNIIVPTDQYEPK
.  |.| .  ..   |                 ..       |.||.|  ..                |..| ||.||| ..  ..|. .  | ..| . 
FGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR--PYYDYPYM

PHDPG----SYVKISEWNRRAKYIK------------PVLDHRLIPVAMNCLQDDPFKRLNASDIIEII
|....     . ..   ...   |.            |  .....  .. | . || ||.....|....
PMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK503.AA TK 20-205 14 2.6e-26 84.57 In-house 5-384 (486) Show / Hide 
Range on Protein: 20-205
Range on HMM: 5-384/486
Sequence Identity: 14% (54 aa)

KELGRGSYG---VVNELRVNGN---------------------------QCAGKKLNDLLAMEDSLLSE--------------FGNAIILHRQ--QHHPN
|.||.| .|   .| . ...|                            ..| | | .  ||..    .              . ... . ..   ||||
KKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPN

IVKLLG-VHYPSGS--------APLPMLVMEYLPY-----SLLQLIEGRVAINKEA--------------------------------------------
||.|.| .. . ..         . .|.|||| |.     ||..    .    ..                                             
IVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDL

----------------------------------ILLDVANGLDYLHLKRP----PIIHRNIKASNILLTVGHN-----------AKITDLSMSK-----
                                  . ...|.|. ||| |.      ..||.. | |.|.. ...           .||.|  .|.     
IKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGV

FGDALKQHHYTTAPGNHFM----------------------------MPPEALVHNP--------VYNKKLDVFSFGCLI
   .. .... .. ... .                            |.||.| ..         ..  | ||.|||.|.
LARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM
S_TKc AqueK503.AA S_TKc 16-281 23 3.1e-25 91.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-281
Range on HMM: 1-231/231
Sequence Identity: 23% (66 aa)

RVTRKELGRGSYGVVNELRVNG--NQCAGKKLNDLLAMEDSLLSEFGNAIILHRQQHHPNIVKLLGVHYPSGSAPLPMLVMEYLPY---SLLQLIEGRVA
    ...|.|..|.|   | ..   ..| |...            . . | .... ||||||||..| .         .||||..    .|...|. |  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGR

------INKEA---ILLDVANGLDYLHLKRPPIIHRNIKASNILLTVGHNAKITDLSMSKFGDALKQHHYTTAPGNHFMMPPEALVHNPVYNK-KLDVFS
      ..      ..  ....|.|.| .   |||| .| .||||.   . ||.|  ....         ||  |  . |.|| |     |.| | |. |
HGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWS

FGCLILHMFTGNIIVPTDQYEPKPHDPGSYVKISEWNRRAKYIKPVLDHRLIPVAMNCLQDDPFKRLNASDIIE----IIIRLQL
.||..  |..|    |         ..    |.              .. ..   ..||| || ||. | .. .    | .   .
CGCILYEMLCGYPPFP---------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK503.AA STE 17-212 21 8e-23 77.5 In-house 1-265 (359) Show / Hide 
Range on Protein: 17-212
Range on HMM: 1-265/359
Sequence Identity: 21% (60 aa)

VTR-KELGRGSYG-VVNELRVN----------------GNQCAGKKLN------------------DLLAMEDSLLSEFGNAIILHRQQH-HPNIVKLLG
 .. ...|.|..| |.  ....                |. .| |..|                  .    ....| |     |... .| |||||| .|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIK---IMKKCNHMHPNIVKYYG

VHYPSGSA----PLPMLVMEYLP-YSLLQLIEGRVAINK-------------EAIL----LDVANG-LDYLHLKRPPIIHRNIKASNILLTVGHNAKITD
 ..  |          ..|||..  || ..|. .  ..|             | ..     ..  | |.||| ..  |||| ||..||||     .|..|
CYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCD

LSMSKFGDA--------------LKQH-HYTTAPGNHFMMPPEALVH-----NPVYNKKLDVFSFGCLILHMFTGN
   ..  .               . .  . .|  |    | || .       .. |. | |. |.||.|..| ||.
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase AqueK503.AA HH498 113-213 36 3.8e-20 60.19 In-house 123-224 (284) Show / Hide 
Range on Protein: 113-213
Range on HMM: 123-224/284
Sequence Identity: 36% (37 aa)

KEAILLDVANGLDYLHL-KRPPIIHRNIKASNILLTVGHNAKITDLSMSKFGDALKQHHYTTAPGNHFMMPPEALVHNPVYNKKLDVFSFGCLILHMFTG
|  | .|||.| .|||    .|||||     |||.     |.. |   | |   .     |  |||   | ||    .  | .| ||||..  |  |.|.
KMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEMHTR

NI
 .
EV
Pkinase AqueK503.AA Pkinase 16-276 22 4.2e-20 72.17 Pfam 1-293 (293) Show / Hide 
Range on Protein: 16-276
Range on HMM: 1-293/293
Sequence Identity: 22% (67 aa)

RVTRKELGRGSYGVVNELRVNGNQ--CAGKKLNDLLAMEDSLLSEFG--NAIILHRQQHHPNIVKLLGVHYPSGSAPLPMLVMEYLPY-----SLLQLIE
 .. . .|.||.|.| . .  |..   | |...   . .. . . .    . |..|  .|||||.|... .  .. .   .||||..      .|  .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-KDHIY--MVMEYCEGGLYVMDLFDYIS

----GRV--AINK-EAILLDVANGLDYLHLKRPPIIHRNIKASNILLT-VGHNA---KITDLSMSKFGDALKQHHYTTAPGNHFMMPPEALVHNPVYNKK
    |..    .    ... .. ||.|.| .   |||| .| .|||.   ||..   ||.|   .|. |  ... .||  |  . |.|| . ... | .|
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

LDVFSFGCLILHMFTGNIIVPTD-------QYEPKPHDPGSYVKISEWNRRAKY------------IKPVLDHRLIPVAMNCLQDDPFKRLNASDIIEI-
 |..|.||..  |..|. . | .       |..    . |  .. .... . ..              . ..  .. .  .||. || ||..| .| .  
VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-I
 .
WF
Kinase AqueK503.AA Ciliate-E2 16-212 19 5.4e-19 61.82 In-house 1-293 (365) Show / Hide 
Range on Protein: 16-212
Range on HMM: 1-293/365
Sequence Identity: 19% (58 aa)

RVTRKELGRGSYGVVNELRVNGNQC-------------------AGKKLNDLLAMEDSLLSEFGNAIILHRQQH----------------HPNIVKLLGV
    | .|.|..|.| . .|  .|.                   . .|.  .  |. . . .. . | . |. .                ||||.|.  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

HY--PSGSAPLPMLVMEYLPY-SLLQLIE------------GRVAINKEAIL---LDVAN---------------GLDYLHLKRPPIIHRNIKASNILLT
 .     .     |||||. . .|...|.            .   .. . |.     ...               .| ||| | . ||||.|| .|||. 
FQEKDDNNI---YLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-

VGHNAKITDLSMSKFGD------------------------------ALKQHHYTTAPGNHFMMPPEALVHNPV--------YNKKLDVFSFGCLILHMF
     ||.|. .||. |                               ..|. . |  |.   |.|| |   .         |..| |..|.|...  | 
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

TGN
.|.
FGK
Kinase AqueK503.AA TK-Unique 71-210 25 1.3e-18 60.87 In-house 63-234 (294) Show / Hide 
Range on Protein: 71-210
Range on HMM: 63-234/294
Sequence Identity: 25% (45 aa)

HPNIVKLLGVHYPSGSAPLPMLVMEYLPYS-LLQLIEGRVAINKEA-----------------------------ILLDVANGLDYLHLKRPPIIHRNIK
|||||..||.   |.    .|..|||.|.. |. ..  .    ..                              .. ..|.|. ||.  |  |.||.. 
HPNIVQCLGCCTKSD--EPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLC

ASNILLTVGHNAKITDLSMSKFGDALKQHHYTT--APGNHFMMPPEALV--HNPVYNKKLDVFSFGCLILHMFT
|.|.||| ....||.|. |.. ... ...  ..   .  .  |.||.|   |.. .. | || |||.|.  .||
ARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase AqueK503.AA TKL-Unique 116-202 36 2.7e-18 61.25 In-house 115-215 (290) Show / Hide 
Range on Protein: 116-202
Range on HMM: 115-215/290
Sequence Identity: 36% (37 aa)

ILLDVANGLDYLHLKRPPIIHRNIKASNILLTVG-----HNAKITDLSMSKFGDALKQHHYT--------TAPGNHFMMPPEALVHN-PVYNKKLDVFSF
. .|.| |..||| . ||||||..| ||.|.. .      |.|| | . ||| .   .  ..        |  |. . |.|| |  |   |..| ||.||
MAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSF

G
|
G
Kinase AqueK503.AA MLK 71-213 26 4.5e-17 55.87 In-house 64-234 (291) Show / Hide 
Range on Protein: 71-213
Range on HMM: 64-234/291
Sequence Identity: 26% (48 aa)

HPN----IVKLLGVHYPSGSAPL-PMLVMEYLPY-SLLQLIEG-RVAIN----------------KEAILLDVANGLDYLHL-KRPPIIHRNIKASNILL
|||    |....||   . . |    .||||... ||  .. | |  ..                .  . |..|.|..|||  ...||||| .| .|||.
HPNNHPCIIQFYGV---CLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILI

TV------GHNAKITDLSMSKFGDALKQHHY----TTAPGNHFMMPPEAL--VHNPVYNKKLDVFSFGCLILHMFTGNI
.       . ..||.|     || . . |.     . ..|.   | ||..    .  |..| ||.|.| ..  |.|. .
DEICHDMHHGTLKICD-----FGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREV
Kinase AqueK503.AA STE-Unique 116-211 20 4.8e-16 52.97 In-house 408-549 (616) Show / Hide 
Range on Protein: 116-211
Range on HMM: 408-549/616
Sequence Identity: 20% (29 aa)

ILLDVANGLDYLHLKRPPIIHRNIKASNILLTVGH-----NAKITDLSMSKFGDALKQ-------------------------------------HHYTT
... .. ||.||| .. |||||..|..||... .      ..|| |   .. . .                                           ..
YTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKY

APGNHFMMPPEALVHN----PVYNKKLDVFSFGCLILHMFTG
 .|. . | || .  .      |. | |..|.||...|| .|
CCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCG
Kinase AqueK503.AA TyrKc 16-276 24 5.8e-15 19.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-276
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

RVTRKELGRGSYGVVNELRVNGNQCAGKKLNDLLAMEDSLLSEFGNAIILHRQ-QHHPNIVKLLGVHYPSG----SAPLPMLVMEYLPY-SLLQLIEGRV
 .  |.||.| .|.| . . .  |.| |.|..    .  ...|   | |...   ||||||.|.||   .|    ... .|.|||| |. .|.. .  . 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--REDFMRE---ARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

----AINKEAILLDVANGLDYLHLKRPPIIHRNIKASNILLTVGHNAKITDLSMSKFGDAL----KQHHYTTA---PGNHFM-----MPPEALVHNPVYN
       .  . ...|.| .||| |  ..||| . | |.|.. .| .||.|  .|....        . | ..    | ..|     |.||.. .. ...
PKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG-KFT

KKLDVFSFGCLILHMFTGNIIVPTDQYEPKPHDP-----GSYVKISEWNRRAKYIKPVLD----------HRLIPVAMNCLQDDPFKRLNASDIIEII
 | ||.||| ..  .||         |  .|.        |   . |. .. .. ..  .            .  .   | . || .| . |.|.|..
TKSDVWSFGVCMWEIFT---------YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK503.AA TKL-ciliate1 116-158 37 1.8e-12 39.03 In-house 108-150 (279) Show / Hide 
Range on Protein: 116-158
Range on HMM: 108-150/279
Sequence Identity: 37% (16 aa)

ILLDVANGLDYLHLKRPPIIHRNIKASNILLTVGHNAKITDLS
.. |.| |. ||| . .|.|||..|  |||. .  . ||.. .
WCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFP
Pkinase_Tyr AqueK503.AA Pkinase_Tyr 10-161 26 1.1e-11 40.21 Pfam 1-159 (270) Show / Hide 
Range on Protein: 10-161
Range on HMM: 1-159/270
Sequence Identity: 26% (44 aa)

LILQRVRVTRKELGRGSYGVVNELRVN------GNQCAGKKLNDLLAMEDS-LLSEFGNAIILHRQQ-HHPNIVKLLGVHY-PSGSAPLPMLVMEYLPY-
... ..      ||.|..|.| . . .      . ..| |.|..  ||..  .. .| . . . .|  ||||||.|.|| .  ...   ...|||| |. 
ITFGKK------LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHG

SLLQLIEG----RVAINKEAIL---LDVANGLDYLHLKRPPIIHRNIKASNILLTVGHNAKITDLSMSK
.||         . ... . .|   ...|.|..||. |.  .||| . | |.|.| .. .||.|  ...
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLAR
Kinase AqueK503.AA STE-Unique 17-79 28 2e-05 14.56 In-house 1-68 (616) Show / Hide 
Range on Protein: 17-79
Range on HMM: 1-68/616
Sequence Identity: 28% (20 aa)

VTRKELGRGSYGVVNELR--VNGNQCAGKKLNDLLAMEDS----LLSEFGNAIILHRQQHHPNIVKLLG
.    .|||| |.|.  .  .....|| |..  |    |.    | . . . | ..   ||.||||..|
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIH-LKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYG
Kinase AqueK503.AA TKL-ciliate1 251-276 34 8.4e-05 12.37 In-house 254-279 (279) Show / Hide 
Range on Protein: 251-276
Range on HMM: 254-279/279
Sequence Identity: 34% (9 aa)

LIPVAMNCLQDDPFKRLNASDIIEII
.. . | |.  .| || |.. ||.|.
FHNLMMRCWCQNPNKRPNFNEIIQIL
Ubiquitin AqueK503.AA ubiquitin 318-367 38 2.3e-10 41.18 Pfam 22-73 (73) Show / Hide 
Range on Protein: 318-367
Range on HMM: 22-73/73
Sequence Identity: 38% (20 aa)

ELKDAITKLKGIPYEHIRLLYEGRQL-ADDMTFKDYKIEKFA-KIYLSLRLI
.|| .| .  ||| . .||.|.|.||  |..| .||.|.. . .|.. ||. 
QLKQKIQQKQGIPPDQQRLIYKGKQLREDHRTLSDYNIQDGSFTIHMVLRQR
Rad60-SLD AqueK503.AA Rad60-SLD 314-356 34 2e-06 28.43 Pfam 22-65 (73) Show / Hide 
Range on Protein: 314-356
Range on HMM: 22-65/73
Sequence Identity: 34% (15 aa)

TRIIELKDAITKLKGIPY-EHIRLLYEGRQLADDMTFKDYKIEK
|.. .|..|  | .|||  . .||.. | .| ...|..|| .|.
TTFSKLMNAYCKKRGIPEHQQVRLIFDGERLDPNDTVEDYDMED
UBQ AqueK503.AA UBQ 300-365 32 0.000121 22.67 SMART 1-72 (72) Show / Hide 
Range on Protein: 300-365
Range on HMM: 1-72/72
Sequence Identity: 32% (24 aa)

TNFFCNISE--DSF-----YET-RIIELKDAITKLKGIPYEHIRLLYEGRQLADDMTFKDYKIEKFAKIYLSLR
 . |.  ..  ..|       .  . |||..| ...||| | .||.|.|. | || |  ||.|.. ..|.| .|
MQIFVKWQNGWKTFTFEVKPSDWTVSELKQHIEDKEGIPPEQQRLIYQGK-LEDD-TLADYNIQPGSTIHLMVR