AqueK508

Species: A.queenslandica
Alias: AqueK508
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a1

Sequence

Name Sequence Type Origin Length Description Download
AqueK508.AA Protein None 308 None Fasta, JSON
AqueK508.kin_dom Protein Kinase Domain None 199 None Fasta, JSON

Protein domain

Protein domains of AqueK508.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK508.AA TKL 21-275 19 5.6e-42 145.78 In-house 1-364 (364) Show / Hide
Range on Protein: 21-275
Range on HMM: 1-364/364
Sequence Identity: 19% (74 aa)

LGRGAYGVVTEVIVSG----------TTCAAKKLHDAIVQGYTL-------------------------KKFCDEVLLHSQQRHPNIVQLIG-VYYPPR-
.|.|..|.|   .  |          .. | ||..   ..  |.                         ...  |....|. |||||||..| . .||  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------SQLPMLVMEYLPL-S-LTQCLEREELPLQMKYSILLDVAKGLCYLHGKR------PPIVHRDLTANNVLLTSSYS--------------AK
         .  ...|||| |  | | . .      .. . .. ||.|.|..||| ..      |||.||||. .|.|. . .               .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

ISDLGVSRLADTFKK------------------HHLTTAPGNAIVMPPEALEDNP---------------VYDHKLDVFSYGCLILHVLTGQFPEP-TNQ
|.|.| ||  .. ..                   .. |  |.   |.||.|....                |. | ||.|.| ..  .||.. |.   . 
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

FVRIPGKEHFRKVSEWDRRSSYIKNIP--------------KETELLPLAKQCLNDASTGRPEMIESCQFI
. .|...  |    ...   ..   ||                ...  |...| .   . || . |  . .
MPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase AqueK508.AA TK 18-204 16 1.3e-33 109.53 In-house 4-384 (486) Show / Hide
Range on Protein: 18-204
Range on HMM: 4-384/486
Sequence Identity: 16% (62 aa)

GKELGRGAYG---VVTEVIVSG---------------------------TTCAAKKLHDAIVQGYTLKK---------------FCDEVLLHSQ--QRHP
||.||.|..|   .| . .. |                           |..| | |..   .  . ..               .. |  . ..   .||
GKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHP

NIVQLIGVYYPPRS----------QLPMLVMEYLPL-----SLTQCLE--REE-----------------------------------------------
|||.|.||   ...          . .|.|||| |.     || . |   |..                                               
NIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDD

----------------------------LPLQMKYSILLDVAKGLCYLHGKRP----PIVHRDLTANNVLLTSSYS-----------AKISDLG------
                            |... .  . ...|.|. ||| |.      .||||| | |.|.....            .||.| |      
LIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGS

--VSRLAD---TFKKHHLTTAPGNAIV-----------------------MPPEALEDNP--------VYDHKLDVFSYGCLI
   .|  .      ...  ......                         |.||.|.|.         .. .| ||.|.|.|.
GVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM

Kinase AqueK508.AA TKL-Unique 17-201 28 2.5e-32 111.38 In-house 1-215 (290) Show / Hide
Range on Protein: 17-201
Range on HMM: 1-215/290
Sequence Identity: 28% (62 aa)

TGKELGRGAYGVVTEVIVSGTTCAAKKLH-DAIVQGYTLKKFCDEVLLHSQQR-HPNIVQLIGVYY---PPRSQLPMLVMEYLPL-SLTQCLE-------
 .. .|.|.||.|  ..  |.  | |..|  . .    ...| .|| . .  . |||||...|.     .. ...  .||||.|. ||   |        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNM-CIVMEYCPGGSLYDVLHQNNNNNN

----REELPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSS-----YSAKISDLGVSRLADTFKKHHLT--------TAPGNAIVMPPEALE
      .|..|..... .|.|.|..||| . ||| ||||.  |.|...      ...||.| | |.....  |  ..        |  |... |.|| |.
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

DN-PVYDHKLDVFSYG
.|   |. | ||.|.|
MNFCQYSEKSDVYSFG

S_TKc AqueK508.AA S_TKc 15-275 22 8.6e-30 106.22 SMART 1-231 (231) Show / Hide
Range on Protein: 15-275
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)

KETGKELGRGAYGVVTEVIV--SGTTCAAKKLHDAIVQGYTLKKFCDEVLLHSQQRHPNIVQLIGVYYPPRSQLPMLVMEYLPL---SLTQCLEREE---
 | ....|.||.|.|  ..   .|  .| |...         .... |. .... .|||||.|..|..    .   .||||..    .| . ...     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLGVSRLADTFKKHHLTTAPGNAIVMPPEALEDNPVYDH-KLDVFSYG
    .|  .  ...  ....| |.| .   |.||||   |.||..    ||.| |..|.         ||  |    |.|| |     |.. | |. | |
LRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCG

CLILHVLTGQFPEP-TNQFVRIPGKEHFRKVSEWDRRSSYIKNIPKETELLPLAKQCLNDASTGRPEMIESCQ---------FI
|..   |.|. | |  ..  .. |                        |.. . ..||.   . ||   |  |         ..
CILYEMLCGYPPFPQMQMMFKKIG----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase AqueK508.AA LRRK 15-213 25 1.3e-29 101.91 In-house 1-282 (351) Show / Hide
Range on Protein: 15-213
Range on HMM: 1-282/351
Sequence Identity: 25% (72 aa)

KETGKELGRGAYG-VVTEVIVSG----------------------------TTCAAKKLHDA-----------------------------IVQGYTLKK
 . ....|||..| .|   .. |                            .. |.||..                               ..   ....
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FCD---EVLLHSQQRHPNIVQLIGVYYPPRSQLPMLVMEYLPL-SLTQCLE---REE-------LPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANN
|.    || . |  .|||||.|.|.   |.    ..||||.|. .| . |.   . .       .. ..|. | |..|||. ||| ..|||.||||.  |
FREFRHEVWIMSHLNHPNIVSLKGFCIHPL----CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPN

VLLTSS------------YSAKISDLGVSR-LADTFKKHHLTTAPGNAIVMPPEALEDN--PVYDHKLDVFSYGCLILHVLTGQ-FP
.|| ||            . |||.| | ||    .|..  . .  || . | || . .|   .|. | |..|.| .. . ||.| .|
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP

Kinase AqueK508.AA Pkinase_Tyr 16-161 30 1e-27 94.52 Pfam 2-160 (270) Show / Hide
Range on Protein: 16-161
Range on HMM: 2-160/270
Sequence Identity: 30% (49 aa)

ETGKELGRGAYGVVTEVIVS------GTTCAAKKLHDAIVQGY-TLKKFCDEVLLHSQQ-RHPNIVQLIGVYYPPRSQ-LPMLVMEYLPL-SLTQCLERE
. ||.||.||.|.| . .        ....| |.| .   .    ...|  |. . .|  .|||||.|.|| .. . .  ...|||| |. .|   | . 
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

-----ELPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLGVSRL
      |..... .. ...|||. ||. |.  ..|||| | |.|.|..  .||.| | .|.
REDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARD

Kinase AqueK508.AA STE 15-213 21 2.3e-27 93.75 In-house 1-267 (359) Show / Hide
Range on Protein: 15-213
Range on HMM: 1-267/359
Sequence Identity: 21% (60 aa)

KETGKELGRGAYGVVTEVIVS-----------------GTTCAAKKLH---------------DAIVQGYTLKKFCDEVLLHSQQR--HPNIVQLIGVYY
 |  ...|.||.|.|   .                   |. .| |...               . ...   ....  |. .... .  |||||. .| |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

---PP---RSQLPMLVMEYLP-LSLTQCLER-----EELP----------LQMKYSILLDVAKG-LCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLG
   ..   ...|  ..|||..  ||.. ...     ..|.           .    |. .. || | ||| ..  |.|||. . |.||     .|..| |
KEGHNHKNDDEL-WICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFG

VSR-LADTFKKH--------------HLTTAPGNAIVMPPEALED-----NPVYDHKLDVFSYGCLILHVLTGQFP
|.  |.|.  .               . .|  |    | || ..      .. || | |. | ||.|.. .||. |
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP

Kinase AqueK508.AA MLK 15-213 24 1.3e-26 89.43 In-house 1-235 (291) Show / Hide
Range on Protein: 15-213
Range on HMM: 1-235/291
Sequence Identity: 24% (58 aa)

KETGKELGRGAYGVVTEVIVSGTT-----CAAKKLH----DAIVQGYTLKKFCDEVLLHSQQRHPN----IVQLIGV-YYPPRSQLPMLVMEYLPL-SLT
 .. . .| |..|.|      ...      | |. .    |. . .   ..|  |. . .  .|||    |.|. ||   ||  .   .||||..  || 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP--CHFCIVMEYCEGGSLY

QCLEREE---------------LPLQMKYSILLDVAKGLCYLHG-KRPPIVHRDLTANNVLLTS------SYSAKISDLGVSRLADTFKKHH---LTTAP
  |  ..                ... . .. |..|.|. |||  ...||.||||   |.|..          .||.| |.||    .....    . ..
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR----DWHQMCTNMMSNA

GNAIVMPPEALE--DNPVYDHKLDVFSYGCLILHVLTGQFP
|... | ||...   .  |. | ||.|.| ..  .||.. |
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP

Kinase AqueK508.AA TK-Unique 15-204 27 1.3e-25 85.31 In-house 1-229 (294) Show / Hide
Range on Protein: 15-204
Range on HMM: 1-229/294
Sequence Identity: 27% (64 aa)

KETGKELGRGAYGVVTEVIVSG-------TTCAAKKLHDAIVQGYTLKKFCDEVLLHSQQR-HPNIVQLIGVYYPPRSQLPMLVMEYLPLS-----LTQC
 | |...|.||.| |    |.|       ..|.| |.. . ... . ..| .|  ....   ||||||..|.   .  . .|..|||.| .     | .|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC

L-----------------------EREELPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLGVSRLADTFKKHHLTTAPGNAI
                        ..|.. ..  |... ..|.|. ||.. |  |||||| | |||||. . .||.|.| .|  .| ...  ..  |  .
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

V--MPPEALE--DNPVYDHKLDVFSYGCLI
.  |.||.|   ... .  | || |.|.|.
IRWMAPESLKCYHGMYHTTKSDVWSFGVLM

Kinase AqueK508.AA HH498 109-213 38 1.4e-25 77.76 In-house 120-225 (284) Show / Hide
Range on Protein: 109-213
Range on HMM: 120-225/284
Sequence Identity: 38% (41 aa)

LQMKYSILLDVAKGLCYLHG-KRPPIVHRDLTANNVLLTSSYSAKISDLGVSRLADTFKKHHLTTAPGNAIVMPPEALEDNPVYDHKLDVFSYGCLILHV
|| |  | .|||.|  |||    .||.||||.  |.|.     |.. | | ||         .|  |||   | ||    .  |. | |||||.  |   
LQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEM

LTGQFP
.|.  |
HTREVP

Kinase AqueK508.AA Dicty4 16-201 29 3.7e-25 81.01 In-house 2-204 (277) Show / Hide
Range on Protein: 16-201
Range on HMM: 2-204/277
Sequence Identity: 29% (61 aa)

ETGKELGRGAYGVVTEVIVSGTTCAAKKL--HDAIVQGYTLKKFCDEVLLHSQQRHPNIVQLIGVYYPPRSQL--PMLVMEYLPL-SLTQCLER------
 .....|.|..| |   .. |.  | |||  |   .  ..|. |  || . .. |||||... |    |||.   .. |.||.|  .|   |        
NIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQ

EELPLQ--MKYS---ILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLGVSR--LADTFKKHHLTTAPGNAIVMPPEALEDNPVYDHKLDV
.. .|.     .   . .|.|.|. .||.  | |.|||| . | |   .. .|..|.| |.    .. .|  ..|| | .  | || .  .| |. | ||
QSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQP-YNEKADV

FSYG
.|.|
YSFG

Kinase AqueK508.AA Pkinase 15-213 24 1.7e-24 87.7 Pfam 1-211 (293) Show / Hide
Range on Protein: 15-213
Range on HMM: 1-211/293
Sequence Identity: 24% (55 aa)

KETGKELGRGAYGVVTEVIVSGTTC-AAKKLHDAIVQGYTLKKFCD-------EVLLHSQQRHPNIVQLIGVYYPPRSQLPMLVMEYLPL-----SLTQC
 ..|. .|.|..|.| . .  || .  | |    |.   . |. .|       |. ..   .|||||.|.....   .. . .||||..      .|   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK----IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDY

LE-REELPL--QMKY--SILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSA----KISDLGVSRLADTFKKHHLTTAPGNAIVMPPEALEDNPVYD
.. ... ..  ...   .... ...|| |.| .   |.||||   |.|. . .      ||.| |.....|. ... .||  |    |.|| . ... |.
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

HKLDVFSYGCLILHVLTGQFP
.| |..|.||..  .|.|..|
PKVDMWSCGCILYEMLCGRPP

Kinase AqueK508.AA RIPK 21-214 24 1.5e-23 77.11 In-house 1-228 (290) Show / Hide
Range on Protein: 21-214
Range on HMM: 1-228/290
Sequence Identity: 24% (55 aa)

LGRGAYGVVTEVI-VSGTTCAAKKL-----HDAIVQGYTLKKFCDEVLLHSQQRHPNIVQLIGVYYPP----RSQLPMLVMEYLPL-SLTQCLEREE---
.|.|. | |  .  ..  . .|||       .. ..    ..   |.    . |. .||.. |.   .     ..|. .|||| .  ||   | ..    
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---LPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLGVSRLADTFKKHH----------LTTAP--GNAIVMPPEALE---DN
   .|.  .  ..  .. | ||||.. ||| ||||   |.|. . . .||.|.|..    . . |            . ..  |  . ||||...    .
HHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKK

P--VYDHKLDVFSYGCLILHVLTGQFPE
|  | . | || |.. ..  |||.  |.
PIKVVTPKYDVYSFAIVMWEVLTQKHPY

Kinase AqueK508.AA TyrKc 15-275 26 7.5e-21 76.52 SMART 1-280 (280) Show / Hide
Range on Protein: 15-275
Range on HMM: 1-280/280
Sequence Identity: 26% (78 aa)

KETGKELGRGAYGVVTEVIVSGTTCAAKKLHDAIVQGYTLKKFCDEVLLHSQQ--RHPNIVQLIGVYYPP-----RSQLPMLVMEYLPL-SLTQCLEREE
 . ||.||.||.|.| . . . ...| |.|..       .. |..|  . ..   .|||||.|.||   .      .. .|.|||| |. .| . | . .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LPLQMKYSILLDVAKGLCYLHGKRPPIVHRDLTANNVLLTSSYSAKISDLGVSRLADTF------KKHHLTTA--PGN--AIV--MPPEALEDNPVYD
  |... . |. ...|.|  ||| |  ...|||| | |.|... . .|||| | ||  .        |.   ..    |.    .  |.||.. .  .. 
PKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

HKLDVFSYGCLILHVLT-GQFPEPT-NQFVRIPGKEHFRKVSEWDRRSSYIKNIP-----KETELLPLAKQCLNDASTGRPEMIESCQFI
.| ||.|.| ..  ..| || | |   |   .. .| ...| . .|.     . |       .|.  . ||| .     || . | ....
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase AqueK508.AA Pkinase_Tyr 180-204 36 3.316968 1.32 Pfam 181-204 (270) Show / Hide
Range on Protein: 180-204
Range on HMM: 181-204/270
Sequence Identity: 36% (9 aa)

MPPEALEDNPVYDHKLDVFSYGCLI
|.||.. ..  . .| || |.| |.
MAPECINYGK-FTTKSDVWSFGVLM