Gene AqueK518 (A.queenslandica)

AqueK518

Species: A.queenslandica
Alias: AqueK518
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a2

Sequence

Name Sequence Type Origin Length Description Download
AqueK518.AA Protein None 641 None Fasta, JSON
AqueK518.kin_dom Protein Kinase Domain None 155 None Fasta, JSON

Protein domain

Protein domains of AqueK518.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK518.AA TKL 453-602 25 2.8e-37 130.16 In-house 1-203 (364) Show / Hide 
Range on Protein: 453-602
Range on HMM: 1-203/364
Sequence Identity: 25% (54 aa)

LGRGGWGVIWIGEFRG----------QRVAVKQMHE------LIKSDE-------------------YMELLHREINTMSQLRHPNLLQFIGAVLDHP--
.|.|| |... |..||          . ||||....       ..|.|                   ... . .||. ||.|||||..||.|.... |  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------SGNPMIITEVM-DTSLRSTYERKELTTDPGCRPVILSIMRDVAVGLNYLHC--L----PDPIIHRDVSSANVLLESKGH----------NK
         .|...|..| .   ||....            ........|.| |.||||        . ||||||  |.|.|. ....          . 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

WKTKISDFGSAKF
|. ||.||| ..|
WCCKICDFGLSRF
Kinase AqueK518.AA TKL-Unique 451-603 31 7.3e-28 95.42 In-house 3-167 (290) Show / Hide 
Range on Protein: 451-603
Range on HMM: 3-167/290
Sequence Identity: 31% (53 aa)

KELGRGGWGVIWIGEFRGQRVAVKQMHELIKSD-EYMELLHREINTMSQLR-HPNLLQFIGAVLDHPSGNP--MIITEVMDT-SLRSTYE---------R
. .|.|| |..  |..||  ||.|| |.. .|  | |. ...|.|.|. |. |||.....|.  ||   .|   |..| ..  ||..            .
NKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

KELTTDPGCRPVILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESK-GHNKWKTKISDFGSAKFA
.... ..    ..... .|.| |..||| .  ||||||  | |.|. ..   ..|. ||.||| .||.
NNCKLNMQ---QRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFN
Kinase AqueK518.AA Dicty4 450-598 31 9.5e-24 76.22 In-house 4-159 (277) Show / Hide 
Range on Protein: 450-598
Range on HMM: 4-159/277
Sequence Identity: 31% (51 aa)

KKELGRGGWGVIWIGEFRGQRVAVKQM--HELIKSDEYMELLHREINTMSQLRHPNLLQFIGAVL--DHPSGNPMIITEVM-DTSLRSTYER------KE
 ...|.|. |    |  ||. |||| .  |    . . .. ...|.. |...||||...| || .     .| ..| || |  ..| |          ..
EQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQS

LTTDPGCRPVILS---IMRDVAVGLNYLHC-LPDPIIHRDVSSANVLLESKGHNKWKTKISDFG
 . |    | |..   ...|.| |.|.|||  |. |||||  |.| |        |. |..|||
IKLD---WPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVD----KNWRVKVCDFG
Kinase AqueK518.AA TK 447-605 15 1.6e-23 75.04 In-house 1-308 (486) Show / Hide 
Range on Protein: 447-605
Range on HMM: 1-308/486
Sequence Identity: 15% (49 aa)

SLSKKELGRGG---WGVIWIGEFRG---------------------------QRVAVKQMHEL--IKSDEYME-LLH---------REINTMSQLR----
    |.||.|    .|... || ||                           ..||||...|     ..| ..  .|         .| . |....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLLQFIGAVLDHPS----------GNPMIITEVMD-TS----LRSTYERKE----------------------------------------------
 |||.....|..... .          . .||..| |.  .    ||.   ..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------LTTDPGCRPVILS-------------------IMRDVAVGLNYLHCLPD----PIIHRDVSSANVLLESKGHNKWK-------TKISDFGSAK-
      .  .| .    |.                   .....| |. ||| ..      ..|||.   |.|. .....||.        ||.||| .. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----FARA
     ||.
GSGVLARD
Kinase AqueK518.AA STE 448-601 22 3.7e-23 78.68 In-house 1-195 (359) Show / Hide 
Range on Protein: 448-601
Range on HMM: 1-195/359
Sequence Identity: 22% (46 aa)

LSK-KELGRGGWGVIWIG-----------------EFRGQRVAVKQMH---------------ELIKSDEYMELLHREINTMSQLR--HPNLLQFIGAVL
. . ...|.|. |.   .                 .  |...|.|||.                 .| .| |. . .||..|....  |||  ...|. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DH---PSG--NPMIITEVMD-TSLRSTYER--KELTTDPGCR--------PVILSIMRDVAVG-LNYLHCLPDPIIHRDVSSANVLLESKGHNKWKTKIS
.     .   .  |. | ||  ||.. ...  . . ...  |        ..|  | |..  | |.||| .   |||||. .||.||          |..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL---------VKLC

DFGSAK
||| ..
DFGVCG
Kinase AqueK518.AA Pkinase 447-602 25 5.7e-18 64.61 Pfam 1-161 (293) Show / Hide 
Range on Protein: 447-602
Range on HMM: 1-161/293
Sequence Identity: 25% (43 aa)

SLSKKELGRGGWGVIWIGEFRGQR--VAVKQMH-ELIKSDEYMELLH-REINTMSQLRHPNLLQFIGAVLDHPSGNPMIITEVMDT-----SLR---STY
   .. .|.|. |. ...  .| .  ||||..  . .||.. ..... .||  |  |.||| ....... |  .... ...| ..      .|    || 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

ERKEL--TTDPGCRPVILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGHNKWKTKISDFGSAKF
... .  . .     .. ..|. .. ||.|.|     |||||. ..|.|. ..||.. . ||.|||.||.
RHGCFYFSEW-----ECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQ
Kinase AqueK518.AA CZAK 450-598 31 6.7e-18 61.71 In-house 4-167 (279) Show / Hide 
Range on Protein: 450-598
Range on HMM: 4-167/279
Sequence Identity: 31% (54 aa)

KKELGRGGWGVIWIGEFRGQRVAVKQMHELIK---SDEY--MELLHREINTMSQLRHPNLLQFIGA-VLDHPSGNPMIITEVMD-TSLRSTY-ERKELTT
 .. |.|  | .  .  ||  ||.| .| ...    ||    .   .|.  || |.||| .||.||  .| |     |..| |   |||    ..  .  
GQTIGQGFFGEVYKAYWRGKDVAIKIIH-RNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGP-NHHCIVMEWMGGGSLRRLLTDHYFYHK

D-PGCRPVILSIMRDVAVGLNYLHC--LPDPIIHRDVSSANVLLESKGH---------NKWKTKISDFG
  |  .   ... .|.| | ||||    | ||.||| || |.||..               . ||.|||
QNPHLQ---WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFG
Pkinase_Tyr AqueK518.AA Pkinase_Tyr 446-524 26 8.1e-17 57.59 Pfam 1-87 (270) Show / Hide 
Range on Protein: 446-524
Range on HMM: 1-87/270
Sequence Identity: 26% (24 aa)

VSLSKKELGRGGWGVIWIGEFR------GQRVAVKQMHELIKSDE-YMELLHREINTMSQL-RHPNLLQFIGAVL--DHPSGNPMIITE
...  |.||.|  |... |. .      .. |||| . |   ... ..| . ||...|.|| .|||.....|...  . |. ...|..|
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVME
Kinase AqueK518.AA DRK 454-526 40 3.7e-16 51.27 In-house 8-79 (258) Show / Hide 
Range on Protein: 454-526
Range on HMM: 8-79/258
Sequence Identity: 40% (30 aa)

GRGGWGVIWIGEFRGQRVAVKQMHELIKS-DEYMELLHREINTMSQLRHPNLLQFIGAVLDHPSGNPMIITEVM
|||..| .. |  ||  |||| .  .     . .  .||||| |.||||||  ||.|. .  |.  . |..| |
GRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPD--ICICMEYM
Kinase AqueK518.AA LISK 452-510 37 3.7e-15 45.51 In-house 1-64 (296) Show / Hide 
Range on Protein: 452-510
Range on HMM: 1-64/296
Sequence Identity: 37% (24 aa)

ELGRGGWGVIWIGEFR--GQRVAVKQMHEL---IKSDEYMELLHREINTMSQLRHPNLLQFIGA
|.|.|. | .  |. |  || .|.|. |..    . .||   . ||. .|  ||||| .||.|.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGV
Kinase AqueK518.AA HH498 547-602 43 3.2e-14 41.11 In-house 121-173 (284) Show / Hide 
Range on Protein: 547-602
Range on HMM: 121-173/284
Sequence Identity: 43% (25 aa)

PVILSIMRDVAVGLNYLHC-LPDPIIHRDVSSANVLLESKGHNKWKTKISDFGSAKF
. .. |  ||| | ||||  |. ||||||  | |.|.   ||     .. |||   |
QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGH----AVVADFGESRF
Kinase AqueK518.AA MLK 447-524 28 1.5e-13 43.54 In-house 1-90 (291) Show / Hide 
Range on Protein: 447-524
Range on HMM: 1-90/291
Sequence Identity: 28% (26 aa)

SLSKKELGRGGWGVIWIGEFRGQR-----VAVKQMH---ELIKSDEY--MELLHREINTMSQLRHPN----LLQFIGAVLDHPSGNPMIITE
 . .. .| |. |. | |..|...     ||||. .   .  |||.|   . . .|..  . |.|||      || |. |..|  .  |..|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP-CHFCIVME
Kinase AqueK518.AA MLK 548-619 29 2.9e-13 42.47 In-house 125-202 (291) Show / Hide 
Range on Protein: 548-619
Range on HMM: 125-202/291
Sequence Identity: 29% (23 aa)

VILSIMRDVAVGLNYLHC-LPDPIIHRDVSSANVLLES--KGHNKWKTKISDFGSAKFARAA---VTAAPGAAVYSAP
...... ..| |..|||. .|.||||||  | |.|.    .  .. . ||.||| ...        . ..| . . ||
HAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAP
Kinase AqueK518.AA S_TKc 447-641 17 5.5e-11 -15.84 SMART 1-230 (231) Show / Hide 
Range on Protein: 447-641
Range on HMM: 1-230/231
Sequence Identity: 17% (44 aa)

SLSKKELGRGGWGVIWIGEFRG--QRVAVKQMHELIKSDEYMELLHREINTMSQLRHPNLLQFIGAVLDHPSGNPMIITEVMDT---SLRSTYERKEL--
    ...|.|. |. . .  ..  ..||.|...         | . |||. ... .|||. .....  |   ..  ...| .|.   .|..  ...    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TTDPGCRPVILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGHNKWKTKISDFGSAKFARAAVTAAPGAAVYSAP-------------------A
.  |    .. ..|. .. .|.|.| .   |||||.  .|.|| .        ||.|||.|..     |   |   | ||                   .
LRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILY

TLAT-----------------------------IHRKKRRQTPKMDS-------HSY
 ...                                .||    .          | .
EMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW
TyrKc AqueK518.AA TyrKc 446-641 17 5.7e-11 -45.24 SMART 1-280 (280) Show / Hide 
Range on Protein: 446-641
Range on HMM: 1-280/280
Sequence Identity: 17% (52 aa)

VSLSKKELGRGGWGVIWIGEFRGQRVAVKQMHELIKSDEYMELLHREINTMSQL--RHPNLLQFIGAVLDH-----PSGNPMIITEVMDT-SLRSTYERK
..| || ||.|  |... |. . . |||| ..|       .| ..||.. |..|  .|||.....|.....      .. .||..| |.  .|..   ..
ITLGKK-LGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

ELTTDPGCRPVILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGHNKWKTKISDFGSAKFARAA--------VTAA----PGA------------
. .    | .  ||.. ..| | .|||    ..||||    |.|. ...      |||||| ...            .  .     |             
RPK---LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

------------------------------AV-----YSAPATLATIHRKKRRQTPKMD---------------------------------SHSY
                                      |.   .. . . .|.  |. |                                  .  
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK518.AA DRK 547-598 42 2.4e-09 27.82 In-house 98-145 (258) Show / Hide 
Range on Protein: 547-598
Range on HMM: 98-145/258
Sequence Identity: 42% (22 aa)

PVILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGHNKWKTKISDFG
| ....| |.| |..||||    |||||  | | |        |. |..|||
PLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVD----EHWQVKVADFG
Kinase AqueK518.AA HH498 450-516 36 6.4e-08 20.78 In-house 4-76 (284) Show / Hide 
Range on Protein: 450-516
Range on HMM: 4-76/284
Sequence Identity: 36% (27 aa)

KKELGRGGWGVIWIGEFRGQRVAVK---QMHELIKSDEY---MELLHREINTMSQLRHPNLLQFIGAVLDHPS
..  | |  | .  ||.|.  ||||    |  . ||| |      . ||.  |..| ||.  ||..| .| ||
HEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPS
Kinase AqueK518.AA LISK 554-598 44 2e-06 16.52 In-house 108-150 (296) Show / Hide 
Range on Protein: 554-598
Range on HMM: 108-150/296
Sequence Identity: 44% (20 aa)

RDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGHNKWKTKISDFG
.|.| |. |||     |||||  | |.|.  .. | |. |. |||
LDIACGMSYLHS--MNIIHRDLKSKNCLVRENDNNQWRIKVCDFG
Kinase AqueK518.AA Pkinase_Tyr 549-598 34 5e-06 21.06 Pfam 113-156 (270) Show / Hide 
Range on Protein: 549-598
Range on HMM: 113-156/270
Sequence Identity: 34% (17 aa)

ILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGHNKWKTKISDFG
.|.. ...| |..||.  .  .||||.   |.|...   |. . ||.|||
LLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE---NN-VVKICDFG