Gene AqueK507 (A.queenslandica)

AqueK507

Species: A.queenslandica
Alias: AqueK507
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a1

Sequence

Name Sequence Type Origin Length Description Download
AqueK507.AA Protein None 248 None Fasta, JSON
AqueK507.kin_dom Protein Kinase Domain None 199 None Fasta, JSON

Protein domain

Protein domains of AqueK507.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK507.AA TKL 24-231 23 1.4e-32 114.6 In-house 1-298 (364) Show / Hide 
Range on Protein: 24-231
Range on HMM: 1-298/364
Sequence Identity: 23% (70 aa)

LGRGSYGVVIELRFNG----------NQCAGKKLR---DFHFLATSTE-------------DRLLSKFGDEVI----LHSQLHHPNIVRLLG-VHYCTG-
.|.|..|.|   ...|          .  | ||..   |  |  .| |             |. .|.| .. .    ..|.|.|||||...| . .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------SQLPMLVMEYLPH-ALLQLIERRGIINKEAILLDVANGLDYLHAKR------PPIIHHNIKASNVLVTVDYK--------------AKITD
         .  ...|||| |.  || ..    .  .  . ||.| |..|||...      ||||| ..| .|.||  ...              .||.|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICD

LSMSKLGDALKEHNYNT------------------FPGNPYLMPPEAFVHNP---------------VYSEKLDVFSFGCLILHMLTGNVIVPTDQYKPS
.  |.  .  .. | .                     |.|. |.||..  ..                |||| ||.||| ..  .||. .  | ..|...
FGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR--PYYDYPYM

PQD
|..
PMI
Kinase AqueK507.AA TK 22-210 14 1.5e-28 92.16 In-house 5-384 (486) Show / Hide 
Range on Protein: 22-210
Range on HMM: 5-384/486
Sequence Identity: 14% (56 aa)

RELGRGSYG---VVIELRFNGN---------------------------QCAGKKLRDFH-FLATSTEDRLLS---------KFGDEVILHSQ--LHHPN
..||.| .|   .| . . .|                            ..| | |.. .   ..  .|. .          ..  |  . ..  .||||
KKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPN

IVRLLG------------VHYCTGSQLPMLVMEYLPH-----ALLQLIE--RRGIINKEA----------------------------------------
||||.|            | . .... .|.|||| ||     .|..     |.. .. .                                         
IVRLYGVCTQGEPKPCFEV-V-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDD

------------------------------------ILLDVANGLDYLHAKRP----PIIHHNIKASNVLVTVDYK-----------AKITDLSMSK---
                                    . ...|.|. |||.|.      ..| .. | |.||. ...           .||.|  .|.   
DLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGS

--LGDALKEHNYNTFPGNPYL----------------------------MPPEAFVHNP--------VYSEKLDVFSFGCLI
  |  .. .. . .  ....                             |.||.. ..         ....| ||.|||.|.
GVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM
Kinase AqueK507.AA STE 18-218 21 5.4e-25 85.27 In-house 1-266 (359) Show / Hide 
Range on Protein: 18-218
Range on HMM: 1-266/359
Sequence Identity: 21% (59 aa)

RETTRELGRGSYG-VVIELRFN----------------GNQCAGKKLR--DF------HFLATSTE-----DRLLSKFGDEVILHSQLH--HPNIVRLLG
 |  ...|.|..| |.  .. .                |. .| |...  .          . . |     .  . ..  |. ......  |||||. .|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQ-EN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYG

VHYCTG------SQLPMLVMEYLPH-ALLQLIERRGIINK-------------EAIL----LDVANG-LDYLHAKRPPIIHHNIKASNVLVTVDYKAKIT
 ..  |      ..|  ..|||..   | ..|.......|             | ..     ..  | |.||| ..  |||  ||..|.|.     .|..
CYFKEGHNHKNDDEL-WICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLC

DLSMSK-LGDALKEH--------------NYNTFPGNPYLMPPEAFVH-----NPVYSEKLDVFSFGCLILHMLTGNV
|   .. | | . .               . ||| | |  | ||         .. |..| |. |.||.|..|.||..
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKP
Kinase AqueK507.AA TK-Unique 63-210 27 1.4e-23 78.26 In-house 48-229 (294) Show / Hide 
Range on Protein: 63-210
Range on HMM: 48-229/294
Sequence Identity: 27% (50 aa)

SKFGDEVILHSQLH-HPNIVRLLGVHYCTGSQ-LPMLVMEYLPHA-LLQLIERRG---------------------------IINKEAI--LLDVANGLD
..| .|  ....|  |||||..||  .|| |.  .|..|||.|   |. .. ...                           |  |  .  . ..|.|. 
QDFLKEIQMMKELGDHPNIVQCLG--CCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGME

YLHAKRPPIIHHNIKASNVLVTVDYKAKITDLSMSKLGDALKEHNYNTFPGNPYL--MPPEAFV--HNPVYSEKLDVFSFGCLI
||.  |  |.|... |.|||.| |...||.|. |.. ... .... ..  |  ..  |.||..   |.. ...| || |||.|.
YLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLM
Kinase AqueK507.AA HH498 118-218 37 7.9e-21 62.41 In-house 123-224 (284) Show / Hide 
Range on Protein: 118-218
Range on HMM: 123-224/284
Sequence Identity: 37% (38 aa)

KEAILLDVANGLDYLHA-KRPPIIHHNIKASNVLVTVDYKAKITDLSMSKLGDALKEHNYNTFPGNPYLMPPEAFVHNPVYSEKLDVFSFGCLILHMLTG
|  | .|||.| .|||    .||||      |.|.  | .|.. |   |     . . |    |||.  | || |  .  ||.| ||||..  |  |.|.
KMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEMHTR

NV
 |
EV
Kinase AqueK507.AA Pkinase 18-221 27 4e-20 72.24 Pfam 1-213 (293) Show / Hide 
Range on Protein: 18-221
Range on HMM: 1-213/293
Sequence Identity: 27% (61 aa)

RETTRELGRGSYGVVIELRFNGNQ--CAGKKLRDFHFLA-TSTEDRLLSKFGDEVILHSQLHHPNIVRLLGVHYCTGSQLPMLVMEYLPH-----ALLQL
 .. | .|.||.|.| . .  |..   | |...  |       ..|.|     |. ..  |.|||||||... .   .. . .||||...      |  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDY

IE--RRGII--NKEA---ILLDVANGLDYLHAKRPPIIHHNIKASNVLVTVDYKA----KITDLSMSKLGDALKEHNYNTFPGNPYLMPPEAFVHNPVYS
|.  |.| .    .    ... .. ||.|.|..   |||  .| .|.|.  ..      ||.|   .|. |  . . ..|| | |. |.||   ... |.
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

EKLDVFSFGCLILHMLTGNVIVP
 | |..|.||..  ||.|. . |
PKVDMWSCGCILYEMLCGRPPFP
Kinase AqueK507.AA TKL-Unique 121-207 36 1.1e-19 66.2 In-house 115-215 (290) Show / Hide 
Range on Protein: 121-207
Range on HMM: 115-215/290
Sequence Identity: 36% (37 aa)

ILLDVANGLDYLHAKRPPIIHHNIKASNVLVTVD-----YKAKITDLSMSKLGDALKEHNYN--------TFPGNPYLMPPEAFVHN-PVYSEKLDVFSF
. .|.| |..||| . ||||| ..| ||.||. .     ...|| | . ||. .   . ..|        |. |..  |.|| .  |   |||| ||.||
MAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSF

G
|
G
Kinase AqueK507.AA LRRK 18-216 24 3.3e-18 61.0 In-house 1-278 (351) Show / Hide 
Range on Protein: 18-216
Range on HMM: 1-278/351
Sequence Identity: 24% (69 aa)

RETTRELGRGSYG-VVIELRFNG----------------------------NQCAGKKLRDFHFLATSTED-----------------------------
 .  ...|||..| .|   ...|                            .  | ||. ...   |.. |                             
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKW-NRDPM-TIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCC

RLLSKFGDEVILHSQLHHPNIVRLLGVHYCTGSQLPMLVMEYLPH-ALLQLIE---RRGI----IN-----KEAILLDVANGLDYLHAKRPPIIHHNIKA
| ...|  || . | |.||||| |.|.    . . ...||||.|| .| ....   . |.    ..     |  | |..| |..||| ..||||| . | 
RAFREFRHEVWIMSHLNHPNIVSLKGF----CIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKS

SNVLV-TV-----------DYKAKITDLSMSK-LGDALKEHNYNTFPGNPYLMPPEAFVHN--PVYSEKLDVFSFGCLILHMLTG
 |.|. .            ...||| | . |     ....   ... |||  | ||    |   .|.|| |..||| .. . ||.
PNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTR
Kinase AqueK507.AA STE-Unique 97-216 22 1.1e-17 58.87 In-house 371-549 (616) Show / Hide 
Range on Protein: 97-216
Range on HMM: 371-549/616
Sequence Identity: 22% (40 aa)

LVMEYLPHALL-QLIERRGI---------INKEAI---LLDVANGLDYLHAKRPPIIHHNIKASNVLVTVDY-----KAKITD--LSMSKLGDALKE---
..|||..| .| |.|.| |.         .  . .   .. .. ||.||| .. ||||...|..|.. . |      |.|| |  .. ..  | .     
IFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNN

--------------------------------HNYNTFPGNPYLMPPEAFVHN----PVYSEKLDVFSFGCLILHMLTG
                                 .  . .|.|  | ||    .      |. | |..|.||...||..|
SKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCG
Kinase AqueK507.AA Ciliate-E2-Unclassified 75-217 23 2.2e-17 56.87 In-house 76-267 (352) Show / Hide 
Range on Protein: 75-217
Range on HMM: 76-267/352
Sequence Identity: 23% (46 aa)

LHHPNIVRLLGVHYCTGSQLPMLVMEYLPHALLQLIER------------------RGIINKEAIL--------LDVANGLDYLHAKRPPIIHHNIKASN
|.||.....  ... .  | . .||||...  |. . .                  | |.  ....          . .||.||| |   ||| .|| .|
LNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPEN

VLVTVDY---KAKITDLSMSKLGDAL--------------KEHNYNTFPGNPYLM----PPEAF-VHNPVYS--EKLDVFSFGCLILHMLTGN
.|.. .    . ||.|.. ||  .                |.....|| |.|. |    .|| .  .|.  |  .| |..|.|...  ||.|.
ILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY
Kinase AqueK507.AA MLK 123-218 29 5.2e-16 52.13 In-house 131-234 (291) Show / Hide 
Range on Protein: 123-218
Range on HMM: 131-234/291
Sequence Identity: 29% (32 aa)

LDVANGLDYLHA-KRPPIIHHNIKASNVLVTV------DYKAKITDLSMSKLGDALKEHNYN-----TFPGNPYLMPPEAF--VHNPVYSEKLDVFSFGC
|..|.|..|||. ...||||. .| .|.|..       . ..||.|      ... .. . .      ..|..  | ||..    .  |||| ||.|.| 
LQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICD------FGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGV

LILHMLTGNV
..  |||. |
VLWEMLTREV
Kinase AqueK507.AA S_TKc 18-248 23 9.1e-16 54.31 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-248
Range on HMM: 1-231/231
Sequence Identity: 23% (62 aa)

RETTRELGRGSYGVVIELRFNG--NQCAGKKLRDFHFLATSTEDRLLSKFGDEVILHSQLHHPNIVRLLGVHYCTGSQLPMLVMEYLPH---ALLQLIER
 |  |..|.|..|.|   | ..   ..| |...               ..  |. .... ||||||.|..| .    .   .||||...    |...|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKK

RG-------IINKEA--ILLDVANGLDYLHAKRPPIIHHNIKASNVLVTVDYKAKITDLSMSKLGDALKEHNYNTFPGNPYLMPPEAFVHNPVYSE-KLD
||       .   .|  ..  ....|.|.| .   |||  .| .|.|..     ||.|  ....         .|| | |. |.|| .     |.  | |
RGRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCD

VFSFGCLILHMLTGNVIVPTDQYKP------SPQDRNSFIKVSEWDRR------AGS----------I
. |.||..  ||.|    |  |..       ||. ..   |  ..| .      |            .
WWSCGCILYEMLCGYPPFP--QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK507.AA TyrKc 18-242 22 6.4e-14 2.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 18-242
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

RETTRELGRGSYGVVIELRFNGNQCAGKKLRDFHFLATSTEDRLLSKFGDEVILHSQL--HHPNIVRLLGVHYCTGS-------QLPMLVMEYLPH-ALL
 .  ..||.| .|.| . . .  |.| |.|.. .          .  | .|  . ..|  ||||||||.||  || .       . .|.|||| || .|.
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGV--CTQQGRNFMYIEPLMIVMEYMPHGDLK

QLIERRG----IINKEAILLDVANGLDYLHAKRPPIIHHNIKASNVLVTVDYKAKITDLSMSKLGDAL----KEHNYNTF----PGNPYL----MPPEAF
. . ...       .  . ...|.| .||| |  ..||  . | |.||. .. .||.|  .|. ..       .. | .      |.  |    |.||..
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

VHNPVYSEKLDVFSFGCLI-----------LHM----LTGNVIVPTDQYK------PS------------------------PQDRNSFIKVSEWD
 .. ....| ||.||| ..             |    ..   ..   .        |.                        | || .|  . |  
NYG-KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK507.AA Pkinase_Tyr 19-167 27 3.5e-13 45.27 Pfam 2-160 (270) Show / Hide 
Range on Protein: 19-167
Range on HMM: 2-160/270
Sequence Identity: 27% (47 aa)

ETTRELGRGSYGVVIELRFN------GNQCAGKKLRDFHFLATSTEDRL--LSKFGDEVILHSQL-HHPNIVRLLGVHYCT-GSQL--PMLVMEYLPH-A
.  ..||.|..|.| . . .      . ..| |.|..      .. ..   . .|  |. . .|| ||||||||.||  ||  ..   ...|||| ||  
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE------GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGV--CTDQGEPNQIYIVMEYMPHGD

LLQLIERR-------GIINKEAILLDVANGLDYLHAKRPPIIHHNIKASNVLVTVDYKAKITDLSMSKL
||    ..        .  .  . ...|.|..||..|.  .||  . | |.||| . ..||.|  ....
LLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARD
Kinase AqueK507.AA STE-Unique 19-85 28 6.1e-08 23.69 In-house 1-68 (616) Show / Hide 
Range on Protein: 19-85
Range on HMM: 1-68/616
Sequence Identity: 28% (20 aa)

ETTRELGRGSYGVVIELR--FNGNQCAGKKLRDFHFLATSTEDRLLSKFGDEVILHSQLHHPNIVRLLG
.    .|||| |.|   .   ....|| |...   |.    |  | ...  |. ... |||.|||...|
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEP-LVNMIISEIEIMKCLHHQNIVKYYG
Kinase AqueK507.AA MLK 18-104 25 7.3e-07 19.98 In-house 1-94 (291) Show / Hide 
Range on Protein: 18-104
Range on HMM: 1-94/291
Sequence Identity: 25% (24 aa)

RETTRELGRGSYGVVIELRFNGNQ-----CAGKKLRDFHFLATSTEDRLLSKFGDEVILHSQLHHPN----IVRLLGVHYCTGSQLPMLVMEYLPH
 .. . .| ||.|.|   |. ..       | |. |   | . | ..    .|  |. . . | |||    |....||  ... .   .||||...
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP-CHFCIVMEYCEG
Kinase AqueK507.AA TKL-Unique 20-104 32 5e-06 17.37 In-house 1-84 (290) Show / Hide 
Range on Protein: 20-104
Range on HMM: 1-84/290
Sequence Identity: 32% (29 aa)

TTRELGRGSYGVVIELRFNGNQCAGKKLRDFHFLATSTEDRLLSKFGDEVILHSQLH-HPNIVRLLGVHYCT--GSQLP--MLVMEYLPH
    .|.|.||.|.   ..| . | |.   ||.   . . ... .| .|| . . || |||||.. |  ||.    . |   .||||.|.
FWNKIGEGGYGQVYKGKWRGYPVAIKQ---FHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMG--YCMDHQVYPPNMCIVMEYCPG
Kinase AqueK507.AA HH498 19-85 26 0.001111 7.1 In-house 2-69 (284) Show / Hide 
Range on Protein: 19-85
Range on HMM: 2-69/284
Sequence Identity: 26% (18 aa)

ETTRELGRGSYGVVIELRFNGNQCAGKKLRDFHFLATST-EDRLLSKFGDEVILHSQLHHPNIVRLLG
|. .  | ||.| |   .. .   | |  |   |.. |     .  .|  || . ..| ||. |. ..
EFHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVY
Kinase AqueK507.AA Pkinase_Tyr 186-210 40 2.161444 1.95 Pfam 181-204 (270) Show / Hide 
Range on Protein: 186-210
Range on HMM: 181-204/270
Sequence Identity: 40% (10 aa)

MPPEAFVHNPVYSEKLDVFSFGCLI
|.||.. ..  ...| || ||| |.
MAPECINYGK-FTTKSDVWSFGVLM